2017-05-12T10:00:31-07:00 2016-12-31 990EZ 2016-01-01 475555752 CHAMP FOUNDATION CHAM 7278712667 2712 LITTLE ROGERS ROAD DURHAM NC 27704 Jeffrey Reynolds President 7278712667 2017-05-12 107.13.128.243 2016 2021-01-29 14:40:06Z X www.thechampfoundation.org X X 189620 X 110214 0 0 0 0 0 0 0 79406 5997 73409 0 0 0 0 183623 50000 0 0 0 0 0 1124 51124 132499 106883 0 239382 106883 239382 0 0 0 0 106883 239382 0 0 106883 239382 The Champ Foundation supports research toward better treatment and a cure for diseases caused by mitochondrial DNA deletions, with an emphasis on Pearson Syndrome. These diseases are very rare; for example, there have only been around 100 cases of Pearson Syndrome described in the literature since its discovery in 1979. Current "treatments" only address symptoms as they present themselves. Therefore, The Champ Foundation seeks to fund research that speeds the development of treatment and a cure. In 2016, The Champ Foundation began to fund research toward better treatment and a cure of Pearson Syndrome and mitochondrial DNA deletion disorders by making its first grant to Dr. Suneet Agarwal at Boston Children's Hospital. "Mitochondrial genome editing for Pearson marrow pancreas syndrome," at Boston Children's Hospital, aims to establish the efficacy of genetic editing tools to shift heteroplasmy (the balance of defective vs. healthy mitochondria). The Champ Foundation made a $100,000 commitment to this project with the stipulation that no portion be used for indirect costs. The funding restarted the laboratory's efforts to understand and treat Pearson Syndrome. These efforts had been abandoned, after significant progress, due to lack of funding. A post-doctoral researcher is dedicated to the project full-time. The project characterizes The Champ Foundation's approach. We seek out talented researchers at excellent institutions, whose intellectual interest in mitochondrial DNA deletion disorders has been hindered by financial concerns. We believe that these diseases can be treated and cured, provided that capable researchers and clinicians are aware of the problem and allowed to pursue a solution. 50000 0 Also in 2016, The Champ Foundation established procedures to call for grants and a peer-review process for those grants prior to funding. This process was constructed an implemented by The Champ Foundation's vice-president, at no cost to the foundation. As a result of the first call for grants, The Champ Foundation's volunteer scientific advisory board reviewed five grants from across the globe. Two of these grants will receive funding in 2017! 0 0 0 Jeffrey Reynolds President 10 0 0 0 Elizabeth Reynolds Vice President 10 0 0 0 Elizabeth Malkin Secretary 1 0 0 0 Tyler Albright Treasurer 1 0 0 0 Walker Cole Arledge Director 1 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 NC NY Jeffrey Reynolds 2712 LITTLE ROGERS ROAD DURHAM NC 27704 7278712667 0 0 0 0 0 0 0 0 0 0 0 NONE NONE 1 X 107586 110214 217800 0 0 0 0 0 0 0 0 0 107586 110214 217800 86500 131300 0 0 0 0 0 0 0 0 0 217800 X RESTRICTED RESTRICTED RESTRICTED RESTRICTED RESTRICTED RESTRICTED RESTRICTED RESTRICTED Buffalo Event 79406 63902 15504 0 0 5997 0 0 0 0 0 79406 63902 15504 0 0 5997 0 0 0 5997 9507 Form 990-EZ, Part I, Line 10 Grant to Boston Children's Hospital to support Dr. Suneet Agarwal's project "Mitochondrial genome editing for Pearson marrow pancreas syndrome." Form 990-EZ, Part I, Line 16 PayPal, CrowdRise and PNC Bank Fees.