2019-05-27T07:29:07-07:00 2018-12-31 990EZ 2018-01-01 475555752 CHAMP FOUNDATION CHAM 7278712667 2712 LITTLE ROGERS ROAD DURHAM NC 27704 Jeffrey Reynolds President 7278712667 2019-05-27 107.13.139.138 2018 2019-02-21 02:37:17Z X www.thechampfoundation.org X X 104144 X 103849 0 0 295 0 0 0 0 0 0 0 0 0 0 0 104144 170000 0 0 0 0 0 923 170923 -66779 239811 0 173032 239811 173032 0 0 0 0 239811 173032 0 0 239811 173032 The Champ Foundation supports research toward better treatment and a cure for diseases caused by mitochondrial DNA deletions, with an emphasis on Pearson Syndrome. These diseases are very rare; for example, there have only been around 100 cases of Pearson Syndrome described in the literature since its discovery in 1979. Current "treatments" only address symptoms as they present themselves. Therefore, The Champ Foundation seeks to fund research that speeds the development of treatment and a cure. In 2017, The Champ Foundation expanded it's research funding through our first call for grants. Our Scientific Advisory Board recommended funding for two projects. The first "CD34+ cells enriched with blood cells derived healthy mitochondria as a treatment for Pearson Syndrome" seeks to employ a novel treatment based on stem cell transplant and is being undertaken at the Sheba Medical Center in Tel Aviv. The second, "Treatments and models for diseases caused by mitochondrial deletions," is being undertaken at the University of Cambridge. We also continued our support to Boston Children's project. All three projects characterize The Champ Foundation's approach. We seek out talented researchers at excellent institutions, whose intellectual interest in mitochondrial DNA deletion disorders has been hindered by financial concerns. We believe that these diseases can be treated and cured, provided that capable researchers and clinicians are aware of the problem and allowed to pursue a solution. 260000 X 0 In 2018, The Champ Foundation continued its support of high quality mitochondrial disease research across the globe. Researchers at Cambridge and the University of Miami published exciting research that has moved gene editing technologies closer to the clinic. In 2018, the team at Sheba Medical Center submitted an IND application to the FDA, which utilized results from The Champ Foundation's grant. The application was approved and enrollment in a Phase I/II clinical trial will begin in 2019. In addition to research funding, The Champ Foundation organized the first conference devoted to mtDNA deletion research. The conference gathered researchers from around the world and has inspired fruitful collaborations. It is important to note that this conference was financed with funds from outside The Champ Foundation. The Champ Foundation remains steadfast in its commitment to research. 170000 X 0 0 Jeffrey Reynolds President 5 0 Elizabeth Reynolds Vice President 5 0 Elizabeth Malkin Secretary 1 0 Tyler Albright Treasurer 1 0 Walker Cole Arledge Director 1 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 NC NY Jeffrey Reynolds 2712 LITTLE ROGERS ROAD DURHAM NC 27704 7278712667 0 0 0 0 0 0 0 0 0 0 0 NONE NONE 1 X 107586 110214 161972 103849 483621 0 0 0 0 0 0 0 0 0 0 0 107586 110214 161972 103849 483621 193582 290039 0 0 102 295 397 0 0 0 0 0 0 0 0 484018 X Form 990-EZ, Part I, Line 10 The Champ Foundation continued funding to research grants at Sheba Medical Center and Cambridge University and initiated a new grant to The University of Miami. Form 990-EZ, Part I, Line 16 Bank, PayPal, Crowdrise and other fees We were under the erroneous assumption that the due date was the end of the 5th month.