2024-10-18T13:45:56-05:00 2022-09-30 911194016 CLARK NUBER PS 10900 NE 4TH STREET SUITE 1400 BELLEVUE WA 98004 990 2021-10-01 910667886 PACIFIC NORTHWEST RESEARCH INSTITUTE PACI 2067261200 720 BROADWAY SEATTLE WA 98122 DIONNE GORDON CFAO 2067261200 2024-10-16 1 MEGAN R RYAN P00737884 4254544919 2024-10-16 2021 2024-10-15 13:58:12Z DIONNE GORDON 720 BROADWAY SEATTLE WA 98122 6580886 0 X WWW.PNRI.ORG X 1956 WA AN INDEPENDENT, BIOMEDICAL RESEARCH INSTITUTE AIMED AT UNDERSTANDING HOW HEALTH IS MAINTAINED IN THE FACE OF GENETIC AND ENVIRONMENTAL RISKS ASSOCIATED WITH DISEASE DEVELOPMENT. 10 10 98 10 0 0 6597150 6134304 1425 925 0 5108 328463 390577 6927038 6530914 71373 51267 0 0 6538248 6874054 0 0 342026 3225103 3509783 9834724 10435104 -2907686 -3904190 26418292 21360540 562438 674993 25855854 20685547 X PACIFIC NORTHWEST RESEARCH INSTITUTE (PNRI), A NONPROFIT CORPORATION, IS AN INDEPENDENT, BIOMEDICAL RESEARCH INSTITUTE CONDUCTING BASIC AND APPLIED RESEARCH AIMED AT UNDERSTANDING HOW HEALTH IS MAINTAINED IN THE FACE OF GENETIC AND ENVIRONMENTAL RISKS ASSOCIATED WITH DISEASE DEVELOPMENT. THE SCIENTIFIC DISCOVERIES HAVE APPLICABILITY IN A VARIETY OF DISEASES, INCLUDING DIABETES, CANCER, NEUROLOGICAL DISORDERS, AMONG MANY OTHERS. 0 0 2910968 29729 INSPIRED TO APPLY HIS NOVEL COMPUTATIONAL APPROACHES TO FIND WAYS TO IMPROVE THE HUMAN CONDITION, DR. GALAS RECENTLY INITIATED THE DECODING STRESS STUDY. THE GOAL OF THE DECODING STRESS STUDY IS TO PINPOINT GENES, NETWORKS, AND PATHWAYS RESPONSIBLE FOR HOW WE RESPOND TO CHRONIC STRESS AND, THUS, IDENTIFY HOW OUR GENETICS AFFECT OUR RISK FOR DEVELOPING STRESS-RELATED DISORDERS, SUCH AS TYPE 2 DIABETES, DEPRESSION, AND ANXIETY. 2051841 THE HAGOPIAN LAB RESEARCHES WAYS TO PREDICT AND PREVENT THE DEVELOPMENT OF TYPE 1 DIABETES, A DISEASE AFFECTING OVER ONE MILLION AMERICAN CHILDREN AND ADULTS. NOT EVERYONE WITH GENETIC RISK FOR TYPE 1 DIABETES DEVELOPS THE DISEASE. WHY NOT? SCIENTISTS IN THE HAGOPIAN LAB BELIEVE ANSWERS LIE IN THE ENVIRONMENT. THEY ARE ONE OF 6 LABS PARTICIPATING IN AN INTERNATIONAL STUDY FOLLOWING 8,000 CHILDREN WITH HIGH GENETIC RISK FOR TYPE 1 DIABETES. THE HAGOPIAN LAB ALSO DEVELOPS POPULATION BASED NEWBORN SCREENING METHODS TO PREDICT WHO IS AT RISK. THE ULTIMATE GOAL IS TO PREVENT THE DISEASE ENTIRELY. 1039934 21538 EXPERIMENTING IN YEAST ALLOWS THE DUDLEY LAB TO MAKE DISCOVERIES THAT GO BEYOND THE LAB WITH THE POWER TO CHANGE HOW SCIENTISTS AROUND THE GLOBE APPROACH GENETIC RESEARCH. FROM PERFORMING LARGESCALE EXPERIMENTS TO DISCOVERING NEW ANTIFUNGAL TREATMENTS, THE DUDLEY LAB IS A WORLD LEADER IN USING YEAST TO ANSWER FUNDAMENTAL QUESTIONS ABOUT BIOLOGY. WE ARE PASSIONATE ABOUT APPLYING AND DEVELOPING NOW TECHNOLOGIES AND ABOUT TRANSLATING DISCOVERIES FROM OUR LAB INTO REALWORLD APPLICATIONS. THE DUDLEY LAB EXPERIMENTS IN YEAST BECAUSE YEAST CELLS FUNCTION IN MUCH THE SAME WAY AS HUMAN CELLS. HOWEVER, WITH YEAST, WE CAN PERFORM EXPERIMENTS MUCH FASTER, AND ON A GRANDER SCALE, THAN SCIENTISTS CAN WITH HUMAN CELLS. 862284 925 THE STUBBS LAB IS FOCUSED ON UNDERSTANDING HOW THE INTERPLAY BETWEEN GENES AND ENVIRONMENT SHAPES BRAIN DEVELOPMENT, AND HOW THAT INTERPLAY ULTIMATELY INFLUENCES BEHAVIOR. WE STUDY THE FOLE OF GENE REGULATION THE PROCESSES RESPONSIBLE FOR ORCHESTRATING HOW GENES ARE USED IN EACH BRAIN CELL TO SPECIFY UNIQUE FUNCTIONS AND HOW WHAT HAPPENS DURING OUR LIFETIME LEADS TO CHANGES IN THOSE PROCESSES. 862284 925 6865027 1 1 0 0 0 0 0 0 0 1 1 0 0 1 1 0 1 0 0 0 0 0 0 0 0 0 0 0 1 1 0 0 0 0 0 0 0 0 1 0 0 0 0 0 0 0 0 1 23 0 98 1 0 0 0 0 0 0 0 0 0 0 0 0 X 10 10 0 0 0 0 0 0 0 1 1 0 0 0 1 1 1 1 1 1 1 0 WA X DIONNE GORDON 2067261200 720 BROADWAY SEATTLE WA 98122 GARY KOCHER SECRETARY 1.00 X X 0 0 0 MATTHEW GAGNIER TREASURER 1.00 X X 0 0 0 THOMAS HAYWARD CHAIR 1.00 X X 0 0 0 ALLISON HANDY BOARD MEMBER 1.00 X 0 0 0 CINDY HABA BOARD MEMBER 1.00 X 0 0 0 TERA EERKES BOARD MEMBER 1.00 X 0 0 0 STEPHAN MARTINEZ BOARD MEMBER 1.00 X 0 0 0 LINDA MAUZY BOARD MEMBER 1.00 X 0 0 0 ASH GUNDERSON BOARD MEMBER 1.00 X 0 0 0 JIM CONGDON BOARD MEMBER 1.00 X 0 0 0 JOHN WECKER CEO 40.00 X 295199 0 41275 BILL REICHERT CFO 40.00 X 143482 0 17134 DAVID GALAS PRINCIPAL INVESTIGATOR 40.00 X 298187 0 0 LISA STUBBS PRINCIPAL INVESTIGATOR 40.00 X 230000 0 40569 WILLIAM HAGOPIAN PRINCIPAL INVESTIGATOR 40.00 X 214674 0 25992 AIMEE DUDLEY PRINCIPAL INVESTIGATOR 40.00 X 177582 0 12600 RICHARD MCLAUGHLIN ASSISTANT PRINCIPAL INVESTIGATOR 40.00 X 136258 0 4129 JUSTIN DUKES DIRECTOR IT 40.00 X 133179 0 0 CLAUDIA FONSECA ASSISTANT INVESTIGATOR 40.00 X 132122 0 4051 MICHAEL METZGER ASSISTANT PRINCIPAL INVESTIGATOR 40.00 X 123592 0 32714 LORI KLOES CHIEF ADVANCEMENT OFFICER 40.00 X 107459 0 0 1991734 0 178464 15 0 1 0 0 4189488 1944816 201060 6134304 VIVARIUM REVENUE 900099 925 925 925 5108 5108 434110 49972 384138 384138 384138 REBATES 900099 6422 6422 17 17 6439 6530914 925 0 395685 X 51267 51267 1496694 999604 497090 4166242 3048325 863036 254881 -8365 -64501 56136 804125 1192788 -395786 7123 415358 415358 54788 48360 6428 91158 91158 1469881 1099424 350734 19723 1749 1749 103127 69540 20971 12616 481406 481406 47980 44539 3385 56 502082 502082 REPAIRS & MAINTENANCE 206617 17131 189486 EQUIPMENT RENT, MAINT. 104558 261359 -156801 DUES & SUBSCRIPTIONS 56144 24301 30669 1174 PUBLICATION FEES 38471 14812 12004 11655 351822 56329 260695 34798 10435104 6865027 3228051 342026 172283 313761 13720667 8740223 961431 676166 19869 533565 27800 11530 429480 386213 14861696 10770306 4215887 4091390 1166972 2052016 57546 42793 5646357 4512883 26418292 21360540 437075 618575 98112 43704 27251 12714 562438 674993 X 20132397 15686420 5723457 4999127 25855854 20685547 26418292 21360540 X -3904190 -132643 -1133474 X 0 1 X 1 1 1 X 7566626 4266327 20450636 6597150 6134304 45015043 7566626 4266327 20450636 6597150 6134304 45015043 15959488 29055555 563654 580512 482111 463827 439218 2529322 2788 3585 1389 9005 6439 23206 47567571 17753 0.61080 0.94390 X SCHEDULE A, PART II, LINE 10, EXPLANATION OF OTHER INCOME: MISCELLANEOUS INCOME - 2017 AMOUNT: $ 58. 2019 AMOUNT: $ 846. 2021 AMOUNT: $ 17. REBATES - 2017 AMOUNT: $ 2,730. 2018 AMOUNT: $ 3,585. 2019 AMOUNT: $ 543. 2020 AMOUNT: $ 9,005. 2021 AMOUNT: $ 6,422. RESTRICTED RESTRICTED RESTRICTED RESTRICTED RESTRICTED RESTRICTED RESTRICTED RESTRICTED 75000 400000 347 347 475000 75000 164 164 75000 75000 131 131 75000 85082 -10057 25 75000 82406 2676 85082 0.00000 1.00000 0.00000 0 0 823359 823359 9477147 7390257 2086890 4561190 3380049 1181141 4091390 BENEFICIAL INTEREST IN PERPETUAL TR 4512883 4512883 ANNUITY PAYABLE 2034 TENANT DEPOSITS 10500 OTHER CURRENT LIABILITIES 180 12714 5314769 -132643 -1133474 -1266117 6580886 -49972 -49972 6530914 10485076 49972 49972 10435104 0 10435104 PART V, LINE 4: THE ORGANIZATION'S ENDOWMENT FUNDS ARE DESIGNATED FOR USE AS OPERATING RESERVES AND SCIENTIST RECRUITMENT. PART XI, LINE 2D - OTHER ADJUSTMENTS: LOSS ON PERPETUAL TRUST -1,133,474. PART XI, LINE 4B - OTHER ADJUSTMENTS: RENTAL EXPENSES -49,972. PART XII, LINE 2D - OTHER ADJUSTMENTS: RENTAL EXPENSES 49,972. 1 TUITION 3 51267 COST TUITION REDUCTION PAYMENTS PART I, LINE 2: THE ORGANIZATION HAS A FORMAL AGREEMENT WITH A UNIVERSITY WHICH INCLUDES TUITION REDUCTION FOR STUDENTS WHO WORK AT PNRI LABS. X X X X 0 0 0 0 0 0 0 0 0 JOHN WECKER CEO 295199 0 0 0 0 0 26000 0 15275 0 336474 0 0 0 DAVID GALAS PRINCIPAL INVESTIGATOR 298187 0 0 0 0 0 0 0 0 0 298187 0 0 0 LISA STUBBS PRINCIPAL INVESTIGATOR 230000 0 0 0 0 0 26000 0 14569 0 270569 0 0 0 WILLIAM HAGOPIAN PRINCIPAL INVESTIGATOR 214674 0 0 0 0 0 25992 0 0 0 240666 0 0 0 AIMEE DUDLEY PRINCIPAL INVESTIGATOR 177582 0 0 0 0 0 12600 0 0 0 190182 0 0 0 BILL REICHERT CFO 143482 0 0 0 0 0 17134 0 0 0 160616 0 0 0 MICHAEL METZGER ASSISTANT PRINCIPAL INVESTIGATOR 123592 0 0 0 0 0 18983 0 13731 0 156306 0 0 0 X 1 201060 FAIR MARKET VALUE 0 0 1 0 PART I, COLUMN (B): NUMBER OF CONTRIBUTIONS RECEIVED. FORM 990, PART I, LINE 6: VOLUNTEERS CONSIST OF UNCOMPENSATED BOARD MEMBERS WHO GAVE THEIR TIME DURING THE YEAR. FORM 990, PART VI, SECTION B, LINE 11B THE CEO, CFAO AND FINANCE COMMITTEE CHAIR WILL REVIEW THE FORM 990 PRIOR TO FILING WITH THE IRS. THE PUBLIC DISCLOSURE COPY WILL BE DISTRIBTED AND DISCUSSED AT A SUBSEQUENT BOARD MEETING. ELECTRONIC COPIES OF THE PUBLIC DISCLOSURE VERSION OF FORM 990 WILL BE DISTRIBUTED TO THE ENTIRE BOARD, AND PHYSICAL COPIES OF THE FULL FORM 990 WILL BE MADE AVAILABLE ONSITE UPON REQUEST. FORM 990, PART VI, SECTION B, LINE 12C ANNUALLY, PER INSTITUTE CONFLICT OF INTEREST POLICY THE FINANCE & AUDIT COMMITTEE SUBMITS A BOARD QUESTIONNAIRE TO ALL TRUSTEES AND KEY STAFF. ALL RESPONSES ARE GATHERED AND REVIEWED BY THE COMMITTEE CHAIR AND THE CFO. THE RESULTS ARE DISCUSSED AT THE FINANCE & AUDIT COMMITTEE MEETING. THE COMMITTEE CHAIR THEN PRESENTS THE RESULTS TO THE FULL BOARD AND ACTION IS TAKEN AS NEEDED. IF A POTENTIAL CONFLICT OF INTEREST AROSE DURING THE YEAR, THE BOARD MEMBER WOULD CONTACT OUR COMMITTEE CHAIR AND DISCLOSE THE MATTER AND BOARD REVIEW AND ACTION WOULD BE TAKEN AT THE NEXT MEETING TO ALERT ALL MEMBERS. FORM 990, PART VI, SECTION B, LINE 15 THE CEO, CFO, AND KEY EMPLOYEES HAVE THEIR INITIAL SALARY AND ANY NON-COST OF LIVING ADJUSTMENT INCREASES DOCUMENTED BY A SALARY SURVEY PROCESS CONDUCTED BY OUR INDEPENDENT HUMAN RESOURCES CONSULTING FIRM. IN ADDITION THE CEO CONTRACT IS APPROVED BY BOARD EXECUTIVE COMMITTEE. COMPENSATION REVIEWS ARE PERFORMED ANNUALLY. FORM 990, PART VI, SECTION C, LINE 19 GOVERNING DOCUMENTS, CONFLICT OF INTEREST POLICY AND FINANCIAL STATEMENTS ARE AVAILABLE UPON REQUEST. FORM 990, PART IX, LINE 11G OTHER FEES: PROGRAM SERVICE EXPENSES 1,099,424. MANAGEMENT AND GENERAL EXPENSES 350,734. FUNDRAISING EXPENSES 19,723. TOTAL EXPENSES 1,469,881. FORM 990, PART XI, LINE 9: LOSS ON PERPETUAL TRUST -1,133,474.