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      <SupplementalInformationDetail>
        <FormAndLineReferenceDesc>Schedule F, Part IV:</FormAndLineReferenceDesc>
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      <LicensedStatesCd>CT</LicensedStatesCd>
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      <LicensedStatesCd>PA</LicensedStatesCd>
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        <PersonNm>Michael A Marletta</PersonNm>
        <TitleTxt>Past President</TitleTxt>
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        <PersonNm>Jim C Paulson</PersonNm>
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        <PersonNm>Peter K Vogt</PersonNm>
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      <SupplementalInformationDetail>
        <FormAndLineReferenceDesc>Part I, Line 1a</FormAndLineReferenceDesc>
        <ExplanationTxt>Business travel and first class travel. The Scripps Research Institute allows for business travel for certain key employees for long haul flights. In certain circumstances, business class service is not available on smaller aircraft. In those circumstances, TSRI allows first class travel.</ExplanationTxt>
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      <SupplementalInformationDetail>
        <FormAndLineReferenceDesc>Part I, Lines 4a-b</FormAndLineReferenceDesc>
        <ExplanationTxt>In conjunction with him no longer being President in 2014, beginning with the last payroll in September 2014, Michael Marletta, received severance of $1,400,000 over two years, which were reported on his 2014 and 2015 Form W2. He received severance of $215,384 in 2014 and $1,184,616 in 2015.</ExplanationTxt>
      </SupplementalInformationDetail>
      <SupplementalInformationDetail>
        <FormAndLineReferenceDesc>Part I, Line 4b:</FormAndLineReferenceDesc>
        <ExplanationTxt>Richard Lerner, M.D. participated in a non-qualified deferred compensation plan. No payments were made during the year. Total TSRI liability at 9/30/2016 was $6,388,000.</ExplanationTxt>
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        <FormAndLineReferenceDesc>Schedule K, Part I, Bond Issues:</FormAndLineReferenceDesc>
        <ExplanationTxt>(a) Issuer Name: California Infrastructure &amp; Economic Development Bank (f) Description of Purpose: Refund and defease bonds previously issued for the benefit of the Institute on 6/29/2000 and 2/23/2005.</ExplanationTxt>
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      <SupplementalInformationDetail>
        <FormAndLineReferenceDesc>Schedule K, Part II, Column A:</FormAndLineReferenceDesc>
        <ExplanationTxt>Issuance- $40,511,601 Refunded- ($30,199,936) Defeasance- ($9,662,961) Actual issuance costs paid- ($648,704)</ExplanationTxt>
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      <SupplementalInformationDetail>
        <FormAndLineReferenceDesc>Schedule K, Part IV, Line 6:</FormAndLineReferenceDesc>
        <ExplanationTxt>This question is being answered without regard to a yield-restricted advance refunding escrow financed with proceeds of the bonds.</ExplanationTxt>
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        <NonCashCheckboxInd>X</NonCashCheckboxInd>
        <ContributionCnt>10</ContributionCnt>
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        <MethodOfDeterminingRevenuesTxt>Cost or selling price</MethodOfDeterminingRevenuesTxt>
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        <FormAndLineReferenceDesc>Part I, Column (b):</FormAndLineReferenceDesc>
        <ExplanationTxt>Securities - Publicly traded - No. of contributions</ExplanationTxt>
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      <SupplementalInformationDetail>
        <FormAndLineReferenceDesc>Part I, Line 32b:</FormAndLineReferenceDesc>
        <ExplanationTxt>Shares of stock gifted to TSRI are transferred into our brokerage account at Salomon Smith Barney and they in turn sell the shares and wire the stock proceeds to TSRI.</ExplanationTxt>
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    <IRS990ScheduleO documentId="RetDoc1044400001">
      <SupplementalInformationDetail>
        <FormAndLineReferenceDesc>Form 990, Part VII, Section B:</FormAndLineReferenceDesc>
        <ExplanationTxt>TSRI patents many of its discoveries. For most of those discoveries, the cost of these patents is recovered from third parties pursuant to the terms of the underlying license.</ExplanationTxt>
      </SupplementalInformationDetail>
      <SupplementalInformationDetail>
        <FormAndLineReferenceDesc>Form 990, Part VI, Section A, line 2</FormAndLineReferenceDesc>
        <ExplanationTxt>TSRI Board of Trustee members Claudia S. Luttrell and Mark S. Skaggs have a family relationship.</ExplanationTxt>
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      <SupplementalInformationDetail>
        <FormAndLineReferenceDesc>Form 990, Part VI, Section A, line 4</FormAndLineReferenceDesc>
        <ExplanationTxt>Effective 10/01/16, the bylaws were amended to implement the affiliation agreement with The California Institute for Biomedical Research, a 501(c)(3) not-for-profit biomedical research institute incorporated in California.</ExplanationTxt>
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      <SupplementalInformationDetail>
        <FormAndLineReferenceDesc>Form 990, Part VI, Section B, line 11</FormAndLineReferenceDesc>
        <ExplanationTxt>On June 21, 2017, the Audit Committee reviewed a draft of the form 990 (including all supplemental schedules). This review included a presentation of the statements by the Chief Financial Officer with particular emphasis on disclosures about governance and about transactions with interested persons. The 990 will be provided to the full Board of Trustees prior to filing.</ExplanationTxt>
      </SupplementalInformationDetail>
      <SupplementalInformationDetail>
        <FormAndLineReferenceDesc>Form 990, Part VI, Section B, line 12c</FormAndLineReferenceDesc>
        <ExplanationTxt>TSRI'S Conflict of interest Policies and Procedures apply to members of the Board of Trustees, officers, key personnel, and their family members, (altogether covered individuals) to protect the interests of TSRI when it is contemplating entering into a transaction or arrangement that could: 1) Benefit the private interest of a covered individual within the meaning of Treasury Regulation Section 1.501(c)(3)-1(d)(1)(ii), 2) Result in a possible excess benefit transaction within the meaning of Section 4958(c) of the Internal Revenue Code of 1986, as amended; or 3) Be a self-dealing transaction within the meaning of Section 5233 of the California Corporations Code (the "Corporations Code"). TSRI's policies and procedures are intended to supplement, but not replace, any state and federal laws governing actual, potential, or apparent conflict of interest applicable to TSRI. Disclosure documents responsive to TSRI's policies are annually submitted by covered individuals, and are reviewed by TSRI administration for pertinent relationships. Any transactions or arrangements involving covered individuals that fall within the scope of the policies are then subject to review and consideration by non-conflicted Board of Trustee members, with conflicted members being recused from any vote to approve or disapprove.</ExplanationTxt>
      </SupplementalInformationDetail>
      <SupplementalInformationDetail>
        <FormAndLineReferenceDesc>Form 990, Part VI, Section B, line 15</FormAndLineReferenceDesc>
        <ExplanationTxt>The compensation of the CEO and certain other key executives was reviewed and approved by the Board of Trustees. This review was based, in part, on analysis performed by the Human Resources department, and included data from outside consultants or internally-conducted research. On an ongoing basis, executives may participate in the normal annual salary increase program, which is based on a recommendation from the Human Resources department based on market research and approved by the Board of Trustees. Any unusual or potentially non-qualified compensation would be reviewed by outside counsel for any tax compliance issues. Patrick R. Griffin, Ph.D. and Linda Sherman, Ph.D. were appointed to the Board of Trustees. However they received the compensation for their work as faculty members, not as trustees.</ExplanationTxt>
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      <SupplementalInformationDetail>
        <FormAndLineReferenceDesc>Form 990, Part VI, Section C, line 19</FormAndLineReferenceDesc>
        <ExplanationTxt>Governing documents and Conflict of Interest Policies are not available to the public at this time. The financial statements are available on the TSRI web-site and are filed with the State of Florida by The Scripps Florida Funding Corporation. The statements are provided to bond holders through TSRI's dissemination agent. The annual information return is provided upon request.</ExplanationTxt>
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      <SupplementalInformationDetail>
        <FormAndLineReferenceDesc>Form 990, Part IX, line 11g</FormAndLineReferenceDesc>
        <ExplanationTxt>Research Contractor: Program service expenses 60,102,455. Management and general expenses 2,518,891. Fundraising expenses 558,555. Total expenses 63,179,901.</ExplanationTxt>
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      <SupplementalInformationDetail>
        <FormAndLineReferenceDesc>Form 990, Part XI, line 9:</FormAndLineReferenceDesc>
        <ExplanationTxt>Rounding -40.</ExplanationTxt>
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      <SupplementalInformationDetail>
        <FormAndLineReferenceDesc>Form 990, Transactions with Interested Persons:</FormAndLineReferenceDesc>
        <ExplanationTxt>Richard A. Lerner, M.D. term as President and CEO of TSRI expired on December 31, 2011. Dr. Lerner serves on the Board of Directors and is the Chair of the Compensation Committee of OPKO Health, Inc. OPKO is a health care company focused on the development of pharmaceuticals, has a use license with TSRI, and may be involved in business transactions with TSRI in the future. TSRI has licenses with Sorrento Therapeutics, and OPKO is an investor in Sorrento Therapeutics.</ExplanationTxt>
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