<?xml version="1.0" encoding="utf-8"?>
<Return xmlns="http://www.irs.gov/efile" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://www.irs.gov/efile" returnVersion="2021v4.2">
  <ReturnHeader binaryAttachmentCnt="0">
    <ReturnTs>2022-04-25T07:54:11-05:00</ReturnTs>
    <TaxPeriodEndDt>2022-01-31</TaxPeriodEndDt>
    <PreparerFirmGrp>
      <PreparerFirmEIN>223462644</PreparerFirmEIN>
      <PreparerFirmName>
        <BusinessNameLine1Txt>EOS ACCOUNTANTS LLP</BusinessNameLine1Txt>
      </PreparerFirmName>
      <PreparerUSAddress>
        <AddressLine1Txt>401 HACKENSACK AVE STE 1001</AddressLine1Txt>
        <CityNm>HACKENSACK</CityNm>
        <StateAbbreviationCd>NJ</StateAbbreviationCd>
        <ZIPCd>07601</ZIPCd>
      </PreparerUSAddress>
    </PreparerFirmGrp>
    <ReturnTypeCd>990PF</ReturnTypeCd>
    <TaxPeriodBeginDt>2021-02-01</TaxPeriodBeginDt>
    <Filer>
      <EIN>815299703</EIN>
      <BusinessName>
        <BusinessNameLine1Txt>ONO PHARMA FOUNDATION</BusinessNameLine1Txt>
      </BusinessName>
      <BusinessNameControlTxt>ONOP</BusinessNameControlTxt>
      <PhoneNum>6092191010</PhoneNum>
      <USAddress>
        <AddressLine1Txt>CO TCC 333 7TH AVE 9TH FL</AddressLine1Txt>
        <CityNm>NEW YORK</CityNm>
        <StateAbbreviationCd>NY</StateAbbreviationCd>
        <ZIPCd>10001</ZIPCd>
      </USAddress>
    </Filer>
    <BusinessOfficerGrp>
      <PersonNm>TETSUYA SUGIYAMA</PersonNm>
      <PersonTitleTxt>PRESIDENT</PersonTitleTxt>
      <PhoneNum>6092191010</PhoneNum>
      <SignatureDt>2022-04-25</SignatureDt>
      <DiscussWithPaidPreparerInd>1</DiscussWithPaidPreparerInd>
    </BusinessOfficerGrp>
    <SigningOfficerGrp>
      <PersonFullName>
        <PersonFirstNm>TETSUYA</PersonFirstNm>
        <PersonLastNm>SUGIYAMA</PersonLastNm>
      </PersonFullName>
      <SSN>XXX-XX-XXXX</SSN>
    </SigningOfficerGrp>
    <PreparerPersonGrp>
      <PreparerPersonNm>SHINJI KOYAMA</PreparerPersonNm>
      <PTIN>P00854436</PTIN>
      <PhoneNum>2018363710</PhoneNum>
      <PreparationDt>2022-04-25</PreparationDt>
    </PreparerPersonGrp>
    <AdditionalFilerInformation>
      <TrustedCustomerGrp>
        <TrustedCustomerCd>3</TrustedCustomerCd>
        <AuthenticationAssuranceLevelCd>AAL1</AuthenticationAssuranceLevelCd>
        <IdentityAssuranceLevelCd>IAL1</IdentityAssuranceLevelCd>
      </TrustedCustomerGrp>
    </AdditionalFilerInformation>
    <TaxYr>2021</TaxYr>
    <BuildTS>2022-09-23 18:48:47Z</BuildTS>
  </ReturnHeader>
  <ReturnData documentCnt="10">
    <IRS990PF documentId="RetDoc1235000001">
      <Organization501c3ExemptPFInd>X</Organization501c3ExemptPFInd>
      <FMVAssetsEOYAmt>16610131</FMVAssetsEOYAmt>
      <MethodOfAccountingAccrualInd>X</MethodOfAccountingAccrualInd>
      <AnalysisOfRevenueAndExpenses>
        <ContriRcvdRevAndExpnssAmt>361696</ContriRcvdRevAndExpnssAmt>
        <CapGainNetIncmNetInvstIncmAmt>0</CapGainNetIncmNetInvstIncmAmt>
        <NetSTCapitalGainAdjNetIncmAmt>0</NetSTCapitalGainAdjNetIncmAmt>
        <TotalRevAndExpnssAmt>361696</TotalRevAndExpnssAmt>
        <TotalNetInvstIncmAmt>0</TotalNetInvstIncmAmt>
        <TotalAdjNetIncmAmt>0</TotalAdjNetIncmAmt>
        <CompOfcrDirTrstRevAndExpnssAmt>0</CompOfcrDirTrstRevAndExpnssAmt>
        <CompOfcrDirTrstNetInvstIncmAmt>0</CompOfcrDirTrstNetInvstIncmAmt>
        <CompOfcrDirTrstAdjNetIncmAmt>0</CompOfcrDirTrstAdjNetIncmAmt>
        <CompOfcrDirTrstDsbrsChrtblAmt>0</CompOfcrDirTrstDsbrsChrtblAmt>
        <LegalFeesRevAndExpnssAmt referenceDocumentId="RetDoc2002100001">9332</LegalFeesRevAndExpnssAmt>
        <LegalFeesNetInvstIncmAmt>0</LegalFeesNetInvstIncmAmt>
        <LegalFeesAdjNetIncmAmt>0</LegalFeesAdjNetIncmAmt>
        <LegalFeesDsbrsChrtblAmt>9332</LegalFeesDsbrsChrtblAmt>
        <AccountingFeesRevAndExpnssAmt referenceDocumentId="RetDoc2002200001">49079</AccountingFeesRevAndExpnssAmt>
        <AccountingFeesNetInvstIncmAmt>0</AccountingFeesNetInvstIncmAmt>
        <AccountingFeesAdjNetIncmAmt>0</AccountingFeesAdjNetIncmAmt>
        <AccountingFeesChrtblPrpsAmt>49079</AccountingFeesChrtblPrpsAmt>
        <OtherProfFeesRevAndExpnssAmt referenceDocumentId="RetDoc2002300001">146560</OtherProfFeesRevAndExpnssAmt>
        <OtherProfFeesNetInvstIncmAmt>0</OtherProfFeesNetInvstIncmAmt>
        <OtherProfFeesAdjNetIncmAmt>0</OtherProfFeesAdjNetIncmAmt>
        <OtherProfFeesDsbrsChrtblAmt>146560</OtherProfFeesDsbrsChrtblAmt>
        <DeprecAndDpltnRevAndExpnssAmt>1302</DeprecAndDpltnRevAndExpnssAmt>
        <DeprecAndDpltnNetInvstIncmAmt>0</DeprecAndDpltnNetInvstIncmAmt>
        <DeprecAndDpltnAdjNetIncmAmt>0</DeprecAndDpltnAdjNetIncmAmt>
        <OtherExpensesRevAndExpnssAmt referenceDocumentId="RetDoc2003200001">24534</OtherExpensesRevAndExpnssAmt>
        <OtherExpensesNetInvstIncmAmt>0</OtherExpensesNetInvstIncmAmt>
        <OtherExpensesAdjNetIncmAmt>0</OtherExpensesAdjNetIncmAmt>
        <OtherExpensesDsbrsChrtblAmt>24534</OtherExpensesDsbrsChrtblAmt>
        <TotOprExpensesRevAndExpnssAmt>230807</TotOprExpensesRevAndExpnssAmt>
        <TotOprExpensesNetInvstIncmAmt>0</TotOprExpensesNetInvstIncmAmt>
        <TotOprExpensesAdjNetIncmAmt>0</TotOprExpensesAdjNetIncmAmt>
        <TotOprExpensesDsbrsChrtblAmt>229505</TotOprExpensesDsbrsChrtblAmt>
        <ContriPaidRevAndExpnssAmt>3132076</ContriPaidRevAndExpnssAmt>
        <ContriPaidDsbrsChrtblAmt>4830000</ContriPaidDsbrsChrtblAmt>
        <TotalExpensesRevAndExpnssAmt>3362883</TotalExpensesRevAndExpnssAmt>
        <TotalExpensesNetInvstIncmAmt>0</TotalExpensesNetInvstIncmAmt>
        <TotalExpensesAdjNetIncmAmt>0</TotalExpensesAdjNetIncmAmt>
        <TotalExpensesDsbrsChrtblAmt>5059505</TotalExpensesDsbrsChrtblAmt>
        <ExcessRevenueOverExpensesAmt>-3001187</ExcessRevenueOverExpensesAmt>
        <NetInvestmentIncomeAmt>0</NetInvestmentIncomeAmt>
        <AdjustedNetIncomeAmt>0</AdjustedNetIncomeAmt>
      </AnalysisOfRevenueAndExpenses>
      <Form990PFBalanceSheetsGrp>
        <CashBOYAmt>2877937</CashBOYAmt>
        <CashEOYAmt>3010565</CashEOYAmt>
        <CashEOYFMVAmt>3010565</CashEOYFMVAmt>
        <PledgesRcvblAmt>13568567</PledgesRcvblAmt>
        <PledgesRcvblBOYAmt>18388971</PledgesRcvblBOYAmt>
        <PledgesRcvblEOYAmt>13568567</PledgesRcvblEOYAmt>
        <PledgesRcvblEOYFMVAmt>13568567</PledgesRcvblEOYFMVAmt>
        <PrepaidExpensesBOYAmt>16667</PrepaidExpensesBOYAmt>
        <PrepaidExpensesEOYAmt>16667</PrepaidExpensesEOYAmt>
        <PrepaidExpensesEOYFMVAmt>16667</PrepaidExpensesEOYFMVAmt>
        <OtherAssetsBOYAmt referenceDocumentId="RetDoc2046600001">0</OtherAssetsBOYAmt>
        <OtherAssetsEOYAmt referenceDocumentId="RetDoc2046600001">14332</OtherAssetsEOYAmt>
        <OtherAssetsEOYFMVAmt referenceDocumentId="RetDoc2046600001">14332</OtherAssetsEOYFMVAmt>
        <TotalAssetsBOYAmt>21283575</TotalAssetsBOYAmt>
        <TotalAssetsEOYAmt>16610131</TotalAssetsEOYAmt>
        <TotalAssetsEOYFMVAmt>16610131</TotalAssetsEOYFMVAmt>
        <AccountsPayableBOYAmt>25</AccountsPayableBOYAmt>
        <AccountsPayableEOYAmt>847</AccountsPayableEOYAmt>
        <GrantsPayableBOYAmt>7611650</GrantsPayableBOYAmt>
        <GrantsPayableEOYAmt>5913726</GrantsPayableEOYAmt>
        <OtherLiabilitiesBOYAmt referenceDocumentId="RetDoc2065700001">6545</OtherLiabilitiesBOYAmt>
        <OtherLiabilitiesEOYAmt referenceDocumentId="RetDoc2065700001">31390</OtherLiabilitiesEOYAmt>
        <TotalLiabilitiesBOYAmt>7618220</TotalLiabilitiesBOYAmt>
        <TotalLiabilitiesEOYAmt>5945963</TotalLiabilitiesEOYAmt>
        <OrganizationFollowsFASB117Ind>X</OrganizationFollowsFASB117Ind>
        <NoDonorRstrNetAssestsBOYAmt>-4723616</NoDonorRstrNetAssestsBOYAmt>
        <NoDonorRstrNetAssestsEOYAmt>-2904399</NoDonorRstrNetAssestsEOYAmt>
        <DonorRstrNetAssetsBOYAmt>18388971</DonorRstrNetAssetsBOYAmt>
        <DonorRstrNetAssetsEOYAmt>13568567</DonorRstrNetAssetsEOYAmt>
        <TotNetAstOrFundBalancesBOYAmt>13665355</TotNetAstOrFundBalancesBOYAmt>
        <TotNetAstOrFundBalancesEOYAmt>10664168</TotNetAstOrFundBalancesEOYAmt>
        <TotalLiabilitiesNetAstBOYAmt>21283575</TotalLiabilitiesNetAstBOYAmt>
        <TotalLiabilitiesNetAstEOYAmt>16610131</TotalLiabilitiesNetAstEOYAmt>
      </Form990PFBalanceSheetsGrp>
      <ChgInNetAssetsFundBalancesGrp>
        <TotNetAstOrFundBalancesBOYAmt>13665355</TotNetAstOrFundBalancesBOYAmt>
        <ExcessRevenueOverExpensesAmt>-3001187</ExcessRevenueOverExpensesAmt>
        <OtherIncreasesAmt>0</OtherIncreasesAmt>
        <SubtotalAmt>10664168</SubtotalAmt>
        <OtherDecreasesAmt>0</OtherDecreasesAmt>
        <TotNetAstOrFundBalancesEOYAmt>10664168</TotNetAstOrFundBalancesEOYAmt>
      </ChgInNetAssetsFundBalancesGrp>
      <ExciseTaxBasedOnInvstIncmGrp>
        <InvestmentIncomeExciseTaxAmt>0</InvestmentIncomeExciseTaxAmt>
        <TaxUnderSection511Amt>0</TaxUnderSection511Amt>
        <SubtotalAmt>0</SubtotalAmt>
        <SubtitleATaxAmt>0</SubtitleATaxAmt>
        <TaxBasedOnInvestmentIncomeAmt>0</TaxBasedOnInvestmentIncomeAmt>
        <EstimatedPlusOvpmtIncmTxAmt>0</EstimatedPlusOvpmtIncmTxAmt>
        <ExemptFrgnOrgTaxWthldAtSrceAmt>0</ExemptFrgnOrgTaxWthldAtSrceAmt>
        <ExtsnRequestIncomeTaxPaidAmt>0</ExtsnRequestIncomeTaxPaidAmt>
        <BackupWithholdingWithheldAmt>0</BackupWithholdingWithheldAmt>
        <TotalPaymentsAndCreditsAmt>0</TotalPaymentsAndCreditsAmt>
        <EsPenaltyAmt>0</EsPenaltyAmt>
        <TaxDueAmt>0</TaxDueAmt>
      </ExciseTaxBasedOnInvstIncmGrp>
      <StatementsRegardingActyGrp>
        <LegislativePoliticalActyInd>0</LegislativePoliticalActyInd>
        <MoreThan100SpentInd>0</MoreThan100SpentInd>
        <Form1120POLFiledInd>0</Form1120POLFiledInd>
        <Section4955OrganizationTaxAmt>0</Section4955OrganizationTaxAmt>
        <Section4955ManagersTaxAmt>0</Section4955ManagersTaxAmt>
        <TaxReimbursedAmt>0</TaxReimbursedAmt>
        <ActivitiesNotPreviouslyRptInd>0</ActivitiesNotPreviouslyRptInd>
        <ChangesToArticlesOrBylawsInd>0</ChangesToArticlesOrBylawsInd>
        <UnrelatedBusIncmOverLimitInd>0</UnrelatedBusIncmOverLimitInd>
        <OrganizationDissolvedEtcInd>0</OrganizationDissolvedEtcInd>
        <Section508eRqrSatisfiedInd>0</Section508eRqrSatisfiedInd>
        <AtLeast5000InAssetsInd>1</AtLeast5000InAssetsInd>
        <Form990PFFiledWithAttyGenInd referenceDocumentId="RetDoc2210600001">0</Form990PFFiledWithAttyGenInd>
        <PrivateOperatingFoundationInd>1</PrivateOperatingFoundationInd>
        <NewSubstantialContributorsInd referenceDocumentId="RetDoc2089200001">1</NewSubstantialContributorsInd>
        <OwnControlledEntityInd>0</OwnControlledEntityInd>
        <DonorAdvisedFundInd>0</DonorAdvisedFundInd>
        <ComplyWithPublicInspRqrInd>1</ComplyWithPublicInspRqrInd>
        <WebsiteAddressTxt>HTTP://WWW.ONOFOUND.ORG</WebsiteAddressTxt>
        <PersonsWithBooksName>
          <BusinessNameLine1Txt>DR TETSUYA SUGIYAMA</BusinessNameLine1Txt>
        </PersonsWithBooksName>
        <PhoneNum>6092191010</PhoneNum>
        <LocationOfBooksUSAddress>
          <AddressLine1Txt>C/O TCC 333 7TH AVE 9TH FL</AddressLine1Txt>
          <CityNm>NEW YORK</CityNm>
          <StateAbbreviationCd>NY</StateAbbreviationCd>
          <ZIPCd>10001</ZIPCd>
        </LocationOfBooksUSAddress>
        <ForeignAccountsQuestionInd>0</ForeignAccountsQuestionInd>
      </StatementsRegardingActyGrp>
      <StatementsRegardingActy4720Grp>
        <SaleOrExchDisqualifiedPrsnInd>0</SaleOrExchDisqualifiedPrsnInd>
        <BrrwOrLendDisqualifiedPrsnInd>0</BrrwOrLendDisqualifiedPrsnInd>
        <FurnGoodsDisqualifiedPrsnInd>0</FurnGoodsDisqualifiedPrsnInd>
        <PayCompDisqualifiedPrsnInd>0</PayCompDisqualifiedPrsnInd>
        <TransferAstDisqualifiedPrsnInd>0</TransferAstDisqualifiedPrsnInd>
        <PaymentToGovernmentOfficialInd>0</PaymentToGovernmentOfficialInd>
        <UncorrectedPriorActsInd>0</UncorrectedPriorActsInd>
        <UndistributedIncomePYInd>0</UndistributedIncomePYInd>
        <BusinessHoldingsInd>0</BusinessHoldingsInd>
        <JeopardyInvestmentsInd>0</JeopardyInvestmentsInd>
        <UncorrectedPYJeopardyInvstInd>0</UncorrectedPYJeopardyInvstInd>
        <InfluenceLegislationInd>0</InfluenceLegislationInd>
        <InfluenceElectionInd>0</InfluenceElectionInd>
        <GrantsToIndividualsInd>0</GrantsToIndividualsInd>
        <GrantsToOrganizationsInd>0</GrantsToOrganizationsInd>
        <NoncharitablePurposeInd>0</NoncharitablePurposeInd>
        <RcvFndsToPayPrsnlBnftCntrctInd>0</RcvFndsToPayPrsnlBnftCntrctInd>
        <PayPremiumsPrsnlBnftCntrctInd>0</PayPremiumsPrsnlBnftCntrctInd>
        <ProhibitedTaxShelterTransInd>0</ProhibitedTaxShelterTransInd>
        <SubjToTaxRmnrtnExPrchtPymtInd>0</SubjToTaxRmnrtnExPrchtPymtInd>
      </StatementsRegardingActy4720Grp>
      <OfficerDirTrstKeyEmplInfoGrp>
        <OfficerDirTrstKeyEmplGrp>
          <PersonNm>TETSUYA SUGIYAMA</PersonNm>
          <ForeignAddress>
            <AddressLine1Txt>1-1 SAKURAI 3CHOME SHIMAMOTO</AddressLine1Txt>
            <CityNm>MISHIMA</CityNm>
            <ProvinceOrStateNm>OSAKA</ProvinceOrStateNm>
            <CountryCd>JA</CountryCd>
            <ForeignPostalCd>618-8585</ForeignPostalCd>
          </ForeignAddress>
          <TitleTxt>PRESIDENT</TitleTxt>
          <AverageHrsPerWkDevotedToPosRt>20.00</AverageHrsPerWkDevotedToPosRt>
          <CompensationAmt>0</CompensationAmt>
          <EmployeeBenefitProgramAmt>0</EmployeeBenefitProgramAmt>
          <ExpenseAccountOtherAllwncAmt>0</ExpenseAccountOtherAllwncAmt>
        </OfficerDirTrstKeyEmplGrp>
        <OfficerDirTrstKeyEmplGrp>
          <PersonNm>HIROSHI OCHIAI</PersonNm>
          <USAddress>
            <AddressLine1Txt>1 MAIN ST UNIT 1050</AddressLine1Txt>
            <CityNm>CAMBRIDGE</CityNm>
            <StateAbbreviationCd>MA</StateAbbreviationCd>
            <ZIPCd>02142</ZIPCd>
          </USAddress>
          <TitleTxt>VICE PRESIDENT</TitleTxt>
          <AverageHrsPerWkDevotedToPosRt>10.00</AverageHrsPerWkDevotedToPosRt>
          <CompensationAmt>0</CompensationAmt>
          <EmployeeBenefitProgramAmt>0</EmployeeBenefitProgramAmt>
          <ExpenseAccountOtherAllwncAmt>0</ExpenseAccountOtherAllwncAmt>
        </OfficerDirTrstKeyEmplGrp>
        <OfficerDirTrstKeyEmplGrp>
          <PersonNm>TOMOYUKI BANDO</PersonNm>
          <USAddress>
            <AddressLine1Txt>1 MAIN ST UNIT 1050</AddressLine1Txt>
            <CityNm>CAMBRIDGE</CityNm>
            <StateAbbreviationCd>MA</StateAbbreviationCd>
            <ZIPCd>02142</ZIPCd>
          </USAddress>
          <TitleTxt>TREASURER</TitleTxt>
          <AverageHrsPerWkDevotedToPosRt>2.00</AverageHrsPerWkDevotedToPosRt>
          <CompensationAmt>0</CompensationAmt>
          <EmployeeBenefitProgramAmt>0</EmployeeBenefitProgramAmt>
          <ExpenseAccountOtherAllwncAmt>0</ExpenseAccountOtherAllwncAmt>
        </OfficerDirTrstKeyEmplGrp>
        <OfficerDirTrstKeyEmplGrp>
          <PersonNm>MASAYA KOKUBO</PersonNm>
          <ForeignAddress>
            <AddressLine1Txt>1-1 SAKURAI 3CHOME SHIMAMOTO</AddressLine1Txt>
            <CityNm>MISHIMA</CityNm>
            <ProvinceOrStateNm>OSAKA</ProvinceOrStateNm>
            <CountryCd>JA</CountryCd>
            <ForeignPostalCd>618-8585</ForeignPostalCd>
          </ForeignAddress>
          <TitleTxt>SECRETARY</TitleTxt>
          <AverageHrsPerWkDevotedToPosRt>5.00</AverageHrsPerWkDevotedToPosRt>
          <CompensationAmt>0</CompensationAmt>
          <EmployeeBenefitProgramAmt>0</EmployeeBenefitProgramAmt>
          <ExpenseAccountOtherAllwncAmt>0</ExpenseAccountOtherAllwncAmt>
        </OfficerDirTrstKeyEmplGrp>
        <CompOfHghstPdEmplOrNONETxt>NONE</CompOfHghstPdEmplOrNONETxt>
        <OtherEmployeePaidOver50kCnt>0</OtherEmployeePaidOver50kCnt>
        <CompOfHghstPdCntrctOrNONETxt>NONE</CompOfHghstPdCntrctOrNONETxt>
        <ContractorPaidOver50kCnt>0</ContractorPaidOver50kCnt>
      </OfficerDirTrstKeyEmplInfoGrp>
      <SummaryOfDirectChrtblActyGrp>
        <Description1Txt>THE PURPOSE OF THE ONO PHARMA BREAKTHROUGH SCIENCE INITIATIVE AWARDS PROGRAM IS TO SUPPORT SCIENTIST PRINCIPAL INVESTIGATORS WITH CREATIVE IDEAS IN SELECTED SCIENTIFIC RESEARCH FIELDS WITH THE MISSION OF SEEKING DISCOVERIES/SOLUTIONS AND DEVELOPMENT OF HIGH IMPACT SCIENCE.</Description1Txt>
        <Expenses1Amt>3299804</Expenses1Amt>
      </SummaryOfDirectChrtblActyGrp>
      <SumOfProgramRelatedInvstGrp>
        <TotalAmt>0</TotalAmt>
      </SumOfProgramRelatedInvstGrp>
      <MinimumInvestmentReturnGrp>
        <AverageMonthlyFMVOfSecAmt>0</AverageMonthlyFMVOfSecAmt>
        <AverageMonthlyCashBalancesAmt>3827828</AverageMonthlyCashBalancesAmt>
        <FMVAllOtherNoncharitableAstAmt>0</FMVAllOtherNoncharitableAstAmt>
        <TotalFMVOfUnusedAssetsAmt>3827828</TotalFMVOfUnusedAssetsAmt>
        <ReductionClaimedAmt>0</ReductionClaimedAmt>
        <AcquisitionIndebtednessAmt>0</AcquisitionIndebtednessAmt>
        <AdjustedTotalFMVOfUnusedAstAmt>3827828</AdjustedTotalFMVOfUnusedAstAmt>
        <CashDeemedCharitableAmt>57417</CashDeemedCharitableAmt>
        <NetVlNoncharitableAssetsAmt>3770411</NetVlNoncharitableAssetsAmt>
        <MinimumInvestmentReturnAmt>188521</MinimumInvestmentReturnAmt>
      </MinimumInvestmentReturnGrp>
      <DistributableAmountGrp>
        <Sect4942j3j5FndtnAndFrgnOrgInd>X</Sect4942j3j5FndtnAndFrgnOrgInd>
      </DistributableAmountGrp>
      <PFQualifyingDistributionsGrp>
        <ExpensesAndContributionsAmt>5059505</ExpensesAndContributionsAmt>
        <ProgramRelatedInvstTotalAmt>0</ProgramRelatedInvstTotalAmt>
        <QualifyingDistributionsAmt>5059505</QualifyingDistributionsAmt>
      </PFQualifyingDistributionsGrp>
      <PrivateOperatingFoundationsGrp>
        <PrivateOperatingFndtnRulingDt>2017-03-29</PrivateOperatingFndtnRulingDt>
        <Section4942j3Ind>X</Section4942j3Ind>
        <LessorAdjNetIncmMinInvstRetGrp>
          <CurrentYearAmt>0</CurrentYearAmt>
          <Year1Amt>0</Year1Amt>
          <Year2Amt>0</Year2Amt>
          <Year3Amt>0</Year3Amt>
          <TotalAmt>0</TotalAmt>
        </LessorAdjNetIncmMinInvstRetGrp>
        <Pct85LessorAdjIncmOrMinRetGrp>
          <CurrentYearAmt>0</CurrentYearAmt>
          <Year1Amt>0</Year1Amt>
          <Year2Amt>0</Year2Amt>
          <Year3Amt>0</Year3Amt>
          <TotalAmt>0</TotalAmt>
        </Pct85LessorAdjIncmOrMinRetGrp>
        <QualifyingDistributionsGrp>
          <CurrentYearAmt>5059505</CurrentYearAmt>
          <Year1Amt>5207120</Year1Amt>
          <Year2Amt>4482924</Year2Amt>
          <Year3Amt>3031661</Year3Amt>
          <TotalAmt>17781210</TotalAmt>
        </QualifyingDistributionsGrp>
        <QualifyingDistriNotUsedDrtGrp>
          <CurrentYearAmt>0</CurrentYearAmt>
          <Year1Amt>0</Year1Amt>
          <Year2Amt>0</Year2Amt>
          <Year3Amt>0</Year3Amt>
          <TotalAmt>0</TotalAmt>
        </QualifyingDistriNotUsedDrtGrp>
        <QualifyingDistriMadeDrtGrp>
          <CurrentYearAmt>5059505</CurrentYearAmt>
          <Year1Amt>5207120</Year1Amt>
          <Year2Amt>4482924</Year2Amt>
          <Year3Amt>3031661</Year3Amt>
          <TotalAmt>17781210</TotalAmt>
        </QualifyingDistriMadeDrtGrp>
        <TotalAssetsGrp>
          <CurrentYearAmt>16610131</CurrentYearAmt>
          <Year1Amt>21283575</Year1Amt>
          <Year2Amt>11005467</Year2Amt>
          <Year3Amt>10425004</Year3Amt>
          <TotalAmt>59324177</TotalAmt>
        </TotalAssetsGrp>
        <TotalAssetsSect4942j3BiGrp>
          <CurrentYearAmt>16610131</CurrentYearAmt>
          <Year1Amt>21283575</Year1Amt>
          <Year2Amt>11005467</Year2Amt>
          <Year3Amt>10425004</Year3Amt>
          <TotalAmt>59324177</TotalAmt>
        </TotalAssetsSect4942j3BiGrp>
        <TwoThirdsMinimumInvstRetGrp>
          <TotalAmt>0</TotalAmt>
        </TwoThirdsMinimumInvstRetGrp>
        <TotalSupportGrp>
          <CurrentYearAmt>361696</CurrentYearAmt>
          <Year1Amt>12980605</Year1Amt>
          <Year2Amt>5602706</Year2Amt>
          <Year3Amt>202141</Year3Amt>
          <TotalAmt>19147148</TotalAmt>
        </TotalSupportGrp>
        <PublicSupportType>
          <TotalAmt>0</TotalAmt>
        </PublicSupportType>
        <LargestSupportFromEOGrp>
          <TotalAmt>0</TotalAmt>
        </LargestSupportFromEOGrp>
        <GrossInvestmentIncomeGrp>
          <TotalAmt>0</TotalAmt>
        </GrossInvestmentIncomeGrp>
      </PrivateOperatingFoundationsGrp>
      <SupplementaryInformationGrp>
        <ApplicationSubmissionInfoGrp>
          <RecipientPersonNm>ONO PHARMA FOUNDATION</RecipientPersonNm>
          <RecipientUSAddress>
            <AddressLine1Txt>C/O TCC 333 7TH AVE 9TH FL</AddressLine1Txt>
            <CityNm>NEW YORK</CityNm>
            <StateAbbreviationCd>NY</StateAbbreviationCd>
            <ZIPCd>10001</ZIPCd>
          </RecipientUSAddress>
          <RecipientPhoneNum>6092191010</RecipientPhoneNum>
          <FormAndInfoAndMaterialsTxt>LETTER OF INTEREST MUST BE SUBMITTED BY ALL NOMINATED, INTERESTED, AND ELIGIBLE PRINCIPAL INVESTIGATORS. A FULL PROPOSAL MUST BE SUBMITTED BY INVITED AND QUALIFIED PRINCIPAL INVESTIGATORS.</FormAndInfoAndMaterialsTxt>
          <SubmissionDeadlinesTxt>LETTER OF INTEREST DUE ON FEB 18, 2021. REQUEST FOR PROPOSAL DUE ON APRIL 22, 2021.</SubmissionDeadlinesTxt>
          <RestrictionsOnAwardsTxt>BRIEF REPORTS WILL BE REQUIRED EVERY SIX MONTHS AFTER THE GRANTING OF THE AWARD. THESE REPORTS WILL BE A MEANS FOR ASSURING THAT THE RESEARCH FOLLOWS THE APPROVED PROPOSAL IN CONTENT AND TIMEFRAME. A FINAL STUDY REPORT WILL BE DUE TWO MONTHS AFTER PROJECT COMPLETION.</RestrictionsOnAwardsTxt>
        </ApplicationSubmissionInfoGrp>
        <GrantOrContributionPdDurYrGrp>
          <RecipientBusinessName>
            <BusinessNameLine1Txt>UNIVERSITY OF CALIFORNIA SAN DIEGO DR WILLIAM MOBLEY</BusinessNameLine1Txt>
          </RecipientBusinessName>
          <RecipientUSAddress>
            <AddressLine1Txt>9500 GILMAN DR</AddressLine1Txt>
            <CityNm>SAN DIEGO</CityNm>
            <StateAbbreviationCd>CA</StateAbbreviationCd>
            <ZIPCd>92093</ZIPCd>
          </RecipientUSAddress>
          <RecipientRelationshipTxt>N/A</RecipientRelationshipTxt>
          <RecipientFoundationStatusTxt>SEC 501(C)(3)</RecipientFoundationStatusTxt>
          <GrantOrContributionPurposeTxt>THE ONO PHARMA BREAKTHROUGH SCIENCE INTITIATIVE AWARDS PROGRAM</GrantOrContributionPurposeTxt>
          <Amt>172500</Amt>
        </GrantOrContributionPdDurYrGrp>
        <GrantOrContributionPdDurYrGrp>
          <RecipientBusinessName>
            <BusinessNameLine1Txt>UNIVERSITY OF CALIFORNIA SAN FRANCISCO DR JACK TAUNTON</BusinessNameLine1Txt>
          </RecipientBusinessName>
          <RecipientUSAddress>
            <AddressLine1Txt>600 16TH ST MC2280</AddressLine1Txt>
            <CityNm>SAN FRANCISCO</CityNm>
            <StateAbbreviationCd>CA</StateAbbreviationCd>
            <ZIPCd>94158</ZIPCd>
          </RecipientUSAddress>
          <RecipientRelationshipTxt>N/A</RecipientRelationshipTxt>
          <RecipientFoundationStatusTxt>SEC 501(C)(3)</RecipientFoundationStatusTxt>
          <GrantOrContributionPurposeTxt>THE ONO PHARMA BREAKTHROUGH SCIENCE INTITIATIVE AWARDS PROGRAM</GrantOrContributionPurposeTxt>
          <Amt>172500</Amt>
        </GrantOrContributionPdDurYrGrp>
        <GrantOrContributionPdDurYrGrp>
          <RecipientBusinessName>
            <BusinessNameLine1Txt>UNIVERSITY OF CALIFORNIA SAN FRANSISCO DR MICHELLE ARKIN</BusinessNameLine1Txt>
          </RecipientBusinessName>
          <RecipientUSAddress>
            <AddressLine1Txt>550 PARNASSUS AVE</AddressLine1Txt>
            <CityNm>SAN FRANCISCO</CityNm>
            <StateAbbreviationCd>CA</StateAbbreviationCd>
            <ZIPCd>94143</ZIPCd>
          </RecipientUSAddress>
          <RecipientRelationshipTxt>N/A</RecipientRelationshipTxt>
          <RecipientFoundationStatusTxt>SEC 501(C)(3)</RecipientFoundationStatusTxt>
          <GrantOrContributionPurposeTxt>THE ONO PHARMA BREAKTHROUGH SCIENCE INTITIATIVE AWARDS PROGRAM</GrantOrContributionPurposeTxt>
          <Amt>172500</Amt>
        </GrantOrContributionPdDurYrGrp>
        <GrantOrContributionPdDurYrGrp>
          <RecipientBusinessName>
            <BusinessNameLine1Txt>YALE UNIVERSITY DR MATTHEW SIMON</BusinessNameLine1Txt>
          </RecipientBusinessName>
          <RecipientUSAddress>
            <AddressLine1Txt>NEW HAVEN</AddressLine1Txt>
            <CityNm>NEW HAVEN</CityNm>
            <StateAbbreviationCd>CT</StateAbbreviationCd>
            <ZIPCd>06520</ZIPCd>
          </RecipientUSAddress>
          <RecipientRelationshipTxt>N/A</RecipientRelationshipTxt>
          <RecipientFoundationStatusTxt>SEC 501(C)(3)</RecipientFoundationStatusTxt>
          <GrantOrContributionPurposeTxt>THE ONO PHARMA BREAKTHROUGH SCIENCE INTITIATIVE AWARDS PROGRAM</GrantOrContributionPurposeTxt>
          <Amt>172500</Amt>
        </GrantOrContributionPdDurYrGrp>
        <GrantOrContributionPdDurYrGrp>
          <RecipientBusinessName>
            <BusinessNameLine1Txt>HARVARD UNIVERSITY DR CHRISTINA WOO</BusinessNameLine1Txt>
          </RecipientBusinessName>
          <RecipientUSAddress>
            <AddressLine1Txt>61 GORHAM ST</AddressLine1Txt>
            <CityNm>CAMBRIDGE</CityNm>
            <StateAbbreviationCd>MA</StateAbbreviationCd>
            <ZIPCd>02138</ZIPCd>
          </RecipientUSAddress>
          <RecipientRelationshipTxt>N/A</RecipientRelationshipTxt>
          <RecipientFoundationStatusTxt>SEC 501(C)(3)</RecipientFoundationStatusTxt>
          <GrantOrContributionPurposeTxt>THE ONO PHARMA BREAKTHROUGH SCIENCE INTITIATIVE AWARDS PROGRAM</GrantOrContributionPurposeTxt>
          <Amt>172500</Amt>
        </GrantOrContributionPdDurYrGrp>
        <GrantOrContributionPdDurYrGrp>
          <RecipientBusinessName>
            <BusinessNameLine1Txt>BROAD INSTITUTE OF HARVARD &amp; MIT DRS ERIC MINIKEL &amp; SONIA VALLABH</BusinessNameLine1Txt>
          </RecipientBusinessName>
          <RecipientUSAddress>
            <AddressLine1Txt>415 MAIN STREET</AddressLine1Txt>
            <CityNm>CAMBRIDGE</CityNm>
            <StateAbbreviationCd>MA</StateAbbreviationCd>
            <ZIPCd>02142</ZIPCd>
          </RecipientUSAddress>
          <RecipientRelationshipTxt>N/A</RecipientRelationshipTxt>
          <RecipientFoundationStatusTxt>SEC 501(C)(3)</RecipientFoundationStatusTxt>
          <GrantOrContributionPurposeTxt>THE ONO PHARMA BREAKTHROUGH SCIENCE INTITIATIVE AWARDS PROGRAM</GrantOrContributionPurposeTxt>
          <Amt>345000</Amt>
        </GrantOrContributionPdDurYrGrp>
        <GrantOrContributionPdDurYrGrp>
          <RecipientBusinessName>
            <BusinessNameLine1Txt>HARVARD UNIVERSITY DR B LIAU</BusinessNameLine1Txt>
          </RecipientBusinessName>
          <RecipientUSAddress>
            <AddressLine1Txt>61 GORHAM ST</AddressLine1Txt>
            <CityNm>CAMBRIDGE</CityNm>
            <StateAbbreviationCd>MA</StateAbbreviationCd>
            <ZIPCd>02138</ZIPCd>
          </RecipientUSAddress>
          <RecipientRelationshipTxt>N/A</RecipientRelationshipTxt>
          <RecipientFoundationStatusTxt>SEC 501(C)(3)</RecipientFoundationStatusTxt>
          <GrantOrContributionPurposeTxt>THE ONO PHARMA BREAKTHROUGH SCIENCE INTITIATIVE AWARDS PROGRAM</GrantOrContributionPurposeTxt>
          <Amt>345000</Amt>
        </GrantOrContributionPdDurYrGrp>
        <GrantOrContributionPdDurYrGrp>
          <RecipientBusinessName>
            <BusinessNameLine1Txt>UNIVERSITY OF CALIFORNIA DR A EDINGER</BusinessNameLine1Txt>
          </RecipientBusinessName>
          <RecipientUSAddress>
            <AddressLine1Txt>836 HEALTH SCIENCES RD</AddressLine1Txt>
            <CityNm>IRVINE</CityNm>
            <StateAbbreviationCd>CA</StateAbbreviationCd>
            <ZIPCd>92697</ZIPCd>
          </RecipientUSAddress>
          <RecipientRelationshipTxt>N/A</RecipientRelationshipTxt>
          <RecipientFoundationStatusTxt>SEC 501(C)(3)</RecipientFoundationStatusTxt>
          <GrantOrContributionPurposeTxt>THE ONO PHARMA BREAKTHROUGH SCIENCE INTITIATIVE AWARDS PROGRAM</GrantOrContributionPurposeTxt>
          <Amt>345000</Amt>
        </GrantOrContributionPdDurYrGrp>
        <GrantOrContributionPdDurYrGrp>
          <RecipientBusinessName>
            <BusinessNameLine1Txt>UNIVERSITY OF CALIFORNIA DR R SPITALE</BusinessNameLine1Txt>
          </RecipientBusinessName>
          <RecipientUSAddress>
            <AddressLine1Txt>836 HEALTH SCIENCES RD</AddressLine1Txt>
            <CityNm>IRVINE</CityNm>
            <StateAbbreviationCd>CA</StateAbbreviationCd>
            <ZIPCd>92697</ZIPCd>
          </RecipientUSAddress>
          <RecipientRelationshipTxt>N/A</RecipientRelationshipTxt>
          <RecipientFoundationStatusTxt>SEC 501(C)(3)</RecipientFoundationStatusTxt>
          <GrantOrContributionPurposeTxt>THE ONO PHARMA BREAKTHROUGH SCIENCE INTITIATIVE AWARDS PROGRAM</GrantOrContributionPurposeTxt>
          <Amt>345000</Amt>
        </GrantOrContributionPdDurYrGrp>
        <GrantOrContributionPdDurYrGrp>
          <RecipientBusinessName>
            <BusinessNameLine1Txt>STANFORD UNIVERSITY DR POLLY FORDYCE</BusinessNameLine1Txt>
          </RecipientBusinessName>
          <RecipientUSAddress>
            <AddressLine1Txt>443 VIA ORGEGA</AddressLine1Txt>
            <CityNm>STANFORD</CityNm>
            <StateAbbreviationCd>CA</StateAbbreviationCd>
            <ZIPCd>94306</ZIPCd>
          </RecipientUSAddress>
          <RecipientRelationshipTxt>N/A</RecipientRelationshipTxt>
          <RecipientFoundationStatusTxt>SEC 501(C)(3)</RecipientFoundationStatusTxt>
          <GrantOrContributionPurposeTxt>THE ONO PHARMA BREAKTHROUGH SCIENCE INTITIATIVE AWARDS PROGRAM</GrantOrContributionPurposeTxt>
          <Amt>345000</Amt>
        </GrantOrContributionPdDurYrGrp>
        <GrantOrContributionPdDurYrGrp>
          <RecipientBusinessName>
            <BusinessNameLine1Txt>THE SCRIPPS RESEARCH INSTITUTE MICHAEL A ERB</BusinessNameLine1Txt>
          </RecipientBusinessName>
          <RecipientUSAddress>
            <AddressLine1Txt>10550 N TORREY PINES RD</AddressLine1Txt>
            <CityNm>LA JOLLA</CityNm>
            <StateAbbreviationCd>CA</StateAbbreviationCd>
            <ZIPCd>92037</ZIPCd>
          </RecipientUSAddress>
          <RecipientRelationshipTxt>N/A</RecipientRelationshipTxt>
          <RecipientFoundationStatusTxt>SEC 501(C)(3)</RecipientFoundationStatusTxt>
          <GrantOrContributionPurposeTxt>THE ONO PHARMA BREAKTHROUGH SCIENCE INTITIATIVE AWARDS PROGRAM</GrantOrContributionPurposeTxt>
          <Amt>345000</Amt>
        </GrantOrContributionPdDurYrGrp>
        <GrantOrContributionPdDurYrGrp>
          <RecipientBusinessName>
            <BusinessNameLine1Txt>BOSTON COLLEGE ERANTHIE WEERAPANA</BusinessNameLine1Txt>
          </RecipientBusinessName>
          <RecipientUSAddress>
            <AddressLine1Txt>2609 BEACON ST</AddressLine1Txt>
            <CityNm>CHESTNUT HILL</CityNm>
            <StateAbbreviationCd>MA</StateAbbreviationCd>
            <ZIPCd>02467</ZIPCd>
          </RecipientUSAddress>
          <RecipientRelationshipTxt>N/A</RecipientRelationshipTxt>
          <RecipientFoundationStatusTxt>SEC 501(C)(3)</RecipientFoundationStatusTxt>
          <GrantOrContributionPurposeTxt>THE ONO PHARMA BREAKTHROUGH SCIENCE INTITIATIVE AWARDS PROGRAM</GrantOrContributionPurposeTxt>
          <Amt>345000</Amt>
        </GrantOrContributionPdDurYrGrp>
        <GrantOrContributionPdDurYrGrp>
          <RecipientBusinessName>
            <BusinessNameLine1Txt>UNIVERSITY OF CALIFORNIA SAN FRANCISCO JASON K SELLO</BusinessNameLine1Txt>
          </RecipientBusinessName>
          <RecipientUSAddress>
            <AddressLine1Txt>600 16TH ST</AddressLine1Txt>
            <CityNm>SAN FRANCISCO</CityNm>
            <StateAbbreviationCd>CA</StateAbbreviationCd>
            <ZIPCd>94158</ZIPCd>
          </RecipientUSAddress>
          <RecipientRelationshipTxt>N/A</RecipientRelationshipTxt>
          <RecipientFoundationStatusTxt>SEC 501(C)(3)</RecipientFoundationStatusTxt>
          <GrantOrContributionPurposeTxt>THE ONO PHARMA BREAKTHROUGH SCIENCE INTITIATIVE AWARDS PROGRAM</GrantOrContributionPurposeTxt>
          <Amt>345000</Amt>
        </GrantOrContributionPdDurYrGrp>
        <GrantOrContributionPdDurYrGrp>
          <RecipientBusinessName>
            <BusinessNameLine1Txt>UNIVERSITY OF CHICAGO YAMUNA KRISHNAN</BusinessNameLine1Txt>
          </RecipientBusinessName>
          <RecipientUSAddress>
            <AddressLine1Txt>929 E 57TH ELLIS AVENUE</AddressLine1Txt>
            <CityNm>CHICAGO</CityNm>
            <StateAbbreviationCd>IL</StateAbbreviationCd>
            <ZIPCd>60637</ZIPCd>
          </RecipientUSAddress>
          <RecipientRelationshipTxt>N/A</RecipientRelationshipTxt>
          <RecipientFoundationStatusTxt>SEC 501(C)(3)</RecipientFoundationStatusTxt>
          <GrantOrContributionPurposeTxt>THE ONO PHARMA BREAKTHROUGH SCIENCE INTITIATIVE AWARDS PROGRAM</GrantOrContributionPurposeTxt>
          <Amt>345000</Amt>
        </GrantOrContributionPdDurYrGrp>
        <GrantOrContributionPdDurYrGrp>
          <RecipientBusinessName>
            <BusinessNameLine1Txt>STANFORD UNIVERSITY JONATHAN Z LONG</BusinessNameLine1Txt>
          </RecipientBusinessName>
          <RecipientUSAddress>
            <AddressLine1Txt>290 JANE STANFORD WAY</AddressLine1Txt>
            <CityNm>STANFORD</CityNm>
            <StateAbbreviationCd>CA</StateAbbreviationCd>
            <ZIPCd>94306</ZIPCd>
          </RecipientUSAddress>
          <RecipientRelationshipTxt>N/A</RecipientRelationshipTxt>
          <RecipientFoundationStatusTxt>SEC 501(C)(3)</RecipientFoundationStatusTxt>
          <GrantOrContributionPurposeTxt>THE ONO PHARMA BREAKTHROUGH SCIENCE INTITIATIVE AWARDS PROGRAM</GrantOrContributionPurposeTxt>
          <Amt>345000</Amt>
        </GrantOrContributionPdDurYrGrp>
        <GrantOrContributionPdDurYrGrp>
          <RecipientBusinessName>
            <BusinessNameLine1Txt>BROAD INSTITUTE OF HARVARD &amp; MIT DR XIAO WANG</BusinessNameLine1Txt>
          </RecipientBusinessName>
          <RecipientUSAddress>
            <AddressLine1Txt>415 MAIN STREET</AddressLine1Txt>
            <CityNm>CAMBRIDGE</CityNm>
            <StateAbbreviationCd>MA</StateAbbreviationCd>
            <ZIPCd>02142</ZIPCd>
          </RecipientUSAddress>
          <RecipientRelationshipTxt>N/A</RecipientRelationshipTxt>
          <RecipientFoundationStatusTxt>SEC 501(C)(3)</RecipientFoundationStatusTxt>
          <GrantOrContributionPurposeTxt>THE ONO PHARMA BREAKTHROUGH SCIENCE INTITIATIVE AWARDS PROGRAM</GrantOrContributionPurposeTxt>
          <Amt>172500</Amt>
        </GrantOrContributionPdDurYrGrp>
        <GrantOrContributionPdDurYrGrp>
          <RecipientBusinessName>
            <BusinessNameLine1Txt>SALK INSTITUTE FOR BIOLOGICAL STUDIES DR ALAN SAGHATELIAN</BusinessNameLine1Txt>
          </RecipientBusinessName>
          <RecipientUSAddress>
            <AddressLine1Txt>10010 N TORREY PINES RD</AddressLine1Txt>
            <CityNm>LA JOLLA</CityNm>
            <StateAbbreviationCd>CA</StateAbbreviationCd>
            <ZIPCd>92037</ZIPCd>
          </RecipientUSAddress>
          <RecipientRelationshipTxt>N/A</RecipientRelationshipTxt>
          <RecipientFoundationStatusTxt>SEC 501(C)(3)</RecipientFoundationStatusTxt>
          <GrantOrContributionPurposeTxt>THE ONO PHARMA BREAKTHROUGH SCIENCE INTITIATIVE AWARDS PROGRAM</GrantOrContributionPurposeTxt>
          <Amt>172500</Amt>
        </GrantOrContributionPdDurYrGrp>
        <GrantOrContributionPdDurYrGrp>
          <RecipientBusinessName>
            <BusinessNameLine1Txt>STANFORD UNIVERSITY DR ELIZABETH SATTELY</BusinessNameLine1Txt>
          </RecipientBusinessName>
          <RecipientUSAddress>
            <AddressLine1Txt>485 BROADWAY 3RD FL</AddressLine1Txt>
            <CityNm>REDWOOD CITY</CityNm>
            <StateAbbreviationCd>CA</StateAbbreviationCd>
            <ZIPCd>94305</ZIPCd>
          </RecipientUSAddress>
          <RecipientRelationshipTxt>N/A</RecipientRelationshipTxt>
          <RecipientFoundationStatusTxt>SEC 501(C)(3)</RecipientFoundationStatusTxt>
          <GrantOrContributionPurposeTxt>THE ONO PHARMA BREAKTHROUGH SCIENCE INTITIATIVE AWARDS PROGRAM</GrantOrContributionPurposeTxt>
          <Amt>172500</Amt>
        </GrantOrContributionPdDurYrGrp>
        <TotalGrantOrContriPdDurYrAmt>4830000</TotalGrantOrContriPdDurYrAmt>
        <GrantOrContriApprvForFutGrp>
          <RecipientBusinessName>
            <BusinessNameLine1Txt>BROAD INSTITUTE OF HARVARD &amp; MIT DRS ERIC MINIKEL &amp; SONIA VALLABH</BusinessNameLine1Txt>
          </RecipientBusinessName>
          <RecipientUSAddress>
            <AddressLine1Txt>415 MAIN STREET</AddressLine1Txt>
            <CityNm>CAMBRIDGE</CityNm>
            <StateAbbreviationCd>MA</StateAbbreviationCd>
            <ZIPCd>02142</ZIPCd>
          </RecipientUSAddress>
          <RecipientRelationshipTxt>N/A</RecipientRelationshipTxt>
          <RecipientFoundationStatusTxt>SEC 501(C)(3)</RecipientFoundationStatusTxt>
          <GrantOrContributionPurposeTxt>THE ONO PHARMA BREAKTHROUGH SCIENCE INTITIATIVE AWARDS PROGRAM</GrantOrContributionPurposeTxt>
          <Amt>170740</Amt>
        </GrantOrContriApprvForFutGrp>
        <GrantOrContriApprvForFutGrp>
          <RecipientBusinessName>
            <BusinessNameLine1Txt>HARVARD UNIVERSITY DR B LIAU</BusinessNameLine1Txt>
          </RecipientBusinessName>
          <RecipientUSAddress>
            <AddressLine1Txt>61 GORHAM ST</AddressLine1Txt>
            <CityNm>CAMBRIDGE</CityNm>
            <StateAbbreviationCd>MA</StateAbbreviationCd>
            <ZIPCd>02138</ZIPCd>
          </RecipientUSAddress>
          <RecipientRelationshipTxt>N/A</RecipientRelationshipTxt>
          <RecipientFoundationStatusTxt>SEC 501(C)(3)</RecipientFoundationStatusTxt>
          <GrantOrContributionPurposeTxt>THE ONO PHARMA BREAKTHROUGH SCIENCE INTITIATIVE AWARDS PROGRAM</GrantOrContributionPurposeTxt>
          <Amt>170740</Amt>
        </GrantOrContriApprvForFutGrp>
        <GrantOrContriApprvForFutGrp>
          <RecipientBusinessName>
            <BusinessNameLine1Txt>UNIVERSITY OF CALIFORNIA DR A EDINGER</BusinessNameLine1Txt>
          </RecipientBusinessName>
          <RecipientUSAddress>
            <AddressLine1Txt>836 HEALTH SCIENCES RD</AddressLine1Txt>
            <CityNm>IRVINE</CityNm>
            <StateAbbreviationCd>CA</StateAbbreviationCd>
            <ZIPCd>92697</ZIPCd>
          </RecipientUSAddress>
          <RecipientRelationshipTxt>N/A</RecipientRelationshipTxt>
          <RecipientFoundationStatusTxt>SEC 501(C)(3)</RecipientFoundationStatusTxt>
          <GrantOrContributionPurposeTxt>THE ONO PHARMA BREAKTHROUGH SCIENCE INTITIATIVE AWARDS PROGRAM</GrantOrContributionPurposeTxt>
          <Amt>170740</Amt>
        </GrantOrContriApprvForFutGrp>
        <GrantOrContriApprvForFutGrp>
          <RecipientBusinessName>
            <BusinessNameLine1Txt>UNIVERSITY OF CALIFORNIA DR R SPITALE</BusinessNameLine1Txt>
          </RecipientBusinessName>
          <RecipientUSAddress>
            <AddressLine1Txt>836 HEALTH SCIENCES RD</AddressLine1Txt>
            <CityNm>IRVINE</CityNm>
            <StateAbbreviationCd>CA</StateAbbreviationCd>
            <ZIPCd>92697</ZIPCd>
          </RecipientUSAddress>
          <RecipientRelationshipTxt>N/A</RecipientRelationshipTxt>
          <RecipientFoundationStatusTxt>SEC 501(C)(3)</RecipientFoundationStatusTxt>
          <GrantOrContributionPurposeTxt>THE ONO PHARMA BREAKTHROUGH SCIENCE INTITIATIVE AWARDS PROGRAM</GrantOrContributionPurposeTxt>
          <Amt>170740</Amt>
        </GrantOrContriApprvForFutGrp>
        <GrantOrContriApprvForFutGrp>
          <RecipientBusinessName>
            <BusinessNameLine1Txt>STANFORD UNIVERSITY DR POLLY FORDYCE</BusinessNameLine1Txt>
          </RecipientBusinessName>
          <RecipientUSAddress>
            <AddressLine1Txt>443 VIA ORGEGA</AddressLine1Txt>
            <CityNm>STANFORD</CityNm>
            <StateAbbreviationCd>CA</StateAbbreviationCd>
            <ZIPCd>94306</ZIPCd>
          </RecipientUSAddress>
          <RecipientRelationshipTxt>N/A</RecipientRelationshipTxt>
          <RecipientFoundationStatusTxt>SEC 501(C)(3)</RecipientFoundationStatusTxt>
          <GrantOrContributionPurposeTxt>THE ONO PHARMA BREAKTHROUGH SCIENCE INTITIATIVE AWARDS PROGRAM</GrantOrContributionPurposeTxt>
          <Amt>170740</Amt>
        </GrantOrContriApprvForFutGrp>
        <GrantOrContriApprvForFutGrp>
          <RecipientBusinessName>
            <BusinessNameLine1Txt>THE SCRIPPS RESEARCH INSTITUTE MICHAEL A ERB</BusinessNameLine1Txt>
          </RecipientBusinessName>
          <RecipientUSAddress>
            <AddressLine1Txt>10550 N TORREY PINES RD</AddressLine1Txt>
            <CityNm>LA JOLLA</CityNm>
            <StateAbbreviationCd>CA</StateAbbreviationCd>
            <ZIPCd>92037</ZIPCd>
          </RecipientUSAddress>
          <RecipientRelationshipTxt>N/A</RecipientRelationshipTxt>
          <RecipientFoundationStatusTxt>SEC 501(C)(3)</RecipientFoundationStatusTxt>
          <GrantOrContributionPurposeTxt>THE ONO PHARMA BREAKTHROUGH SCIENCE INTITIATIVE AWARDS PROGRAM</GrantOrContributionPurposeTxt>
          <Amt>508311</Amt>
        </GrantOrContriApprvForFutGrp>
        <GrantOrContriApprvForFutGrp>
          <RecipientBusinessName>
            <BusinessNameLine1Txt>BOSTON COLLEGE ERANTHIE WEERAPANA</BusinessNameLine1Txt>
          </RecipientBusinessName>
          <RecipientUSAddress>
            <AddressLine1Txt>2609 BEACON ST</AddressLine1Txt>
            <CityNm>CHESTNUT HILL</CityNm>
            <StateAbbreviationCd>MA</StateAbbreviationCd>
            <ZIPCd>02467</ZIPCd>
          </RecipientUSAddress>
          <RecipientRelationshipTxt>N/A</RecipientRelationshipTxt>
          <RecipientFoundationStatusTxt>SEC 501(C)(3)</RecipientFoundationStatusTxt>
          <GrantOrContributionPurposeTxt>THE ONO PHARMA BREAKTHROUGH SCIENCE INTITIATIVE AWARDS PROGRAM</GrantOrContributionPurposeTxt>
          <Amt>508311</Amt>
        </GrantOrContriApprvForFutGrp>
        <GrantOrContriApprvForFutGrp>
          <RecipientBusinessName>
            <BusinessNameLine1Txt>UNIVERSITY OF CALIFORNIA SAN FRANCISCO JASON K SELLO</BusinessNameLine1Txt>
          </RecipientBusinessName>
          <RecipientUSAddress>
            <AddressLine1Txt>600 16TH ST</AddressLine1Txt>
            <CityNm>SAN FRANCISCO</CityNm>
            <StateAbbreviationCd>CA</StateAbbreviationCd>
            <ZIPCd>94158</ZIPCd>
          </RecipientUSAddress>
          <RecipientRelationshipTxt>N/A</RecipientRelationshipTxt>
          <RecipientFoundationStatusTxt>SEC 501(C)(3)</RecipientFoundationStatusTxt>
          <GrantOrContributionPurposeTxt>THE ONO PHARMA BREAKTHROUGH SCIENCE INTITIATIVE AWARDS PROGRAM</GrantOrContributionPurposeTxt>
          <Amt>508311</Amt>
        </GrantOrContriApprvForFutGrp>
        <GrantOrContriApprvForFutGrp>
          <RecipientBusinessName>
            <BusinessNameLine1Txt>UNIVERSITY OF CHICAGO YAMUNA KRISHNAN</BusinessNameLine1Txt>
          </RecipientBusinessName>
          <RecipientUSAddress>
            <AddressLine1Txt>929 E 57TH ELLIS AVENUE</AddressLine1Txt>
            <CityNm>CHICAGO</CityNm>
            <StateAbbreviationCd>IL</StateAbbreviationCd>
            <ZIPCd>60637</ZIPCd>
          </RecipientUSAddress>
          <RecipientRelationshipTxt>N/A</RecipientRelationshipTxt>
          <RecipientFoundationStatusTxt>SEC 501(C)(3)</RecipientFoundationStatusTxt>
          <GrantOrContributionPurposeTxt>THE ONO PHARMA BREAKTHROUGH SCIENCE INTITIATIVE AWARDS PROGRAM</GrantOrContributionPurposeTxt>
          <Amt>508311</Amt>
        </GrantOrContriApprvForFutGrp>
        <GrantOrContriApprvForFutGrp>
          <RecipientBusinessName>
            <BusinessNameLine1Txt>STANFORD UNIVERSITY JONATHAN Z LONG</BusinessNameLine1Txt>
          </RecipientBusinessName>
          <RecipientUSAddress>
            <AddressLine1Txt>290 JANE STANFORD WAY</AddressLine1Txt>
            <CityNm>STANFORD</CityNm>
            <StateAbbreviationCd>CA</StateAbbreviationCd>
            <ZIPCd>94306</ZIPCd>
          </RecipientUSAddress>
          <RecipientRelationshipTxt>N/A</RecipientRelationshipTxt>
          <RecipientFoundationStatusTxt>SEC 501(C)(3)</RecipientFoundationStatusTxt>
          <GrantOrContributionPurposeTxt>THE ONO PHARMA BREAKTHROUGH SCIENCE INTITIATIVE AWARDS PROGRAM</GrantOrContributionPurposeTxt>
          <Amt>508311</Amt>
        </GrantOrContriApprvForFutGrp>
        <GrantOrContriApprvForFutGrp>
          <RecipientBusinessName>
            <BusinessNameLine1Txt>BROAD INSTITUTE OF HARVARD &amp; MIT DR XIAO WANG</BusinessNameLine1Txt>
          </RecipientBusinessName>
          <RecipientUSAddress>
            <AddressLine1Txt>415 MAIN STREET</AddressLine1Txt>
            <CityNm>CAMBRIDGE</CityNm>
            <StateAbbreviationCd>MA</StateAbbreviationCd>
            <ZIPCd>02142</ZIPCd>
          </RecipientUSAddress>
          <RecipientRelationshipTxt>N/A</RecipientRelationshipTxt>
          <RecipientFoundationStatusTxt>SEC 501(C)(3)</RecipientFoundationStatusTxt>
          <GrantOrContributionPurposeTxt>THE ONO PHARMA BREAKTHROUGH SCIENCE INTITIATIVE AWARDS PROGRAM</GrantOrContributionPurposeTxt>
          <Amt>839491</Amt>
        </GrantOrContriApprvForFutGrp>
        <GrantOrContriApprvForFutGrp>
          <RecipientBusinessName>
            <BusinessNameLine1Txt>SALK INSTITUTE FOR BIOLOGICAL STUDIES DR ALAN SAGHATELIAN</BusinessNameLine1Txt>
          </RecipientBusinessName>
          <RecipientUSAddress>
            <AddressLine1Txt>10010 N TORREY PINES RD</AddressLine1Txt>
            <CityNm>LA JOLLA</CityNm>
            <StateAbbreviationCd>CA</StateAbbreviationCd>
            <ZIPCd>92037</ZIPCd>
          </RecipientUSAddress>
          <RecipientRelationshipTxt>N/A</RecipientRelationshipTxt>
          <RecipientFoundationStatusTxt>SEC 501(C)(3)</RecipientFoundationStatusTxt>
          <GrantOrContributionPurposeTxt>THE ONO PHARMA BREAKTHROUGH SCIENCE INTITIATIVE AWARDS PROGRAM</GrantOrContributionPurposeTxt>
          <Amt>839491</Amt>
        </GrantOrContriApprvForFutGrp>
        <GrantOrContriApprvForFutGrp>
          <RecipientBusinessName>
            <BusinessNameLine1Txt>STANFORD UNIVERSITY DR ELIZABETH SATTELY</BusinessNameLine1Txt>
          </RecipientBusinessName>
          <RecipientUSAddress>
            <AddressLine1Txt>485 BROADWAY 3RD FL</AddressLine1Txt>
            <CityNm>REDWOOD CITY</CityNm>
            <StateAbbreviationCd>CA</StateAbbreviationCd>
            <ZIPCd>94305</ZIPCd>
          </RecipientUSAddress>
          <RecipientRelationshipTxt>N/A</RecipientRelationshipTxt>
          <RecipientFoundationStatusTxt>SEC 501(C)(3)</RecipientFoundationStatusTxt>
          <GrantOrContributionPurposeTxt>THE ONO PHARMA BREAKTHROUGH SCIENCE INTITIATIVE AWARDS PROGRAM</GrantOrContributionPurposeTxt>
          <Amt>839491</Amt>
        </GrantOrContriApprvForFutGrp>
        <TotalGrantOrContriApprvFutAmt>5913728</TotalGrantOrContriApprvFutAmt>
      </SupplementaryInformationGrp>
      <AnalysisIncomeProducingActyGrp>
        <SubtotalsIncmProducingActyGrp>
          <UnrelatedBusinessTaxblIncmAmt>0</UnrelatedBusinessTaxblIncmAmt>
          <ExclusionAmt>0</ExclusionAmt>
          <RelatedOrExemptFunctionIncmAmt>0</RelatedOrExemptFunctionIncmAmt>
        </SubtotalsIncmProducingActyGrp>
        <TotalIncomeProducingActyAmt>0</TotalIncomeProducingActyAmt>
      </AnalysisIncomeProducingActyGrp>
      <TrnsfrTransRlnNonchrtblEOGrp>
        <TrnsfrOfCashToNonchrtblEOInd>0</TrnsfrOfCashToNonchrtblEOInd>
        <TrnsfrOtherAssetNonchrtblEOInd>0</TrnsfrOtherAssetNonchrtblEOInd>
        <SalesOrExchangesOfAssetsInd>0</SalesOrExchangesOfAssetsInd>
        <PurchaseOfAssetsNonchrtblEOInd>0</PurchaseOfAssetsNonchrtblEOInd>
        <RentalOfFacilitiesOthAssetsInd>0</RentalOfFacilitiesOthAssetsInd>
        <ReimbursementArrangementsInd>0</ReimbursementArrangementsInd>
        <LoansOrLoanGuaranteesInd>0</LoansOrLoanGuaranteesInd>
        <PerformanceOfServicesEtcInd>0</PerformanceOfServicesEtcInd>
        <SharingOfFacilitiesEtcInd>0</SharingOfFacilitiesEtcInd>
        <RelationshipsNonchrtblEOInd>0</RelationshipsNonchrtblEOInd>
      </TrnsfrTransRlnNonchrtblEOGrp>
    </IRS990PF>
    <IRS990ScheduleB documentId="RetDoc1234500001">
      <Organization501c3ExemptPFInd>X</Organization501c3ExemptPFInd>
      <GeneralRuleInd>X</GeneralRuleInd>
      <ContributorInformationGrp>
        <ContributorNum>1</ContributorNum>
        <ContributorBusinessName>
          <BusinessNameLine1Txt>ONO PHARMACEUTICAL CO LTD</BusinessNameLine1Txt>
        </ContributorBusinessName>
        <ContributorForeignAddress>
          <AddressLine1Txt>8-2 KYUTAROMACHI 1-CHOME</AddressLine1Txt>
          <CityNm>CHUOKU</CityNm>
          <ProvinceOrStateNm>OSAKA</ProvinceOrStateNm>
          <CountryCd>JA</CountryCd>
          <ForeignPostalCd>541-8564</ForeignPostalCd>
        </ContributorForeignAddress>
        <TotalContributionsAmt>5182100</TotalContributionsAmt>
        <PersonContributionInd>X</PersonContributionInd>
      </ContributorInformationGrp>
    </IRS990ScheduleB>
    <AccountingFeesSchedule documentId="RetDoc2002200001">
      <AccountingFeesDetail>
        <CategoryTxt>ACCCOUNTING SERVICE FEE</CategoryTxt>
        <Amt>49079</Amt>
        <NetInvestmentIncomeAmt>0</NetInvestmentIncomeAmt>
        <AdjustedNetIncomeAmt>0</AdjustedNetIncomeAmt>
        <DisbursementsCharitablePrpsAmt>49079</DisbursementsCharitablePrpsAmt>
      </AccountingFeesDetail>
    </AccountingFeesSchedule>
    <ExplnOfNonFilingWithAGStmt documentId="RetDoc2210600001">
      <ExplanationTxt>NONE</ExplanationTxt>
    </ExplnOfNonFilingWithAGStmt>
    <LegalFeesSchedule documentId="RetDoc2002100001">
      <LegalFeesGrp>
        <CategoryTxt>LEGAL PROFESSIONAL FEE</CategoryTxt>
        <LegalFeesAmt>9332</LegalFeesAmt>
        <NetInvestmentIncomeAmt>0</NetInvestmentIncomeAmt>
        <AdjustedNetIncomeAmt>0</AdjustedNetIncomeAmt>
        <DisbursementsCharitablePrpsAmt>9332</DisbursementsCharitablePrpsAmt>
      </LegalFeesGrp>
    </LegalFeesSchedule>
    <OtherAssetsSchedule documentId="RetDoc2046600001">
      <OtherAssetsScheduleGrp>
        <Desc>INTANGIBLE ASSETS</Desc>
        <EOYBookValueAmt>14332</EOYBookValueAmt>
        <EOYFMVAmt>14332</EOYFMVAmt>
      </OtherAssetsScheduleGrp>
    </OtherAssetsSchedule>
    <OtherExpensesSchedule documentId="RetDoc2003200001">
      <OtherExpensesScheduleGrp>
        <Desc>INSURANCE</Desc>
        <RevenueAndExpensesPerBooksAmt>2388</RevenueAndExpensesPerBooksAmt>
        <NetInvestmentIncomeAmt>0</NetInvestmentIncomeAmt>
        <AdjustedNetIncomeAmt>0</AdjustedNetIncomeAmt>
        <DisbursementsCharitablePrpsAmt>2388</DisbursementsCharitablePrpsAmt>
      </OtherExpensesScheduleGrp>
      <OtherExpensesScheduleGrp>
        <Desc>DUE &amp; SUB</Desc>
        <RevenueAndExpensesPerBooksAmt>21168</RevenueAndExpensesPerBooksAmt>
        <NetInvestmentIncomeAmt>0</NetInvestmentIncomeAmt>
        <AdjustedNetIncomeAmt>0</AdjustedNetIncomeAmt>
        <DisbursementsCharitablePrpsAmt>21168</DisbursementsCharitablePrpsAmt>
      </OtherExpensesScheduleGrp>
      <OtherExpensesScheduleGrp>
        <Desc>MISC</Desc>
        <RevenueAndExpensesPerBooksAmt>978</RevenueAndExpensesPerBooksAmt>
        <NetInvestmentIncomeAmt>0</NetInvestmentIncomeAmt>
        <AdjustedNetIncomeAmt>0</AdjustedNetIncomeAmt>
        <DisbursementsCharitablePrpsAmt>978</DisbursementsCharitablePrpsAmt>
      </OtherExpensesScheduleGrp>
    </OtherExpensesSchedule>
    <OtherLiabilitiesSchedule documentId="RetDoc2065700001">
      <OtherLiabilitiesDetail>
        <Desc>ACCRED EXPENSES</Desc>
        <BOYBookValueAmt>6545</BOYBookValueAmt>
        <EOYBookValueAmt>31390</EOYBookValueAmt>
      </OtherLiabilitiesDetail>
    </OtherLiabilitiesSchedule>
    <OtherProfessionalFeesSchedule documentId="RetDoc2002300001">
      <OtherProfessionalFeesDetail>
        <CategoryTxt>OTHER PROFESSIONAL FEE</CategoryTxt>
        <Amt>146560</Amt>
        <NetInvestmentIncomeAmt>0</NetInvestmentIncomeAmt>
        <AdjustedNetIncomeAmt>0</AdjustedNetIncomeAmt>
        <DisbursementsCharitablePrpsAmt>146560</DisbursementsCharitablePrpsAmt>
      </OtherProfessionalFeesDetail>
    </OtherProfessionalFeesSchedule>
    <SubstantialContributorsSch documentId="RetDoc2089200001">
      <SubstantialContributorDetail>
        <BusinessName>
          <BusinessNameLine1Txt>ONO PHARMACEUTICAL CO LTD</BusinessNameLine1Txt>
        </BusinessName>
        <ForeignAddress>
          <AddressLine1Txt>8-2 KYUTAROMACHI 1-CHOME</AddressLine1Txt>
          <CityNm>CHUOKU</CityNm>
          <ProvinceOrStateNm>OSAKA</ProvinceOrStateNm>
          <CountryCd>JA</CountryCd>
          <ForeignPostalCd>541-8564</ForeignPostalCd>
        </ForeignAddress>
      </SubstantialContributorDetail>
    </SubstantialContributorsSch>
  </ReturnData>
</Return>
