2025-11-13T15:32:01-06:00 2025-06-30 WithumSmithBrown PC ONE TOWER CENTER BLVD 14TH FL EAST BRUNSWICK NJ 08816 990 2024-07-01 851293789 Food Allergy Science Initiative Inc % THE ORGANIZATION FOOD 6179998561 PO Box 990692 Boston MA 02199 CARLOS BOSQUES CEO 6179998561 2025-11-15 true true Israel Tannenbaum P01589203 7328281614 2024 2025-03-06 01:10:19Z CARLOS BOSQUES PO Box 990692 Boston MA 02199 8942516 false X www.foodallergyscience.org X 2020 MA To accelerate the development of breakthrough discoveries that will transform the lives of people living with food allergies. (SEE SCHEDULE O FOR CONTINUATION) 6 6 6 6 0 6274385 8620366 0 0 386556 320297 921 1853 6661862 8942516 2917301 4365322 0 0 1150036 1368259 0 0 386459 627318 596439 4694655 6330020 1967207 2612496 6340472 7792816 3798191 2638039 2542281 5154777 X TO ACCELERATE THE DEVELOPMENT OF BREAKTHROUGH DISCOVERIES THAT WILL TRANSFORM THE LIVES OF PEOPLE LIVING WITH FOOD ALLERGIES. false false 5407368 4365322 SEE SCHEDULE O 5407368 true true false false false false false false false false true false false false false true true false false false true false false false false false false true false true false false false false false false false false false false false false false false false false false true 18 0 true 6 true false false false false false false false false false false false false X 6 6 false false false false false false false true true false false true true true true true true true true false MA X X THE ORGANIZATION 6179998561 PO BOX 990692 BOSTON MA 02199 Carlos Bosques CEO 40.0 0.0 X 364330 0 19950 Christopher John Beneduce Jr PRINCIPAL SCIENTIST 40.0 0.0 X 175061 0 18308 Nicole Yin Yee Lai Senior Scientist 40.0 0.0 X 160000 0 10360 Christine Olsen MD BOARD CHAIR, DIRECTOR 1.0 0.0 X X 0 0 0 Lesley Solomon MBA DIRECTOR 1.0 0.0 X X 0 0 0 Justine Levin-Allerhand PhD TREASURER, DIRECTOR 1.0 0.0 X X 0 0 0 Eric Edwards MD PhD DIRECTOR 1.0 0.0 X 0 0 0 Erica Colleran DIRECTOR 1.0 0.0 X 0 0 0 Ning Drako Director 1.0 0.0 X 0 0 0 699391 0 48618 3 false true false 0 2531179 6089187 8620366 0 320297 320297 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 OTHER INCOME 900099 1853 1853 1853 8942516 1853 320297 4365322 4365322 0 0 0 395926 207938 75195 112793 0 787655 474772 187354 125529 33566 12991 10785 9790 58556 30892 14501 13163 92556 52715 20884 18957 0 9752 9752 66480 66480 0 0 0 301965 229646 72319 105156 423 12140 92593 11772 272 11441 59 37483 1752 30575 5156 0 0 32464 10150 18003 4311 0 9071 9071 0 0 2238 2238 20058 11424 4526 4108 6330020 5407368 536193 386459 X 0 0 6323980 6057884 0 1636403 0 0 0 0 0 0 0 0 0 0 14254 81959 18267 18267 2238 0 0 0 0 0 0 0 0 0 0 16570 6340472 7792816 222769 136666 3575422 2501373 0 0 0 0 0 0 0 0 0 0 0 0 0 0 3798191 2638039 X 2542281 4918895 0 235882 2542281 5154777 6340472 7792816 X 2612496 X false true X true true true X 2882050 6457645 8215093 6274385 8620366 32449539 0 0 2882050 6457645 8215093 6274385 8620366 32449539 0 32449539 505 11021 203264 386556 320297 921643 0 301 777 2749 921 1853 6601 33377783 X RESTRICTED RESTRICTED RESTRICTED RESTRICTED RESTRICTED RESTRICTED RESTRICTED RESTRICTED 18267 18267 0 0 0 0 0 X 8942516 8942516 8942516 6330020 6330020 6330020 SCHEDULE D, PART X, LINE 2: The Organization is exempt from federal income tax under Section 501(c)(3) of the United States Internal Revenue Code and exempt from state income taxes under state law, and no provision for such income tax has been reflected in the accompanying financial statements. The Organization has evaluated uncertain tax positions with respect to its operations and concluded there are no such positions at June 30, 2025 and 2024.The Organization did not recognize any tax-related interest or penalties during the period presented in these financial statements. SCHEDULE D, PART XII, LINE 4b: Grants Refunded $ 356,671 Europe (Including Iceland and Greenland) 0 0 Program Services Research 118762 0 0 0 0 118762 118762 false false false false false false true BRIGHAM AND WOMEN'S HOSPITAL 75 FRANCIS ST BOSTON MA 02115 042312909 501(C)(3) 56250 Research Massachusetts General Hospital 55 Fruit Street Boston MA 02114 041564655 501(C)(3) 369250 Research Yale University PO Box 208327 25 Science Park 150 New Haven CT 065208327 060646973 501(C)(3) 1439637 Research Northwestern University 633 Clark Street Evanston IL 60208 362167817 501(C)(3) 100000 RESEARCH Arizona State University 1151 S Forest Ave Tempe Tempe AZ 85281 860196696 501(C)(3) 75000 RESEARCH The Rockefeller University 1230 York Avenue New York NY 10065 131624158 501(C)(3) 773905 Research Harvard College Massachusetts Hall Cambridge MA 02138 042103580 501(C)(3) 352595 Research Harvard Medical School 1635 Tremont Street boston MA 02120 042103580 501(C)(3) 392434 Research Boston Children's Hospital 300 Longwood Avenue BOSTON MA 02115 042774441 501(c)(3) 494868 Research Beth Israel Deaconess Medical Center Inc 330 Brookline Avenue boston MA 02215 042103545 501(c)(3) 310510 Research 10 SCHEDULE I, PART I, LINE 2 There is a formal grant review process and disbursements are all documented. All funded grantees are required to submit bi-annual reports on their progress and work towards reaching their benchmarks. The Scientific Advisory Board reviews the science and makes recommendations on whether we continue to fund or not. Additionally, we have bi-monthly meetings with the labs to discuss data and help identify additional ways to collaborate. X X false false false false false false false true false Carlos Bosques CEO 364330 0 0 0 0 0 14235 0 5715 0 384280 0 0 0 Christopher John Beneduce Jr PRINCIPAL SCIENTIST 175061 0 0 0 0 0 7360 0 10948 0 193369 0 0 0 Nicole Yin Yee Lai Senior Scientist 160000 0 0 0 0 0 6400 0 3960 0 170360 0 0 0 FORM 990, PART III, LINE 4A THE FOOD ALLERGY SCIENCE INITIATIVE ("FASI") WAS FOUNDED IN 2016 BY A GROUP OF PARENTS UNITED THROUGH A SHARED EXPERIENCE THAT NO PARENT SHOULD HAVE TO GO THROUGH: WITNESSING THEIR CHILD EXPERIENCE A LIFE-THREATENING ALLERGIC REACTION. FRUSTRATED BY THE LACK OF OPTIONS TO TREAT FOOD ALLERGIES, THEY IDENTIFIED A FUNDAMENTAL ISSUE: DESPITE MANY DECADES OF RESEARCH INTO THE IMMUNE SYSTEM AND ADVANCES IN CLINICAL MEDICINE, SHOCKINGLY LITTLE IS KNOWN ABOUT THE FUNDAMENTAL BIOLOGY BEHIND THE CAUSE AND PATHOLOGICAL DRIVERS OF FOOD ALLERGIES. IMPORTANTLY, WHAT HAPPENS WHEN AN INDIVIDUAL FIRST BECOMES SENSITIZED TO AN ALLERGEN? WHY ARE CERTAIN FOODS MORE LIKELY TO BE ALLERGENIC? WHY DO SOME PEOPLE REACT MORE VIGOROUSLY TO ALLERGENS, OR NATURALLY OUTGROW SOME FOOD ALLERGIES, OR RESPOND DIFFERENTLY TO TREAMENTS, WHILE OTHERS DO NOT? WHAT CHANGES MIGHT BE HAPPENING IN OUR ENVIRONMENTS AND OUR EXPOSURES THAT ARE CONTRIBUTING TO THE PROLIFIC RISE IN FOOD ALLERGIES? BY RECOGNIZING THAT A COMPREHENSIVE UNDERSTANDING OF THE MULTIPLE AND COMPLEX MECHANISMS UNDERLYING FOOD ALLERGY PATHOLOGY CANNOT BE ACHIEVED BY MYOPIC RESEARCH, THE FOUNDERS OF FASI WERE DRIVEN TO ORGANIZE A LANDMARK SYMPOSIUM IN 2015 THAT BROUGHT TOGETHER WORLD-CLASS EXPERTS FROM MULTIPLE DISCIPLINES OF SCIENCE TO DISCUSS HOW THEIR RESEARCH SHEDS LIGHT ON THIS ENORMOUSLY COMPLEX PROBLEM AND HOW THEIR RESEARCH COULD SYNERGIZE TO MAKE INROADS IN DEVELOPING A MUCH NEEDED CURE. THUS, IN 2016 FASI WAS LAUNCHED WITH THE BROAD INSTITUTE OF MIT AND HARVARD (THE "BROAD"). WITH JUST SIX LABS AT INCEPTION, FASI HAS GROWN AND EVOLVED INTO AN INDEPENDENT 501(C)(3) MULTI-FACETED NON-PROFIT RESEARCH ORGANIZATION, AND AS OF JUNE 2024, OPERATES WITH MORE THAN 20 WORLD-CLASS LABS AND OVER 100+ SCIENTISTS ACROSS THE UNITED STATES. THE FASI NETWORK BRINGS TOGETHER CLINICAL EXPERTS IN FOOD ALLERGIES, TYPE 2 INFLAMMATORY DISORDERS, CHRONIC INFLAMMATORY DISEASES, AS WELL AS RESEARCH EXPERTS WITH DEEP EXPERTISE IN STUDYING THE IMMUNE SYSTEM, THE DIGESTIVE SYSTEM, THE NERVOUS SYSTEM, AND THE GUT MICROBIOME, ALL OF WHICH INTERSECT AND CONTRIBUTE TO THE UNDERLYING CAUSES OF FOOD ALLERGIES. THOUGH A COLLABORATIVE OPERATING MODEL, FASI'S TEAM OF RESEARCHERS ARE LASER FOCUSED ON UNDERSTANDING THE ROOT CAUSES OF FOOD ALLERGIES, TRANSLATING THESE FINDINGS FROM LABS TO CLINICS, AND BEGINNING TO INTERVENE THROUGH THE GENERATION OF NOVEL THERAPEUTIC CANDIDATES TO ONE DAY DELIVER A CURE TO THOSE AFFECTED BY FOOD ALLERGIES. SOME OF OUR ACHIEVEMENTS: -FASI'S SCIENTIFIC FOUNDER, RUSLAN MEDZHITOV, HAS BEEN VISIONARY IN DEVELOPING A CONCEPTUAL FRAMEWORK OF FOOD ALLERGY BY PROPOSING THAT THE ALLERGIC RESPONSE IS A HYPERACTIVE REACTION OF THE BODY'S FOOD QUALITY CONTROL SYSTEM - A PARADIGM SHIFT THAT HAS GUIDED FASI'S INTER-DISCIPLINARY COLLABORATIVE RESEARCH APPROACH. -FASI IS CREATING A DETAILED UNBIASED CELLULAR ATLAS COMPARING GUTS FROM FOOD ALLERGIC AND NON-ALLERGIC PATIENTS. BY EXAMINING DIFFERENCES THAT UNDERLIE DISEASE-RELEVANT HUMAN TISSUES, THIS ATLAS WILL HELP US - AND THE WIDER SCIENTIFIC COMMUNITY AS A WHOLE - IDENTIFY AND CHARACTERIZE WHICH CELLS-TYPES ARE EXPANDED AND DYSREGULATED IN FOOD ALLERGY PATHOLOGY, AND TO IDENTIFY PATHWAYS OF THERAPEUTIC INTERVENTION TO REVERSE PATHOLOGICAL DIFFERENCES. -FASI SCIENTISTS WERE AMONG THE FIRST TO IDENTIFY CRUCIAL LINKS BETWEEN THE GUT IMMUNE AND NERVOUS SYSTEMS BY IDENTIFYING SPECIFIC CELL-TYPES AND MOLECULAR MEDIATORS INVOLVED IN THE PROCESS OF ALLERGIC SENSITIZATION AND AUGMENTATION OF ALLERGIC IMMUNE RESPONSES. THESE CRITICAL INTERACTIONS SERVE AS DECISION CHECKPOINTS FOR HOW THE BODY DECIDES TO EITHER TRIGGER AN ALLERGIC REACTION OR MAINTAIN NORMAL PHYSIOLOGICAL FUNCTIONING. -FASI IS UNCOVERING PATHWAYS OF BI-DIRECTIONAL COMMUNICATIONS BETWEEN THE GUT AND THE BRAIN. THE BRAIN PERFORMS THE CRITICAL FUNCTION OF SENSING INTERNAL CHANGES WITH THE BODY AND ORCHESTRATING SYSTEMIC PHYSIOLOGICAL RESPONSES, INCLUDING MOBILIZING ENERGY RESERVES TO MEET METABOLIC DEMANDS, ACTIVATING IMMUNOLOGICAL RESOURCES TO DEFEND BARRIER SURFACES, MODIFYING BEHAVIORS AND FORMING MEMORIES FOR PRO-SURVIVAL ADAPTIVE PURPOSES. UNDERSTANDING THIS UNDEREXPLORED AREA PROMISES TO REVEAL NOVEL AVENUES FOR THERAPEUTIC INTERVENTIONS. -FASI RESEARCHERS ARE WORKING TO ELUCIDATE HOW ADJUVANTS - SUBSTANCES CAPABLE OF MAGNIFYING THE IMMUNE RESPONSE - ARE FOUND IN UNEXPECTED PLACES, INCLUDING THE FOODS WE CONSUME AND THE ENVIRONMENTS WE ARE EXPOSED TO, AND OUR RESEARCH SHOWS THAT THESE ADJUVANTS ARE CRITICAL CONTRIBUTORS TO THE DEVELOPMENT OF ALLERGIC DISEASES. THESE ADJUVANTS DERIVED FROM PLANTS, ANIMALS, OR STANDARD INDUSTRIAL PROCESSING PRACTICES, CAN BE FURTHER MODIFIED BY THE MICROBIOME IN OUR GUT, ARE SENSED BY SPECIALIZED CELLS THAT LINE THE GUT WALL, AND CAN SKEW THE IMMUNE RESPONSE TOWARD A HYPERALLERGIC STATE. -FASI SCIENTISTS ARE STUDYING FOOD ALLERGIC PATIENTS UNDERGOING INTERVENTIONAL TREATMENTS, SUCH AS ORAL IMMUNOTHERAPY (OIT), TO UNDERSTAND HOW IMMUNE RESPONSES ADAPT DURING THERAPEUTIC INTERVENTIONS. THROUGH DETAILED PROFILING OF INDIVIDUALS' IMMUNE RESPONSES, WE HAVE IDENTIFIED IMMUNOLOGICAL CHANGES THAT HELP EXPLAIN WHY OIT CAN INDUCE LONG-TERM DESENSITIZATION TO ALLERGENS, WHILE IS ONLY TRANSIENTLY PROTECTIVE IN OTHER INDIVIDUALS AFTER TREATMENT IS STOPPED. UNDERSTANDING THE IMMUNE MECHANISMS CONTRIBUTING TO THESE DIFFERING RESPONSES WILL GUIDE US TOWARD CRITICAL PATHWAYS LEADING TO LONG-TERM DESENSIZATION SUCCESS, AND ULTIMATELY A DISEASE-MODIFYING CURE. -FASI SCIENTISTS HAVE MADE BREAKTHOUGH CONNECTIONS IN UNDERSTANDING THE SKIN'S ROLE IN FOOD ALLERGIES, INCLUDING HOW THE SKIN CAN ACT AS A SITE OF INITIAL SENSITIZATION. FASI RESEARCHERS WERE THE FIRST TO IDENTIFY HOW SOME ALLERGENS ARE CAPABLE OF DIRECTLY ACTIVATING NERVES IN THE SKIN, WHICH CAN LEAD TO THE SENSATION OF ITCH, BUT ALSO THAT SKIN-INNERVATING NERVES CAN ACTIVATE IMMUNE CELLS AND DRIVE THEM TO INITIATE AN ALLERGIC RESPONSEY. THIS RESEARCH IS HELPING US UNDERSTAND HOW SKIN DISORDERS, SUCH AS ITCH AND ATOPIC DERMATITIS, ARE LINKED AND ARE OFTEN RISK FACTORS IN THE DEVELOPMENT OF FOOD ALLERGIES. BLOCKING THIS PATHWAY COULD BE AN IMPORTANT THERAPEUTIC STRATEGY TO PREVENT THE DEVELOPMENT OF FOOD ALLERGIES IN HIGH-RISK INDIVIDUALS. -FASI INVESTIGATORS COMPLETED IN-DEPTH ANALYSIS OF ANTIBODY-PRODUCING PLASMA CELLS FROM HUMAN BONE MARROW OF PEANUT-ALLERGIC INDIVIDUALS AND FOUND SOME PLASMA CELLS PRODUCING PATHOLOGICAL IGE ANTIBODIES THAT BOUND PEANUT. THIS WORK IDENTIFIED BONE MARROW AS A CRITICAL TISSUE RESERVOIR FOR PATHOGENIC IGE-PRODUCING PLASMA CELLS. -FASI HAS ESTABLISHED A DRUG DEVELOPMENT TEAM WITH DECADES OF PHARMA/BIOTECH EXPERIENCE ADVANCING SMALL MOLECULES AND LARGE BIOLOGICS FROM EARLY TARGET IDENTIFICATION STAGES INTO THE CLINIC. THIS TEAM IS WORKING TO BUILD CRITICAL TOOLS AND PARTNERSHIPS TO ADVANCE EXCITING NOVEL THERAPEUTIC CANDIDATES FOR THE DEVELOPMENT OF THE NEXT GENERATION OF FOOD ALLERGY TREATMENTS. -FASI'S INVESTIGATIONAL RESEARCH HAS LED TO 6 PATENTS, 100+ PUBLICATIONS AND OVER 6490+ CITATIONS IN THE MEDICAL LITERATURE. THROUGH FASI'S COLLABORATIVE, INTERDISCIPLINARY RESEARCH APPROACH, FASI'S TEAM OF SCIENTISTS AND DRUG DEVELOPERS HAVE BUILT A DYNAMIC DRUG DISCOVERY ENGINE TO IDENTIFY INNOVATIVE THERAPUTIC INTERVENTIONS, AND ACCELERATE THE DEVELOPMENT OF BREAKTHROUGH DISCOVERIES TO TRANSFORM THE LIVES OF PATIENTS LIVING WITH FOOD ALLERGIES. FORM 990, PART VI, SECTION B, LINE 11B THE ORGANIZATION'S FORM 990 IS PREPARED BY A REPUTABLE CPA FIRM SPECIALIZING IN NOT FOR PROFIT TAX. THE FORM 990 IS PROVIDED TO THE CEO FOR REVIEW AND COMMENT AND ANY CHANGES ARE INCORPORATED. THE ORGANIZATION PROVIDES A DRAFT COPY OF FORM 990 FOR THE BOARD TO REVIEW PRIOR TO FILING. UPON APPROVAL THE ORGANIZATION FILES ITS 990. FORM 990, PART VI, SECTION B, LINE 12C Each FASI Director, Advisor and staff member SIGNS A CONFLICT OF INTEREST FORM AND receives an annual reminder of Conflict of Interest Policy in January of each year. While reaffirmation of the Policy is not required, existing FASI Directors, Advisors and staff must notify the Executive Director and/or his/her delegate immediately of any change in status related to potential Conflict of Interest issues. In addition, FASI will conduct periodic reviews of arrangements and policies to ensure that FASI operates in a manner consistent with charitable purposes and does not engage in activities that could jeopardize its tax-exempt status. FORM 990, PART VI, SECTION B, LINE 15: COMPENSATION PROCESS FOR TOP OFFICIAL: THE ORGANIZATION USES THE DEPARTMENT OF LABOR STATISTICS AND SALARY GUIDE TO OBTAIN COMPARABLE DATA ON POSITIONS. FURTHERMORE, THE ORGANIZATION PERIODICALLY REVIEW THE COMPENSATION ARRANGEMENTS AND BENEFITS TO ENSURE THAT THEY ARE REASONABLE, BASED ON COMPETENT SURVEY INFORMATION AND THE RESULT OF ARM'S LENGTH BARGAINING. FORM 990, PART VI, SECTION C, LINE 19 GOVERNING DOCUMENTS, DISCLOSURE EXPLANATION, THE FINANCIAL STATEMENTS, AND OTHER DOCUMENTS, SUCH AS THE CONFLICT OF INTEREST POLICY AND GOVERNING DOCUMENTS ARE AVAILABLE UPON REQUEST. FORM 990, PART XI, LINE 9: Grants refunded $ 356,671