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          <FormAndInfoAndMaterialsTxt>LETTER OF INTEREST MUST BE SUBMITTED BY ALL NOMINATED, INTERESTED, AND ELIGIBLE PRINCIPAL INVESTIGATORS. A FULL PROPOSAL MUST BE SUBMITTED BY INVITED AND QUALIFIED PRINCIPAL INVESTIGATORS.</FormAndInfoAndMaterialsTxt>
          <SubmissionDeadlinesTxt>LETTER OF INTEREST DUE ON FEB 20, 2020. REQUEST FOR PROPOSAL DUE ON APRIL 23, 2020.</SubmissionDeadlinesTxt>
          <RestrictionsOnAwardsTxt>BRIEF REPORTS WILL BE REQUIRED EVERY SIX MONTHS AFTER THE GRANTING OF THE AWARD. THESE REPORTS WILL BE A MEANS FOR ASSURING THAT THE RESEARCH FOLLOWS THE APPROVED PROPOSAL IN CONTENT AND TIMEFRAME. A FINAL STUDY REPORT WILL BE DUE TWO MONTHS AFTER PROJECT COMPLETION.</RestrictionsOnAwardsTxt>
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        <GrantOrContributionPdDurYrGrp>
          <RecipientBusinessName>
            <BusinessNameLine1Txt>STANFORD UNIVERSITY DR LINGYIN LI</BusinessNameLine1Txt>
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            <AddressLine1Txt>3160 PORTER DRIVE</AddressLine1Txt>
            <CityNm>STANFORD</CityNm>
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          <GrantOrContributionPurposeTxt>THE ONO PHARMA BREAKTHROUGH SCIENCE INTITIATIVE AWARDS PROGRAM</GrantOrContributionPurposeTxt>
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        <GrantOrContributionPdDurYrGrp>
          <RecipientBusinessName>
            <BusinessNameLine1Txt>THE BROAD INSTITUTE INC DR BRIDGET WAGNER</BusinessNameLine1Txt>
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            <AddressLine1Txt>415 MAIN STREET</AddressLine1Txt>
            <CityNm>CAMBRIDGE</CityNm>
            <StateAbbreviationCd>MA</StateAbbreviationCd>
            <ZIPCd>02142</ZIPCd>
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          <GrantOrContributionPurposeTxt>THE ONO PHARMA BREAKTHROUGH SCIENCE INTITIATIVE AWARDS PROGRAM</GrantOrContributionPurposeTxt>
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        </GrantOrContributionPdDurYrGrp>
        <GrantOrContributionPdDurYrGrp>
          <RecipientBusinessName>
            <BusinessNameLine1Txt>UNIVERSITY OF MASSACHUSETTS DR JONATHAN WATTS</BusinessNameLine1Txt>
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            <StateAbbreviationCd>MA</StateAbbreviationCd>
            <ZIPCd>015457808</ZIPCd>
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          <GrantOrContributionPurposeTxt>THE ONO PHARMA BREAKTHROUGH SCIENCE INTITIATIVE AWARDS PROGRAM</GrantOrContributionPurposeTxt>
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        </GrantOrContributionPdDurYrGrp>
        <GrantOrContributionPdDurYrGrp>
          <RecipientBusinessName>
            <BusinessNameLine1Txt>MASSACHUSETTS INSTITUTE OF TECHNOLOGY DR ANGELA KOEHLER</BusinessNameLine1Txt>
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          <RecipientUSAddress>
            <AddressLine1Txt>77 MASSACHUSETTS AVE NE18-901</AddressLine1Txt>
            <CityNm>CAMBRIDGE</CityNm>
            <StateAbbreviationCd>MA</StateAbbreviationCd>
            <ZIPCd>021394307</ZIPCd>
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          <RecipientFoundationStatusTxt>SEC 501(C)(3)</RecipientFoundationStatusTxt>
          <GrantOrContributionPurposeTxt>THE ONO PHARMA BREAKTHROUGH SCIENCE INTITIATIVE AWARDS PROGRAM</GrantOrContributionPurposeTxt>
          <Amt>172500</Amt>
        </GrantOrContributionPdDurYrGrp>
        <GrantOrContributionPdDurYrGrp>
          <RecipientBusinessName>
            <BusinessNameLine1Txt>UNIVERSITY OF CALIFORNIA SAN DIEGO DR WILLIAM MOBLEY</BusinessNameLine1Txt>
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          <RecipientUSAddress>
            <AddressLine1Txt>9500 GILMAN DR</AddressLine1Txt>
            <CityNm>SAN DIEGO</CityNm>
            <StateAbbreviationCd>CA</StateAbbreviationCd>
            <ZIPCd>92093</ZIPCd>
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          <RecipientFoundationStatusTxt>SEC 501(C)(3)</RecipientFoundationStatusTxt>
          <GrantOrContributionPurposeTxt>THE ONO PHARMA BREAKTHROUGH SCIENCE INTITIATIVE AWARDS PROGRAM</GrantOrContributionPurposeTxt>
          <Amt>345000</Amt>
        </GrantOrContributionPdDurYrGrp>
        <GrantOrContributionPdDurYrGrp>
          <RecipientBusinessName>
            <BusinessNameLine1Txt>UNIVERSITY OF CALIFORNIA SAN FRANCISCO DR JACK TAUNTON</BusinessNameLine1Txt>
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          <RecipientUSAddress>
            <AddressLine1Txt>600 16TH ST MC2280</AddressLine1Txt>
            <CityNm>SAN FRANCISCO</CityNm>
            <StateAbbreviationCd>CA</StateAbbreviationCd>
            <ZIPCd>94158</ZIPCd>
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          <RecipientRelationshipTxt>N/A</RecipientRelationshipTxt>
          <RecipientFoundationStatusTxt>SEC 501(C)(3)</RecipientFoundationStatusTxt>
          <GrantOrContributionPurposeTxt>THE ONO PHARMA BREAKTHROUGH SCIENCE INTITIATIVE AWARDS PROGRAM</GrantOrContributionPurposeTxt>
          <Amt>345000</Amt>
        </GrantOrContributionPdDurYrGrp>
        <GrantOrContributionPdDurYrGrp>
          <RecipientBusinessName>
            <BusinessNameLine1Txt>UNIVERSITY OF CALIFORNIA SAN FRANSISCO DR MICHELLE ARKIN</BusinessNameLine1Txt>
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          <RecipientUSAddress>
            <AddressLine1Txt>550 PARNASSUS AVE</AddressLine1Txt>
            <CityNm>SAN FRANCISCO</CityNm>
            <StateAbbreviationCd>CA</StateAbbreviationCd>
            <ZIPCd>94143</ZIPCd>
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          <RecipientRelationshipTxt>N/A</RecipientRelationshipTxt>
          <RecipientFoundationStatusTxt>SEC 501(C)(3)</RecipientFoundationStatusTxt>
          <GrantOrContributionPurposeTxt>THE ONO PHARMA BREAKTHROUGH SCIENCE INTITIATIVE AWARDS PROGRAM</GrantOrContributionPurposeTxt>
          <Amt>345000</Amt>
        </GrantOrContributionPdDurYrGrp>
        <GrantOrContributionPdDurYrGrp>
          <RecipientBusinessName>
            <BusinessNameLine1Txt>YALE UNIVERSITY DR MATTHEW SIMON</BusinessNameLine1Txt>
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          <RecipientUSAddress>
            <AddressLine1Txt>NEW HAVEN</AddressLine1Txt>
            <CityNm>NEW HAVEN</CityNm>
            <StateAbbreviationCd>CT</StateAbbreviationCd>
            <ZIPCd>06520</ZIPCd>
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          <RecipientRelationshipTxt>N/A</RecipientRelationshipTxt>
          <RecipientFoundationStatusTxt>SEC 501(C)(3)</RecipientFoundationStatusTxt>
          <GrantOrContributionPurposeTxt>THE ONO PHARMA BREAKTHROUGH SCIENCE INTITIATIVE AWARDS PROGRAM</GrantOrContributionPurposeTxt>
          <Amt>345000</Amt>
        </GrantOrContributionPdDurYrGrp>
        <GrantOrContributionPdDurYrGrp>
          <RecipientBusinessName>
            <BusinessNameLine1Txt>HARVARD UNIVERSITY DR CHRISTINA WOO</BusinessNameLine1Txt>
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          <RecipientUSAddress>
            <AddressLine1Txt>61 GORHAM ST</AddressLine1Txt>
            <CityNm>CAMBRIDGE</CityNm>
            <StateAbbreviationCd>MA</StateAbbreviationCd>
            <ZIPCd>02138</ZIPCd>
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          <RecipientFoundationStatusTxt>SEC 501(C)(3)</RecipientFoundationStatusTxt>
          <GrantOrContributionPurposeTxt>THE ONO PHARMA BREAKTHROUGH SCIENCE INTITIATIVE AWARDS PROGRAM</GrantOrContributionPurposeTxt>
          <Amt>345000</Amt>
        </GrantOrContributionPdDurYrGrp>
        <GrantOrContributionPdDurYrGrp>
          <RecipientBusinessName>
            <BusinessNameLine1Txt>BROAD INSTITUTE OF HARVARD &amp; MIT DRS ERIC MINIKEL &amp; SONIA VALLABH</BusinessNameLine1Txt>
          </RecipientBusinessName>
          <RecipientUSAddress>
            <AddressLine1Txt>415 MAIN STREET</AddressLine1Txt>
            <CityNm>CAMBRIDGE</CityNm>
            <StateAbbreviationCd>MA</StateAbbreviationCd>
            <ZIPCd>02142</ZIPCd>
          </RecipientUSAddress>
          <RecipientRelationshipTxt>N/A</RecipientRelationshipTxt>
          <RecipientFoundationStatusTxt>SEC 501(C)(3)</RecipientFoundationStatusTxt>
          <GrantOrContributionPurposeTxt>THE ONO PHARMA BREAKTHROUGH SCIENCE INTITIATIVE AWARDS PROGRAM</GrantOrContributionPurposeTxt>
          <Amt>345000</Amt>
        </GrantOrContributionPdDurYrGrp>
        <GrantOrContributionPdDurYrGrp>
          <RecipientBusinessName>
            <BusinessNameLine1Txt>HARVARD UNIVERSITY DR B LIAU</BusinessNameLine1Txt>
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          <RecipientUSAddress>
            <AddressLine1Txt>61 GORHAM ST</AddressLine1Txt>
            <CityNm>CAMBRIDGE</CityNm>
            <StateAbbreviationCd>MA</StateAbbreviationCd>
            <ZIPCd>02138</ZIPCd>
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          <RecipientRelationshipTxt>N/A</RecipientRelationshipTxt>
          <RecipientFoundationStatusTxt>SEC 501(C)(3)</RecipientFoundationStatusTxt>
          <GrantOrContributionPurposeTxt>THE ONO PHARMA BREAKTHROUGH SCIENCE INTITIATIVE AWARDS PROGRAM</GrantOrContributionPurposeTxt>
          <Amt>345000</Amt>
        </GrantOrContributionPdDurYrGrp>
        <GrantOrContributionPdDurYrGrp>
          <RecipientBusinessName>
            <BusinessNameLine1Txt>UNIVERSITY OF CALIFORNIA DR A EDINGER</BusinessNameLine1Txt>
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          <RecipientUSAddress>
            <AddressLine1Txt>836 HEALTH SCIENCES RD</AddressLine1Txt>
            <CityNm>IRVINE</CityNm>
            <StateAbbreviationCd>CA</StateAbbreviationCd>
            <ZIPCd>92697</ZIPCd>
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          <RecipientRelationshipTxt>N/A</RecipientRelationshipTxt>
          <RecipientFoundationStatusTxt>SEC 501(C)(3)</RecipientFoundationStatusTxt>
          <GrantOrContributionPurposeTxt>THE ONO PHARMA BREAKTHROUGH SCIENCE INTITIATIVE AWARDS PROGRAM</GrantOrContributionPurposeTxt>
          <Amt>345000</Amt>
        </GrantOrContributionPdDurYrGrp>
        <GrantOrContributionPdDurYrGrp>
          <RecipientBusinessName>
            <BusinessNameLine1Txt>UNIVERSITY OF CALIFORNIA DR R SPITALE</BusinessNameLine1Txt>
          </RecipientBusinessName>
          <RecipientUSAddress>
            <AddressLine1Txt>836 HEALTH SCIENCES RD</AddressLine1Txt>
            <CityNm>IRVINE</CityNm>
            <StateAbbreviationCd>CA</StateAbbreviationCd>
            <ZIPCd>92697</ZIPCd>
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          <RecipientRelationshipTxt>N/A</RecipientRelationshipTxt>
          <RecipientFoundationStatusTxt>SEC 501(C)(3)</RecipientFoundationStatusTxt>
          <GrantOrContributionPurposeTxt>THE ONO PHARMA BREAKTHROUGH SCIENCE INTITIATIVE AWARDS PROGRAM</GrantOrContributionPurposeTxt>
          <Amt>345000</Amt>
        </GrantOrContributionPdDurYrGrp>
        <GrantOrContributionPdDurYrGrp>
          <RecipientBusinessName>
            <BusinessNameLine1Txt>STANFORD UNIVERSITY DR POLLY FORDYCE</BusinessNameLine1Txt>
          </RecipientBusinessName>
          <RecipientUSAddress>
            <AddressLine1Txt>443 VIA ORGEGA</AddressLine1Txt>
            <CityNm>STANFORD</CityNm>
            <StateAbbreviationCd>CA</StateAbbreviationCd>
            <ZIPCd>94306</ZIPCd>
          </RecipientUSAddress>
          <RecipientRelationshipTxt>N/A</RecipientRelationshipTxt>
          <RecipientFoundationStatusTxt>SEC 501(C)(3)</RecipientFoundationStatusTxt>
          <GrantOrContributionPurposeTxt>THE ONO PHARMA BREAKTHROUGH SCIENCE INTITIATIVE AWARDS PROGRAM</GrantOrContributionPurposeTxt>
          <Amt>345000</Amt>
        </GrantOrContributionPdDurYrGrp>
        <GrantOrContributionPdDurYrGrp>
          <RecipientBusinessName>
            <BusinessNameLine1Txt>THE SCRIPPS RESEARCH INSTITUTE MICHAEL A ERB</BusinessNameLine1Txt>
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          <RecipientUSAddress>
            <AddressLine1Txt>10550 N TORREY PINES RD</AddressLine1Txt>
            <CityNm>LA JOLLA</CityNm>
            <StateAbbreviationCd>CA</StateAbbreviationCd>
            <ZIPCd>92037</ZIPCd>
          </RecipientUSAddress>
          <RecipientRelationshipTxt>N/A</RecipientRelationshipTxt>
          <RecipientFoundationStatusTxt>SEC 501(C)(3)</RecipientFoundationStatusTxt>
          <GrantOrContributionPurposeTxt>THE ONO PHARMA BREAKTHROUGH SCIENCE INTITIATIVE AWARDS PROGRAM</GrantOrContributionPurposeTxt>
          <Amt>172500</Amt>
        </GrantOrContributionPdDurYrGrp>
        <GrantOrContributionPdDurYrGrp>
          <RecipientBusinessName>
            <BusinessNameLine1Txt>BOSTON COLLEGE ERANTHIE WEERAPANA</BusinessNameLine1Txt>
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          <RecipientUSAddress>
            <AddressLine1Txt>2609 BEACON ST</AddressLine1Txt>
            <CityNm>CHESTNUT HILL</CityNm>
            <StateAbbreviationCd>MA</StateAbbreviationCd>
            <ZIPCd>02467</ZIPCd>
          </RecipientUSAddress>
          <RecipientRelationshipTxt>N/A</RecipientRelationshipTxt>
          <RecipientFoundationStatusTxt>SEC 501(C)(3)</RecipientFoundationStatusTxt>
          <GrantOrContributionPurposeTxt>THE ONO PHARMA BREAKTHROUGH SCIENCE INTITIATIVE AWARDS PROGRAM</GrantOrContributionPurposeTxt>
          <Amt>172500</Amt>
        </GrantOrContributionPdDurYrGrp>
        <GrantOrContributionPdDurYrGrp>
          <RecipientBusinessName>
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          <RecipientUSAddress>
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            <StateAbbreviationCd>CA</StateAbbreviationCd>
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          <RecipientRelationshipTxt>N/A</RecipientRelationshipTxt>
          <RecipientFoundationStatusTxt>SEC 501(C)(3)</RecipientFoundationStatusTxt>
          <GrantOrContributionPurposeTxt>THE ONO PHARMA BREAKTHROUGH SCIENCE INTITIATIVE AWARDS PROGRAM</GrantOrContributionPurposeTxt>
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        </GrantOrContributionPdDurYrGrp>
        <GrantOrContributionPdDurYrGrp>
          <RecipientBusinessName>
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          <RecipientUSAddress>
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            <StateAbbreviationCd>IL</StateAbbreviationCd>
            <ZIPCd>60637</ZIPCd>
          </RecipientUSAddress>
          <RecipientRelationshipTxt>N/A</RecipientRelationshipTxt>
          <RecipientFoundationStatusTxt>SEC 501(C)(3)</RecipientFoundationStatusTxt>
          <GrantOrContributionPurposeTxt>THE ONO PHARMA BREAKTHROUGH SCIENCE INTITIATIVE AWARDS PROGRAM</GrantOrContributionPurposeTxt>
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        </GrantOrContributionPdDurYrGrp>
        <GrantOrContributionPdDurYrGrp>
          <RecipientBusinessName>
            <BusinessNameLine1Txt>STANFORD UNIVERSITY JONATHAN Z LONG</BusinessNameLine1Txt>
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            <StateAbbreviationCd>CA</StateAbbreviationCd>
            <ZIPCd>94306</ZIPCd>
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          <RecipientRelationshipTxt>N/A</RecipientRelationshipTxt>
          <RecipientFoundationStatusTxt>SEC 501(C)(3)</RecipientFoundationStatusTxt>
          <GrantOrContributionPurposeTxt>THE ONO PHARMA BREAKTHROUGH SCIENCE INTITIATIVE AWARDS PROGRAM</GrantOrContributionPurposeTxt>
          <Amt>172500</Amt>
        </GrantOrContributionPdDurYrGrp>
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        <GrantOrContriApprvForFutGrp>
          <RecipientBusinessName>
            <BusinessNameLine1Txt>UNIVERSITY OF CALIFORNIA SAN DIEGO DR WILLIAM MOBLEY</BusinessNameLine1Txt>
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          <RecipientUSAddress>
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            <ZIPCd>92093</ZIPCd>
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          <RecipientFoundationStatusTxt>SEC 501(C)(3)</RecipientFoundationStatusTxt>
          <GrantOrContributionPurposeTxt>THE ONO PHARMA BREAKTHROUGH SCIENCE INTITIATIVE AWARDS PROGRAM</GrantOrContributionPurposeTxt>
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        <GrantOrContriApprvForFutGrp>
          <RecipientBusinessName>
            <BusinessNameLine1Txt>UNIVERSITY OF CALIFORNIA SAN FRANCISCO DR JACK TAUNTON</BusinessNameLine1Txt>
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          <RecipientUSAddress>
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          <RecipientFoundationStatusTxt>SEC 501(C)(3)</RecipientFoundationStatusTxt>
          <GrantOrContributionPurposeTxt>THE ONO PHARMA BREAKTHROUGH SCIENCE INTITIATIVE AWARDS PROGRAM</GrantOrContributionPurposeTxt>
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        </GrantOrContriApprvForFutGrp>
        <GrantOrContriApprvForFutGrp>
          <RecipientBusinessName>
            <BusinessNameLine1Txt>UNIVERSITY OF CALIFORNIA SAN FRANSISCO DR MICHELLE ARKIN</BusinessNameLine1Txt>
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          <RecipientUSAddress>
            <AddressLine1Txt>550 PARNASSUS AVE</AddressLine1Txt>
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            <StateAbbreviationCd>CA</StateAbbreviationCd>
            <ZIPCd>94143</ZIPCd>
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          <RecipientRelationshipTxt>N/A</RecipientRelationshipTxt>
          <RecipientFoundationStatusTxt>SEC 501(C)(3)</RecipientFoundationStatusTxt>
          <GrantOrContributionPurposeTxt>THE ONO PHARMA BREAKTHROUGH SCIENCE INTITIATIVE AWARDS PROGRAM</GrantOrContributionPurposeTxt>
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        </GrantOrContriApprvForFutGrp>
        <GrantOrContriApprvForFutGrp>
          <RecipientBusinessName>
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            <StateAbbreviationCd>CT</StateAbbreviationCd>
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          <RecipientBusinessName>
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          <RecipientUSAddress>
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            <StateAbbreviationCd>MA</StateAbbreviationCd>
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          <GrantOrContributionPurposeTxt>THE ONO PHARMA BREAKTHROUGH SCIENCE INTITIATIVE AWARDS PROGRAM</GrantOrContributionPurposeTxt>
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          <RecipientBusinessName>
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          <RecipientUSAddress>
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            <StateAbbreviationCd>MA</StateAbbreviationCd>
            <ZIPCd>02142</ZIPCd>
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          <RecipientFoundationStatusTxt>SEC 501(C)(3)</RecipientFoundationStatusTxt>
          <GrantOrContributionPurposeTxt>THE ONO PHARMA BREAKTHROUGH SCIENCE INTITIATIVE AWARDS PROGRAM</GrantOrContributionPurposeTxt>
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        <GrantOrContriApprvForFutGrp>
          <RecipientBusinessName>
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          <RecipientUSAddress>
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            <StateAbbreviationCd>MA</StateAbbreviationCd>
            <ZIPCd>02138</ZIPCd>
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          <RecipientRelationshipTxt>N/A</RecipientRelationshipTxt>
          <RecipientFoundationStatusTxt>SEC 501(C)(3)</RecipientFoundationStatusTxt>
          <GrantOrContributionPurposeTxt>THE ONO PHARMA BREAKTHROUGH SCIENCE INTITIATIVE AWARDS PROGRAM</GrantOrContributionPurposeTxt>
          <Amt>510477</Amt>
        </GrantOrContriApprvForFutGrp>
        <GrantOrContriApprvForFutGrp>
          <RecipientBusinessName>
            <BusinessNameLine1Txt>UNIVERSITY OF CALIFORNIA DR A EDINGER</BusinessNameLine1Txt>
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          <RecipientUSAddress>
            <AddressLine1Txt>836 HEALTH SCIENCES RD</AddressLine1Txt>
            <CityNm>IRVINE</CityNm>
            <StateAbbreviationCd>CA</StateAbbreviationCd>
            <ZIPCd>92697</ZIPCd>
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          <RecipientRelationshipTxt>N/A</RecipientRelationshipTxt>
          <RecipientFoundationStatusTxt>SEC 501(C)(3)</RecipientFoundationStatusTxt>
          <GrantOrContributionPurposeTxt>THE ONO PHARMA BREAKTHROUGH SCIENCE INTITIATIVE AWARDS PROGRAM</GrantOrContributionPurposeTxt>
          <Amt>510477</Amt>
        </GrantOrContriApprvForFutGrp>
        <GrantOrContriApprvForFutGrp>
          <RecipientBusinessName>
            <BusinessNameLine1Txt>UNIVERSITY OF CALIFORNIA DR R SPITALE</BusinessNameLine1Txt>
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          <RecipientUSAddress>
            <AddressLine1Txt>836 HEALTH SCIENCES RD</AddressLine1Txt>
            <CityNm>IRVINE</CityNm>
            <StateAbbreviationCd>CA</StateAbbreviationCd>
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