2024-10-14T14:27:40-05:00 2023-11-30 861065772 DELOITTE TAX LLP 50 SOUTH SIXTH STREET SUITE 280 MINNEAPOLIS MN 55402 990 2022-12-01 522000823 VAN ANDEL RESEARCH INSTITUTE VANA 6162345000 333 BOSTWICK AVENUE NE GRAND RAPIDS MI 49503 TIMOTHY J MYERS VICE PRESIDENT & CAO 6162345368 2024-10-14 0 1 MORGAN DAHLKE P02279974 6123974000 2022 2024-10-15 13:58:12Z TIMOTHY J MYERS 333 BOSTWICK AVENUE NE GRAND RAPIDS MI 49503 340344367 0 X WWW.VAI.ORG X 1996 MI MEDICAL RESEARCH ORGANIZATION 5 4 554 0 13470 0 129397836 327656765 1224115 882195 2782256 99948 10374075 11372978 143778282 340011886 2745739 2717278 0 0 57365730 63920211 0 0 808463 53606869 45406956 113718338 112044445 30059944 227967441 219998295 197193153 264510310 16821217 -44512015 180371936 MEDICAL RESEARCH ORGANIZATION VAN ANDEL RESEARCH INSTITUTE IS AN INDEPENDENT BIOMEDICAL RESEARCH ORGANIZATION COMMITTED TO IMPROVING THE HEALTH AND ENHANCING THE LIVES OF CURRENT AND FUTURE GENERATIONS. 0 0 14124851 1077274 154671 DEPARTMENT OF EPIGENETICSSCHEDULE O PROVIDES FURTHER INFORMATION REGARDING THIS PROGRAM'S ACCOMPLISHMENTS. 10294816 183333 0 DEPARTMENT OF NEURODEGENERATIVE SCIENCESCHEDULE O PROVIDES FURTHER INFORMATION REGARDING THIS PROGRAM'S ACCOMPLISHMENTS. 7093531 287883 0 DEPARTMENT OF METABOLISM AND NUTRITIONAL PROGRAMMINGSEE SCHEDULE O FOR FURTHER INFORMATION ABOUT THIS PROGRAM'S ACCOMPLISHMENTS. 42414576 1168788 727524 42414576 1168788 727524 73927774 1 1 0 1 0 0 0 0 0 1 1 0 0 0 0 1 0 1 0 0 1 0 0 0 1 0 0 1 1 1 0 0 0 0 0 0 0 0 0 0 0 0 1 1 1 1 0 0 1 158 0 1 554 1 1 1 0 0 0 0 1 1 0 0 0 0 1 0 X 5 4 1 0 0 0 0 1 0 1 1 0 0 1 1 1 1 1 1 1 1 0 MI X TIMOTHY J MYERS VP & CAO 6162345368 333 BOSTWICK AVENUE NE GRAND RAPIDS MI 495032518 DAVID VAN ANDEL CHAIRMAN / CEO 23.00 17.00 X X 621229 0 230734 DR JAMES FAHNER TRUSTEE 1.00 1.00 X 9500 2000 0 DR MAX WICHA TRUSTEE 1.00 0.00 X 14000 0 0 DR MICHELLE LEBEAU TRUSTEE 1.00 0.00 X 9000 0 0 DR TOM DEMEESTER TRUSTEE (END 12/12/2022) 1.00 0.00 X 8000 0 0 DR RALPH DEBERARDINIS TRUSTEE (BEG. 11/20/2023) 1.00 0.00 X 2000 0 0 DR JANA HALL CHIEF OPERATIONS OFFICER 44.00 1.00 X 570615 0 199977 TIMOTHY MYERS V.P. & CHIEF FINANCIAL OFFICER 42.00 3.00 X 429420 0 141837 DR PETER JONES CHIEF SCIENTIFIC OFFICER & RES. DIR. 44.00 1.00 X 909200 0 313089 THOMAS CURRAN JR GENERAL COUNSEL 42.00 3.00 X 477531 0 145590 GERALD CALLAHAN CHIEF STRATEGIC OFFICER 43.00 2.00 X 470651 0 158502 KATHY VOGELSANG CHIEF INVESTMENT OFFICER 45.00 0.00 X 1100527 0 484712 AUSTIN WAY SENIOR PORTFOLIO MANAGER 45.00 0.00 X 454273 0 257548 DR PETER LAIRD DISTINGUISHED INVESTIGATOR 45.00 0.00 X 490598 0 101690 TED HEILMAN ASSOC DIRECT-SR. PORTFOLIO MGR. 45.00 0.00 X 707489 0 374712 DR GERD PFEIFER SR. SCIENTIFIC INVESTIGATOR 45.00 0.00 X 438778 0 68230 6712811 2000 2476621 126 0 1 0 HURON CONSULTING GROUP INC PO BOX 71223 CHICAGO IL 60694 CONSULTING SERVICES 1342423 TWO BY FOUR LTD 10 N DEARBORN SUITE 1000 CHICAGO IL 60602 CONSULTING SERVICES 1261455 MCPC INC 21500 AEROSPACE PARKWAY CLEVELAND OH 44142 HELPDESK SERVICES 512623 BLUEWATER TECHNOLOGIES INC 30303 BECK ROAD WIXOM MI 48393 AUDIO/VISUAL SERVICES 321032 ILLUMINA 12864 COLLECTIONS CENTER DRIVE CHICAGO IL 60693 MAINTENANCE SERVICES 294577 29 548443 286296293 33530186 7281843 327656765 RESEARCH BILLED REV 541700 882195 882195 882195 69207 69207 38057 38057 115500 107064 8436 8436 8436 75000 44259 30741 30741 30741 76289 548443 177202 -100913 -100913 17426 3956 13470 13470 ALLOCATED ADMIN. EXP. 561000 11032802 11032802 EDUCATIONAL PROGRAMS 611710 309247 309247 REIMBURSED EXPENSES 900099 29397 29397 42482 42482 11413928 340011886 882195 13470 11459456 689500 689500 2022778 2022778 5000 5000 4105624 997060 3108564 47005351 29152344 17462161 390846 4293326 2778295 1480369 34662 5241166 3391661 1807191 42314 3274744 2119151 1129155 26438 561645 141393 420252 61683 61683 96000 96000 4267604 2406149 1860652 803 2254456 30959 2051413 172084 65378 22483 38685 4210 384055 125892 244837 13326 2728122 2257577 470545 1298951 937105 314367 47479 501955 409058 87824 5073 1317022 1079988 237034 12375602 11046989 1328613 907545 571252 336293 LAB SUPPLIES & SERVICES 7287526 7287526 EQUIPMENT & SOFTWARE 5757192 3184915 2568894 3383 OTHER SCIENTIFIC 1503784 1503784 FED / STATE INCOME TAX 426 426 4038010 1766915 2203250 67845 112044445 73927774 37308208 808463 31471094 1022317 4688272 5763820 6206622 12329240 536560 92287 305710 335429 2270010 2879312 328227278 159906569 163115281 168320709 6404746 6450039 5000000 0 219998295 197193153 20248601 15331023 884155 1490194 219703968 0 23673586 0 264510310 16821217 X -50209306 173639772 5697291 6732164 -44512015 180371936 219998295 197193153 X 227967441 55924 -3139414 X 0 1 X 1 1 1 X COREWELL HEALTH GRAND RAPIDS MI RESTRICTED RESTRICTED RESTRICTED RESTRICTED RESTRICTED RESTRICTED RESTRICTED RESTRICTED 96000 96000 111948445 112044445 1000000 250000 0 0 1000000 1000000 1000000 1000000 4000000 6000000 96000 96000 96000 96000 384000 250000 250000 250000 250000 1000000 1500000 921757 11200 55924 193 988688 914174 16000 -8216 201 921757 790427 16000 107939 192 914174 723759 15000 51845 177 790427 626264 45000 54479 1984 723759 1.00000 0 1 1 5288315 5288315 239241969 97564789 141677180 101150 101150 0 81043717 62047891 18995826 2552127 192739 2359388 168320709 X 329307442 55924 284266 340190 328967252 11044634 11044634 340011886 104423491 3423680 3423680 100999811 11044634 11044634 112044445 PART X, LINE 2: THERE ARE NO UNCERTAIN TAX POSITIONS RELATED TO VARI. PART XI, LINE 2D - OTHER ADJUSTMENTS: RENTAL EXPENSES 107,064. FUNDRAISING EVENT EXPENSE 177,202. PART XI, LINE 4B - OTHER ADJUSTMENTS: NET ALLOCATED 11,032,802. BAD DEBT ADJUSTMENTS 9,282. ROYALTY PAYOUTS 2,550. PART XII, LINE 2D - OTHER ADJUSTMENTS: RENTAL EXPENSES 107,064. FUNDRAISING EVENT EXPENSE 177,202. LOSS ON INTEREST RATE SWAP 3,139,414. PART XII, LINE 4B - OTHER ADJUSTMENTS: NET ALLOCATED 11,032,802. BAD DEBT ADJUSTMENT 9,282. ROYALTY PAYOUTS 2,550. PART V VAN ANDEL INSTITUTE (A RELATED ORGANIZATION) MAINTAINS ENDOWED FUNDS FOR THE BENEFIT OF BOTH VARI AND VAN ANDEL EDUCATION INSTITUTE (A RELATED ORGANIZATION) TO FUND OPERATING EXPENSES. PART XI AND XII, LINE 4B EXPENSE ALLOCATIONS PRESENTED WITHIN REVENUE. EUROPE 0 0 PROGRAM SERVICES RESEARCH COLLABORATION - RESEARCH SERVICES 182203 SOUTH ASIA 0 0 SOFTWARE DEVELOPMENT 1236 NORTH AMERICA 0 0 PROGRAM SERVICES RESEARCH COLLABORATION - RESEARCH SERVICES 50949 EAST ASIA AND THE PACIFIC 0 0 PROGRAM SERVICES RESEARCH COLLABORATION - RESEARCH SERVICES 23001 SUB-SAHARAN AFRICA 0 0 PROGRAM SERVICES RESEARCH COLLABORATION - RESEARCH SERVICES 488 0 0 0 0 0 0 257877 0 257877 0 0 0 0 0 0 PART III ACCOUNTING METHOD: BEEBRAVE 5K RACE 89043 60043 29000 1395 4623 2903 WEST OTTAWA PURPLE POWER 85549 85549 947 13031 12 450140 402851 47289 1050 41293 111445 624732 548443 76289 2445 45916 947 127379 176687 -100398 1 THE ECONOMIC CLUB OF GRAND RAPIDS 220 LYON STREET NW STE 220 GRAND RAPIDS MI 49503 237442555 501C6 25000 0 GROWING ECONOMIC HEALTH OF GRAND RAPIDS STAND UP TO CANCER 10880 WILSHIRE BLVD SUITE 1400 LOS ANGELES CA 90024 951644609 501C3 625000 0 RESEARCH COLLABORATION GORDON RESEARCH 5586 POST RD G02 EAST GREENWICH RI 02818 260150662 501C3 7500 0 FUNDING METABOLOMICS AND HUMAN HEALTH CONFERENCE FRIENDS OF CRESCENT PARK 333 BOSTWICK AVENUE NE GRAND RAPIDS MI 49503 264562012 501C3 17000 0 SUPPORT MAINTENANCE OF CRESCENT PARK 3 1 GRADUATE STUDENT STIPENDS FOR MICHIGAN STATE UNIVERSITY STUDENTS 1 39720 GRADUATE STUDENT STIPENDS FOR UNIVERSITY OF KENTUCKY STUDENTS 3 113041 GRADUATE STUDENT STIPENDS VAN ANDEL INSTITUTE GRADUATE SCHOOL 18 388547 GUEST WORKER STIPENDS 4 15937 POSTDOCTORAL FELLOWSHIP STIPENDS 8 448868 VAN ANDEL INSTITUTE GRADUATE SCHOOL STUDENT TUITION AND FEES REMISSION 50 1016665 TUITION REMISSION. PART I, LINE 2: STUDENTS RECEIVE A STIPEND FOR LIVING EXPENSE AND INSURANCE. GRANT FUNDS TO INSTITUTIONS ARE MONITORED BY QUARTERLY EXPENDITURE REPORTS BEFORE DISBURSING INCREMENTAL FUNDING. PROGRESS REPORTS ARE REQUIRED ANNUALLY AND REVIEWED BY VAN ANDEL RESEARCH INSTITUTE AND A THIRD PARTY. X 1 1 X X X X 0 0 0 1 0 0 0 0 0 KATHY VOGELSANG CHIEF INVESTMENT OFFICER 535750 0 540000 0 24777 0 470500 0 14212 0 1585239 0 540000 0 DR PETER JONES CHIEF SCIENTIFIC OFFICER & RES. DIR. 693409 0 189890 0 25901 0 298877 0 14212 0 1222289 0 189890 0 TED HEILMAN ASSOC DIRECT-SR. PORTFOLIO MGR. 332218 0 351000 0 24271 0 360500 0 14212 0 1082201 0 351000 0 DAVID VAN ANDEL CHAIRMAN / CEO 451461 0 150563 0 19205 0 224023 0 6711 0 851963 0 150563 0 DR JANA HALL CHIEF OPERATIONS OFFICER 443287 0 119602 0 7726 0 185765 0 14212 0 770592 0 119602 0 AUSTIN WAY SENIOR PORTFOLIO MANAGER 234452 0 219375 0 446 0 243336 0 14212 0 711821 0 0 0 GERALD CALLAHAN CHIEF STRATEGIC OFFICER 358164 0 90641 0 21846 0 144290 0 14212 0 629153 0 90641 0 THOMAS CURRAN JR GENERAL COUNSEL 379422 0 90383 0 7726 0 131378 0 14212 0 623121 0 90383 0 DR PETER LAIRD DISTINGUISHED INVESTIGATOR 432689 0 53946 0 3963 0 87478 0 14212 0 592288 0 51308 0 TIMOTHY MYERS V.P. & CHIEF FINANCIAL OFFICER 349030 0 79085 0 1305 0 127625 0 14212 0 571257 0 79085 0 DR GERD PFEIFER SR. SCIENTIFIC INVESTIGATOR 412273 0 19084 0 7421 0 54019 0 14212 0 507009 0 19084 0 PART I, LINE 1A VARI ALLOWS FOR FIRST-CLASS OR CHARTER TRAVEL FOR OFFICERS AND TRUSTEES. PART I, LINE 5 BONUS IS PAID BASED ON VARIABLE PAY PROGRAM OBJECTIVES FOR ELIGIBLE PROGRAM PARTICIPANTS. FORM 990, PART VI, SECTION A, LINE 2 VARI, VAI, VAEI, AND VAIGS SHARE COMMON MANAGEMENT. DAVID VAN ANDEL, DR. JANA HALL AND TIMOTHY MYERS ARE ALSO OFFICERS OF VAI, AND DAVID VAN ANDEL AND TIMOTHY MYERS ARE OFFICERS OF VAEI AND VAIGS. THOMAS CURRAN JR. IS ALSO AN OFFICER OF VAIGS. GERALD CALLAHAN AND THOMAS CURRAN JR. ARE KEY EMPLOYEES OF VAI AND VAEI. FORM 990, PART VI, SECTION A, LINE 2 BUSINESS RELATIONSHIP: DAVID VAN ANDEL, GERALD CALLAHAN FORM 990, PART VI, SECTION A, LINE 7A THE TRUSTEES OF VAN ANDEL INSTITUTE HAVE THE AUTHORITY TO ELECT ONE OR MORE MEMBERS OF VARI'S GOVERNING BODY. FORM 990, PART VI, SECTION B, LINE 11B FOLLOWING COMPLETION OF THE FINANCIAL STATEMENT AUDIT, THE FORM 990 IS PREPARED AND REVIEWED BY MANAGEMENT. IT IS THEN CIRCULATED TO THE FULL BOARD PRIOR TO FILING WITH THE IRS. FORM 990, PART VI, SECTION B, LINE 12C VARI HAS WRITTEN CONFLICT OF INTEREST ("COI") POLICIES AND PROCEDURES WHICH ADMINISTER AND ENFORCE A PROCESS TO IDENTIFY, EVALUATE, AND MANAGE POTENTIAL CONFLICTS OF INTEREST. THESE POLICIES HAVE BEEN APPROVED BY THE BOARD OF TRUSTEES. VAI ADMINISTERS COI POLICIES AND PROCEDURES THROUGH TWO STANDING COMMITTEES: THE CONFLICTS COMMITTEE ("CC") AND THE INSTITUTIONAL COI COMMITTEE ("ICOIC"). COI POLICIES AND PROCEDURES APPLY TO AND SERVE AS A GUIDE FOR EVERYONE IN THE ORGANIZATION. IN PARTICULAR, THEY PROVIDE A USEFUL RESOURCE FOR DEVELOPING ACTIVITIES OR RELATIONSHIPS WITH OUTSIDE ENTITIES OR PERSONS, AND ESTABLISH A PROCESS FOR COMMITTEES TO REVIEW AND MANAGE POTENTIAL CONFLICTS OF INTEREST AS THEY MAY ARISE. THE CC AND ICOIC ARE CHAIRED BY THE GENERAL COUNSEL. THE CC REQUIRES ANNUAL AND UPDATED DISCLOSURES BY COVERED PERSONS AND REVIEWS AND APPROVES MANAGEMENT PLANS. ICOIC POLICIES AND PROCEDURES SERVE AS A GUIDE FOR BOARDS OF TRUSTEES AND SENIOR EXECUTIVES. IN THE EVENT A POTENTIAL COI ARISES AT THE BOARD OR SENIOR EXECUTIVE LEVEL, THE ICOIC MEETS TO REVIEW AND DETERMINE HOW TO MANAGE SUCH A POTENTIAL CONFLICT OF INTEREST IN ACCORDANCE WITH THE COI POLICIES AND PROCEDURES. FORM 990, PART VI, SECTION B, LINE 15 COMPARABILITY DATA FROM AN EXPERT THIRD PARTY IS OBTAINED AND REVIEWED BY THE INDEPENDENT, JOINT COMPENSATION COMMITTEE OF VAN ANDEL RESEARCH INSTITUTE AND RELATED ORGANIZATIONS TO DETERMINE APPROPRIATE COMPENSATION FOR THE CEO, EXECUTIVE MANAGEMENT OFFICIALS, OFFICERS, AND KEY EMPLOYEES, ON BEHALF OF VAN ANDEL RESEARCH INSTITUTE. FORM 990, PART VI, SECTION C, LINE 19 ALL DOCUMENTS REQUIRED TO BE MADE AVAILABLE TO THE PUBLIC ARE AVAILABLE FOR PUBLIC INSPECTION UPON WRITTEN REQUEST. FORM 990, PART XI, LINE 9: LOSS ON INTEREST RATE SWAP -3,139,414. FORM 990, PART III, LINE 2 VAN ANDEL RESEARCH INSTITUTE (VARI) IS DEDICATED TO DETERMINING THE EPIGENETIC, GENETIC, MOLECULAR, METABOLIC, AND CELLULAR ORIGINS OF CANCER, PARKINSON'S DISEASE, AND OTHER DISORDERS AND TO TRANSLATING THOSE FINDINGS INTO EFFECTIVE THERAPIES. THE INSTITUTE'S SCIENTISTS WORK IN ONSITE LABORATORIES AND PARTICIPATE IN COLLABORATIONS THAT SPAN THE GLOBE. WITH EPIGENETICS AS ITS COMMON THREAD, THE INSTITUTE IS ORGANIZED INTO FIVE DEPARTMENTS: EPIGENETICS, NEURODEGENERATIVE SCIENCE, CELL BIOLOGY, METABOLISM AND NUTRITIONAL PROGRAMMING, AND STRUCTURAL BIOLOGY. IN 2021, THE INSTITUTE ESTABLISHED ITS CANCER CENTER AND PARKINSON'S DISEASE CENTER, WHICH SERVE AS COLLABORATIVE PLATFORMS TO FACILITATE CLINICAL TRANSLATION AND TRIALS. THE INSTITUTE'S LABS ARE SUPPORTED BY AN OUTSTANDING CORE TECHNOLOGIES AND SERVICES GROUP, WHICH PROVIDES A VIVARIUM, A BIOREPOSITORY, AND VALUABLE ONSITE CAPABILITIES IN IMAGING, PATHOLOGY, BIOINFORMATICS AND BIOSTATISTICS, GENOMICS, FLOW CYTOMETRY, MASS SPECTROMETRY, TRANSGENICS, AND CRYO-ELECTRON MICROSCOPY. IN 2023, VARI SCIENTISTS PUBLISHED 124 ARTICLES IN PEER-REVIEWED JOURNALS SUCH AS NATURE, CELL, CANCER CELL, JOURNAL OF CLINICAL ONCOLOGY, NATURE REVIEWS NEUROSCIENCE, IMMUNITY, NATURE GENETICS, CANCER DISCOVERY, CELL METABOLISM, AND SCIENCE IMMUNOLOGY, AMONG OTHERS. FORM 990, PART III, LINE 4A LINE 4A - PROGRAM SERVICE ACTIVITY #1 DEPARTMENT OF EPIGENETICS AS OF NOVEMBER 2023, THE DEPARTMENT OF EPIGENETICS, LED BY INTERIM CHAIR DR. XIAOBING SHI, COMPRISED 11 LABORATORIES AND ONE DIRECTOR'S SCHOLAR THAT SEEK TO UNDERSTAND HOW EPIGENETIC CHANGES EITHER PROTECT US FROM OR PREDISPOSE US TO DISEASES SUCH AS CANCER, PARKINSON'S, AND METABOLIC DISORDERS. BY INVESTIGATING THE EPIGENETIC PROCESSES THAT FINE-TUNE DNA, THE DEPARTMENT'S SCIENTISTS AIM TO PINPOINT THE ORIGINS OF THESE DISEASES AND DETERMINE HOW THEY ARE IMPACTED BY OUR PAST AND PRESENT, AND HOW THEY INFLUENCE FUTURE GENERATIONS. IN THIS FISCAL YEAR, RESEARCHERS AND TRAINEES WITHIN THE DEPARTMENT EARNED AWARDS AND/OR SUBAWARDS FROM THE NATIONAL INSTITUTES OF HEALTH, THE CHAN ZUCKERBERG INITIATIVE DAF, AMERICAN SOCIETY OF HEMATOLOGY (ASH), THE NATIONAL SCIENCE FOUNDATION, AND THE GRAY FOUNDATION. FUNDING WAS ALSO RECEIVED THROUGH THE STATE OF MICHIGAN. FORM 990, PART III, LINE 4B LINE 4B - PROGRAM SERVICE ACTIVITY #2 DEPARTMENT OF NEURODEGENERATIVE SCIENCE AS OF NOVEMBER 2023, THE DEPARTMENT OF NEURODEGENERATIVE SCIENCE, CHAIRED BY DR. DARREN MOORE, COMPRISED SEVEN LABORATORIES THAT INVESTIGATE THE COMPLEX FACTORS THAT GIVE RISE TO NEURODEGENERATIVE AND PSYCHIATRIC DISORDERS, INCLUDING GENETICS, EPIGENETICS, AGING, INFLAMMATION, THE STRUCTURE OF THE BRAIN, AND THE ROLES OF THE GUT AND IMMUNE SYSTEM. BY LEVERAGING DISCOVERIES MADE IN THE INSTITUTE'S LABS AND COLLABORATING WITH RESEARCHERS AROUND THE WORLD, SCIENTISTS IN THE DEPARTMENT ARE WORKING TO TRANSLATE BREAKTHROUGHS INTO LIFE-CHANGING NEW TREATMENTS FOR PARKINSON'S, ALZHEIMER'S AND RELATED DEMENTIAS, AND DEPRESSION. IN THIS FISCAL YEAR, RESEARCHERS AND TRAINEES WITHIN THE DEPARTMENT EARNED AWARDS AND/OR SUBAWARDS FROM THE DEPARTMENT OF DEFENSE, NATIONAL INSTITUTES OF HEALTH, RESEARCH!AMERICA, MICHAEL J. FOX FOUNDATION FOR PARKINSON'S RESEARCH, PARKINSON'S FOUNDATION, AND THE ALS ASSOCIATION. FORM 990, PART III, LINE 4C LINE 4C - PROGRAM SERVICE ACTIVITY #3 DEPARTMENT OF METABOLISM AND NUTRITIONAL PROGRAMMING AS OF NOVEMBER 2023, THE DEPARTMENT OF METABOLISM AND NUTRITIONAL PROGRAMMING, CHAIRED BY DR. RUSSELL JONES, COMPRISED SIX LABORATORIES THAT EXPLORE THE INTRICATE MECHANICS OF CELLULAR METABOLISM AND ITS IMPLICATIONS FOR HEALTH AND DISEASE. USING CUTTING-EDGE TECHNIQUES, THEY INVESTIGATE METABOLISM'S INTERACTION WITH OTHER CRITICAL SYSTEMS, SUCH AS THE IMMUNE SYSTEM, AND ARE REVEALING HOW ENVIRONMENTAL EXPOSURES AND METABOLIC DYSFUNCTION CONTRIBUTE TO COMPLEX DISEASES SUCH AS DIABETES, AUTOIMMUNITY, CANCER, AND NEURODEGENERATION. THEY ALSO PARSE THE RIPPLE EFFECT THAT NUTRITION MAY HAVE THROUGH THE GENERATIONS BY EXPLORING HOW DIET COULD LAY THE EPIGENETIC FOUNDATIONS FOR THE HEALTH OF FUTURE GENERATIONS. IN THIS FISCAL YEAR, RESEARCHERS AND TRAINEES WITHIN THE DEPARTMENT EARNED AWARDS AND/OR SUBAWARDS FROM THE NATIONAL INSTITUTES OF HEALTH, DAMON RUNYON CANCER RESEARCH FOUNDATION, CHAN ZUCKERBERG INITIATIVE DAF, AND CANADIAN INSTITUTES OF HEALTH RESEARCH. FORM 990, PART III, LINE 4D LINE 4D - OTHER PROGRAM SERVICES DEPARTMENT OF CELL BIOLOGY AS OF NOVEMBER 2023, THE DEPARTMENT OF CELL BIOLOGY, LED BY INTERIM CHAIR DR. TAO YANG, COMPRISED FIVE LABS THAT PURSUE FUNDAMENTAL RESEARCH TO UNDERSTAND HOW CELLS GROW, COMMUNICATE, SURVIVE, ASSEMBLE INTO TISSUES AND ORGANS, RESPOND TO THE ENVIRONMENT, AND CHANGE WITH AGE. THIS TRANSFORMATIVE WORK AIMS TO YIELD NEW DIAGNOSTIC AND TREATMENT STRATEGIES TO IMPROVE THE QUALITY OF LIFE FOR PEOPLE WITH CANCER, BONE DISEASES, AND RARE DISORDERS. ONE FACULTY MEMBER HOLDS A JOINT APPOINTMENT AS DIRECTOR OF THE INSTITUTE'S CORE TECHNOLOGIES AND SERVICES. IN THIS FISCAL YEAR, RESEARCHERS AND TRAINEES WITHIN THE DEPARTMENT EARNED AWARDS FROM THE NATIONAL INSTITUTES OF HEALTH, PHRMA FOUNDATION, AND AMERICAN CANCER SOCIETY. DEPARTMENT OF STRUCTURAL BIOLOGY AS OF NOVEMBER 2023, THE DEPARTMENT OF STRUCTURAL BIOLOGY, CHAIRED BY DR. HUILIN LI, COMPRISED FOUR LABORATORIES THAT HARNESS THE POWER OF CRYO-ELECTRON MICROSCOPY (CRYO-EM) AND OTHER TECHNIQUES TO VISUALIZE MOLECULES THAT SERVE AS THE FOUNDATION FOR HEALTH AND DISEASE. THESE MOLECULES MAY SERVE AS DRUG TARGETS FOR CANCER, NEUROLOGICAL DISORDERS, METABOLIC DISEASES, INFECTIOUS DISEASES, AND MORE. DEPARTMENT SCIENTISTS HAVE INTERESTS IN DNA REPLICATION, CELLULAR SIGNALING, AND EPIGENETICS. IN THIS FISCAL YEAR, RESEARCHERS AND TRAINEES WITHIN THE DEPARTMENT EARNED AWARDS FROM THE NATIONAL INSTITUTES OF HEALTH. VAN ANDEL INSTITUTE CANCER CENTER THE VAN ANDEL INSTITUTE-STAND UP TO CANCER EPIGENETICS DREAM TEAM, LED BY DR. PETER A. JONES AND DR. STEPHEN BAYLIN, CONTINUES TO FOSTER COLLABORATION TOWARD DEVELOPMENT OF NEW COMBINATION THERAPIES FOR CANCER AND MOVING THESE PROMISING THERAPIES INTO CLINICAL TRIALS. THE TEAM FOCUSES ON EPIGENETIC MECHANISMS IN CELLS, WHICH HELP CONTROL WHETHER GENES ARE SWITCHED "ON OR "OFF" WITHOUT CHANGING THE DNA SEQUENCE ITSELF. VAN ANDEL INSTITUTE PARKINSON'S DISEASE CENTER INTERNATIONAL LINKED CLINICAL TRIALS (ILCT) IS A PROGRAM THAT IDENTIFIES POTENTIAL NEW THERAPIES THAT MAY SLOW OR STOP PARKINSON'S PROGRESSION FROM MEDICATIONS DEVELOPED OR APPROVED TO TREAT OTHER CONDITIONS. THE PROGRAM IS SPEARHEADED BY CURE PARKINSON'S IN COLLABORATION WITH THE INSTITUTE. IT AIMS TO REDUCE THE TIME IT TAKES FOR A POTENTIAL TREATMENT TO MOVE FROM THE LAB INTO CLINICAL TRIALS AND, ULTIMATELY, TO IMPLEMENTATION IN THE CLINIC. DR. DARREN MOORE REPRESENTS VAI ON THE ILCT COMMITTEE. FORM 990, PART IX, COLUMN D FUNDRAISING EXPENSES AT VARI WERE INCURRED TO SUPPORT THE MISSION OF THE RESEARCH INSTITUTE THROUGH DONOR SOLICITATION, GRANT SOLICITATION AND EXTRAMURAL PROPOSAL PREPARATION. VAI INNOVATIONS LLC 333 BOSTWICK AVENUE NE GRAND RAPIDS MI 495032518 522000823 LICENSING INTELLECTUAL PROPERTY OF VARI MI 44882 0 VAN ANDEL RESEARCH INSTITUTE BOSTWICK EVENT MANAGEMENT 333 BOSTWICK AVENUE NE GRAND RAPIDS MI 495032518 522000823 EVENT MANAGEMENT MI 31588 123629 VAN ANDEL RESEARCH INSTITUTE C3 LEARNING DEVELOPMENT LLC 333 BOSTWICK AVENUE NE GRAND RAPIDS MI 495032518 522000823 EDUCATIONAL PROGRAMS FOR K-12 STUDENTS AND TEACHERS MI 389480 222067 VAN ANDEL RESEARCH INSTITUTE VAN ANDEL INSTITUTE 333 BOSTWICK AVENUE NE GRAND RAPIDS MI 495032518 522000820 SUPPORTING ORGANIZATION FOR VARI AND VAEI MI 501(C)(3) 12C N/A 0 VAN ANDEL EDUCATION INSTITUTE 333 BOSTWICK AVENUE NE GRAND RAPIDS MI 495032518 522000824 OPERATING A SCIENCE EDUCATION PROGRAM MI 501(C)(3) 2 VAN ANDEL INSTITUTE 1 VAN ANDEL INSTITUTE GRADUATE SCHOOL 333 BOSTWICK AVENUE NE GRAND RAPIDS ME 495032518 203340886 OPERATING A GRADUATE SCHOOL MI 501(C)(3) 2 VAN ANDEL EDUCATION INSTITUTE 1 0 0 1 0 0 0 0 0 0 0 0 0 0 1 1 1 1 0 0 VAN ANDEL INSTITUTE C 286296293 ACTUAL AMOUNT PAID VAN ANDEL INSTITUTE N 69669 ALLOCATION BASED ON SQ. FOOTAGE VAN ANDEL INSTITUTE P 1393384 ACTUAL AMOUNT PAID VAN ANDEL INSTITUTE N 374859 ALLOCATION BASED ON EFFORT VAN ANDEL INSTITUTE O 1772943 ALLOCATION BASED ON EFFORT VAN ANDEL EDUCATION INSTITUTE P 1006319 ACTUAL AMOUNT PAID VAN ANDEL EDUCATION INSTITUTE Q 1640768 ACTUAL AMOUNT RECEIVED VAN ANDEL EDUCATION INSTITUTE N 94591 ALLOCATION BASED ON EFFORT VAN ANDEL EDUCATION INSTITUTE O 447378 ALLOCATION BASED ON EFFORT VAN ANDEL INSTITUTE GRADUATE SCHOOL Q 279997 ACTUAL AMOUNT RECEIVED VAN ANDEL INSTITUTE Q 7559755 ACTUAL AMOUNT RECEIVED VAN ANDEL INSTITUTE GRADUATE SCHOOL P 1016665 ACTUAL AMOUNT PAID VAN ANDEL INSTITUTE GRADUATE SCHOOL O 234719 ALLOCATION BASED ON EFFORT VAN ANDEL INSTITUTE O 100232 ALLOCATION BASED ON EFFORT