2026-07-06T10:28:22-05:00 2025-09-30 420714325 RSM US LLP 1001 WATER ST STE 500 TAMPA FL 33602 990 2024-10-01 521238026 AMERICAN INSTITUTE FOR CANCER RESEARCH AMER 2023287744 1560 WILSON BOULEVARD 425 ARLINGTON VA 22209 JOHN MCCALLA SECRETARY 2023287744 2026-07-05 1 1 KRISTEN BARNETT P01234578 8133162300 2026-07-05 2024 2025-03-06 01:10:19Z JOHN MCCALLA 1560 WILSON BOULEVARD 425 ARLINGTON VA 22209 14944912 0 X WWW.AICR.ORG X 1981 DC AICR'S PRIMARY OBJECTIVES ARE TO PROMOTE, EXPAND, AND ENCOURAGE PUBLIC KNOWLEDGE ON HOW THE RISK OF CANCER IS REDUCED BY HEALTHY FOOD AND NUTRITION, PHYSICAL ACTIVITY, AND WEIGHT MANAGEMENT, THE CAUSES AND TREATMENT OF CANCER IN GENERAL, AND TO FUND, SUPPORT, AND ENCOURAGE INNOVATIVE SCIENTIFIC RESEARCH AS TO THE CAUSES, PREVENTION, AND TREATMENT OF CANCER. 7 7 31 26098 0 0 8592095 8944882 1280717 1121572 692898 832400 143680 112338 10709390 11011192 1393198 2636163 0 0 2536887 2547390 484998 263166 2372336 6149806 6545815 10564889 11992534 144501 -981342 17919717 17759055 4615514 5142193 13304203 12616862 X AICR CHAMPIONS THE LATEST AND MOST AUTHORITATIVE SCIENTIFIC RESEARCH FROM AROUND THE WORLD ON CANCER PREVENTION AND SURVIVAL THROUGH DIET, WEIGHT AND PHYSICAL ACTIVITY, SO THAT WE CAN HELP PEOPLE MAKE INFORMED LIFESTYLE CHOICES TO REDUCE THEIR CANCER RISK. 0 0 5223172 698136 1112016 SEE SCHEDULE O. EDUCATIONEDUCATION PROGRAMSTHE AMERICAN INSTITUTE FOR CANCER RESEARCH (AICR) CHAMPIONS THE LATEST AND MOST AUTHORITATIVE SCIENTIFIC RESEARCH ON CANCER PREVENTION AND SURVIVAL THROUGH DIET, WEIGHT AND PHYSICAL ACTIVITY SO THAT WE CAN HELP PEOPLE MAKE INFORMED LIFESTYLE CHOICES TO REDUCE THEIR RISK.AICR'S EDUCATION PROGRAMS ARE EVIDENCE-BASED. THIS EVIDENCE COMES FROM BOTH THE RESEARCH WE FUND, AND THE CONCLUSIONS DRAWN IN OUR SCIENTIFIC REPORTS. FROM THESE FINDINGS WE PRODUCE EDUCATIONAL MATERIALS TO MEET A WIDE VARIETY OF NEEDS, ACROSS ALL STAGES OF THE CANCER CONTINUUM.NEWSLETTERS AND EDUCATIONAL EMAILSAICR'S CURRENTLY ACTIVE COMMUNICATIONS COVER THREE CORE AREAS: HOW TO START LIVING FOR LOWER CANCER RISK TODAY; BREAKING NEWS AND CURRENT RESEARCH IN THE FIGHT AGAINST CANCER; AND RESEARCH, RECIPES AND FOODS THAT HELP SURVIVORS NAVIGATE THEIR CANCER JOURNEY. IN FY25, AICR MAILED 563,919 PRINT NEWSLETTER PIECES AND INCLUDED LINKS TO DOWNLOADABLE NEWSLETTERS IN CANCER FOCUS EMAILS. CANCER FOCUS EMAIL SENDS TOTALED 1,506,771.VOLUNTEERSIN FY25, AICR WORKED WITH 26,098 VOLUNTEERS TO PROVIDE NEIGHBORHOOD EDUCATIONAL MATERIALS AND HELP RAISE FUNDS TO FURTHER ITS MISSION.AICR WEBSITE, BLOG AND DIGITAL RESOURCESIN FY25, MORE THAN ONE MILLION USERS ACCESSED AICR'S WEBSITE, BLOG AND DIGITAL RESOURCES FOR EVIDENCE-BASED INFORMATION ON CANCER PREVENTION AND SURVIVORSHIP. MONTHLY REPORTING CONSISTENTLY SHOWED STRONG INTEREST IN PRACTICAL FOOD AND NUTRITION CONTENT, INCLUDING FOOD FACTS, RECIPES, CANCER PREVENTION GUIDANCE AND CONSUMER NUTRITION ARTICLES. AICR ALSO SUPPLIED MORE THAN 14,000 PDF RESOURCE DOWNLOADS DURING THE YEAR.HEALTHY10 CHALLENGETHE HEALTHY10 CHALLENGE IS A 10-WEEK, FREE, INTERACTIVE ONLINE PROGRAM DESIGNED TO HELP INDIVIDUALS IMPROVE THEIR DIET, NUTRITION, PHYSICAL ACTIVITY AND WEIGHT FOR LOWER CANCER RISK AND BETTER OVERALL HEALTH. IN FY25, MORE THAN 16,000 USERS ACCESSED HEALTHY10 CHALLENGE CONTENT, INCLUDING WEEKLY GOALS AND PRACTICAL DOWNLOADABLE TOOLS SUCH AS SHOPPING GUIDES, PRODUCE GUIDES AND PANTRY CHECKLISTS.CANCER HEALTH CHECKCANCER HEALTH CHECK IS AN ONLINE ASSESSMENT TOOL TO HELP INDIVIDUALS UNDERSTAND HOW THE LIFESTYLE CHOICES THEY MAKE EVERY DAY CAN REDUCE THEIR RISK FOR CANCER. IN FY25, THOUSANDS OF USERS ACCESSED THE TOOL AND ITS RESULTS PAGES, AND AICR CONTINUED TO SEE ONLINE ACCESS TO ITS SPANISH, FRENCH AND PORTUGUESE CANCER HEALTH CHECK CONTENT.LIVING WITH CANCER AND BEYOND: CANCER RESOURCE PROGRAMAICR CONTINUED TO SEE INTEREST IN ITS LIVING WITH CANCER AND BEYOND CANCER RESOURCE PUBLICATIONS AND INFORMATION, WHICH PROVIDE PRACTICAL GUIDANCE FOR NEWLY DIAGNOSED CANCER PATIENTS AND THEIR LOVED ONES. 2770802 1938027 9556 SEE SCHEDULE O.RESEARCHRESEARCH PROGRAMSSCIENTIFIC STUDY OF THE RELATIONSHIP OF DIET, PHYSICAL ACTIVITY AND WEIGHT MANAGEMENT TO CANCER RISK AND SURVIVORSHIP CONTINUES TO BE THE PRIMARY FOCUS OF AMERICAN INSTITUTE FOR CANCER RESEARCH (AICR) RESEARCH INVESTMENT AND ACTIVITIES. EVIDENCE SHOWS THAT WEIGHT MANAGEMENT, PHYSICAL ACTIVITY, FOOD AND NUTRITION PLAY IMPORTANT ROLES IN CANCER PREVENTION, TREATMENT AND SURVIVORSHIP. RESEARCH SHOWS THAT APPROXIMATELY 40% OF ALL CANCERS COULD BE PREVENTED IF EVERYONE REACHED AND MAINTAINED A HEALTHY WEIGHT, FOLLOWED THE RECOMMENDATIONS FOR REGULAR PHYSICAL ACTIVITY, CONSUMED A HEALTHY DIET, AVOIDED USE OF TOBACCO PRODUCTS AND FOLLOWED APPROPRIATE SCREENING AND VACCINATION GUIDELINES.AICR IS UNIQUE IN ITS FOCUS ON PREVENTING CANCER AND IMPROVING SURVIVAL THROUGH DIET, NUTRITION, BODY COMPOSITION AND PHYSICAL ACTIVITY. WE COLLATE AND INTERPRET THE LATEST AND MOST AUTHORITATIVE GLOBAL SCIENTIFIC RESEARCH ON THE LINKS BETWEEN CANCER AND DIET, NUTRITION, BODY COMPOSITION AND PHYSICAL ACTIVITY. WE THEN TRANSLATE OUR FINDINGS INTO PRACTICAL, CLEAR, EVIDENCE-BASED RECOMMENDATIONS ON CANCER PREVENTION FOR USE BY HEALTH PROFESSIONALS, LAY INDIVIDUALS AND GOVERNMENTS WORLDWIDE.IN TOTAL, THROUGH FY25, AICR HAS COMMITTED MORE THAN $113 MILLION FOR HUNDREDS OF INDIVIDUAL RESEARCH PROJECTS AT UNIVERSITIES, HOSPITALS AND RESEARCH CENTERS.AICR PIONEERED THE FUNDING OF RESEARCH EXAMINING DIET AND CANCER AND WAS THE FIRST ORGANIZATION TO DEVOTE ITSELF TO STUDYING THE ROLE OF DIET AND OTHER LIFESTYLE FACTORS IN LOWERING CANCER RISK. THE RESEARCH THAT WE HAVE FUNDED HAS HELPED TRANSFORM THE ONCE-RADICAL NOTION THAT EVERYDAY CHOICES CAN DRAMATICALLY REDUCE CANCER RISK INTO A UNIVERSALLY ACCEPTED MEDICAL FACT AND PUBLIC HEALTH POLICY.OUR MULTI-FACETED INVESTMENT IN RESEARCH CONTINUES ACROSS SEVERAL CORE ACTIVITIES.AICR GRANT PROGRAMSTHE AICR GRANT PROGRAMS ARE DEDICATED TO FUNDING RESEARCH ON CANCER PREVENTION, TREATMENT AND SURVIVAL RELATED TO DIET, NUTRITION, BODY COMPOSITION AND PHYSICAL ACTIVITY. ALL APPLICATIONS ARE SUBJECTED TO RIGOROUS PEER REVIEW.INSPIRE RESEARCH CHALLENGEAICR CONTINUED THE INSPIRE RESEARCH CHALLENGE IN PARTNERSHIP WITH THE WORLD CANCER RESEARCH FUND (WCRF) INTERNATIONAL TO SUPPORT INNOVATIVE IDEAS FROM EARLY CAREER RESEARCHERS IN CANCER PREVENTION AND SURVIVORSHIP.FOR THE 2025 CYCLE OF THE INSPIRE RESEARCH CHALLENGE, 33 LETTERS OF INTENT WERE RECEIVED: 14 ON CANCER PREVENTION AND 19 ON CANCER SURVIVORSHIP. SIXTEEN APPLICANTS WERE INVITED TO SUBMIT FULL APPLICATIONS AND 16 APPLICATIONS WERE RECEIVED FOR PEER REVIEW.THE GRANT REVIEW PANEL WAS CHAIRED BY DR. RICHARD SIMPSON (UNIVERSITY OF ARIZONA) AND DR. ELLEN KAMPMAN (WAGENINGEN UNIVERSITY), WITH REVIEW FROM ADDITIONAL PANEL MEMBERS.REVIEWERSRICHARD SIMPSON, PHD, FACSM, UNIVERSITY OF ARIZONA (CHAIR)ELLEN KAMPMAN, PHD, WAGENINGEN UNIVERSITY (CO-CHAIR)YIKYUNG PARK, SCD, WASHINGTON UNIVERSITYKATHRYN BECK, PHD, PGDIPDIET, MASSEY UNIVERSITYCHRISTINA DAHM, PHD, AARHUS UNIVERSITYJAMES TURNER, PHD, FHEA, UNIVERSITY OF BIRMINGHAMCERI STEELE, LAY PANEL MEMBERINVESTIGATOR-INITIATED RESEARCH GRANT (IIG) PROGRAMFOR THE 2025 CYCLE OF THE INVESTIGATOR-INITIATED RESEARCH GRANT PROGRAM, WE RECEIVED 126 LETTERS OF INTENT: 51 ON CANCER PREVENTION, 55 ON CANCER SURVIVORSHIP AND 20 COVERING BOTH AREAS. WE INVITED 31 APPLICANTS TO SUBMIT FULL APPLICATIONS AND RECEIVED 31 FOR OUR GRANT PANEL TO REVIEW AND DISCUSS.THE GRANT REVIEW PANEL WAS CO-CHAIRED BY DR. PAUL SPAGNUOLO (ASSOCIATE PROFESSOR IN THE DEPARTMENT OF FOOD SCIENCE, UNIVERSITY OF GUELPH) AND DR. CARRIE DANIEL-MACDOUGALL (PROFESSOR OF EPIDEMIOLOGY, THE UNIVERSITY OF TEXAS MD ANDERSON CANCER CENTER). THE PANEL INCLUDED 12 ADDITIONAL EXPERTS WITH THE DEPTH AND BREADTH OF EXPERTISE TO EVALUATE THE SCIENTIFIC MERIT AND IMPACT OF THE PROPOSED RESEARCH.REVIEWERSJUSTIN BROWN, PHD, ADVENTIST HEALTH SYSTEM/SUNBELT, INC. DBA ADVENTHEALTH ORLANDODORATHA BYRD, PHD, MPH, H. LEE MOFFITT CANCER CENTER & RESEARCH INSTITUTE, INC.KATHERINE COOK, PHD, WAKE FOREST UNIVERSITY HEALTH SCIENCESILONA CSIZMADI, PHD, UNIVERSITY OF CALGARYMICHAEL DE LISIO, PHD, UNIVERSITY OF OTTAWACHRISTINA DIELI-CONWRIGHT, PHD, MPH, DANA-FARBER CANCER INSTITUTEHANSEUL KIM, PHD, HARVARD TH CHAN SCHOOL OF PUBLIC HEALTHEMILY LAVOY, PHD, UNIVERSITY OF HOUSTONGERARDO MACKENZIE, PHD, UNIVERSITY OF CALIFORNIA, DAVISERIK NELSON, PHD, UNIVERSITY OF ILLINOIS URBANA-CHAMPAIGNTONYA ORCHARD, PHD, RDN, THE OHIO STATE UNIVERSITYKERI SCHADLER, PHD, UNIVERSITY OF TEXAS M.D. ANDERSON CANCER CENTERFUNDED GRANTSIIG1. DIETARY FATTY ACID MODULATION FOR THE PREVENTION AND TREATMENT OF SQUAMOUS CELL CARCINOMAS. BRIAN CAPELL, MD, PHD, THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA.2. REAL-TIME TRACKING OF NEIGHBORHOOD ENVIRONMENTS AND ACTIVITY SPACES ON HEALTH BEHAVIORS, PERCEIVED STRESS AND WELL-BEING AMONG YOUNG ADULTS WITH CANCER. KATIE DARABOS, PHD, RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY-RBHS-SPH.3. DIETARY FIBER, GUT MICROBIOME, AND EARLY- AND LATER-ONSET COLORECTAL CANCER RISK IN A PROSPECTIVE STUDY OF MEXICAN WOMEN. MARTIN LAJOUS, DSC, NATIONAL INSTITUTE OF PUBLIC HEALTH OF MEXICO (INSTITUTO NACIONAL DE SALUD PUBLICA, INSP), MEXICO.4. IMPACT OF MENOPAUSAL TRANSITIONS AND HORMONE LEVELS ON WEIGHT LOSS IN PREMENOPAUSAL BREAST CANCER SURVIVORS: A COMPANION STUDY TO THE BREAST CANCER WEIGHT LOSS (BWEL) TRIAL. JENNIFER LIGIBEL, MD, DANA-FARBER CANCER INSTITUTE.5. REGULATION OF ENDOGENOUS AND MICROBIAL TRYPTOPHAN METABOLISM THROUGH A MEDITERRANEAN DIET AS A STRATEGY TO REDUCE CRC DISPARITIES. PATRICIA WOLF, PHD, PURDUE UNIVERSITY.6. SMART SCANS, STRONGER FUTURES: USING AI TO UNCOVER CT-BASED BODY COMPOSITION'S ROLE IN PEDIATRIC CANCER SURVIVORSHIP. PAUL YI, MD, ST. JUDE CHILDREN'S RESEARCH HOSPITAL, INC.INSPIRE (FUNDED BY THE WCRF/AICR NETWORK)7. IMPACT OF AN INTEGRATED NUTRITION AND EXERCISE PROGRAM FOR POST-TREATMENT SURVIVORS ON SLEEP QUALITY, PERCEIVED STRESS, AND BIOMARKERS OF IMMUNE DYSREGULATION. EMILY HILL, RDN, PHD, UNIVERSITY OF COLORADO ANSCHUTZ MEDICAL CAMPUS.8. REDUCING COLORECTAL CANCER RISK WITH CRICKET POWDER AND CHITIN: ANALYSIS OF EPIGENETIC AND INFLAMMATORY BIOMARKERS FROM A RANDOMIZED CONTROLLED TRIAL. CARMEN RODRIGUEZ-GARCIA, PHD, UNIVERSITY OF ALMERIA, SPAIN.AICR EXPERT REPORTSTHE GLOBAL CANCER UPDATE PROGRAMME (CUP GLOBAL) IS WORLD CANCER RESEARCH FUND INTERNATIONAL'S FLAGSHIP RESEARCH PROGRAMME, PROVIDING AN AUTHORITATIVE AND INDEPENDENT ASSESSMENT OF HOW DIET, NUTRITION, PHYSICAL ACTIVITY, AND BODY COMPOSITION AFFECT CANCER RISK AND SURVIVORSHIP. THROUGH TRANSPARENT AND RIGOROUS METHODS, CUP GLOBAL WORKS WITH COLLABORATORS AND AN INDEPENDENT PANEL OF INTERNATIONAL EXPERTS TO REVIEW EVIDENCE, INFORM RECOMMENDATIONS, SUPPORT GUIDANCE, AND IDENTIFY GAPS FOR FUTURE RESEARCH.IN FY25, CUP GLOBAL REPORTED A MAJOR DIETARY AND LIFESTYLE PATTERNS REPORT ON CANCER RISK AND A NEW PUBLICATION ON EARLY-LIFE BODY SIZE AND LATER COLORECTAL CANCER RISK. FY25 MATERIALS ALSO DESCRIBE PEER-REVIEWED FINDINGS ON ULTRA-PROCESSED AND PROCESSED FOOD CONSUMPTION AND COLORECTAL CANCER RISK; THE JOINT IMPORTANCE OF WAIST CIRCUMFERENCE AND PHYSICAL ACTIVITY FOR CANCER PREVENTION; EXCESS ADIPOSITY AND ELEVATED CANCER RISK; BODY MASS INDEX AND POSTMENOPAUSAL BREAST CANCER RISK; DIET QUALITY AND MORTALITY AMONG CANCER SURVIVORS; AND ADIPOSITY DISTRIBUTION ACROSS OBESITY-RELATED CANCERS. AICR ALSO USED PUBLIC-FACING MATERIALS TO POINT READERS TO PUBLISHED RESEARCH ON THE BENEFITS OF PHYSICAL ACTIVITY FOR COLON CANCER SURVIVORS.EXTERNAL EVENTSIN FY25, AICR REPRESENTATIVES PARTICIPATED IN THE SOCIETY OF BEHAVIORAL MEDICINE'S 2025 MEET THE FUNDERS NETWORKING SESSION, ENGAGING WITH RESEARCHERS ABOUT FUNDING PRIORITIES IN CANCER PREVENTION AND SURVIVORSHIP.PRESENTATIONSAICR ALSO SHARED RESEARCH FINDINGS WITH PROFESSIONAL AUDIENCES, INCLUDING A MARCH 2025 PRESENTATION TO THE AMERICAN COLLEGE OF LIFESTYLE MEDICINE CANCER MEMBER INTEREST GROUP ON RESEARCH REGARDING PHYSICAL ACTIVITY FOR COLON CANCER SURVIVORS.PEER-REVIEWED PUBLICATIONSFY25 MATERIALS REPORT PEER-REVIEWED FINDINGS ON ULTRA-PROCESSED AND PROCESSED FOOD CONSUMPTION AND COLORECTAL CANCER RISK; THE JOINT IMPORTANCE OF WAIST CIRCUMFERENCE AND PHYSICAL ACTIVITY FOR CANCER PREVENTION; EXCESS ADIPOSITY AND ELEVATED CANCER RISK; BODY MASS INDEX AND POSTMENOPAUSAL BREAST CANCER RISK; DIET QUALITY AND MORTALITY AMONG CANCER SURVIVORS; AND ADIPOSITY DISTRIBUTION ACROSS OBESITY-RELATED CANCERS. AICR ALSO USED PUBLIC-FACING MATERIALS TO POINT READERS TO PUBLISHED RESEARCH ON THE BENEFITS OF PHYSICAL ACTIVITY FOR COLON CANCER SURVIVORS. 7993974 1 1 0 0 0 0 0 0 0 1 1 0 1 1 1 1 1 0 0 0 1 1 0 1 1 0 0 1 0 1 0 0 0 0 0 0 0 1 0 0 0 0 0 1 1 1 0 0 1 X 34 0 1 31 1 0 1 UK NL HK FR 0 0 0 0 0 0 0 0 0 0 X 7 7 0 0 0 0 0 0 0 1 1 0 0 1 1 1 1 1 1 1 1 0 AL AR CA FL GA HI IL IN KS KY MD MA MI MN MS NH NJ NM NY NC OR PA RI SC TN VA WV WI ND CT OK X X JENNIFER MERCER 2023287744 1560 WILSON BOULEVARD 425 ARLINGTON VA 22209 X MARILYN GENTRY PRESIDENT 3.00 X X 0 0 0 JOHN MCCALLA BOARD CHAIR (09/25/25) & SECRETARY 2.00 X X 0 0 0 FRANK JACKSON HILL BOARD TREASURER 2.00 X X 0 0 0 MELVIN HUTSON BOARD MEMBER 2.00 X 0 0 0 JOSEPH SWARTZ BOARD MEMBER 2.00 X 0 0 0 TED WATSON BOARD MEMBER (02/20/25) 2.00 X 0 0 0 CAITLIN MAHONEY BOARD MEMBER (09/25/25) 2.00 X 0 0 0 JENNIFER MERCER SENIOR VP DEVELOPMENT 40.00 X 199611 0 34245 MICHAEL MCCARN CHIEF INFORMATION OFFICER 40.00 X 148022 0 36573 NIGEL BROCKTON VP RESEARCH 40.00 X 148358 0 36329 CYNTHIA L MATLACK CONTROLLER 40.00 X 132951 0 6436 MARY HOLLANDER SR. DIR. GOV. BOARD & EXEC SVCS 40.00 X 107457 0 29414 736399 0 142997 7 0 1 0 PRINT MAIL COMMUNICATIONS INC 4333 DAVENPORT ROAD FREDERICKSBURG VA 22408 DIRECT MAIL PROCESSING 1581726 SOUTHWEST PUBLISHING & MAILING CORP 4000 SE ADAMS ST 2 TOPEKA KS 66609 DIRECT MAIL PROCESSING 688308 THE DATA CENTER INC 9720 CAPITAL COURT SUITE 101 MANASSAS VA 20110 DATA PROCESSING FEES 514490 CHLORINE LLC 1627 L STREET NW SUITE 710 WASHINGTON DC 20006 REAL ESTATE MANAGEMENT 457483 DIRECT RESPONSE CONSULTING SERVICES 7918 JONES BRANCH DRIVE MCLEAN VA 22102 FUNDRAISING CONSULTANT 275653 11 50598 371112 8523172 20279 8944882 BROCHURE SALES 900099 1112016 1112016 SERVICE FEES 900099 9556 9556 1121572 412080 412080 4343738 3923418 420320 420320 420320 0 50598 10302 -10302 -10302 MAILING LIST RENTAL 900099 120763 120763 OTHER INCOME 900099 1877 1877 122640 11011192 1121572 0 944738 1219485 1219485 1416678 1416678 2040915 1212222 575616 253077 50241 18620 12235 19386 303804 151528 109893 42383 152430 76027 55138 21265 25968 13778 6205 5985 132799 70460 31732 30607 263166 263166 66294 44152 8982 13160 887820 610688 275026 2106 221077 125241 38659 57177 93651 55969 32502 5180 158151 88667 46136 23348 68534 29656 34739 4139 2775 2709 19 47 39757 39757 65640 65640 3417 1948 1025 444 22170 12637 6651 2882 POSTAGE & DELIVERY 1840352 1138562 50573 651217 PRINTING & PUBLICATION 1099876 683620 70811 345445 DATA PROCESSING 924577 425794 194255 304528 MAILHOUSE FEES 537769 309215 8535 220019 355188 220678 27735 106775 11992534 7993974 1626224 2372336 X 3259761 2007713 1291 1250757 3329472 3095673 2084946 1938853 104695 136021 276476 399833 404526 367789 32127 36737 2669918 2294270 7944621 8327363 1477462 1530305 17919717 17759055 693970 758805 1698011 2484928 2223533 1898460 4615514 5142193 X 5072350 5044640 8231853 7572222 13304203 12616862 17919717 17759055 X -981342 287463 6538 X X 0 1 X 1 0 X 10837807 12273935 10094745 8592095 8944882 50743464 10837807 12273935 10094745 8592095 8944882 50743464 2373959 48369505 208468 275814 237474 321671 345786 1389213 1555351 203990 155338 143680 122640 2180999 54313676 6381387 0.89060 0.88970 X SCHEDULE A, PART II, LINE 10, EXPLANATION OF OTHER INCOME: OTHER INCOME - 2020 AMOUNT: $ 1,555,351. 2021 AMOUNT: $ 203,990. 2022 AMOUNT: $ 155,338. 2023 AMOUNT: $ 143,680. 2024 AMOUNT: $ 122,640. RESTRICTED RESTRICTED RESTRICTED RESTRICTED RESTRICTED RESTRICTED RESTRICTED RESTRICTED 2549352 10500 292533 0 197002 0 2655383 2190339 31525 524382 196894 2549352 2084888 18145 261636 174330 2190339 2504791 290307 -537422 172788 2084888 2045005 297100 367867 205181 2504791 0.15000 0.26000 0.59000 0 0 5900 5900 3625 690 2935 320343 301381 18962 74658 65718 8940 36737 CHARITABLE GIFT ANNUITIES 1321829 F CHARITABLE REMAINDER UNITRUSTS 899620 F CANCER RESEARCH FUND 6105914 F 8327363 BENEFICIAL INT. IN PERPETUAL TRUST 380884 DUE FROM AFFILIATES 555058 RIGHT OF USE ASSETS 594363 1530305 LIABILITY CHARITABLE GIFT ANNUITIES 687458 LIABILITY CHARITABLE REMAINDER 352450 RIGHT OF USE LIABILITIES 608552 DEFERRED RENT 250000 1898460 X 11249201 287463 6538 294001 10955200 66294 -10302 55992 11011192 11936542 10302 10302 11926240 66294 66294 11992534 PART V, LINE 4: THE ORGANIZATION'S ENDOWMENT FUNDS ARE ESTABLISHED TO FURTHER THE MISSION OF THE AMERICAN INSTITUTE FOR CANCER RESEARCH. THE PERSON ESTABLISHING THE FUND DESIGNATED THE PURPOSE OF THEIR FUND, (I.E., CANCER RESEARCH, EDUCATION OR GENERAL OPERATING). PART X, LINE 2: THE INSTITUTE IS RECOGNIZED AS EXEMPT FROM FEDERAL INCOME TAX UNDER SECTION 501(C)(3) OF THE INTERNAL REVENUE CODE ON INCOME OTHER THAN UNRELATED BUSINESS INCOME. NO PROVISION FOR INCOME TAXES IS REQUIRED AS OF SEPTEMBER 30, 2025 AND 2024, SINCE THE INSTITUTE HAD NO UNRELATED BUSINESS INCOME. THE INSTITUTE HAS BEEN RECOGNIZED BY THE INTERNAL REVENUE SERVICE AS A PUBLICLY SUPPORTED ORGANIZATION AND IS THEREFORE NOT A PRIVATE FOUNDATION. MANAGEMENT ANNUALLY REVIEWS ITS TAX POSITION AND HAS DETERMINED THAT THERE ARE NO UNCERTAIN TAX POSITIONS THAT REQUIRE RECOGNITION IN THE FINANCIAL STATEMENTS. PART XI, LINE 2D - OTHER ADJUSTMENTS: CHANGE IN VALUE OF SPLIT INTEREST AGREEMENT LIABILITY - ANNUITIES -18,960. LOSS ON FOREIGN EXCHANGE TRANSACTIONS -16,796. NET GAIN ON INTEREST IN PERPETUAL TRUST 9,555. CHANGE IN VALUE OF SPLIT INTEREST AGREEMENT LIABILITY - ANNUITIES 32,739. PART XI, LINE 4B - OTHER ADJUSTMENTS: FUNDRAISING EXPENSES INCLUDED IN PART VIII -10,302. PART XII, LINE 2D - OTHER ADJUSTMENTS: FUNDRAISING EXPENSES INCLUDED IN PART VIII 10,302. 1 EUROPE (INCLUDING ICELAND & GREENLAND) 0 0 GRANTMAKING 1169248 NORTH AMERICA 0 0 GRANTMAKING 247430 0 0 0 0 0 0 1416678 0 1416678 EUROPE (INCLUDING ICELAND & GREENLAND) RESEARCH 100000 WIRE 0 EUROPE (INCLUDING ICELAND & GREENLAND) EDUCATION 1069248 WIRE 0 NORTH AMERICA RESEARCH 247430 WIRE 0 3 0 0 0 1 0 0 0 PART I, LINE 2: AT THE END OF THE FIRST YEAR OF ANY TWO-YEAR GRANT, THE PRINCIPAL INVESTIGATOR MUST SUBMIT A PROGRESS REPORT, INCLUDING ABSTRACTS AND PUBLICATIONS OF RESEARCH SUPPORTED IN WHOLE OR IN PART BY AICR. AT THE DISCRETION OF AICR, FUNDS FOR THE SECOND YEAR OF THE GRANT MAY BE WITHHELD BASED ON THE PROGRESS REPORT OR IF PROGRESS REPORTS ARE NOT SUBMITTED. FINAL SCIENTIFIC REPORT: WITHIN THREE MONTHS OF THE COMPLETION OF THE GRANT PERIOD, AICR REQUIRES A FINAL COMPREHENSIVE REPORT TO OUTLINE THE PROJECT'S ACCOMPLISHMENTS. FAILURE TO SUBMIT A FINAL REPORT WILL RESULT IN AUTOMATIC DISQUALIFICATION FROM SUBMITTING A GRANT APPLICATION TO AICR FOR TWO YEARS. FINAL FINANCIAL REPORT: A FINAL REPORT OF EXPENDITURES MUST BE SUBMITTED WITHIN THREE MONTHS OF THE TERMINATION OF THE GRANT, TOGETHER WITH THE REFUND OF ANY UNSPENT FUNDS. UNSPENT FUNDS FROM AN EXISTING GRANT MAY ONLY BE CARRIED FORWARD AS A NO-COST EXTENSION TO THE GRANT TERM WITH THE WRITTEN PERMISSION OF AICR. BEFORE GRANT RECOMMENDATIONS ARE PRESENTED TO THE BOARD OF DIRECTORS FOR APPROVAL, ALL APPLICANTS ARE CHECKED AND CLEARED AGAINST THE FOLLOWING TERRORIST WATCH LISTS: SPECIALLY DESIGNATED NATIONALS (SDN), STATE DEPARTMENT TERRORIST EXCLUSIONS LIST, UNITED NATIONS CONSOLIDATED LIST WITH RESPECT TO AL-QAEDA, THE TALIBAN, AND THE EUROPEAN UNION TERRORIST LIST. PART I, LINE 3: GRANTMAKING EXPENDITURES ARE RECORDED ON THE ACCRUAL BASIS. X X X X X 1 DIRECT RESPONSE CONSULTING 7918 JONES BRANCH DRIVE MCLEAN VA 22102 DIRECT MAIL 0 3664141 234108 3430033 INFOCISION MANAGEMENT CORP 325 SPRINGSIDE DR AKRON OH 44144 PHONE 0 128398 29058 99340 3792539 263166 3529373 AL AR CA FL GA HI IL IN KS KY MD MA MI MN MS NH NJ NM NY NC OR PA RI SC TN VA WV WI ND CT OK LONDON MARATHON 25714 25714 294 PUTT FORE PREVENTION 24884 24884 10008 50598 50598 10008 294 10302 -10302 SCHEDULE G, PART I: PAYMENTS TO INFOCISION MANAGEMENT CORPORATION INCLUDE FEES FOR PROFESSIONAL FUNDRAISING SERVICES PLUS FUNDRAISING EXPENSES - LIST DEVELOPMENT, DATA PROCESSING, PRINTING AND MAILHOUSE FEES. INVOICES CLEARLY DISTINGUISH FUNDRAISING FEES FROM FUNDRAISING EXPENSES. ADDITIONAL COSTS, SUCH AS CAGING, BANK CHARGES, OTHER DATA PROCESSING AND POSTAGE ASSOCIATED WITH PHONE SOLICITATIONS ARE PAID DIRECTLY TO THE VENDOR AND THEREFORE NOT INCLUDED IN SCHEDULE G, COLUMN (V) AMOUNTS. PAYMENTS TO DIRECT RESPONSE CONSULTING SERVICES ARE FOR PROFESSIONAL FUNDRAISING SERVICES ONLY. ALL OTHER FUNDRAISING EXPENSES ASSOCIATED WITH DIRECT MAIL FUNDRAISING ARE PAID DIRECTLY TO THE VENDOR PROVIDING THE SERVICE AND THEREFORE NOT INCLUDED IN SCHEDULE G, COLUMN (V) AMOUNTS. 1 THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA 3451 WALNUT STREET 5TH FLR FRANKLIN BLDG PHILADELPHIA PA 191046205 231352685 501(C)(3) 167002 0 RESEARCH UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL PUBLIC HEALTH FOUNDATION INC PO BOX 309 CHAPEL HILL NC 275140309 561717285 501(C)(3) 375000 0 RESEARCH ST JUDE CHILDREN'S RESEARCH HOSPITAL 262 DANNY THOMAS PL MEMPHIS TN 381053678 620646012 501(C)(3) 164993 0 RESEARCH DANA-FARBER CANCER INSTITUTE 450 BROOKLINE AVENUE BOSTON MA 021155418 042263040 501(C)(3) 165000 0 RESEARCH PURDUE UNIVERSITY 2550 NORTHWESTERN AVE WEST LAFAYETTE IN 47906 356002041 501(C)(3) 165000 0 RESEARCH RUTGERS THE STATE UNIVERSITY OF NEW JERSEY 3 RUTGERS PLAZA NEW BRUNSWICK NJ 089018559 226001086 501(C)(3) 82490 0 RESEARCH UNIVERSITY OF COLORADO -ANSCHUTZ MEDICAL CAMPUS 13001 EAST 17TH PLACE AURORA CO 80045 846000555 501(C)(3) 100000 0 RESEARCH 7 0 PART I, LINE 2: PROGRESS REPORT: AT THE END OF THE FIRST YEAR OF ANY TWO-YEAR GRANT, THE PRINCIPAL INVESTIGATOR MUST SUBMIT A PROGRESS REPORT, INCLUDING ABSTRACTS AND PUBLICATIONS OF RESEARCH SUPPORTED IN WHOLE OR IN PART BY AICR. AT THE DISCRETION OF AICR, FUNDS FOR THE SECOND YEAR OF THE GRANT MAY BE WITHHELD BASED ON THE PROGRESS REPORT OR IF PROGRESS REPORTS ARE NOT SUBMITTED. FINAL SCIENTIFIC REPORT: WITHIN THREE MONTHS OF THE COMPLETION OF THE GRANT PERIOD, AICR REQUIRES A FINAL COMPREHENSIVE REPORT TO OUTLINE THE PROJECT'S ACCOMPLISHMENTS. FAILURE TO SUBMIT A FINAL REPORT WILL RESULT IN AUTOMATIC DISQUALIFICATION FROM SUBMITTING A GRANT APPLICATION TO AICR FOR TWO YEARS. FINAL FINANCIAL REPORT: A FINAL REPORT OF EXPENDITURES MUST BE SUBMITTED WITHIN THREE MONTHS OF THE TERMINATION OF THE GRANT, TOGETHER WITH THE REFUND OF ANY UNSPENT FUNDS. UNSPENT FUNDS FROM AN EXISTING GRANT MAY ONLY BE CARRIED FORWARD AS A NO-COST EXTENSION TO THE GRANT TERM WITH THE WRITTEN PERMISSION OF AICR. BEFORE GRANT RECOMMENDATIONS ARE PRESENTED TO THE BOARD OF DIRECTORS FOR APPROVAL, ALL APPLICANTS ARE CHECKED AND CLEARED AGAINST THE FOLLOWING TERRORIST WATCH LISTS: SPECIALLY DESIGNATED NATIONALS (SDN), STATE DEPARTMENT TERRORIST EXCLUSIONS LIST, UNITED NATIONS CONSOLIDATED LIST WITH RESPECT TO AL-QAEDA, THE TALIBAN, AND THE EUROPEAN UNION TERRORIST LIST. X X X 0 0 0 0 0 0 0 1 0 JENNIFER MERCER SENIOR VP DEVELOPMENT 179352 0 20000 0 259 0 6085 0 28160 0 233856 0 0 0 NIGEL BROCKTON VP RESEARCH 148060 0 0 0 298 0 4712 0 31617 0 184687 0 0 0 MICHAEL MCCARN CHIEF INFORMATION OFFICER 146423 0 0 0 1599 0 4612 0 31961 0 184595 0 0 0 PART I, LINE 7 THE ORGANIZATION PAID A ONE TIME BONUS PAYMENT TO THE SENIOR VP DEVELOPMENT WHO COVERED ADDITIONAL JOB RESPONSIBILITIES DUE TO THE RESIGNATION OF AN EXECUTIVE VICE PRESIDENT. DIRECT RESPONSE CONSULTING SERVICES 100% CONTROLLED ENTITY OF ONE OF THE FOUNDERS OF AICR 245724 FUNDRAISING CONSULTANT 0 FORM 990, PART VI, SECTION B, LINE 11B THE 990 FORM IS REVIEWED BY KEY STAFF IN THE AICR ACCOUNTING DEPARTMENT. THE 990 FORM IS THEN REVIEWED BY AICR EXECUTIVE MANAGEMENT, RSM TAX AND THE LAW FIRM STEPTOE & JOHNSON. FORM 990, PART VI, SECTION B, LINE 12C THE INSTITUTE'S BOARD OF DIRECTORS HAS A CONFLICT OF INTEREST POLICY IN EFFECT. A COPY OF THE POLICY IS PROVIDED TO EACH DIRECTOR, OFFICER AND STAFF MEMBER OF AICR WHO IS PRESENTLY SERVING IN A CAPACITY WHERE A CONFLICT OF INTEREST COULD ARISE. THE POLICY IS REVIEWED ANNUALLY. IF THE BOARD DETERMINES THAT CHANGES DO NOT NEED TO BE MADE, THE POLICY IS REAFFIRMED. NEW DIRECTORS, OFFICERS, AND STAFF MEMBERS ARE ADVISED OF THE POLICY IN EFFECT UPON TAKING OFFICE OR UPON THE START OF EMPLOYMENT, AS THE CASE MAY BE. SINCE FISCAL YEAR 2010, DIRECTORS, OFFICERS, EXECUTIVES, AND SENIOR LEVEL MANAGEMENT STAFF HAVE BEEN REQUIRED TO SIGN A "DECLARATION OF LACK OF CONFLICT OF INTEREST." THE POLICY PROVIDES THAT IN THE EVENT OF A CONFLICT OF INTEREST RELEVANT TO A MATTER REQUIRING ACTION BY THE BOARD, THE PERSON SHALL CALL IT TO THE ATTENTION OF THE BOARD (OR COMMITTEE OF THE BOARD, AS THE CASE MAY BE), AND SUCH PERSON SHALL NOT VOTE ON THE MATTER. THE PERSON HAVING A CONFLICT OF INTEREST SHALL PROVIDE THE BOARD (OR COMMITTEE OF THE BOARD, AS THE CASE MAY BE), WITH ANY AND ALL RELEVANT INFORMATION, AND SHALL RETIRE FROM THE ROOM IN WHICH THE BOARD (OR COMMITTEE OF THE BOARD, AS THE CASE MAY BE) IS MEETING CONCERNING SUCH MATTER, AND SHALL NOT PARTICIPATE IN THE FINAL DELIBERATION OR DECISION REGARDING THE MATTER UNDER CONSIDERATION. THE MINUTES OF THE MEETING OF THE BOARD (OR COMMITTEE OF THE BOARD, AS THE CASE MAY BE) SHALL REFLECT THAT THE CONFLICT OF INTEREST WAS DISCLOSED AND THAT THE INTERESTED PERSON WAS NOT PRESENT DURING THE FINAL DISCUSSION OF SUCH MATTER OR VOTE AND DID NOT VOTE ON SUCH MATTER. WHEN THERE IS A DOUBT AS TO WHETHER A CONFLICT OF INTEREST EXISTS, THE MATTER SHALL BE RESOLVED BY VOTE OF THE BOARD OF DIRECTORS (OR COMMITTEE OF THE BOARD, AS THE CASE MAY BE), EXCLUDING THE INTERESTED PERSON. FORM 990, PART VI, SECTION B, LINE 15 COMPARABILITY DATA IS USED TO DETERMINE COMPENSATION FOR ALL EMPLOYEES. SUCH DATA INCLUDES IRS FORM 990 INFORMATION FROM PEER NONPROFIT ORGANIZATIONS IN THE DC/MD/VA REGION, COMPENSATIONS SURVEYS, AS WELL AS OTHER INDEPENDENT AND RELEVANT MARKET DATA. THE COMPENSATION REVIEW PROCESS IS MANAGED BY THE HUMAN RESOURCES DIRECTOR. FINDINGS AND RECOMMENDATIONS ARE REVIEWED WITH THE APPROPRIATE SUPERVISORY PERSONNEL AND THE SENIOR VP OF DEVELOPMENT. SALARY INCREASES AND COMPENSATION ADJUSTMENTS ARE REVIEWED AND RECOMMENDATIONS ARE MADE BY SENIOR MANAGEMENT, SUBJECT TO BOARD APPROVAL. SALARIES AND COMPENSATION BENEFITS ARE INCORPORATED INTO THE ANNUAL BUDGET, WHICH IS REVIEWED AND APPROVED BY THE BOARD OF DIRECTORS AND DOCUMENTED CONTEMPORANEOUSLY IN THE MINUTES. FORM 990, PART VI, SECTION C, LINE 19 ALL GOVERNING DOCUMENTS AND FINANCIAL STATEMENTS ARE AVAILABLE TO THE PUBLIC UPON REQUEST FOR THE SAME PERIOD OF DISCLOSURE AS SET FORTH IN SECTION 6104(D). FORM 990, PART XI, LINE 9: CHANGE IN VALUE OF SPLIT INTEREST AGREEMENT LIABILITY - ANNUITIES -18,960. NET GAIN ON INTEREST IN PERPETUAL TRUST 9,555. CURRENCY LOSS -16,796. CHANGE IN VALUE OF SPLIT INTEREST AGREEMENT LIABILITY - TRUSTS 32,739. FORM 990, PART XII, LINE 2C: THE PROCESS FOR OVERSEEING THE AUDIT OF THE FINANCIAL STATEMENTS AND SELECTION OF AN INDEPENDENT ACCOUNTANT THAT AUDITED THE FINANCIAL STATEMENTS HAS BEEN CONSISTENT WITH PRIOR YEARS. WORLD CANCER RESEARCH FUND 140 PENTONVILLE RD LONDON UK N1 9FW AFFILIATED CHARITY UK AICR 1 WCRF (TRADING) LTD 1 BLOSSOM YARD FOURTH FLOOR LONDON UK E1 6RS LIST RENTAL UK WORLD CANCER RESEARCH FUND C 0 CHARITABLE REMAINDER TRUST 1560 WILSON BOULEVARD SUITE 1000 ARLINGTON VA 22209 UNITRUST CA N/A T 0 PERPETUAL TRUST 1560 WILSON BOULEVARD SUITE 1000 ARLINGTON VA 22209 PERPETUAL TRUST PA N/A T 0 0 1 0 0 0 0 0 0 0 0 0 0 0 0 0 1 1 0 0 WORLD CANCER RESEARCH FUND B 371112 CASH WORLD CANCER RESEARCH FUND P 30437 CASH WORLD CANCER RESEARCH FUND Q 39348 CASH SCHEDULE R, PART IV, COLUMN (C): A CHARITABLE REMAINDER TRUST IS DOMICILED IN CALIFORNIA.