2022-11-11T14:35:38-07:00 2022-06-30 990 2021-07-01 030485196 MYELIN REPAIR FOUNDATION INC MYEL 20111 Edinburgh Drive Saratoga CA 95070 Scott Johnson Chief Executive Officer 4087610201 2022-11-01 1 11 1 AAL2 2021 2022-09-23 18:48:47Z Scott Johnson 20111 Edinburgh Drive Saratoga CA 95070 285427 0 X myelinrepair.org X 2002 CA Accelerating the development of new therapeutics to prevent or repair damage to myelin caused by MS 5 4 1 0 0 0 478580 262804 0 0 699 914 51048 21709 530327 285427 24964 327257 0 0 139250 137838 0 0 2788 71305 73855 235519 538950 294808 -253523 1468414 1330627 377528 493264 1090886 837363 Accelerating the development of new therapeutics to prevent or repair damage to myelin caused by Multiple Sclerosis. The MRF is helping to identify biomarkers of myelin repair for use in myelin repair drug development and clinical trials 0 0 530804 327257 285426 We only have one area of program services and that is scientific research to benefit Multiple Sclerosis (MS) patients. Currently our research is focused on experiments to identify biomarkers to indicate repair of myelin damaged by MS. Over the last year, we focused our research on extracellular vesicles(EVs) isolated from blood. We currently have 13 investigations underway spread across Europe and North America. We have encouraging preliminary data showing that we can clearly distinguish MS patient EV's from healthy controls and may be able to identify sub-types of MS. 0 0 0 530804 1 1 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 1 1 1 0 0 0 0 0 1 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 1 5 0 1 1 1 0 0 0 0 0 0 0 0 0 0 0 0 0 0 X 5 4 0 0 0 0 0 0 0 1 1 1 0 1 1 1 1 1 1 1 0 0 CA X Louise Savoie 4088885542 2198 Hillstone Dr San Jose CA 95138 Scott Johnson CEO 20.00 0 X X 120000 0 0 Casey Mcglynn Director 1.0 0 X 0 0 0 Andy Cates Director 1 0 X 0 0 0 Bobby Mehta Director 1 0 X 0 0 0 Jim Gidwitz Director 1 0 X 0 0 0 120000 0 0 1 0 0 0 0 0 0 0 0 0 262804 0 262804 0 914 914 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 21709 21709 0 0 21709 285427 22623 0 0 X 212057 212057 0 0 115200 115200 120000 120000 8004 6563 480 961 9834 8064 590 1180 0 3965 3965 61375 61375 5391 4421 323 647 3124 3124 538950 530804 5358 2788 314692 271165 846722 847220 307000 212000 242 1468414 1330627 356606 493264 20922 0 377528 493264 X 1090886 837363 0 0 1090886 837363 1468414 1330627 -253523 0 0 0 0 0 X 0 0 0 X 1007500 287392 253579 478580 262804 2289855 1007500 287392 253579 478580 262804 2289855 612259 1677596 6926 11669 699 914 20208 70054 51048 21709 142811 2452874 0 0.68393 0.48278 X Schedule A, Part II, Line 10 Forgiveness of Paycheck Protection Plan loan and refund of underspent funds for a Sponsored Research Agreement RESTRICTED RESTRICTED RESTRICTED RESTRICTED RESTRICTED RESTRICTED RESTRICTED RESTRICTED 1 Europe (including Iceland and Greenland) 0 0 Program Services Scientific Research 115200 0 0 115200 Europe (including Iceland and Greenland) Scientific Research. MRF funds scientist at Lausanne University to identify new bionmarkers in relapsing and progressive MS, first using human iPSC derived astrocytes from CSF and blood from MS patients and healthy controls 65200 Cash progress payments 0 contractual amount Europe (including Iceland and Greenland) Scientific Research. MRF began funding a study at the University of Barcelona to evaluate whether EVs from astrocytes can indicate whether the CNS environment is promoting or inhibiting repair. (In MS, remyelination of demyelinated axons may be inhibited by stressed or activated astrocytes). 50000 Cash progress payments 0 Contractual amount 2 0 0 0 0 0 0 0 Schedule F, Part I, Line 2 Grants outside of the United States are treated the same as grants within the United States with regular required reports and conversations with recipients 1 Cornell University 102 Prospect Street Ithaca NY 14850 150532082 26000 0 contractual amount MRF funds work at Cornell University to determine whether brain endothelial cell EVs, oligodendrocyte EVs and microglial EVs from MS patients' blood, changes with various MS sub-types Oregon Health & Science University 0690 SW Bancroft St Portland OR 97239 931176109 49948 0 contractual amount MRF funds the addition of EVs to OHSU experiment that is using evoked potentials as a measure of demyelination. Evoked potentials are a possible way to measure repair by measuring the conduction speed of signals along axons John Hopkins School of Medicine 12529 Collections Center Drive Chicago IL 60693 520595110 135610 0 contractual amount MRF funds two projects at John Hopkins. One is to study oligodendrocyte extacellular vesicles as possible biomarkers of remyelination. The second is to study macrophage migration inhibitor factor(MIF) as a biomarker of neuronal and oligodendrocyte death and disease severity in MS 3 0 Schedule I, Part I, Line 2 The Universities are subject to terms and conditions of the sponsored research agreement between Universities and MRF. The researchers' work are reviewed by the MRF committee and by the MRF president. Form 990, Part VI, Section A, Line 9 These are the addresses for the board members. Andy's and Casey's are work addresses. 1.Andy Cates 429 N. Main Street, suite 100 Memphis ,TN 38103. 2. Jim Gidwitz 440 S LaSalle, suite 3100, Chicago, IL 60605-5020. 3. Casey McGlynn 650 Page Mill Road, Palo Alto, CA 94304-1001. 4. Bobby Mehta 159 E. Walton Street, Chicago, IL 60611. Form 990, Part VI, Section B, Line 11b Form 990 is reviewed by the CEO and once the CEO approves, it is then forwarded to the board members for their review prior to filing. Board members are encouraged to review and forward their questions, if any, to the CEO Form 990, Part VI, Section B, Line 12c Officers, directors, and key employees are covered. Any and all conflicts are reviewed by disinterested board members and, if needed, by legal counsel. Persons with a conflict of interest will be restricted from making any key decisions for MRF as they relate to the interest unless otherwise approved by the majority of the disinterested parties. Form 990, Part VI, Section B, Line 15 Compensation is determined by the board of directors Form 990, Part VI, Section C, Line 19 Financial Statements, governing documents and policies are available upon request for the same period of time set forth in Sec.6104(D) Form 990, Part IX, Line 11g General Consulting