2025-05-06T12:44:52-05:00 2024-09-30 814234542 BPM LLP 10 Almaden Boulevard Suite 1000 San Jose CA 951132238 990 2023-10-01 770207331 Palo Alto Veterans Institute for Research PALO 6502392800 3801 Miranda Avenue Palo Alto CA 94304 Elaine Staats CEO 6502392802 2025-05-01 1 1 Tamara L McInerney P00011797 4089616300 2025-05-01 2023 2025-03-06 01:10:19Z PAVIR Elaine Staats 3801 Miranda Avenue Palo Alto CA 94304 31694278 0 X www.pavir.org X 1988 CA Advancing veteran and public health through innovative research. 13 2 248 0 0 0 21413596 23286921 8615163 7728039 450437 602254 24202 29413 30503398 31646627 0 0 0 0 17658723 18983304 0 0 0 13077942 15371897 30736665 34355201 -233267 -2708574 20719365 17246189 12724388 12030150 7994977 5216039 X See Schedule OPAVIR's mission is advancing Veterans and public health through innovative research. PAVIR works with more than 100 Principal Investigators and 200 research staff to support basic science, clinical and health services research to realize its mission. PAVIR's diverse studies span the entire spectrum of health research from the investigation of diseases in the laboratory through testing new drug treatments and developing improved models of health care delivery to looking at outcomes both individually and on a large scale. PAVIR's research addresses health challenges that have been faced especially by Veterans, including post-traumatic stress disorder, traumatic brain injury, geriatric medicine, rehabilitation, sleep and other Veterans and public health issues. PAVIR's investigators have appointments at the VA Palo Alto Health Care System and most also hold appointments at the Stanford University School of Medicine. 0 0 1885114 1885114 All of Us Research Program. Principal investigators: Philip Tsao, Ph.D.The All of Us Research Program (All of Us) is a large collaborative initiative sponsored by the National Institutes of Health (NIH). All of Us includes a consortium of awardees from multiple institutions, including the Department of Veterans Affairs. All of Us is working to improve healthcare through research by building a diverse database of participant self-report information, biospecimens, and Electronic Health Records that can inform future research on a variety of health conditions.continued in Schedule OVA participation in All of Us is overseen by three Co-PIs, located at the VA Palo Alto Health Care System and the VA Boston Healthcare System. These two institutions serve as the Coordinating Centers for VA responsible for centralized recruitment, engagement campaigns, and compliance with program requirements. 1376923 611799 Cell Atlas of Human Intestinal Lumphoid Tissues and Changes in Crohn's Disease: Eugene Butcher, M.D. The Helmsley funded project is part of a multi-year research study designed to generate a comprehensive atlas of the gastrointentinal (GI) tract at single cell resolution. Our focus is on the lymphoid tissues and immune cells of the gut wall in healthy and Crohn's disease patients, and in cooperation with our colleagues from Lund University of Sweden, we have produced transcriptomal profiles of over a million cells representing both immune (esp CD4 lymphocytes) and stromal cell populations.continued in Schedule OThese data are being incorporated into public datasets with interactive interfaces to allow scientists throughout the world to mine them for insights into the healthy and diseased intestinal immune system. This year we continued integration efforts towards this end. In addition, we used our generated data with others for key insights into the complexity, tissue imprinting, and lineage-specific precursors within the mononuclear phagocyte compartment of the human intestines. And the project data generated at the VA Palo Alto supported our discovery of a novel lymphocyte trafficking program, the CXCL17-GPR25 axis that directs lymphocytes and controls immune responses and tolerance in non-intestinal mucosa including the airways, nose, eye, stomach, oral cavity, vagina and GU tract and biliary tract (Nature, 2024). The study has yielded over 25 peer reviewed manuscripts, with this seminal Nature study published in the last year. Additionally, presentations at both national and international meetings have been made to share the progress of this study. 1192502 1192502 Clinical Translation of Allogeneic Regenerative Cell Therapy for White Matter Stroke and Vascular Dementia: Irene Lorenzo Llorente, Ph.D.Stroke is the leading cause of adult disability and the second leading cause of dementia. White matter stroke (WMS) constitutes up to 30% of all stroke subtypes and it is a distinct process from "large artery stroke". continued in Schedule OWMS starts as small infarcts in deep penetrating blood vessels in the brain but progresses, accumulates, and expands from preexisting lesions into adjacent white matter to produce hemiparesis with incomplete recovery, gait abnormalities, cognitive decline, and difficulties in executive functioning that present as vascular dementia. Unlike "large artery stroke", WMS does not damage neuronal cell bodies but damages axonal tracts and glial cells. Therefore, a cell-based therapy that can replace lost glia and induce structural repair in WMS/VaD is of great promise. We have developed a unique allogenic human induced pluripotent stem cell (hiPSC) derived Glial Enriched Progenitor (GEP) cell therapy product for the treatment of WMS and VaD. We have demonstrated that hiPSC-GEPs transplanted into the brain after WMS/VaD promoted motor and cognitive recovery through 3 mechanisms of action: axonal growth, astrocytic modulation, oligodendrocyte differentiation, and remyelination. To date, we have also qualified the entire manufacturing process for the intended therapeutic candidate, hiPSC-GEPs, through safety, identity, purity, activity, and stability qualification assays. To demonstrate the scale-up manufacturing capabilities of the potential therapeutic product, we have developed a new cGMP manufacturing protocol and produced well above the necessary number of cells for phases 1 and 2 of a future clinical application. This preliminary work could pave the way for a faster route to pre-IND, FDA approval, and a future clinical application. 24816731 7728039 PAVIR is privileged to work with a large community of uniquely talented medical researchers across a broad spectrum of research areas as we fulfill our mission of advancing Veterans and public health through innovative research. The range of research activities is broad and includes special emphasis on major disease categories, all of which are prevalent in the VA's patient population. These include cardiovascular medicine, mental health, chronic inflammatory disease, stem cell/regenerative medicine, pain, sleep disorders, and many others. In addition to disease specific research, PAVIR is engaged in supporting research aimed at enhancing health care. PAVIR's research portfolio includes comparative studies in which research teams are learning which treatments are superior to others, how to augment or improve standard of care, as well as how to enhance the operation of health care. Furthermore, PAVIR is supporting educational activities, especially in areas of advancing clinical care for Veterans and fostering the professional development of our expert staff. 24816731 7728039 29271270 1 1 0 0 0 0 0 0 0 0 1 0 0 0 0 1 1 0 0 0 0 0 0 0 0 0 0 0 0 1 0 0 0 0 0 0 0 0 0 0 0 0 0 1 0 1 0 1 43 0 1 248 1 0 0 0 0 0 0 0 0 0 0 0 0 X 13 2 0 0 0 0 0 1 1 1 1 0 0 1 1 1 1 1 1 1 1 0 CA X Lily Ibragimov 6502392805 3801 Miranda Avenue Palo Alto CA 94304 X Odette Harris Director, Board Chair 1.00 40.00 X X 0 0 0 Paul Heidenreich Director, Secretary/Treasurer 0.50 40.00 X X 0 0 0 Maheen Adamson Director 0.50 40.00 X 0 0 0 Ngan Huang Director 0.50 40.00 X 0 0 0 Meghan Kemnec Statutory non-VA Director 0.50 X 0 0 0 Mike Kozal Statutory VA Director 0.50 40.00 X 0 0 0 Ware Kuschner Director 0.50 40.00 X 0 0 0 Jennifer Lee Statutory VA Director 0.50 40.00 X 0 0 0 Lawrence Leung Director, Audit Committee Chair 0.50 40.00 X 0 0 0 Payam Massaband Statutory VA Director 0.50 40.00 X 0 0 0 Jean Gurga Statutory VA Director 0.50 40.00 X 0 0 0 Robert Sloss Statutory non-VA Director 0.50 X 0 0 0 Philip Tsao Director to 9/30/24 0.50 40.00 X 0 0 0 Elaine Staats CEO 40.00 X 268411 0 64472 Lisa Clark HR Director 40.00 X 191158 0 17864 Mary L Thornton Director of Operations 40.00 X 181211 0 32236 Lily Ibragimov Director of Finance & Accounting 40.00 X 177437 0 31877 Allison Malate Associate Director of Sponsored Research 40.00 X 173275 0 30957 Xinguo Jiang Research Scientist II 40.00 X 153445 0 47503 Calvert Lee Clinical Research Manager 40.00 X 149154 0 42217 Stephanie L Hensey Data Base Analyst II 40.00 X 147124 0 31608 Jenny Nhu-Thuy Dao Accounting Manager 40.00 X 140647 0 43849 Kevin Chow System Administrator II 40.00 X 133512 0 45157 1715374 0 387740 36 0 1 0 0 19720182 3566739 23286921 Personnel reimbursements-VAPAHCS 541700 3754540 3754540 Medical research 541700 3490731 3490731 Government fees & contracts 541700 482768 482768 7728039 602254 602254 47651 47651 0 Miscellaneous income 900099 29413 29413 29413 31646627 7728039 0 631667 X 1242422 30012 1212410 13951113 11533728 2417385 943183 753957 189226 1703528 1288834 414694 1143058 889727 253331 44641 42574 2067 91568 91568 4743768 4651688 92080 108834 100389 8445 512952 290254 222698 193980 175406 18574 194770 194770 170001 129304 40697 233668 229805 3863 81029 81029 Subrecipients 6141808 6141808 Research material cost 2587654 2587654 Equipment maintenance 76765 76518 247 Other personnel cost 23540 492 23048 166919 154350 12569 34355201 29271270 5083931 0 2053321 2531128 14201612 8881528 3540479 4969563 141049 104137 3872226 3112393 782904 759833 20719365 17246189 3508152 4533705 9216236 7496445 12724388 12030150 X 6199789 4883176 1795188 332863 7994977 5216039 20719365 17246189 X -2708574 -64202 -6162 X 0 1 X 1 1 1 X VA Palo Alto Health Care System Palo Alto CA RESTRICTED RESTRICTED RESTRICTED RESTRICTED RESTRICTED RESTRICTED RESTRICTED RESTRICTED 3872226 3112393 759833 759833 X 31576263 -64202 -6162 -70364 31646627 0 31646627 34355201 0 34355201 0 34355201 Part X, Line 2: The Organization is a nonprofit corporation exempt from federal income tax under Internal Revenue Code Section 501(c)(3) and state income tax under California Revenue and Taxation Code Section 23701d. However, income from certain activities not directly related to the Organization's tax-exempt purpose may be subject to taxation as unrelated business income. The Organization qualifies for the charitable contribution deduction under IRC Section 170(b)(1)(A)(iii) and has been classified as an Organization that is not a private foundation under Section 509(a)(1). As of September 30, 2024 and 2023, the Organization had no unrecognized tax benefits or uncertain tax positions requiring accrual. Therefore, no provision for income taxes has been provided in the financial statements. Part XI, Line 2d - Other Adjustments: Returned Contributions -6,162. X X X 0 0 0 0 0 0 0 0 0 Elaine Staats CEO 268411 0 0 0 0 0 25515 0 38957 0 332883 0 0 0 Mary L Thornton Director of Operations 181211 0 0 0 0 0 16791 0 15445 0 213447 0 0 0 Lily Ibragimov Director of Finance & Accounting 177437 0 0 0 0 0 16431 0 15446 0 209314 0 0 0 Lisa Clark HR Director 191158 0 0 0 0 0 17239 0 625 0 209022 0 0 0 Allison Malate Associate Director of Sponsored Rese 173275 0 0 0 0 0 15937 0 15020 0 204232 0 0 0 Xinguo Jiang Research Scientist II 153445 0 0 0 0 0 14678 0 32825 0 200948 0 0 0 Calvert Lee Clinical Research Manager 149154 0 0 0 0 0 14098 0 28119 0 191371 0 0 0 Jenny Nhu-Thuy Dao Accounting Manager 140647 0 0 0 0 0 13813 0 30036 0 184496 0 0 0 Stephanie L Hensey Data Base Analyst II 147124 0 0 0 0 0 13822 0 17786 0 178732 0 0 0 Kevin Chow System Administrator II 133512 0 0 0 0 0 12376 0 32781 0 178669 0 0 0 Form 990, Part VI, Section A, line 7a PAVIR is a nonprofit corporation authorized by Title 38 US Code Sections 7361 through 7366 to be established at and affiliated with the Department of Veterans Affairs Palo Alto Health Care System (VAPAHCS). The referenced statute dictates that four Directors shall be those persons holding the VAPAHCS positions of Director, Chief of Staff, Associate Chief of Staff for Research and Associate Chief of Staff for Education. Form 990, Part VI, Section A, line 7b As stated in response to Form 990, Part VI, Line 7a above, VA has authority to impose requirements and restrictions on the organization through the referenced statute and regulations prescribed by the Secretary of Veterans Affairs. Form 990, Part VI, Section B, line 11b The Form 990 has been provided to all Board members for their review prior to the filing of related tax forms. Form 990, Part VI, Section B, line 12c Directors, officers and key employees complete training in and attest to compliance with PAVIR's conflict of interest policy, as well as disclosing interests which could give rise to conflicts, upon joining PAVIR and annually thereafter. Management tracks the dates, sends reminders and documents receipt of training, attestations, and disclosures, assuring compliance in each calendar year. Form 990, Part VI, Section B, line 15 Annually, PAVIR collects and analyzes market, salary survey and compensation study data based on comparable industry and revenue. The Board's Compensation Committee reviews the data, taking into account performance and accomplishments when establishing the CEO's compensation. The Compensation Committee keeps minutes of its meetings and reports its actions to the full Board. Key employees' salaries are set by the CEO utilizing information from PAVIR's annual salary schedules. Form 990, Part VI, Section C, line 19 The most resent audited financial statements are available on PAVIR's website Form 990, Part VII and Schedule J, Part II: We wrote to each of the 11 Board members who were compensated by the VA Palo Health Care System requesting permission to obtain his/her compensation information for the calendar year ended December 31, 2023. All members declined in writing to provide their compensation information. None of the Board members received compensation in relation to their duties as Board members of PAVIR. Form 990, Part IX, line 11g Outside Services: Program service expenses 1,580,296. Management and general expenses 19,402. Fundraising expenses 0. Total expenses 1,599,698. Non-employee personnel costs: Program service expenses 3,071,392. Management and general expenses 72,678. Fundraising expenses 0. Total expenses 3,144,070. Form 990, Part XI, line 9: Returned contributions -6,162. VA Palo Alto Health Care System 3801 Miranda Avenue Palo Alto CA 94304 941179505 Teaching hospital, providing a full range of patient care services CA 501(c)(1) N/A 0 0 0 0 0 0 0 0 0 0 0 0 1 1 1 1 1 1 0 0 VA Palo Alto Health Care System O 3754540 accrual VA Palo Alto Health Care System P 417293 accrual