2022-10-25T14:09:19-05:00 2021-12-31 042571780 AAFCPAS INC 50 WASHINGTON STREET WESTBOROUGH MA 01581 990 2021-01-01 043462719 ALS THERAPY DEVELOPMENT FOUNDATION INC D/B/A ALS THERAPY DEVELOPMENT INSTITUTE ALST 6174417200 480 ARSENAL STREET SUITE 201 WATERTOWN MA 02472 FERNANDO VIEIRA CEO/CSO 6174417200 2022-09-01 1 FERNANDO VIEIRA XXX-XX-XXXX THOMAS F MULDOON CPA P01561688 5083669100 2022-09-01 3 AAL1 IAL1 2021 2022-09-23 18:48:47Z FERNANDO VIEIRA 480 ARSENAL STREET SUITE 201 WATERTOWN MA 02472 12901794 0 X WWW.ALS.NET X 1999 MA WE ARE COMMITTED TO CREATING AND LEADING A TRANSPARENT COLLABORATIVE RESEARCH PROCESS THAT INVOLVES ALS PATIENTS TODAY AND HONORS THOSE WHOSE JOURNEY WITH THIS DISEASE HAS ENDED. WE ARE GUIDED BY PASSION, LOVE AND THE SPIRIT OF ENTREPRENEURSHIP UPON WHICH WE WERE FOUNDED. 17 17 48 500 0 0 8062216 11401098 265315 628036 1118667 8195 802415 333322 10248613 12370651 0 0 0 0 4424215 4112758 0 0 384423 5105092 4874728 9529307 8987486 719306 3383165 29996989 19047011 2792824 2525249 27204165 16521762 OUR MISSION IS TO IDENTIFY VIABLE TARGETS FOR THERAPY DEVELOPMENT AND EXPEDITIOUSLY MANAGE THE CREATION OF THOSE TREATMENTS THAT WILL ARREST THE SUFFERING OF TODAY'S ALS PATIENTS. 0 0 7892961 631830 ALS TDI COMBINES THE PASSION AND DEDICATION OF A NONPROFIT ORGANIZATION WITH THE ENTREPRENEURIAL AND SCIENTIFIC SPIRIT OF A BIOTECHNOLOGY COMPANY. OUR LABORATORY IS THE LEADING DRUG DISCOVERY PROGRAM FOR ALS, AND IT BRIDGES A CRITICAL RESEARCH GAP. OUR IN-HOUSE EXPERTISE TRANSLATES RESEARCH INTO POTENTIAL DRUG CANDIDATES BY SCREENING DRUGS IN THE SOD1 MOUSE MODEL OF ALS. OUR SCIENTIFIC COLLABORATIONS ARE DESIGNED TO BRING THE MOST PROMISING LEADS CLOSER TO PATIENT USE. WE SHARE EMERGING KNOWLEDGE ON THE DISEASE WITH PATIENTS, PHYSICIANS, AND RESEARCHERS AS QUICKLY AND COMPREHENSIVELY AS POSSIBLE. EVERY DECISION IS MADE IN THE INTEREST OF FINDING EFFECTIVE TREATMENTS FOR PEOPLE LIVING WITH ALS. OUR UNIQUE APPROACH ACCELERATES DRUG DEVELOPMENT FOR ALS. 7892961 1 1 0 0 0 0 0 0 0 0 1 0 0 0 1 1 1 0 0 0 0 0 0 0 1 0 0 0 0 1 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 1 21 0 1 48 1 0 0 0 0 0 1 1 0 0 0 0 0 0 X 17 17 1 0 0 0 0 0 0 1 1 0 0 1 1 1 1 1 1 1 1 0 AL AK AZ AR CA CO CT DE FL GA HI ID IL IN IA KS KY LA ME MD MA MI MN MS MO MT NE NV NH NJ NM NY NC ND OH OK OR PA RI SC TN TX SD UT VT VA WA WV WY WI X X INSOURCE SERVICES INC 7812351490 148 LINDEN STREET WELLESLEY MA 02482 DR STANLEY H APPEL MD BOARD MEMBER 2.50 X 0 0 0 ALEXANDER CAPPELLO BOARD MEMBER 2.50 X 0 0 0 DR SPIROS JAMAS SCD BOARD MEMBER 2.50 X 0 0 0 JAMES ALLEN HEYWOOD BOARD MEMBER 2.50 X 0 0 0 JOHN B HEYWOOD PHD SCD BOARD MEMBER 2.50 X 0 0 0 AUGIE NIETO CHAIRMAN AND BOARD MEMBER 2.50 X X 0 0 0 ROB RODIN BOARD MEMBER 2.50 X 0 0 0 PAUL SALLABERRY BOARD MEMBER 2.50 X 0 0 0 THEODORE REICH JD CPA TREASURER AND BOARD MEMBER 2.50 X X 0 0 0 ROBERT SEPUCHA BOARD MEMBER 2.50 X 0 0 0 JENNY DWYER BOARD MEMBER 2.50 X 0 0 0 MIKE SMITH BOARD MEMBER 2.50 X 0 0 0 LYNNE NIETO BOARD MEMBER 2.50 X 0 0 0 JULIE SWAN BOARD MEMBER 2.50 X 0 0 0 KENT JACKSON BRANSFORD MD BOARD MEMBER 2.50 X 0 0 0 ANDREW NIBLOCK BOARD MEMBER 2.50 X 0 0 0 STEVEN PERRIN PHD VICE CHAIR 2.50 X X 0 0 0 FERNANDO VIEIRA CEO / CSO 40.00 X X 274971 0 19314 ALAN GILL VP OF RESEARCH 40.00 X 170347 0 12244 MATVEY LUKASHEV VP OF TRANSLATION SCIENCES 40.00 X 173583 0 7159 BASHAR AL-NAKHALA CHIEF OPERATING OFFICER 40.00 X 194993 0 20173 THEO HATZIPETROS DIRECTOR OF PHARMACOLOGY 40.00 X 121058 0 19314 KENNETH THOMPSON DIRECTOR OF LAB 40.00 X 116998 0 16166 1051950 0 94370 11 0 1 0 INSOURCE SERVICES INC PO BOX 427 NEWTON UPPER FALLS MA 02464 FINANCE, HR & IT 490644 MICROCONSTANTS 9050 CAMINO SANTA FE SAN DIEGO CA 92121 RESEACH 121080 LATHROP GAGE 2345 GRAND BLVD SUITE 2800 KANSAS CITY MO 64108 LEGAL 109544 3 4505375 1709482 5186241 11401098 PHARMACEUTICAL CONTRACTS 541700 628036 628036 628036 8195 8195 860671 4505375 531143 329528 329528 CONTRACTED SERVICES 541900 3794 3794 3794 12370651 631830 0 337723 294285 235429 29428 29428 3057364 2760047 194167 103150 30880 27615 2054 1211 460123 410517 34368 15238 270106 241364 18333 10409 47408 47408 184852 184852 555035 522777 32258 116470 87624 415 28431 436587 409042 7203 20342 1502521 1435129 60028 7364 69430 69346 84 5728 5728 202664 181376 13358 7930 63396 56728 4111 2557 TESTING AND LAB EXPENSE 1412115 1412115 MISCELLANEOUS 73192 9386 63711 95 BANK AND CREDIT CARD PR 70668 4308 66360 FUNDRAISING 54578 54578 80084 28738 14016 37330 8987486 7892961 710102 384423 4667402 3608722 3080830 7350760 255000 45000 206940 1049523 382139 233017 2853223 2601686 282980 251537 20414009 5845830 707689 662622 29996989 19047011 293124 393423 2495 232684 95059 65565 896400 739875 1505746 1093702 2792824 2525249 X 26954165 16521762 250000 0 27204165 16521762 29996989 19047011 X 3383165 -14568179 502611 X X 0 1 X 1 0 X 14163205 12729824 11823260 8062216 10588016 57366521 14163205 12729824 11823260 8062216 10588016 57366521 4304220 53062301 9636 34605 50014 17725 8195 120175 292007 396903 279636 90017 3794 1062357 58549053 4146585 0.90630 0.90210 X SCHEDULE A, PART II, LINE 10, EXPLANATION OF OTHER INCOME: OTHER INCOME RESTRICTED RESTRICTED RESTRICTED RESTRICTED RESTRICTED RESTRICTED RESTRICTED RESTRICTED 0 0 62470 56963 5507 2790753 2544723 246030 251537 DEFERRED RENT LIABILITY 1093702 1093702 X -1688119 -14568179 6798 502611 -14058770 12370651 0 12370651 8994284 6798 6798 8987486 0 8987486 PART X, LINE 2: ALS TDI ACCOUNTS FOR UNCERTAINTY IN INCOME TAXES IN ACCORDANCE WITH ASC TOPIC, INCOME TAXES. THIS STANDARD CLARIFIES THE ACCOUNTING FOR UNCERTAINTY IN TAX POSITIONS AND PRESCRIBES A RECOGNITION THRESHOLD AND MEASUREMENT ATTRIBUTE FOR THE FINANCIAL STATEMENTS REGARDING A TAX POSITION TAKEN OR EXPECTED TO BE TAKEN IN A TAX RETURN. ALS TDI HAS DETERMINED THAT THERE ARE NO UNCERTAIN TAX POSITIONS WHICH QUALIFY FOR EITHER RECOGNITION OR DISCLOSURE IN THEIR FINANCIAL STATEMENTS AT DECEMBER 31, 2021. THE INFORMATIONAL RETURNS OF ALS TDI ARE SUBJECT TO EXAMINATION BY THE FEDERAL AND STATE JURISDICTIONS AND GENERALLY REMAIN OPEN FOR THE MOST RECENT THREE YEARS. PART XI, LINE 2D - OTHER ADJUSTMENTS: WRITE-OFF OF DEFERRED RENT 502,611. VIRTUAL TREK 694551 661551 33000 29731 17516 1400 14170 VIRTUAL WHITE COAT AFFAIR 164720 164720 1 4506775 3679104 827671 271059 128282 127 68858 5366046 4505375 860671 300790 145798 1527 83028 531143 329528 X X X X 0 0 0 0 0 0 0 0 0 FERNANDO VIEIRA CEO / CSO 274971 0 0 0 0 0 0 0 19314 0 294285 0 0 0 BASHAR AL-NAKHALA CHIEF OPERATING OFFICER 194993 0 0 0 0 0 0 0 20173 0 215166 0 0 0 ALAN GILL VP OF RESEARCH 170347 0 0 0 0 0 0 0 12244 0 182591 0 0 0 MATVEY LUKASHEV VP OF TRANSLATION SCIENCES 173583 0 0 0 0 0 0 0 7159 0 180742 0 0 0 FORM 990, PART VI, SECTION A, LINE 2 JAMES HEYWOOD, BOARD MEMBER, IS THE SON OF JOHN HEYWOOD, MEMBER OF THE BOARD OF DIRECTORS. ADDITIONALLY, LYNNE NIETO AND KENT BRANSFORD, BOARD MEMBERS, ARE THE WIFE AND BROTHER-IN-LAW, RESPECTIVELY, OF AUGIE NIETO, BOARD MEMBER. FORM 990, PART VI, SECTION B, LINE 11B FORM 990 IS REVIEWED BY THE CHIEF FINANCIAL OFFICER AND THEN APPROVED BY THE BOARD OF DIRECTORS. FORM 990, PART VI, SECTION B, LINE 12C ALS TDI HAS A WRITTEN CONFLICT OF INEREST POLICY WHICH REQUIRES ANNUAL SIGNOFFS BY OFFICERS, DIRECTORS AND KEY EMPLOYEES. FORM 990, PART VI, SECTION B, LINE 15 THE PROCESS TO DETERMINE THE COMPENSATION OF THE PRESIDENT CONSISTS OF EVALUATING COMPARABLE DATA FOR FUNCTIONALLY SIMILAR POSITIONS AT SIMILAR ORGANIZATIONS, ALONG WITH THE REVIEW AND APPROVAL BY THE EXECUTIVE COMPENSATION COMMITTEE OF THE BOARD OF DIRECTORS WHICH IS COMPRISED OF INDEPENDENT MEMBERS. FORM 990, PART VI, SECTION B, LINE 15B: THE PROCESS TO ESTABLISH COMPENSATION OF OTHER OFFICERS AND KEY EMPLOYEES IS COMPLETED ON AN ANNUAL BASIS BY EVALUATING COMPARABLE DATA FOR FUNCTIONALLY SIMILAR POSITIONS AT SIMILAR ORGANIZATIONS, PRESENTING RECOMMENDATIONS TO THE EXECUTIVE COMPENSATION COMMITTEE OF THE BOARD OF DIRECTORS WHICH IS COMPRISED OF INDEPENDENT MEMBERS AND DOCUMENTING SUCH DISCUSSIONS IN THE BOARD MINUTES. FORM 990, PART VI, SECTION C, LINE 18 ALS TDI'S FORM 990 IS AVAILABLE FOR PUBLIC INSPECTION ON ALS TDI'S WEBSITE AND AT WWW.GUIDESTAR.COM. ALS TDI'S FORM 1023 IS AVAILABLE UPON REQUEST. FORM 990, PART VI, SECTION C, LINE 19 FINANCIAL STATEMENTS ARE MADE AVAILABLE ON ALS TDI'S WEBSITE AND ARE AVAILABLE BY MAIL UPON REQUEST. GOVERNING DOCUMENTS AND ALS TDI'S CONFLICT OF INTEREST POLICY ARE AVAILABLE UPON REQUEST. FORM 990, PART XI, LINE 9: WRITE-OFF OF DEFERRED RENT 502,611. FORM 990, PART XII, LINE 2C: DURING 2021, THE ORGANIZATION DID NOT CHANGE THE WAY IN WHICH ITS COMMITTEE ASSUMES RESPONSIBILITY FOR OVERSIGHT OF THE AUDIT, ITS FINANCIAL STATEMENTS, AND SELECTION OF AN INDEPENDENT ACCOUNTANT.