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      <SupplementalInformationDetail>
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        <ExplanationTxt>The Foundation is subject to the provisions of the Financial Accounting Standards Board's ("FASB") Accounting Standards Codification ("ASC") Topic 740, Income Taxes, relating to the accounting and reporting for uncertainty in income taxes. For the Foundation, these provisions could BE APPLICABLE TO THE INCURRENCE OF UNRELATED BUSINESS INCOME TAX ("UBIT") ON the DISALLOWED TRANSIT AND QUALIFIED PARKING FRINGe BENEFITS. Because the Foundation has accrued the tax liability for UBIT and because of the Foundations tax-exempt status, management believes ASC Topic 740 has not had, and is not expected to have, a material impact on the Foundation's financial statements.</ExplanationTxt>
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      <SupplementalInformationDetail>
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        <ExplanationTxt>THE FOUNDATION AWARDS RESERACH GRANTS BASED UPON THE GUIDANCE AND INPUT OF THE SCIENTIFIC ADVISORY COMMITTEE AND OTHER HIGHLY REGARDED SCIENTISTS SPECIALIZING IN CANCER RESEARCH. THE FOUNDATION CLOSELY MONITORS THE PROGRESS OF EACH GRANT AWARDED. THERE IS FREQUENT COMMUNICATION BETWEEN GRANTEES AND FOUNDATION STAFF REGARDING THE PROGRESS OF EACH GRANT. IN THE CASE OF MULTI-YEAR GRANTS, PROGRESS IS VERIFIED BEFORE ADDITIONAL GRANTS ARE AWARDED.</ExplanationTxt>
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      <SupplementalInformationDetail>
        <FormAndLineReferenceDesc>FORM 990, SCHEDULE F, PART I, LINE 3, COLUMN (F)</FormAndLineReferenceDesc>
        <ExplanationTxt>AMOUNT REPORTED USING THE ACCRUAL METHOD OF ACCOUNTING.</ExplanationTxt>
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          <CityNm>Philadelphia</CityNm>
          <StateAbbreviationCd>PA</StateAbbreviationCd>
          <ZIPCd>19106</ZIPCd>
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          <CityNm>Durham</CityNm>
          <StateAbbreviationCd>NC</StateAbbreviationCd>
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          <CityNm>New York</CityNm>
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      <SupplementalInformationDetail>
        <FormAndLineReferenceDesc>FORM 990, PART VI, SECTION A, LINE 2</FormAndLineReferenceDesc>
        <ExplanationTxt>TWO MEMBERS OF THE BOARD OF DIRECTORS ARE EMPLOYEES OF PAMPLONA CAPITAL MANAGEMENT LLC. ALEX KNASTER (FOUNDER OF THE MARK FOUNDATION FOR CANCER RESEARCH (U.S.) LTD.) IS THE FOUNDER AND CEO OF PAMPLONA CAPITAL MANAGEMENT LLC. MR. KNASTER DOES NOT HOLD A BOARD SEAT ON THE FOUNDATION'S BOARD.</ExplanationTxt>
      </SupplementalInformationDetail>
      <SupplementalInformationDetail>
        <FormAndLineReferenceDesc>FORM 990, PART VI, SECTION A, LINE 8B</FormAndLineReferenceDesc>
        <ExplanationTxt>GIVEN THE CURRENT SIZE OF THE FOUNDATION'S BOARD OF DIRECTORS, THE FOUNDATION HAS YET TO CREATE COMMITTEES. ALL GOVERNING RELATED BUSINESS OF THE FOUNDATION IS CONDUCTED BY THE EXISTING DIRECTORS.</ExplanationTxt>
      </SupplementalInformationDetail>
      <SupplementalInformationDetail>
        <FormAndLineReferenceDesc>FORM 990, PART VI, SECTION B, LINE 11B</FormAndLineReferenceDesc>
        <ExplanationTxt>A COPY OF THE FOUNDATION'S 990 IS PROVIDED TO THE BOARD OF DIRECTORS FOR REVIEW AND COMMENT PRIOR TO ITS ELECTRONIC FILING WITH THE INTERNAL REVENUE SERVICE.</ExplanationTxt>
      </SupplementalInformationDetail>
      <SupplementalInformationDetail>
        <FormAndLineReferenceDesc>FORM 990, PART VI, SECTION B, LINE 12C</FormAndLineReferenceDesc>
        <ExplanationTxt>ALL MEMBERS OF THE BOARD OF DIRECTORS AND KEY MEMBERS OF MANAGEMENT ARE REQUIRED TO REVIEW THE CONFLICT OF INTEREST POLICY AND SIGN IT ON AN ANNUAL BASIS.</ExplanationTxt>
      </SupplementalInformationDetail>
      <SupplementalInformationDetail>
        <FormAndLineReferenceDesc>FORM 990, PART VI, SECTION B, LINES 15A AND 15B</FormAndLineReferenceDesc>
        <ExplanationTxt>THE CHIEF EXECUTIVE OFFICER'S COMPENSATION IS REVIEWED ON AN ANNUAL BASIS BY THE BOARD OF DIRECTORS USING COMPARABLE MARKET DATA. COMPENSATION OF KEY EMPLOYEES IS DETERMINED BY THE CHIEF EXECUTIVE OFFICER AND APPROVED BY THE BOARD OF DIRECTORS ON AN ANNUAL BASIS, AS PART OF THE FOUNDATION'S BUDGET PROCESS.</ExplanationTxt>
      </SupplementalInformationDetail>
      <SupplementalInformationDetail>
        <FormAndLineReferenceDesc>FORM 990, PART VI, SECTION C, LINE 19</FormAndLineReferenceDesc>
        <ExplanationTxt>THE FOUNDATION'S FORM 990 IS AVAILABLE UPON REQUEST. GOVERNING DOCUMENTS ARE ONLY DISTRIBUTED INTERNALLY TO THE BOARD OF DIRECTORS AND MANAGEMENT.</ExplanationTxt>
      </SupplementalInformationDetail>
      <SupplementalInformationDetail>
        <FormAndLineReferenceDesc>FORM 990, PART VII, SECTION A, LINE 2</FormAndLineReferenceDesc>
        <ExplanationTxt>ROSS LEVINE MD, PH.D RECEIVED AN HONORARIUM FROM THE FOUNDATION FOR HIS CONTRIBUTIONS TO THE FOUNDATION AS THE CHAIR OF THE FOUNDATION'S SCIENTIFIC ADVISORY COMMITTEE; NOT IN HIS CAPACITY AS A MEMBER OF THE BOARD OF DIRECTORS.</ExplanationTxt>
      </SupplementalInformationDetail>
      <SupplementalInformationDetail>
        <FormAndLineReferenceDesc>FORM 990, PART XI, LINE 9</FormAndLineReferenceDesc>
        <ExplanationTxt>ADJUSTMENT TO OPENING NET ASSETS TO APPROPRIATELY REFLECT PRIOR YEAR BALANCE.</ExplanationTxt>
      </SupplementalInformationDetail>
    </IRS990ScheduleO>
  </ReturnData>
</Return>