2025-10-14T09:59:09-05:00 2024-11-30 861065772 DELOITTE TAX LLP 50 SOUTH SIXTH STREET SUITE 280 MINNEAPOLIS MN 55402 990 2023-12-01 522000823 VAN ANDEL RESEARCH INSTITUTE VANA 6162345000 333 BOSTWICK AVENUE NE GRAND RAPIDS MI 49503 TIMOTHY J MYERS VICE PRESIDENT & CAO/CFO 6162345368 2025-10-14 0 1 MORGAN SEVERSON P02279974 6123974000 2023 2025-03-06 01:10:19Z TIMOTHY J MYERS 333 BOSTWICK AVENUE NE GRAND RAPIDS MI 49503 113451538 0 X WWW.VAI.ORG X 1996 MI MEDICAL RESEARCH ORGANIZATION 6 5 596 0 22487 0 327656765 99075223 882195 1311102 99948 -339084 11372978 12691244 340011886 112738485 2717278 3760021 0 0 63920211 67657719 0 0 2039778 45406956 47496046 112044445 118913786 227967441 -6175301 197193153 190464759 16821217 16145740 180371936 174319019 MEDICAL RESEARCH ORGANIZATION VAN ANDEL RESEARCH INSTITUTE IS AN INDEPENDENT BIOMEDICAL RESEARCH ORGANIZATION COMMITTED TO IMPROVING THE HEALTH AND ENHANCING THE LIVES OF CURRENT AND FUTURE GENERATIONS. 0 0 16328121 1197533 65581 DEPARTMENT OF EPIGENETICSSCHEDULE O PROVIDES FURTHER INFORMATION REGARDING THIS PROGRAM'S ACCOMPLISHMENTS. 9656310 947028 16054 DEPARTMENT OF NEURODEGENERATIVE SCIENCESCHEDULE O PROVIDES FURTHER INFORMATION REGARDING THIS PROGRAM'S ACCOMPLISHMENTS. 7093695 453381 0 DEPARTMENT OF METABOLISM AND NUTRITIONAL PROGRAMMINGSEE SCHEDULE O FOR FURTHER INFORMATION ABOUT THIS PROGRAM'S ACCOMPLISHMENTS. 44615423 1162079 1229467 44615423 1162079 1229467 77693549 1 1 0 1 0 0 0 0 0 1 1 0 0 0 0 1 0 1 0 0 1 1 0 0 1 0 0 1 1 1 0 0 0 0 0 0 0 0 0 0 0 0 1 1 1 1 0 0 1 144 0 1 596 1 1 1 0 0 0 0 1 1 0 0 0 0 1 0 X 6 5 1 0 0 0 0 1 0 1 1 0 0 1 1 1 1 1 1 1 1 0 MI X TIMOTHY J MYERS VP & CAOCFO 6162345368 333 BOSTWICK AVENUE NE GRAND RAPIDS MI 495032518 DAVID VAN ANDEL CHAIRMAN / CEO 23.00 17.00 X X 691507 0 108088 DR JAMES FAHNER TRUSTEE 1.00 1.00 X 7000 4750 0 DR MAX WICHA TRUSTEE 1.00 0.00 X 9500 1000 0 DR MICHELLE LEBEAU TRUSTEE 1.00 0.00 X 9500 0 0 DR RALPH DEBERARDINIS TRUSTEE 1.00 0.00 X 7500 0 0 DR HENRY PAULSON TRUSTEE (BEG. 9/23/2024) 1.00 0.00 X 0 0 0 DR JANA HALL CHIEF OPERAT. OFFICER (END 4/1/2024) 44.00 1.00 X 635819 0 101074 TIMOTHY MYERS VICE PRESIDENT & CAO/CFO 42.00 3.00 X 492899 0 93423 DR PETER JONES CHIEF SCIENTIFIC OFFICER & RES. DIR. 44.00 1.00 X 953170 0 165515 THOMAS CURRAN JR GENERAL COUNSEL 42.00 3.00 X 517831 0 95142 GERALD CALLAHAN CHIEF STRAT. OFFICER (END 7/5/2024) 43.00 2.00 X 508121 0 95178 KATHY VOGELSANG CHIEF INVESTMENT OFFICER 45.00 0.00 X 1125167 0 597404 AUSTIN WAY SENIOR PORTFOLIO MANAGER 45.00 0.00 X 530219 0 313619 DR PETER LAIRD DISTINGUISHED INVESTIGATOR 45.00 0.00 X 513955 0 62535 TED HEILMAN ASSOC DIRECT-SR. PORTFOLIO MGR. 45.00 0.00 X 782302 0 458404 DR HUILIN LI SR. SCIENTIFIC INVESTIGATOR & DEPT. CHAIR 45.00 0.00 X 433939 0 72186 7218429 5750 2162568 119 0 1 0 HURON CONSULTING GROUP INC PO BOX 71223 CHICAGO IL 60694 CONSULTING SERVICES 1804360 OWEN-AMES-KIMBALL CO 126 OTTAWA AVE NW SUITE 600 GRAND RAPIDS MI 49503 CONSTRUCTION SERVICES 560293 MCPC INC 21500 AEROSPACE PARKWAY CLEVELAND OH 44142 HELPDESK SERVICES 467128 FEI COMPANY 5350 NE DAWSON CREEK DRIVE HILLSBORO OR 97124 MAINTENANCE SERVICES 435430 TWO BY FOUR LTD 10 N DEARBORN SUITE 1000 CHICAGO IL 60602 CONSULT. & ADVERT. SERVICES 358093 26 272273 61431822 32720750 4650378 16403 99075223 RESEARCH BILLED REV 541700 1311102 1311102 1311102 7220 7220 45000 44811 189 189 189 220093 566397 -346304 -346304 -346304 153234 272273 94295 58939 58939 30037 7550 22487 22487 ALLOCATED ADMIN. EXP. 561000 12134713 12134713 EDUCATIONAL PROGRAMS 611710 334937 334937 REIMBURSED EXPENSES 900099 97802 97802 42177 42177 12609629 112738485 1311102 22487 12329673 673000 673000 2297021 2297021 790000 790000 3500121 871533 2628588 51545057 31210574 19072394 1262089 4328910 2624801 1583062 121047 4869110 2952347 1780611 136152 3414521 2070369 1248674 95478 458292 77271 381021 133335 133335 96000 96000 4406771 2718601 1688170 2796447 70378 2434413 291656 27121 1734 25100 287 709593 121058 558153 30382 16613 16613 2921054 2491213 429841 1353322 1020312 307965 25045 525502 437030 85438 3034 11829 5548 6281 13665696 11999973 1665723 1029810 638482 391328 LAB SUPPLIES & SERVICES 7464454 7463658 796 EQUIPMENT & SOFTWARE 5903439 3395467 2500518 7454 OTHER SCIENTIFIC 1509022 1509022 FED / STATE INCOME TAX 58721 57096 1625 4409025 2254157 2089339 65529 118913786 77693549 39180459 2039778 1022317 458289 5763820 6344698 12329240 8984611 92287 45025 335429 343024 2879312 3104997 333530264 168919373 168320709 164610891 6450039 6573224 197193153 190464759 15331023 15676704 1490194 469036 16821217 16145740 X 173639772 167369888 6732164 6949131 180371936 174319019 197193153 190464759 -6175301 122384 0 X 0 1 X 1 1 1 X COREWELL HEALTH GRAND RAPIDS MI RESTRICTED RESTRICTED RESTRICTED RESTRICTED RESTRICTED RESTRICTED RESTRICTED RESTRICTED 96000 96000 118817786 118913786 1000000 250000 0 0 1000000 1000000 1000000 1000000 4000000 6000000 96000 96000 96000 96000 384000 250000 250000 250000 250000 1000000 1500000 988688 1000 122384 198 1111874 921757 11200 55924 193 988688 914174 16000 -8216 201 921757 790427 16000 107939 192 914174 723759 15000 51845 177 790427 1.00000 0 1 1 5288315 5288315 240411928 104093363 136318565 101150 101150 0 84148835 64498926 19649909 3580036 225934 3354102 164610891 X 100866646 122384 139106 261490 100605156 12133329 12133329 112738485 106919563 139106 139106 106780457 12133329 12133329 118913786 PART X, LINE 2: THERE ARE NO UNCERTAIN TAX POSITIONS RELATED TO VARI. PART XI, LINE 2D - OTHER ADJUSTMENTS: RENTAL EXPENSES 44,811. FUNDRAISING EVENT EXPENSE 94,295. PART XI, LINE 4B - OTHER ADJUSTMENTS: NET ALLOCATED 12,134,713. ROYALTY PAYOUTS -1,384. PART XII, LINE 2D - OTHER ADJUSTMENTS: RENTAL EXPENSES 44,811. FUNDRAISING EVENT EXPENSE 94,295. PART XII, LINE 4B - OTHER ADJUSTMENTS: NET ALLOCATED 12,134,713. ROYALTY PAYOUTS -1,384. PART V VAN ANDEL INSTITUTE (A RELATED ORGANIZATION) MAINTAINS ENDOWED FUNDS FOR THE BENEFIT OF BOTH VARI AND VAN ANDEL EDUCATION INSTITUTE (A RELATED ORGANIZATION) TO FUND OPERATING EXPENSES. PART XI AND XII, LINE 4B EXPENSE ALLOCATIONS PRESENTED WITHIN REVENUE. 1 EUROPE 0 0 PROGRAM SERVICES RESEARCH COLLABORATION - RESEARCH SERVICES 436407 SOUTH ASIA 0 0 SOFTWARE DEVELOPMENT 48075 NORTH AMERICA 0 0 PROGRAM SERVICES RESEARCH COLLABORATION - RESEARCH SERVICES 33256 SOUTH ASIA 0 0 PROGRAM SERVICES RESEARCH COLLABORATION - RESEARCH SERVICES 900 EAST ASIA AND THE PACIFIC 0 0 LEGAL SERVICES 13319 EAST ASIA AND THE PACIFIC 0 0 PROGRAM SERVICES RESEARCH COLLABORATION - RESEARCH SERVICES 14769 0 0 0 0 0 0 546726 0 546726 EUROPE TO FUND LINKED CLINICAL TRIALS RESEARCH COLLABORATION 790000 INTERNATIONAL WIRE 0 1 0 0 0 0 0 0 0 PART I, LINE 2: A FINANCIAL REPORT REFLECTING PROJECT PLANS IS RECEIVED AND REVIEWED BEFORE THE PROJECT BEGINS TO ENSURE ALIGNMENT WITH THE GRANT'S GOALS. DURING THE PROJECT PERIOD, PERIODIC REPORTS ARE RECEIVED PROVIDING PROJECT AIM PROGRESS. ALL DISPERSED FUNDS REQUIRE AUTHORIZED SIGNATURES FROM TWO DULY AUTHORIZED REPRESENTATIVES, ONE ON BEHALF OF VARI, AND ONE ON BEHALF OF CURE PARKINSON'S TRUST. BEEBRAVE 5K RACE 108328 45447 62881 1686 SOUTHSIDE HOCKEY FIGHTS 79032 50387 28645 104 29020 7 238147 176439 61708 13839 13848 35798 425507 272273 153234 15629 13848 64818 94295 58939 1 THE ECONOMIC CLUB OF GRAND RAPIDS 220 LYON STREET NW STE 220 GRAND RAPIDS MI 49503 237442555 501C6 25000 0 GROWING ECONOMIC HEALTH OF GRAND RAPIDS STAND UP TO CANCER 10880 WILSHIRE BLVD SUITE 1400 LOS ANGELES CA 90024 951644609 501C3 625000 0 RESEARCH COLLABORATION GORDON RESEARCH 5586 POST RD G02 EAST GREENWICH RI 02818 260150662 501C3 15000 0 FUNDING METABOLOMICS AND HUMAN HEALTH CONFERENCE FRIENDS OF CRESCENT PARK 333 BOSTWICK AVENUE NE GRAND RAPIDS MI 49503 264562012 501C3 8000 0 SUPPORT MAINTENANCE OF CRESCENT PARK 3 1 GRADUATE STUDENT STIPENDS FOR MICHIGAN STATE UNIVERSITY STUDENTS 1 37726 GRADUATE STUDENT STIPENDS FOR UNIVERSITY OF KENTUCKY STUDENTS 3 103031 GRADUATE STUDENT STIPENDS VAN ANDEL INSTITUTE GRADUATE SCHOOL 20 415807 GUEST WORKER STIPENDS 1 5400 POSTDOCTORAL FELLOWSHIP STIPENDS 10 675474 VAN ANDEL INSTITUTE GRADUATE SCHOOL STUDENTTUITION AND FEES REMISSION 51 1059582 0 PART I, LINE 2: STUDENTS RECEIVE A STIPEND FOR LIVING EXPENSE AND INSURANCE. GRANT FUNDS TO INSTITUTIONS ARE MONITORED BY QUARTERLY EXPENDITURE REPORTS BEFORE DISBURSING INCREMENTAL FUNDING. PROGRESS REPORTS ARE REQUIRED ANNUALLY AND REVIEWED BY VAN ANDEL RESEARCH INSTITUTE AND A THIRD PARTY. X 1 1 X X X X 1 0 0 1 0 0 0 0 0 KATHY VOGELSANG CHIEF INVESTMENT OFFICER 566103 0 533000 0 26064 0 587000 0 10404 0 1722571 0 440000 0 TED HEILMAN ASSOC DIRECT-SR. PORTFOLIO MGR. 356488 0 399750 0 26064 0 448000 0 10404 0 1240706 0 330000 0 DR PETER JONES CHIEF SCIENTIFIC OFFICER & RES. DIR. 673768 0 254959 0 24443 0 155112 0 10404 0 1118686 0 254959 0 AUSTIN WAY SENIOR PORTFOLIO MANAGER 263234 0 266500 0 485 0 303215 0 10404 0 843838 0 220000 0 DAVID VAN ANDEL CHAIRMAN / CEO 454091 0 218213 0 19203 0 107063 0 1025 0 799595 0 208773 0 DR JANA HALL CHIEF OPERAT. OFFICER (END 4/1/2024) 458945 0 170016 0 6858 0 90670 0 10404 0 736893 0 155265 0 THOMAS CURRAN JR GENERAL COUNSEL 398577 0 115690 0 3564 0 84739 0 10404 0 612974 0 101228 0 GERALD CALLAHAN CHIEF STRAT. OFFICER (END 7/5/2024) 369551 0 113790 0 24780 0 84774 0 10404 0 603299 0 113790 0 TIMOTHY MYERS VICE PRESIDENT & CAO/CFO 379619 0 111000 0 2280 0 83019 0 10404 0 586322 0 97125 0 DR PETER LAIRD DISTINGUISHED INVESTIGATOR 454692 0 55700 0 3563 0 52131 0 10404 0 576490 0 55700 0 DR HUILIN LI SR. SCIENTIFIC INVESTIGATOR & DEPT. 354180 0 54937 0 24822 0 61782 0 10404 0 506125 0 0 0 PART I, LINE 1A VARI ALLOWS FOR FIRST-CLASS OR CHARTER TRAVEL FOR OFFICERS AND TRUSTEES. PART I, LINE 4A JANA HALL RETIRED ON 4/1/2024. JERRY CALLAHAN RETIRED ON 7/5/2024. BOTH RECEIVED SEVERANCE PAYMENTS FOLLOWING THEIR RETIREMENT. PART I, LINE 5 BONUS IS PAID BASED ON VARIABLE PAY PROGRAM OBJECTIVES FOR ELIGIBLE PROGRAM PARTICIPANTS. FORM 990, PART VI, SECTION A, LINE 2 VARI, VAI, VAEI, AND VAIGS SHARE COMMON MANAGEMENT. DAVID VAN ANDEL, DR. JANA HALL AND TIMOTHY MYERS ARE ALSO OFFICERS OF VAI, AND DAVID VAN ANDEL AND TIMOTHY MYERS ARE OFFICERS OF VAEI AND VAIGS. THOMAS CURRAN JR. IS ALSO AN OFFICER OF VAIGS. GERALD CALLAHAN AND THOMAS CURRAN JR. ARE KEY EMPLOYEES OF VAI AND VAEI. FORM 990, PART VI, SECTION A, LINE 2 BUSINESS RELATIONSHIP: DAVID VAN ANDEL, GERALD CALLAHAN FORM 990, PART VI, SECTION A, LINE 7A THE TRUSTEES OF VAN ANDEL INSTITUTE HAVE THE AUTHORITY TO ELECT ONE OR MORE MEMBERS OF VARI'S GOVERNING BODY. FORM 990, PART VI, SECTION B, LINE 11B FOLLOWING COMPLETION OF THE FINANCIAL STATEMENT AUDIT, THE FORM 990 IS PREPARED AND REVIEWED BY MANAGEMENT. IT IS THEN CIRCULATED TO THE FULL BOARD PRIOR TO FILING WITH THE IRS. FORM 990, PART VI, SECTION B, LINE 12C VARI HAS WRITTEN CONFLICT OF INTEREST ("COI") POLICIES AND PROCEDURES WHICH ADMINISTER AND ENFORCE A PROCESS TO IDENTIFY, EVALUATE, AND MANAGE POTENTIAL CONFLICTS OF INTEREST. THESE POLICIES HAVE BEEN APPROVED BY THE BOARD OF TRUSTEES. VAI ADMINISTERS COI POLICIES AND PROCEDURES THROUGH TWO STANDING COMMITTEES: THE CONFLICTS COMMITTEE ("CC") AND THE INSTITUTIONAL COI COMMITTEE ("ICOIC"). COI POLICIES AND PROCEDURES APPLY TO AND SERVE AS A GUIDE FOR EVERYONE IN THE ORGANIZATION. IN PARTICULAR, THEY PROVIDE A USEFUL RESOURCE FOR DEVELOPING ACTIVITIES OR RELATIONSHIPS WITH OUTSIDE ENTITIES OR PERSONS, AND ESTABLISH A PROCESS FOR COMMITTEES TO REVIEW AND MANAGE POTENTIAL CONFLICTS OF INTEREST AS THEY MAY ARISE. THE CC AND ICOIC ARE CHAIRED BY THE GENERAL COUNSEL. THE CC REQUIRES ANNUAL AND UPDATED DISCLOSURES BY COVERED PERSONS AND REVIEWS AND APPROVES MANAGEMENT PLANS. ICOIC POLICIES AND PROCEDURES SERVE AS A GUIDE FOR BOARDS OF TRUSTEES AND SENIOR EXECUTIVES. IN THE EVENT A POTENTIAL COI ARISES AT THE BOARD OR SENIOR EXECUTIVE LEVEL, THE ICOIC MEETS TO REVIEW AND DETERMINE HOW TO MANAGE SUCH A POTENTIAL CONFLICT OF INTEREST IN ACCORDANCE WITH THE COI POLICIES AND PROCEDURES. FORM 990, PART VI, SECTION B, LINE 15 COMPARABILITY DATA FROM AN EXPERT THIRD PARTY IS OBTAINED AND REVIEWED BY THE INDEPENDENT, JOINT COMPENSATION COMMITTEE OF VAN ANDEL RESEARCH INSTITUTE AND RELATED ORGANIZATIONS TO DETERMINE APPROPRIATE COMPENSATION FOR THE CEO, EXECUTIVE MANAGEMENT OFFICIALS, OFFICERS, AND KEY EMPLOYEES, ON BEHALF OF VAN ANDEL RESEARCH INSTITUTE. FORM 990, PART VI, SECTION C, LINE 19 ALL DOCUMENTS REQUIRED TO BE MADE AVAILABLE TO THE PUBLIC ARE AVAILABLE FOR PUBLIC INSPECTION UPON WRITTEN REQUEST. FORM 990, PART III, LINE 2 VAN ANDEL RESEARCH INSTITUTE (VARI) IS DEDICATED TO DETERMINING THE EPIGENETIC, GENETIC, MOLECULAR, METABOLIC, AND CELLULAR ORIGINS OF CANCER, PARKINSON'S DISEASE, AND OTHER DISORDERS AND TO TRANSLATING THOSE FINDINGS INTO EFFECTIVE THERAPIES. THE INSTITUTE'S SCIENTISTS WORK IN ONSITE LABORATORIES AND PARTICIPATE IN COLLABORATIONS THAT SPAN THE GLOBE. WITH EPIGENETICS AS ITS COMMON THREAD, THE INSTITUTE IS ORGANIZED INTO FIVE DEPARTMENTS: EPIGENETICS, NEURODEGENERATIVE SCIENCE, CELL BIOLOGY, METABOLISM AND NUTRITIONAL PROGRAMMING, AND STRUCTURAL BIOLOGY. THE INSTITUTE'S LABS ARE SUPPORTED BY AN OUTSTANDING CORE TECHNOLOGIES AND SERVICES GROUP, WHICH PROVIDES A VIVARIUM, A BIOREPOSITORY, AND VALUABLE ONSITE CAPABILITIES IN IMAGING, PATHOLOGY, BIOINFORMATICS AND BIOSTATISTICS, GENOMICS, FLOW CYTOMETRY, MASS SPECTROMETRY, TRANSGENICS, AND CRYO-ELECTRON MICROSCOPY. IN ADDITION TO BASIC RESEARCH, THE INSTITUTE PARTICIPATES IN COLLABORATIVE EFFORTS TO SUPPORT CLINICAL TRIALS IN CANCER AND PARKINSON'S DISEASE. IN 2024, VARI SCIENTISTS PUBLISHED 122 ARTICLES IN PEER-REVIEWED JOURNALS SUCH AS CELL, CELL METABOLISM, MOLECULAR PSYCHIATRY, NATURE, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES USA, SCIENCE, SCIENCE ADVANCES, GENES & DEVELOPMENT, JOURNAL OF CLINICAL INVESTIGATION, JOURNAL OF EXPERIMENTAL MEDICINE, AND NUCLEIC ACIDS RESEARCH, AMONG OTHERS. FORM 990, PART III, LINE 4A LINE 4A - PROGRAM SERVICE ACTIVITY #1 DEPARTMENT OF EPIGENETICS AS OF NOVEMBER 2024, THE DEPARTMENT OF EPIGENETICS, LED BY CHAIR DR. J. ANDREW POSPISILIK, COMPRISED 12 LABORATORIES AND ONE DIRECTOR'S SCHOLAR THAT SEEK TO UNDERSTAND HOW EPIGENETIC CHANGES EITHER PROTECT US FROM OR PREDISPOSE US TO DISEASES SUCH AS CANCER, PARKINSON'S, AND METABOLIC DISORDERS. BY INVESTIGATING THE EPIGENETIC PROCESSES THAT FINE-TUNE DNA, THE DEPARTMENT'S SCIENTISTS AIM TO PINPOINT THE ORIGINS OF THESE DISEASES AND DETERMINE HOW THEY ARE IMPACTED BY OUR PAST AND PRESENT, AND HOW THEY INFLUENCE FUTURE GENERATIONS. IN THIS FISCAL YEAR, RESEARCHERS AND TRAINEES WITHIN THE DEPARTMENT EARNED NEW AWARDS FROM THE NATIONAL INSTITUTES OF HEALTH. FORM 990, PART III, LINE 4B LINE 4B - PROGRAM SERVICE ACTIVITY #2 DEPARTMENT OF NEURODEGENERATIVE SCIENCE AS OF NOVEMBER 2024, THE DEPARTMENT OF NEURODEGENERATIVE SCIENCE, CHAIRED BY DR. DARREN MOORE, COMPRISED SEVEN LABORATORIES THAT INVESTIGATE THE COMPLEX FACTORS THAT GIVE RISE TO NEURODEGENERATIVE AND PSYCHIATRIC DISORDERS, INCLUDING GENETICS, EPIGENETICS, AGING, INFLAMMATION, THE STRUCTURE OF THE BRAIN, AND THE ROLES OF THE GUT AND IMMUNE SYSTEM. BY LEVERAGING DISCOVERIES MADE IN THE INSTITUTE'S LABS AND COLLABORATING WITH RESEARCHERS AROUND THE WORLD, SCIENTISTS IN THE DEPARTMENT ARE WORKING TO TRANSLATE BREAKTHROUGHS INTO LIFE-CHANGING NEW TREATMENTS FOR PARKINSON'S, ALZHEIMER'S AND RELATED DEMENTIAS, AND DEPRESSION. IN THIS FISCAL YEAR, A TRAINEE WITHIN THE DEPARTMENT EARNED A NEW AWARD FROM THE NATIONAL INSTITUTES OF HEALTH. A SUBAWARD WITH A PRIME SPONSOR OF THE MICHAEL J. FOX FOUNDATION FOR PARKINSON'S RESEARCH WAS RECEIVED FROM NORTHWESTERN UNIVERSITY. FORM 990, PART III, LINE 4C LINE 4C - PROGRAM SERVICE ACTIVITY #3 DEPARTMENT OF METABOLISM AND NUTRITIONAL PROGRAMMING AS OF NOVEMBER 2024, THE DEPARTMENT OF METABOLISM AND NUTRITIONAL PROGRAMMING, CHAIRED BY DR. RUSSELL JONES, COMPRISED SIX LABORATORIES THAT EXPLORE THE INTRICATE MECHANICS OF CELLULAR METABOLISM AND ITS IMPLICATIONS FOR HEALTH AND DISEASE. USING CUTTING-EDGE TECHNIQUES, THEY INVESTIGATE METABOLISM'S INTERACTION WITH OTHER CRITICAL SYSTEMS, SUCH AS THE IMMUNE SYSTEM, AND ARE REVEALING HOW ENVIRONMENTAL EXPOSURES AND METABOLIC DYSFUNCTION CONTRIBUTE TO COMPLEX DISEASES SUCH AS DIABETES, AUTOIMMUNITY, CANCER, AND NEURODEGENERATION. THEY ALSO PARSE THE RIPPLE EFFECT THAT NUTRITION MAY HAVE THROUGH THE GENERATIONS BY EXPLORING HOW DIET COULD LAY THE EPIGENETIC FOUNDATIONS FOR HEALTH. IN THIS FISCAL YEAR, RESEARCHERS AND TRAINEES WITHIN THE DEPARTMENT EARNED NEW AWARDS FROM THE NATIONAL INSTITUTES OF HEALTH AND THE NATIONAL SCIENCE FOUNDATION. FORM 990, PART III, LINE 4D LINE 4D - OTHER PROGRAM SERVICES DEPARTMENT OF CELL BIOLOGY AS OF NOVEMBER 2024, THE DEPARTMENT OF CELL BIOLOGY, LED BY INTERIM CHAIR DR. YVONNE FONDUFE-MITTENDORF, COMPRISED SIX LABS THAT PURSUE FUNDAMENTAL RESEARCH TO UNDERSTAND HOW CELLS GROW, COMMUNICATE, SURVIVE, ASSEMBLE INTO TISSUES AND ORGANS, RESPOND TO THE ENVIRONMENT, AND CHANGE WITH AGE. THIS TRANSFORMATIVE WORK AIMS TO YIELD NEW DIAGNOSTIC AND TREATMENT STRATEGIES TO IMPROVE THE QUALITY OF LIFE FOR PEOPLE WITH CANCER, BONE DISEASES, AND RARE DISORDERS. ONE FACULTY MEMBER HOLDS AN APPOINTMENT AS DIRECTOR OF THE INSTITUTE'S CORE TECHNOLOGIES AND SERVICES. DR. FONDUFE-MITTENDORF HOLDS A PRIMARY APPOINTMENT IN THE DEPARTMENT OF EPIGENETICS. IN THIS FISCAL YEAR, RESEARCHERS WITHIN THE DEPARTMENT EARNED NEW AWARDS FROM THE NATIONAL INSTITUTES OF HEALTH AND THE AMERICAN CANCER SOCIETY. A SUBAWARD WITH A PRIME SPONSOR OF THE NATIONAL INSTITUTES OF HEALTH WAS RECEIVED FROM THE UNIVERSITY OF PITTSBURGH. DEPARTMENT OF STRUCTURAL BIOLOGY AS OF NOVEMBER 2024, THE DEPARTMENT OF STRUCTURAL BIOLOGY, CHAIRED BY DR. HUILIN LI, COMPRISED SIX LABORATORIES THAT HARNESS THE POWER OF CRYO-ELECTRON MICROSCOPY (CRYO-EM) AND OTHER TECHNIQUES TO VISUALIZE MOLECULES, COMPLEXES, AND STRUCTURES THAT SERVE AS THE FOUNDATION FOR HEALTH AND DISEASE. THESE MOLECULES MAY SERVE AS DRUG TARGETS FOR CANCER, NEUROLOGICAL DISORDERS, METABOLIC DISEASES, INFECTIOUS DISEASES, AND MORE. DEPARTMENT SCIENTISTS HAVE INTERESTS IN DNA REPLICATION, CELLULAR SIGNALING, RNA BIOLOGY, NEURODEGENERATION, IMMUNOLOGY, AND EPIGENETICS. IN THIS FISCAL YEAR, RESEARCHERS AND TRAINEES WITHIN THE DEPARTMENT EARNED NEW AWARDS FROM THE NATIONAL INSTITUTES OF HEALTH AND AMERICAN HEART ASSOCIATION. SUBAWARDS WITH A PRIME SPONSOR OF THE NATIONAL INSTITUTES OF HEALTH WERE RECEIVED FROM CORNELL UNIVERSITY AND CORIELL INSTITUTE FOR MEDICAL RESEARCH. CLINICAL COLLABORATIONS THE VAN ANDEL INSTITUTE-STAND UP TO CANCER EPIGENETICS DREAM TEAM, LED BY DR. PETER A. JONES AND DR. STEPHEN BAYLIN, CONTINUES TO FOSTER COLLABORATION TOWARD DEVELOPMENT OF NEW COMBINATION THERAPIES FOR CANCER BY MOVING THESE PROMISING THERAPIES INTO CLINICAL TRIALS. THE TEAM FOCUSES ON EPIGENETIC MECHANISMS IN CELLS, WHICH HELP CONTROL WHETHER GENES ARE SWITCHED "ON OR "OFF" WITHOUT CHANGING THE DNA SEQUENCE ITSELF. INTERNATIONAL LINKED CLINICAL TRIALS IS A PROGRAM THAT IDENTIFIES POTENTIAL NEW THERAPIES THAT MAY SLOW OR STOP PARKINSON'S PROGRESSION FROM MEDICATIONS DEVELOPED OR APPROVED TO TREAT OTHER CONDITIONS. THE PROGRAM IS SPEARHEADED BY CURE PARKINSON'S IN COLLABORATION WITH THE INSTITUTE. IT AIMS TO REDUCE THE TIME IT TAKES FOR A POTENTIAL TREATMENT TO MOVE FROM THE LAB INTO CLINICAL TRIALS AND, ULTIMATELY, TO IMPLEMENTATION IN THE CLINIC. DR. DARREN MOORE REPRESENTS VAI ON THE ILCT COMMITTEE. FORM 990, PART IX, COLUMN D FUNDRAISING EXPENSES AT VARI WERE INCURRED TO SUPPORT THE MISSION OF THE RESEARCH INSTITUTE THROUGH DONOR SOLICITATION, GRANT SOLICITATION AND EXTRAMURAL PROPOSAL PREPARATION. VAI INNOVATIONS LLC 333 BOSTWICK AVENUE NE GRAND RAPIDS MI 495032518 522000823 LICENSING INTELLECTUAL PROPERTY OF VARI MI 48799 0 VAN ANDEL RESEARCH INSTITUTE BOSTWICK EVENT MANAGEMENT 333 BOSTWICK AVENUE NE GRAND RAPIDS MI 495032518 522000823 EVENT MANAGEMENT MI 143317 128151 VAN ANDEL RESEARCH INSTITUTE C3 LEARNING DEVELOPMENT LLC 333 BOSTWICK AVENUE NE GRAND RAPIDS MI 495032518 522000823 EDUCATIONAL PROGRAMS FOR K-12 STUDENTS AND TEACHERS MI 487962 204930 VAN ANDEL RESEARCH INSTITUTE VAN ANDEL INSTITUTE 333 BOSTWICK AVENUE NE GRAND RAPIDS MI 495032518 522000820 SUPPORTING ORGANIZATION FOR VARI AND VAEI MI 501(C)(3) 12C N/A 0 VAN ANDEL EDUCATION INSTITUTE 333 BOSTWICK AVENUE NE GRAND RAPIDS MI 495032518 522000824 OPERATING A SCIENCE EDUCATION PROGRAM MI 501(C)(3) 2 VAN ANDEL INSTITUTE 1 VAN ANDEL INSTITUTE GRADUATE SCHOOL 333 BOSTWICK AVENUE NE GRAND RAPIDS ME 495032518 203340886 OPERATING A GRADUATE SCHOOL MI 501(C)(3) 2 VAN ANDEL EDUCATION INSTITUTE 1 0 0 1 0 0 0 0 0 0 0 0 0 0 1 1 1 1 0 0 VAN ANDEL INSTITUTE C 61431822 ACTUAL AMOUNT RECEIVED VAN ANDEL INSTITUTE N 289454 ALLOCATION BASED ON EFFORT VAN ANDEL INSTITUTE O 1075017 ALLOCATION BASED ON EFFORT VAN ANDEL EDUCATION INSTITUTE Q 1721726 ACTUAL AMOUNT RECEIVED VAN ANDEL EDUCATION INSTITUTE N 176020 ALLOCATION BASED ON EFFORT VAN ANDEL EDUCATION INSTITUTE O 602032 ALLOCATION BASED ON EFFORT VAN ANDEL INSTITUTE GRADUATE SCHOOL Q 911396 ACTUAL AMOUNT RECEIVED VAN ANDEL INSTITUTE Q 12039983 ACTUAL AMOUNT RECEIVED VAN ANDEL INSTITUTE GRADUATE SCHOOL P 1622510 ACTUAL AMOUNT PAID VAN ANDEL INSTITUTE GRADUATE SCHOOL N 166241 ALLOCATION BASED ON EFFORT VAN ANDEL INSTITUTE GRADUATE SCHOOL O 782448 ALLOCATION BASED ON EFFORT VAN ANDEL INSTITUTE GRADUATE SCHOOL M 1059582 ACTUAL AMOUNT PAID