2023-08-15T14:10:49-05:00 2022-09-30 861065772 DELOITTE TAX LLP 695 TOWN CENTER DRIVE SUITE 1000 COSTA MESA CA 92626 990 2021-10-01 330435954 THE SCRIPPS RESEARCH INSTITUTE SCRI 8587841000 10550 NORTH TORREY PINES ROAD LA JOLLA CA 92037 JARED MACHADO VP, TREAS. & CORP. FINANCE 8587849817 2023-08-15 1 JARED MACHADO XXX-XX-XXXX JOHN W SADOFF JR P00540589 7144367100 3 AAL1 IAL1 2021 2023-04-26 12:10:37Z PETER SCHULTZ PHD 10550 NORTH TORREY PINES ROAD LA JOLLA CA 92037 1237453037 0 X WWW.SCRIPPS.EDU X 1924 CA TSRI CONDUCTS BIOMEDICAL AND BIOCHEMICAL RESEARCH AND POSTGRADUATE TRAINING PROGRAMS. X 17 15 2196 15 593244 0 418691076 385396446 2261518 1280071 39422523 96765180 76712642 151538720 537087759 634980417 82523976 467412781 0 0 217363929 238179882 0 0 6257669 173956048 179368979 473843953 884961642 63243806 -249981225 1160188604 828320768 438180180 379483920 722008424 448836848 X THE SCRIPPS RESEARCH INSTITUTE ("TSRI") PERFORMS HIGH IMPACT BASIC BIOMEDICAL RESEARCH, IMPROVES THE HUMAN CONDITION BY FOSTERING TRANSLATION OF ITS DISCOVERIES INTO USEFUL PRODUCTS AND ENGAGES IN THE HIGHEST QUALITY GRADUATE SCIENTIFIC EDUCATION AND POST GRADUATE SCIENTIFIC TRAINING. TSRI IS KNOWN FOR ITS ENTREPRENEURIAL ENVIRONMENT AND ITS EMPHASIS IN RESEARCH RELATING TO SYNTHETIC CHEMISTRY, THE RELATIONSHIP BETWEEN MOLECULAR STRUCTURE AND ACTIVITY AND CHEMICAL BIOLOGY. 0 1 819703498 453397396 1280071 GROUNDBREAKING SCIENTIFIC RESEARCH IS CONDUCTED AT TSRI CAMPUSES IN LA JOLLA, CALIFORNIA, AND JUPITER, FLORIDA, SUPPORTED BY GRANTS, CONTRACTS AND FELLOWSHIPS FROM PUBLIC AND PRIVATE INSTITUTES AND INDIVIDUALS. TSRI'S UNIQUE STRUCTURE MERGES BASIC SCIENTIFIC STUDIES IN BIOLOGY, CHEMISTRY AND BIOINFORMATICS WITH TRANSLATIONAL SCIENCE TO PRODUCE THE NEXT GENERATION OF DRUGS AND ADVANCES IN DIGITAL AND PRECISION MEDICINE. SCIENTIFIC DISCOVERIES AT TSRI SEED JOINT DRUG DISCOVERY PROJECTS AT CALIBR, A DIVISION OF TSRI, CREATING A PIPELINE OF DRUG CANDIDATES THAT WILL IMPACT PATIENTS FOR YEARS TO COME. THE SCRIPPS RESEARCH TRANSLATIONAL INSTITUTE, ANOTHER DIVISION OF TSRI, AIMS TO INDIVIDUALIZE HEALTHCARE BY LEVERAGING THE PROGRESS BEING MADE IN HUMAN GENOMICS AND COMBINING IT WITH THE POWER OF WIRELESS DIGITAL TECHNOLOGIES AND ARTIFICIAL INTELLIGENCE. 26322909 14015385 TSRI IS COMMITTED TO EDUCATING, TRAINING AND INSPIRING THE SCIENTISTS OF TOMORROW. THE INSTITUTE'S SKAGGS GRADUATE SCHOOL OF CHEMICAL AND BIOLOGICAL SCIENCES, RANKED ONE OF THE TEN BEST GRADUATE PROGRAMS IN THE COUNTRY, EMPOWERS STUDENTS TO MAKE HIGH-IMPACT DISCOVERIES AT THE INTERFACE OF CHEMISTRY AND BIOLOGY. STUDENTS IN THE SKAGGS GRADUATE SCHOOL ARE IMMERSED IN INTENSIVE LABORATORY RESEARCH FROM DAY ONE AND PURSUE AMBITIOUS INVESTIGATIONS ACROSS SCIENTIFIC DISCIPLINES. GRADUATES OF THE SCHOOL BECOME EDUCATORS AT TOP UNIVERSITIES AND RESEARCH INSTITUTES, THOUGHT LEADERS WITHIN GOVERNMENT DEPARTMENTS AND INNOVATORS AT PHARMACEUTICAL AND BIOTECHNOLOGY COMPANIES. POSTDOCTORAL ASSOCIATES ARRIVE AT TSRI FROM ALL OVER THE GLOBE, SEEKING TO EXPAND THEIR KNOWLEDGE AND TRAINING BY WORKING ALONGSIDE OUR WORLD-RENOWNED SCIENTISTS. THE SCRIPPS FELLOWS PROGRAM IDENTIFIES INDIVIDUALS WITH AN OUTSTANDING RECORD OF GRADUATE RESEARCH AND MOVES THEM INTO THEIR OWN LABORATORIES, ALLOWING THEM TO LEAPFROG THEIR POSTDOCTORAL YEARS OF STUDY AND BEGIN PUSHING THE FRONTIERS OF SCIENTIFIC DISCOVERY. 846026407 1 1 0 0 0 0 0 0 0 1 1 1 0 0 1 0 1 0 0 0 1 1 0 0 0 0 0 1 1 1 1 0 0 0 0 0 0 0 0 0 0 1 0 0 1 1 1 1 1 0 0 1 339 0 1 2196 1 1 1 0 0 0 0 0 0 0 0 0 1 0 X 17 15 0 0 0 0 0 0 0 1 1 0 0 1 1 1 1 1 1 1 1 0 AL AR CA CO DC FL GA HI IL KS KY MA MD MI MN MS NC NH NJ NM NY OH OR PA RI SC TN UT VA WI WV X JARED MACHADO 8587841000 10550 N TORREY PINES DRIVE LA JOLLA CA 92037 PETER G SCHULTZ PRESIDENT/CEO 40.00 0.00 X X 1239681 0 77183 ARDEM PATAPOUTIAN DIRECTOR/PROFESSOR (START 10/21) 9.20 0.00 X 82916 0 16583 BERNARD SAINT-DONAT PHD DIRECTOR (END 10/21) 1.00 0.00 X 0 0 0 BENEDICT GROSS DIRECTOR 1.00 0.00 X 0 0 0 CHRISTOPHER T WALSH DIRECTOR (END 06/22) 1.00 0.00 X 0 0 0 CLAUDIA S LUTTRELL DIRECTOR 1.00 0.00 X 0 0 0 GE LI DIRECTOR 1.00 0.00 X 0 0 0 GERALD CHAN DIRECTOR 1.00 0.00 X 0 0 0 HERBERT WERTHEIM DIRECTOR 1.00 0.00 X 0 0 0 JEN RUBIO DIRECTOR (START 1/22) 1.00 0.00 X 0 0 0 JOHN D DIEKMAN BOARD CHAIR 1.00 0.00 X 0 0 0 JOANNE STUBBE DIRECTOR 1.00 0.00 X 0 0 0 LILLIAN LOU DIRECTOR 1.00 0.00 X 0 0 0 MARK EDWARDS DIRECTOR 1.00 0.00 X 0 0 0 MARK PEARSON DIRECTOR 1.00 0.00 X 0 0 0 PETER C FARRELL PHD D SC DIRECTOR 1.00 0.00 X 0 0 0 RON BURKLE DIRECTOR 1.00 0.00 X 0 0 0 SHERRY LANSING DIRECTOR 1.00 0.00 X 0 0 0 TOM DANIEL DIRECTOR 1.00 0.00 X 0 0 0 WILLIAM R HEARST III DIRECTOR (END 01/22) 1.00 0.00 X 0 0 0 MATTHEW S TREMBLAY CHIEF OPERATING OFFICER 40.00 0.00 X 707113 0 80213 ALICE T FENG CFO & TREASURER (END 01/22) 40.00 0.00 X 393039 0 78157 JARED M MACHADO TREAS.(BEG 1/22)/VP,TREAS.&CORP.FIN. 40.00 0.00 X 283861 0 76517 ALANNA RUTAN SECRETARY/CHIEF COMPLIANCE OFFICER 40.00 0.00 X 234041 0 42444 MARY WANG ASSISTANT SECRETARY/DIRECTOR SP 40.00 0.00 X 206145 0 28667 CAROLINE MOON CFO (START 6/22) 40.00 0.00 X 0 0 0 JAMES R WILLIAMSON VP RSCH & ACADEMIC AFFAIRS 40.00 0.00 X 428506 0 74550 KELLY SAN GEORGE CFO VP ADM. CALIBR 40.00 0.00 X 289522 0 54848 DOUGLAS A BINGHAM SECRETARY/EVP SCRIPPS FL (END 4/22) 40.00 0.00 X 389126 0 70276 ERIC TOPOL PROFESSOR/EXEC VP 40.00 0.00 X 1236257 0 72958 JIN-QUAN YU PHD PROFESSOR 40.00 0.00 X 416175 0 76161 VADIM KLYUSHNICHENKO VP PHARMACEUTICAL DEV & QUAL 40.00 0.00 X 406197 0 79805 TRAVIS SCOTT YOUNG SR. DIRECTOR, CALIBR 40.00 0.00 X 407934 0 61252 PETER E WRIGHT PROFESSOR 40.00 0.00 X 378893 0 73516 DEMETRIOS I ANDRIKOS FORMER SECRETARY 0.40 0.00 X 234565 0 7092 7333971 0 970222 359 1 1 1 BEHMER & BLACKFORD LLP 12526 HIGH BLUFF DRIVE SUITE 300 SAN DIEGO CA 92130 LEGAL SERVICES 1318311 WILSON SONSINI GOODRICH & ROSATI PO BOX 742866 LOS ANGELES CA 90074 LEGAL SERVICES 1198824 SCHWEGMAN LUNDBERG WOESSNER PA 121 SOUTH EIGHTH STREET MINNEAPOLIS MN 55402 LEGAL SERVICES 857356 HOLLAND & KNIGHT LLP PO BOX 864084 ORLANDO FL 32886 LEGAL SERVICES 477698 DELOITTE & TOUCHE LLP PO BOX 844708 DALLAS TX 75284 AUDIT & TAX SERVICES 469852 12 242135467 143260979 908576 385396446 PATENT OFFICE 900099 1280071 1280071 1280071 3644864 593244 3051620 139177066 139177066 2206376 1448380 757996 757996 757996 551659374 142485182 601011214 13026 -49351840 142472156 93120316 93120316 INSURANCE SETTLEMENT 900099 6100000 6100000 GRADUATE OFFICE COST R 900099 3114551 3114551 SHARED SRVCS-SCRIPPS H 900099 569762 569762 1819345 1819345 11603658 634980417 1280071 593244 247710656 X 451905079 451905079 14015385 14015385 1492317 1492317 4466925 1167030 3299895 200952685 183507489 15429870 2015326 -7619867 -6899495 -650390 -69982 26069884 24498701 1190782 380401 14310255 12957382 1221445 131428 5095225 5095225 8308743 8308743 697314 697314 48732787 45623842 1979512 1129433 3546335 3214975 174275 157085 9772979 7617417 2155337 225 2632009 2423546 142800 65663 4993554 4993554 25761485 25759046 2439 3021755 2253415 5466 762874 CONTRACTED SVCS - OTHER 40130142 34806547 4152164 1171431 LAB SUPPLIES 15352319 11623242 3576410 152667 UTILITIES 11324332 10965653 0 358679 884961642 846026407 32677566 6257669 196423177 150464867 73942523 59315416 483949 3859762 1184571 1665893 23170563 19978242 543722207 380185787 301968082 163536420 291006964 173859658 223115953 221429038 530000 378571 48362822 33832901 1160188604 828320768 79866253 70685226 166769573 141358103 24615041 20889555 106075000 105920000 60854313 40631036 438180180 379483920 X 448091646 213749076 273916778 235087772 722008424 448836848 1160188604 828320768 -249981225 -23190351 0 X 0 1 X 1 1 1 X 347588971 366278398 361859000 418691076 372859914 1867277359 347588971 366278398 361859000 418691076 372859914 1867277359 131981604 1735295755 22130806 36426682 33129194 77075770 145028308 313790760 1329949 978397 1742646 3005052 24140190 31196234 2212264353 10987186 0.78440 0.88290 X SCHEDULE A, PART II, LINE 10, EXPLANATION OF OTHER INCOME: OTHER INCOME - 2017 AMOUNT: $ 1,329,949. 2018 AMOUNT: $ 978,397. 2019 AMOUNT: $ 1,742,646. 2020 AMOUNT: $ 3,005,052. 2021 AMOUNT: $ 24,140,190. RESTRICTED RESTRICTED RESTRICTED RESTRICTED RESTRICTED RESTRICTED RESTRICTED RESTRICTED 237833719 13591076 -37099889 9648746 204676160 198444686 22060000 23746007 6416974 237833719 181126346 12474348 9370382 4526390 198444686 166946785 15554839 3809084 5184362 181126346 136651781 29186503 7711800 6603299 166946785 0.07000 0.66000 0.27000 0 0 19645590 19645590 286015734 189418457 96597277 22651825 21964280 687545 209947812 164980510 44967302 5461246 3822540 1638706 163536420 INVESTMENT IN LIMITED PARTNERSHIPS 221429038 F 221429038 PENSION LIABILITY 6687740 LEASE LIABILITY 33689592 UNITRUST 253704 40631036 613213684 -23190351 1423618 -21766733 634980417 0 634980417 886386678 1425036 1425036 884961642 0 884961642 PART V, LINE 4: INVESTMENT RETURN FROM THE ENDOWMENTS SUPPORTS SCIENTIFIC PROJECTS CONSISTENT WITH THE MISSION AND PRINCIPLES OF THE SCRIPPS RESEARCH INSTITUTE. PART XI, LINE 2D - OTHER ADJUSTMENTS: RENTAL EXPENSES NETTED AGAINST RENTAL REVENUE 1,448,380. GAIN ON DISPOSAL OF EQUIPMENT -24,762. PART XII, LINE 2D - OTHER ADJUSTMENTS: RENTAL EXPENSES NETTED AGAINST RENTAL REVENUE 1,448,380. GAIN ON DISPOSAL OF EQUIPMENT -24,762. ROUNDING 1,418. 1 EAST ASIA AND THE PACIFIC 0 0 PROGRAM SERVICES GRANTS FOR SCIENTIFIC RESEARCH 53139 EUROPE (INCLUDING ICELAND & GREENLAND) 0 0 PROGRAM SERVICES GRANTS FOR SCIENTIFIC RESEARCH 999529 NORTH AMERICA 0 0 PROGRAM SERVICES GRANTS FOR SCIENTIFIC RESEARCH 69790 SUB-SAHARAN AFRICA 0 0 PROGRAM SERVICES GRANTS FOR SCIENTIFIC RESEARCH 369859 CENTRAL AMERICA AND THE CARIBBEAN 0 0 INVESTMENTS 70088060 0 0 0 0 0 0 71580377 0 71580377 NORTH AMERICA GRANTS FOR SCIENTIFIC RESEARCH 69790 CHECK 0 EUROPE (INCLUDING ICELAND & GREENLAND) GRANTS FOR SCIENTIFIC RESEARCH 481723 ELECTRONIC FUND/WIRE TRANSFER 0 SUB-SAHARAN AFRICA GRANTS FOR SCIENTIFIC RESEARCH 98595 ELECTRONIC FUND/WIRE TRANSFER 0 EAST ASIA AND THE PACIFIC GRANTS FOR SCIENTIFIC RESEARCH 53139 ELECTRONIC FUND/WIRE TRANSFER 0 SUB-SAHARAN AFRICA GRANTS FOR SCIENTIFIC RESEARCH 41499 ELECTRONIC FUND/WIRE TRANSFER 0 SUB-SAHARAN AFRICA GRANTS FOR SCIENTIFIC RESEARCH 77119 ELECTRONIC FUND/WIRE TRANSFER 0 SUB-SAHARAN AFRICA GRANTS FOR SCIENTIFIC RESEARCH 19967 ELECTRONIC FUND/WIRE TRANSFER 0 EUROPE (INCLUDING ICELAND & GREENLAND) GRANTS FOR SCIENTIFIC RESEARCH 126673 ELECTRONIC FUND/WIRE TRANSFER 0 EUROPE (INCLUDING ICELAND & GREENLAND) GRANTS FOR SCIENTIFIC RESEARCH 198391 ELECTRONIC FUND/WIRE TRANSFER 0 EUROPE (INCLUDING ICELAND & GREENLAND) GRANTS FOR SCIENTIFIC RESEARCH 86902 ELECTRONIC FUND/WIRE TRANSFER 0 EUROPE (INCLUDING ICELAND & GREENLAND) GRANTS FOR SCIENTIFIC RESEARCH 105840 CHECK 0 SUB-SAHARAN AFRICA GRANTS FOR SCIENTIFIC RESEARCH 132679 ELECTRONIC FUND/WIRE TRANSFER 0 12 0 1 0 1 0 1 0 PART I, LINE 2: TSRI MONITORS THE AMOUNTS PROVIDED TO THE FOREIGN ORGANIZATION BY ADHERENCE TO A GRANT CONTRACT AND MONITORS DETAILED BILLING STATEMENTS OF RESEARCH EXPENDITURES. 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OF MASSACHUSETTS MEDICAL SCHOOL 333 SOUTH STREET SUITE 450 SHREWSBURY MA 01545 043167352 501(C)(3) 164055 0 GRANTS FOR SCIENTIFIC RESEARCH UNIVERSITY OF MIAMI PO BOX 248106 CORAL GABLES FL 33124 590624458 501(C)(3) 299485 0 GRANTS FOR SCIENTIFIC RESEARCH UNIVERSITY OF MICHIGAN 515 E JEFFERSON ANN ARBOR MI 48109 386006309 501(C)(3) 81785 0 GRANTS FOR SCIENTIFIC RESEARCH UNIVERSITY OF PITTSBURGH 128 NORTH CRAIG STREET PITTSBURGH PA 15260 250965591 501(C)(3) 66248 0 GRANTS FOR SCIENTIFIC RESEARCH UNIVERSITY OF ROCHESTER 910 GENESEE ST STE 200 ROCHESTER NY 14611 160743209 501(C)(3) 36825 0 GRANTS FOR SCIENTIFIC RESEARCH UNIVERSITY OF SOUTHERN CALIFORNIA 3551 TROUSDALE PARKWAY STE 160 LOS ANGELES CA 90089 951642394 501(C)(3) 118581 0 GRANTS FOR SCIENTIFIC RESEARCH UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER 5323 HARRY HINES BLVD DALLAS TX 75390 756002868 501(C)(3) 701528 0 GRANTS FOR SCIENTIFIC RESEARCH UNIVERSITY OF UTAH 201 S PRESIDENTS CIR RM 145 SALT LAKE CITY UT 84112 876000525 501(C)(3) 25794 0 GRANTS FOR SCIENTIFIC RESEARCH UNIVERSITY OF VIRGINIA PO BOX 400195 CHARLOTTESVILLE VA 22904 546001796 501(C)(3) 49362 0 GRANTS FOR SCIENTIFIC RESEARCH UNIVERSITY OF WASHINGTON 4295 EAST STEVENS WAY NE SEATTLE WA 98195 916001537 501(C)(3) 58981 0 GRANTS FOR SCIENTIFIC RESEARCH UNIVERSITY OF WISCONSIN 21 N PARK STREET SUITE 6301 MADISON WI 53715 396006492 501(C)(3) 408046 0 GRANTS FOR SCIENTIFIC RESEARCH URBAN ONE INC 1010 WAYNE AVE SILVER SPRING MD 20910 521166660 35000 0 GRANTS FOR SCIENTIFIC RESEARCH VANDERBILT UNIVERSITY MEDICAL CENTER 3322 WEST END AVENUE SUITE 900 NASHVILLE TN 37203 352528741 501(C)(3) 88777 0 GRANTS FOR SCIENTIFIC RESEARCH VETERANS MEDICAL RESEARCH FOUNDATION 3350 LA JOLLA VILLAGE DR 151A SAN DIEGO CA 92161 330189397 501(C)(3) 264637 0 GRANTS FOR SCIENTIFIC RESEARCH WALGREENS 108 WILMOT ROAD DEERFIELD IL 60015 471758322 947034 0 GRANTS FOR SCIENTIFIC RESEARCH WEB MD 395 HUDSON STREET NEW YORK NY 10014 202783228 862500 0 GRANTS FOR SCIENTIFIC RESEARCH YALE UNIVERSITY PO BOX 2038 NEW HAVEN CT 06521 060646973 501(C)(3) 158976 0 GRANTS FOR SCIENTIFIC RESEARCH 82 12 SCHOLARSHIPS & STIPENDS, TSRI GRADUATE SCHOOL 346 14015385 PART I, LINE 2: TSRI MONITORS THE AMOUNTS PROVIDED TO THE DOMESTIC ORGANIZATION BY ADHERENCE TO A GRANT CONTRACT AND MONITORS DETAILED BILLING STATEMENTS OF RESEARCH EXPENDITURES. GRADUATE STUDENT STIPENDS ARE PROCESSED VIA PERSONNEL ACTION FORMS WHICH ARE APPROVED BY THE GRADUATE OFFICE AND HUMAN RESOURCES PRIOR TO BEING SENT TO THE PAYROLL OFFICE. ONCE APPROVED, GRADUATE STUDENTS ARE SET UP IN TSRI'S PAYROLL SYSTEM AND ARE DISPERSED ON THE 1ST AND 15TH OF EACH MONTH. MONITORING IS DONE VIA THE INTERACTION BETWEEN THE STUDENT AND FACULTY ADVISOR. AS LONG AS THE STUDENT IS PROGRESSING, SHE/HE WOULD CONTINUE TO BE PAID. X 1 1 X X X X 1 0 0 0 0 0 0 0 0 PETER G SCHULTZ PRESIDENT/CEO 819463 0 391421 0 28797 0 58000 0 19183 0 1316864 0 0 0 ERIC TOPOL PROFESSOR/EXEC VP 1235689 0 0 0 568 0 58000 0 14958 0 1309215 0 0 0 MATTHEW S TREMBLAY CHIEF OPERATING OFFICER 514490 0 190675 0 1948 0 58000 0 22213 0 787326 0 0 0 JAMES R WILLIAMSON VP RSCH & ACADEMIC AFFAIRS 382732 0 38403 0 7371 0 58000 0 16550 0 503056 0 0 0 JIN-QUAN YU PHD PROFESSOR 401638 0 0 0 14537 0 58000 0 18161 0 492336 0 0 0 VADIM KLYUSHNICHENKO VP PHARMACEUTICAL DEV & QUAL 257491 0 80275 0 68431 0 58000 0 21805 0 486002 0 0 0 ALICE T FENG CFO & TREASURER (END 01/22) 302284 0 36001 0 54754 0 58000 0 20157 0 471196 0 0 0 TRAVIS SCOTT YOUNG SR. DIRECTOR, CALIBR 263867 0 133000 0 11067 0 41701 0 19551 0 469186 0 0 0 DOUGLAS A BINGHAM SECRETARY/EVP SCRIPPS FL (END 4/22) 319848 0 29122 0 40156 0 58000 0 12276 0 459402 0 0 0 PETER E WRIGHT PROFESSOR 368790 0 0 0 10103 0 58000 0 15516 0 452409 0 0 0 JARED M MACHADO TREAS.(BEG 1/22)/VP,TREAS.&CORP.FIN. 227038 0 26000 0 30823 0 52420 0 24097 0 360378 0 0 0 KELLY SAN GEORGE CFO VP ADM. CALIBR 203930 0 57512 0 28080 0 35259 0 19589 0 344370 0 0 0 ALANNA RUTAN SECRETARY/CHIEF COMPLIANCE OFFICER 191224 0 26876 0 15941 0 29900 0 12544 0 276485 0 0 0 DEMETRIOS I ANDRIKOS FORMER SECRETARY 22568 0 0 0 211997 0 5500 0 1592 0 241657 0 0 0 MARY WANG ASSISTANT SECRETARY/DIRECTOR SP 151327 0 42670 0 12148 0 16348 0 12319 0 234812 0 0 0 PART I, LINE 1A BUSINESS TRAVEL AND FIRST CLASS TRAVEL. THE SCRIPPS RESEARCH INSTITUTE ALLOWS FOR BUSINESS TRAVEL FOR CERTAIN KEY EMPLOYEES FOR LONG HAUL FLIGHTS. IN CERTAIN CIRCUMSTANCES, BUSINESS CLASS IS NOT AVAILABLE ON SMALLER AIRCRAFT. IN THOSE CIRCUMSTANCES, TSRI ALLOWS FIRST CLASS TRAVEL. PART I, LINE 4A SEVERANCE IS PROVIDED TO CERTAIN DEPARTING EMPLOYEES AND IS DETERMINED BASED ON LEVEL AND YEARS OF SERVICE AT THE INSTITUTE AS WELL AS THE INSTITUTE'S NEED TO ACCESS THE DEPARTED EMPLOYEE FOR TRANSITION PURPOSES. DEMETRIOS I. ANDRIKOS RECEIVED A SEVERANCE PAYMENT OF $160,000 DURING 2021. OTHER INFORMATION RELATED TO FORM 990, PART VII, LINE 5: ERIC TOPOL, M.D., RECEIVED COMPENSATION FROM AN UNRELATED ORGANIZATION, SCRIPPS CLINIC MEDICAL GROUP, FOR SERVICES PROVIDED TO THE SCRIPPS RESEARCH INSTITUTE. IN 2021, IN EXCHANGE FOR THESE SERVICES, THE SCRIPPS RESEARCH INSTITUTE REIMBURSED THE SCRIPPS MEDICAL GROUP $937,500. A CALIFORNIA INFRASTRUCTURE & ECONOMIC DEVELOPMENT BANK 630304653 13034AMU1 2016-08-30 40511601 SEE PART VI 0 0 0 A 14105000 40511601 1103259 648704 39236172 2016 1 1 1 1 A 0 0 0 1 0 0.00000 0.00000 0.00000 0 0 1 A 0 0 0 1 0 0 0 0 1 A 1 DATE REBATE COMPUTATION PERFORMED ISSUER NAME: CALIFORNIA INFRASTRUCTURE & ECONOMIC DEVELOPMENT BANK DATE THE REBATE COMPUTATION WAS PERFORMED: 06/29/2022 SCHEDULE K, PART I, BOND ISSUES: (A) ISSUE NAME: CALIFORNIA INFRASTRUCTURE & ECONOMIC DEVELOPMENT BANK (F) DESCRIPTION ON PURPOSE: REFUND AND DEFEASE BONDS PREVIOUSLY ISSUED FOR THE BENEFIT OF THE INSTITUTE ON 06/29/2000 AND 02/23/2005. SCHEDULE K, PART III, LINE 3D: OVERALL PRIVATE USE ISN'T MATERIAL AND OUTSIDE COUNSEL WOULD REVIEW ANY SIGNIFICANT AGREEMENTS. SCHEDULE K, PART IV, LINE 6: THIS QUESTION IS BEING ANSWERED WITHOUT REGARD TO A YIELD-RESTRICTED ADVANCE REFUNDING ESCROW FINANCED WITH PROCEEDS OF THE BONDS. X 14 908576 COST OR SELLING PRICE 0 0 1 0 PART I, COLUMN (B): NUMBER OF CONTRIBUTIONS OF PUBLICLY TRADED STOCK. PROPERTY, CASH, CASH EQUIVALENTS 2022-04-01 396176835 APPRAISALS 596002052 UNIVERSITY OF FLORIDA PO BOX 113201 STE 1250 EAS GAINESVILLE FL 32611 501(C)(3) 0 1 0 0 PART II, LINE 2E: EXPLANATION OF INVOLVEMENT: DOUGLAS A. BINGHAM, KEY EMPLOYEE, WAS HIRED BY THE TRANSFEREE ORGANIZATION. PART II, LINE 1 SCRIPPS FLORIDA WAS ESTABLISHED IN JANUARY 2004 AS AN OPERATING DIVISION OF SCRIPPS RESEARCH WITH A PRIMARY FOCUS ON BASIC BIOMEDICAL RESEARCH AND DRUG DISCOVERY. SCRIPPS FLORIDA WAS OPERATED FROM 2004 THROUGH TO THE EFFECTIVE DATE OF THE ASSET TRANSFER AGREEMENT ENTERED INTO IN 2021, AND EFFECTIVE IN MARCH 2022. THIS ASSET TRANSFER AGREEMENT WAS ENTERED INTO BETWEEN SCRIPPS RESEARCH AND A THIRD-PARTY NOT-FOR-PROFIT ENTITY STATING THAT SCRIPPS RESEARCH WILL CONTRIBUTE ALL ITS ASSETS AND RELATED LIABILITIES FROM THE FLORIDA RESEARCH FACILITY TO THIS NOT-FOR-PROFIT ENTITY. A FAIR VALUE APPRAISAL OF THE FLORIDA ASSETS WAS OBTAINED, WHICH RESULTED IN A NET GAIN AND WRITE-UP OF ASSETS OF $142 MILLION RECORDED IN OTHER REVENUE AND SUPPORT AND A RESULTING CONTRIBUTION EXPENSE OF $396 MILLION WAS RECORDED IN CONTRIBUTION EXPENSE AND OTHER IN THE ACCOMPANYING STATEMENT OF ACTIVITIES. $88.2 MILLION OF THE TOTAL CONTRIBUTION EXPENSE WAS TRANSFERRED IN CASH. ALL ASSETS TRANSFERRED AT FAIR VALUE WERE CONSIDERED PART OF THE CONTRIBUTION EXPENSE. FORM 990, PART III, LINE 3 SCRIPPS FLORIDA WAS ESTABLISHED IN JANUARY 2004 AS AN OPERATING DIVISION OF SCRIPPS RESEARCH WITH A PRIMARY FOCUS ON BASIC BIOMEDICAL RESEARCH AND DRUG DISCOVERY. SCRIPPS FLORIDA WAS OPERATED FROM 2004 THROUGH TO THE EFFECTIVE DATE OF THE ASSET TRANSFER AGREEMENT ENTERED INTO IN 2021, AND EFFECTIVE IN MARCH 2022. THIS ASSET TRANSFER AGREEMENT WAS ENTERED INTO BETWEEN SCRIPPS RESEARCH AND A THIRD-PARTY NOT-FOR-PROFIT ENTITY STATING THAT SCRIPPS RESEARCH WILL CONTRIBUTE ALL ITS ASSETS AND RELATED LIABILITIES FROM THE FLORIDA RESEARCH FACILITY TO THIS NOT-FOR-PROFIT ENTITY. A FAIR VALUE APPRAISAL OF THE FLORIDA ASSETS WAS OBTAINED, WHICH RESULTED IN A NET GAIN AND WRITE-UP OF ASSETS OF $142 MILLION RECORDED IN OTHER REVENUE AND SUPPORT AND A RESULTING CONTRIBUTION EXPENSE OF $396 MILLION WAS RECORDED IN CONTRIBUTION EXPENSE AND OTHER IN THE ACCOMPANYING STATEMENT OF ACTIVITIES. $88.2 MILLION OF THE TOTAL CONTRIBUTION EXPENSE WAS TRANSFERRED IN CASH. ALL ASSETS TRANSFERRED AT FAIR VALUE WERE CONSIDERED PART OF THE CONTRIBUTION EXPENSE. FORM 990, PART VI, SECTION B, LINE 11B ON JUNE 30, 2023, THE AUDIT COMMITTEE REVIEWED A DRAFT OF THE FORM 990 (INCLUDING ALL SUPPLEMENTAL SCHEDULES). THIS REVIEW INCLUDED A PRESENTATION OF THE STATEMENTS BY THE STAFF WITH PARTICULAR EMPHASIS ON DISCLOSURES ABOUT GOVERNANCE AND ABOUT TRANSACTIONS WITH INTERESTED PERSONS. THE 990 WILL BE PROVIDED TO THE FULL BOARD OF DIRECTORS PRIOR TO FILING. FORM 990, PART VI, SECTION B, LINE 12C TSRI'S CONFLICT OF INTEREST POLICIES AND PROCEDURES APPLY TO MEMBERS OF THE BOARD OF DIRECTORS, OFFICERS, KEY PERSONNEL, AND THEIR FAMILY MEMBERS (ALTOGETHER COVERED INDIVIDUALS) TO PROTECT THE INTERESTS OF TSRI WHEN IT IS CONTEMPLATING ENTERING INTO A TRANSACTION OR ARRANGEMENT THAT COULD: 1) BENEFIT THE PRIVATE INTEREST OF A COVERED INDIVIDUAL WITHIN THE MEANING OF TREASURY REGULATION SECTION 1.501(C)(3)-1(D)(1)(II), 2) RESULT IN A POSSIBLE EXCESS BENEFIT TRANSACTION WITHIN THE MEANING OF SECTION 4958(C) OF THE INTERNAL REVENUE CODE OF 1986, AS AMENDED; OR 3) BE A SELF-DEALING TRANSACTION WITHIN THE MEANING OF SECTION 5233 OF THE CALIFORNIA CORPORATIONS CODE (THE "CORPORATIONS CODE"). TSRI'S POLICIES AND PROCEDURES ARE INTENDED TO SUPPLEMENT, BUT NOT REPLACE, ANY STATE AND FEDERAL LAWS GOVERNING ACTUAL, POTENTIAL, OR APPARENT CONFLICT OF INTEREST APPLICABLE TO TSRI. DISCLOSURE DOCUMENTS RESPONSIVE TO TSRI'S POLICIES ARE ANNUALLY SUBMITTED BY COVERED INDIVIDUALS, AND ARE REVIEWED BY TSRI ADMINISTRATION FOR PERTINENT RELATIONSHIPS. ANY TRANSACTIONS OR ARRANGEMENTS INVOLVING COVERED INDIVIDUALS THAT FALL WITHIN THE SCOPE OF THE POLICIES ARE THEN SUBJECT TO REVIEW AND CONSIDERATION BY NON-CONFLICTED BOARD OF DIRECTOR MEMBERS, WITH CONFLICTED MEMBERS BEING RECUSED FROM ANY DEBATE AND VOTE TO APPROVE OR DISAPPROVE. FORM 990, PART VI, SECTION B, LINE 15 THE COMPENSATION OF THE CEO AND CERTAIN OTHER KEY EXECUTIVES WAS REVIEWED ON SEPTEMBER 28, 2021, AND APPROVED BY THE BOARD OF DIRECTORS. THIS REVIEW WAS BASED, IN PART, ON ANALYSIS PERFORMED BY THE HUMAN RESOURCES DEPARTMENT, AND INCLUDED DATA FROM OUTSIDE CONSULTANTS OR INTERNALLY-CONDUCTED RESEARCH. ON AN ONGOING BASIS, EXECUTIVES MAY PARTICIPATE IN THE NORMAL ANNUAL SALARY INCREASE PROGRAM, WHICH IS BASED ON A RECOMMENDATION FROM THE HUMAN RESOURCES DEPARTMENT BASED ON MARKET RESEARCH. ANY UNUSUAL OR POTENTIALLY NON-QUALIFIED COMPENSATION WOULD BE REVIEWED BY OUTSIDE COUNSEL FOR ANY TAX COMPLIANCE ISSUES. FORM 990, PART VI, SECTION C, LINE 19 GOVERNING DOCUMENTS AND CONFLICT OF INTEREST POLICIES ARE NOT AVAILABLE TO THE PUBLIC AT THIS TIME. THE FINANCIAL STATEMENTS ARE PROVIDED TO BOND HOLDERS THROUGH TSRI'S DISSEMINATION AGENT. THE ANNUAL INFORMATION RETURN IS PROVIDED UPON REQUEST. FORM 990, PART IX, LINE 11G PURCHASED SERVICES AND MAINTENANCE: PROGRAM SERVICE EXPENSES 45,623,842. MANAGEMENT AND GENERAL EXPENSES 1,979,512. FUNDRAISING EXPENSES 1,129,433. TOTAL EXPENSES 48,732,787. STRIDE LLC 10550 NORTH TORREY PINES ROAD LA JOLLA CA 92037 825129385 FACILITATE BASIC RESEARCH CA 105470 62283 THE SCRIPPS RESEARCH INSTITUTE CALM THERAPEUTICS INC 10550 NORTH TORREY PINES ROAD LA JOLLA CA 92037 825375039 RESEARCH DE THE SCRIPPS RESEARCH INSTITUTE C -66856 105023 0.62020 1 BIOSURF INC 10550 NORTH TORREY PINES ROAD LA JOLLA CA 92037 825117568 RESEARCH DE THE SCRIPPS RESEARCH INSTITUTE C -2364 0.60600 1 0 0 0 0 0 0 0 0 0 0 0 1 0 0 1 0 0 0 0 CALM THERAPEUTICS INC L 167753 CASH METHOD