2016-10-17T00:00:00-05:00 2015-12-31 911194016 CLARK NUBER PS 10900 NE 4TH STREET SUITE 1700 BELLEVUE WA 98004 990 2015-01-01 912003593 INSTITUTE FOR SYSTEMS BIOLOGY INST 2067321200 401 TERRY AVENUE N SEATTLE WA 98109 KATHY SCANLAN COO & TREASURER 2067321200 2016-10-07 1 JENNIFER BECKER HARRIS P00183358 4254544919 2016-10-07 2015 2017-02-10 21:41:12Z LEROY HOOD 401 TERRY AVENUE N SEATTLE WA 98109 36187308 0 X WWW.SYSTEMSBIOLOGY.ORG X 1999 WA USING THE SCIENCE OF SYSTEMS BIOLOGY TO PREDICT, PREVENT, AND CURE DISEASE. 13 12 224 25 394245 353020 29320438 29000917 949413 554699 -285900 100034 1680094 1864385 31664045 31520035 266653 0 0 0 18436848 18422448 0 0 134051 14720217 14819071 33423718 33241519 -1759673 -1721484 42554882 38939866 26338863 24430245 16216019 14509621 X THE INSTITUTE FOR SYSTEMS BIOLOGY (ISB) IS A NON-PROFIT RESEARCH INSTITUTE FOUNDED IN SEATTLE IN 1999 TO ADVANCE A SYSTEMS (OR HOLISTIC AND CROSS-DISCIPLINARY) APPROACH TO SCIENCE; PERSONALIZED MEDICINE; GLOBAL HEALTH AND ENVIRONMENTAL SUSTAINABILITY; SCIENCE EDUCATION; AND THE PIONEERING AND INVENTION OF BIOLOGICAL AND TECHNOLOGICAL METHODS AND TOOLS. OUR MISSION STATEMENT IS: REVOLUTIONIZE SCIENCE, TRANSFORM HUMAN HEALTH, AND ENSURE ENVIRONMENTAL SUSTAINABILITY. 0 0 24155828 231408 BIOMOLECULAR RESEARCH: IN 2015, ISB RESEARCHERS PUBLISHED 112 ACADEMIC RESEARCH PAPERS IN A RANGE OF HIGH-PROFILE JOURNALS, COVERING GENOMICS, MICROFLUIDICS, PROTEOMICS, HIGH-THROUGHPUT COMPUTATION, MULTISCALE MODELING, SYSTEMS BIOLOGY APPLICATIONS, BIOINFORMATICS, GLOBAL HEALTH (TUBERCULOSIS, DENGUE VIRUS), AND CANCERS (GASTRIC, THYROID, THERAPIES, DIAGNOSIS). 738013 323291 SCIENCE EDUCATION: ISB'S LOGAN CENTER FOR EDUCATION PROVIDES TRAINING FOR K-12 SCIENCE AND MATH TEACHERS AS WELL AS UNDERGRADUATE SYSTEMS BIOLOGY FACULTY. IN 2015, THE LOGAN CENTER SERVED MORE THAN 800 EDUCATORS REPRESENTING 22 SCHOOL SYSTEMS. 24893841 1 1 0 0 0 0 0 0 0 1 1 0 0 0 1 0 1 0 0 0 0 0 0 0 1 0 0 0 0 1 0 0 0 0 0 0 0 0 1 0 0 0 0 0 0 0 0 1 41 0 1 224 1 1 1 0 0 0 0 1 1 0 0 0 0 X 13 12 1 0 0 0 0 0 0 1 1 0 0 1 1 1 1 1 1 1 1 0 WA CA X GARY C STREICHER 2067321200 401 TERRY AVENUE N SEATTLE WA 98109 WILLIAM K BOWES JR DIRECTOR 1.50 0.00 X 0 0 0 THOMAS J CABLE DIRECTOR 1.00 1.00 X 0 0 0 STEPHEN GRAHAM DIRECTOR 4.00 0.00 X 0 0 0 DANIEL T LING DIRECTOR 1.00 0.00 X 0 0 0 ROGER PERLMUTTER MD PHD DIRECTOR 1.00 0.00 X 0 0 0 DREW SENYEI MD DIRECTOR 1.00 0.00 X 0 0 0 CRAIG MUNDIE DIRECTOR 1.00 0.00 X 0 0 0 DOUGLAS HOWE DIRECTOR 1.50 0.00 X 0 0 0 MARY WOOLLEY DIRECTOR 1.00 0.00 X 0 0 0 DOUGLAS WALKER DIRECTOR 1.00 0.00 X 0 0 0 BRIAN TURNER DIRECTOR 1.00 0.00 X 0 0 0 DAVID A SABEY DIRECTOR /CHAIR 3.00 0.00 X X 0 0 0 LEROY HOOD MD PHD PRESIDENT 84.00 7.00 X X 383425 0 26999 MARK ASHIDA TREASURER, SECRETARY, & COO 36.00 0.00 X X 330229 0 10686 KATHY SCANLAN TREASURER & CHIEF OPERATING OFFICER 40.00 0.00 X 231182 0 34126 NITIN BALIGA PHD SVP DIRECTOR OF INTEGRATIVE SCIENCE /PROFESSOR 60.00 0.00 X 269289 0 34104 CYNTHIA SHUMATE JD CHIEF LEGAL OFFICER, CCO & SECRETARY 40.00 0.00 X 234160 0 45575 ILYA SHMULEVICH PHD PROFESSOR 60.00 0.00 X 250505 0 44042 NATHAN PRICE PHD ASSOC. DIR. OF INTEGRATIVE SCIENCE 60.00 1.00 X 231682 0 45365 SUI HUANG MD PHD PROFESSOR 60.00 0.00 X 241292 0 27474 ROBERT L MORTIZ PHD ASSOCIATE PROFESSOR 60.00 0.00 X 198919 0 26644 JEFFREY A RANISH PHD ASSOCIATE PROFESSOR 60.00 0.00 X 162427 0 31403 LAWRENCE A RANGE DIRECTOR OF INFORMATION TECHNOLOGY 40.00 0.00 X 145625 0 31136 JOHN D AITCHISON PHD PROFESSOR /FORMER OFFICER (SVP) 40.00 0.00 X 107500 0 13513 2786235 0 371067 31 1 1 0 SRA INTERNATIONAL 3434 WASHINGTON SQUARE BLVD ARLINGTON VA 22209 RESEARCH GRANT SUBCONTRACTOR 976059 UNIVERSITY OF WASHINGTON 4014 UNIVERSITY WAY NE SEATTLE WA 981051130 RESEARCH GRANT SUBCONTRACTOR 437569 GOOGLE INC 345 SPEAR ST SAN FRANCISCO CA 94139 RESEARCH GRANT SUBCONTRACTOR 349547 NEW YORK MEDICAL COLLEGE 40 SUNSHINE RD VALHALLA NY 10595 RESEARCH GRANT SUBCONTRACTOR 306500 DEFENSE SCIENCE AND TECHNOLOGY LABORATOR PORTSDOWN HILL RD FAREHAM UK P017 6AD RESEARCH GRANT SUBCONTRACTOR 267747 14 8086 86100 18460338 10446393 1001853 29000917 SCIENCE EDUCATION 541900 323291 323291 LAB AND RESEARCH SRVCS 541700 231408 231408 554699 89834 89834 1116233 1116233 4148097 3648047 500050 500050 394245 105805 1010472 1000272 10200 10200 10200 3050 86100 18954 -15904 -15904 COST REIMBURSEMENTS 900099 264006 264006 264006 31520035 554699 394245 1570174 1894321 672418 1221903 11404778 8078006 3281866 44906 865050 587959 273920 3171 3168731 2219734 936780 12217 1089568 705681 380233 3654 269388 15442 253946 110917 110917 730211 508914 221297 47119 3575 43461 83 255321 14696 235749 4876 151242 27475 123767 4324397 4167116 132819 24462 372792 217974 153093 1725 199387 58177 127196 14014 98248 70117 27718 413 1951461 1862695 64468 24298 138477 138477 SUBCONTRACTS 2846044 2846044 SUPPLIES & SERVICES 1204075 1192129 11882 64 LABORATORY 1073458 1073449 9 UNRELATED BUS. INC. TAX 92128 92128 954406 572240 381998 168 33241519 24893841 8213627 134051 300 300 16927305 15310857 12213802 12088385 169623 272911 7500 0 1020324 962645 33559093 24897027 10578164 8662066 217656 229844 1282208 1274858 138000 138000 42554882 38939866 2774165 3024796 3731408 3023951 7782302 7782302 12050988 10599196 26338863 24430245 X -194510 -1369162 7739029 7207283 8671500 8671500 16216019 14509621 42554882 38939866 -1721484 15086 0 X 0 1 X 1 1 1 X 23892848 24894172 27126210 29320438 29000917 134234585 23892848 24894172 27126210 29320438 29000917 134234585 16294897 117939688 1062338 896402 1170390 3645895 4051746 10826771 139884 244876 378341 763101 84799 50264 130284 60285 264006 589638 146414095 54311409 0.80550 0.82090 X SCHEDULE A, PART II, LINE 10, EXPLANATION OF OTHER INCOME: COST REIMBURSEMENTS - 2011 AMOUNT: $ 84,799. 2012 AMOUNT: $ 50,264. 2013 AMOUNT: $ 130,284. 2014 AMOUNT: $ 60,285. 2015 AMOUNT: $ 264,006. RESTRICTED RESTRICTED RESTRICTED RESTRICTED RESTRICTED RESTRICTED RESTRICTED RESTRICTED 8671500 79000 79000 8671500 8671500 80000 80000 8671500 8671500 82381 82381 8671500 8671500 82548 82548 8671500 8671500 84324 84324 8671500 1.00000 0 0 14374259 6826541 7547718 19184834 18070486 1114348 8662066 DEFERRED RENT PAYABLE 10599196 10599196 35202122 15086 15086 35187036 -3667001 -3667001 31520035 36908520 3667001 3667001 33241519 0 33241519 PART V, LINE 4: THESE ENDOWMENT FUNDS ARE PLEDGED AS COLLATERAL FOR THE ORGANIZATION'S LONG-TERM DEBT. EARNINGS ON THE ENDOWMENT FUNDS ARE USED TO PARTIALLY FUND PAYMENT OF PRINCIPAL & INTEREST DUE ON THE DEBT. PART XI, LINE 4B - OTHER ADJUSTMENTS: RENTAL EXPENSES NETTED AGAINST REVENUES ON FINANCIAL STATEMENTS -3,648,047. SPECIAL EVENT DEDUCTIONS -18,954. PART XII, LINE 2D - OTHER ADJUSTMENTS: RENTAL EXPENSES NETTED AGAINST REVENUES ON FINANCIAL STATEMENTS 3,648,047. SPECIAL EVENT DEDUCTIONS 18,954. LOGAN LUNCHEON 89150 86100 3050 4915 8977 5062 89150 86100 3050 4915 8977 5062 18954 -15904 X X X 1 0 0 0 0 0 0 0 0 LEROY HOOD MD PHD PRESIDENT 374685 0 0 0 8740 0 18501 0 8498 0 410424 0 0 0 MARK ASHIDA TREASURER, SECRETARY, & COO 50063 0 0 0 280166 0 4249 0 6437 0 340915 0 0 0 KATHY SCANLAN TREASURER & CHIEF OPERATING OFFICER 227174 0 0 0 4008 0 18427 0 15699 0 265308 0 0 0 NITIN BALIGA PHD SVP DIRECTOR OF INTEGRATIVE SCIENCE 267689 0 0 0 1600 0 0 0 34104 0 303393 0 0 0 CYNTHIA SHUMATE JD CHIEF LEGAL OFFICER, CCO & SECRETARY 232409 0 0 0 1751 0 19299 0 26276 0 279735 0 0 0 ILYA SHMULEVICH PHD PROFESSOR 248845 0 0 0 1660 0 20150 0 23892 0 294547 0 0 0 NATHAN PRICE PHD ASSOC. DIR. OF INTEGRATIVE SCIENCE 230190 0 0 0 1492 0 18896 0 26469 0 277047 0 0 0 SUI HUANG MD PHD PROFESSOR 240000 0 0 0 1292 0 19299 0 8175 0 268766 0 0 0 ROBERT L MORTIZ PHD ASSOCIATE PROFESSOR 197386 0 0 0 1533 0 16085 0 10559 0 225563 0 0 0 JEFFREY A RANISH PHD ASSOCIATE PROFESSOR 161294 0 0 0 1133 0 13271 0 18132 0 193830 0 0 0 LAWRENCE A RANGE DIRECTOR OF INFORMATION TECHNOLOGY 144545 0 0 0 1080 0 12012 0 19124 0 176761 0 0 0 JOHN D AITCHISON PHD PROFESSOR /FORMER OFFICER (SVP) 100000 0 0 0 7500 0 7850 0 5663 0 121013 0 0 0 PART I, LINE 4A MARK ASHIDA LEFT ISB IN JANUARY 2015. AS PART OF THE SEPARATION FROM EMPLOYMENT HE RECEIVED A SEVERANCE PAYMENT OF $280,000. X 3 1001853 FMV 0 0 1 0 PART I, COLUMN (B): THE NUMBER IN SCHEDULE M, PART I, COLUMN B IS BASED ON THE NUMBER OF CONTRIBUTIONS RECEIVED DURING THE YEAR. FORM 990, PART I, LINE 6: TWELVE VOLUNTEERS SERVED AS INDIVIDUAL DIRECTORS ON ISB'S BOARD OF DIRECTORS DURING 2015. OTHER VOLUNTEERS ASSISTED WITH FUNDRAISING MAILINGS AND OTHER RELATED TASKS. FORM 990, PART VI, SECTION A, LINE 2 LEROY HOOD AND MARK ASHIDA HAVE A BUSINESS RELATIONSHIP. FORM 990, PART VI, SECTION B, LINE 11 FORM 990 IS PREPARED WITH ASSISTANCE FROM A PAID PROFESSIONAL ADVISOR BASED ON INFORMATION PREPARED BY STAFF. THE DRAFT RETURN IS REVIEWED IN TURN BY THE DIRECTOR OF FINANCE, THE COO, AND THEN BY THE AUDIT COMMITTEE OF THE BOARD OF DIRECTORS. THE FILING VERSION OF THE RETURN IS DISTRIBUTED ELECTRONICALLY TO ALL BOARD MEMBERS PRIOR TO FILING WITH THE IRS. FORM 990, PART VI, SECTION B, LINE 12C ISB HAS FORMAL WRITTEN CONFLICT OF INTEREST (COI) POLICIES FOR ALL FIDUCIARIES (BOARD MEMBERS AND OFFICERS) AND RESEARCH INVESTIGATORS. BOTH POLICIES REQUIRE DISCLOSURES OF ANY POTENTIAL CONFLICTS THAT MIGHT EXIST TO BE DISCLOSED WHEN CONFLICTS ARISE AND TO BE SUMMARIZED ANNUALLY BY COMPLETION OF A QUESTIONNAIRE. THE BOARD OF DIRECTORS DELEGATES INVESTIGATION AND EVALUATION OF POTENTIAL CONFLICTS TO A COI COMMITTEE (COIC). THE ISB COIC IS A COMMITTEE TO WHICH THE INSTITUTE DELEGATES THE AUTHORITY TO CREATE POLICIES AND PROCEDURES TO ADDRESS ACTUAL AND APPARENT CONFLICTS OF INTEREST (FCOI) RELATING TO INSTITUTE RESEARCH. IF IT IS DETERMINED THAT A FCOI EXISTS, THE ISB COIC WILL CREATE AND MONITOR A MANAGEMENT PLAN DESIGNED TO ADDRESS THE FCOI. THE COIC IS CHARGED WITH PROVIDING APPROPRIATE OVERSIGHT VIA THE ISB INVESTIGATOR COI POLICY, WHICH IS INTENDED TO ENSURE THAT ALL FINANCIAL INTERESTS ARE DISCLOSED, THAT THE CONDUCT OF FUNDED RESEARCH IS NOT BIASED BY FCOI, AND THAT THE INTERESTS OF ISB ARE PROTECTED. IN ADDITION, THE COIC REVIEWS ISB SPIN-OUT OR START-UP COMPANIES AND ADVISES THE ISB BOARD'S TECHNOLOGY TRANSFER COMMITTEE (TTC) ON ANY POTENTIAL FCOI ISSUES ARISING FROM ISB PERSONNEL ACTIVITIES AND/OR INTERESTS IN THE PROSPECTIVE COMPANY. THE COIC IS COMPRISED OF 8 MEMBERS: 5 PERMANENT VOTING, 2 ROTATING VOTING, AND 1 EX-OFFICIO AS FOLLOWS: ASSOCIATE DIRECTOR, COMPLIANCE (CHAIR OF COIC) DIRECTOR OF SPONSORED PROJECTS (DESIGNATED INSTITUTIONAL OFFICIAL) DIRECTOR OF HUMAN RESOURCES DIRECTOR OF FINANCE CHIEF OPERATING OFFICER FACULTY REPRESENTATIVE (1 YEAR TERM) SENIOR RESEARCH SCIENTIST (1 YEAR TERM) CHIEF COMPLIANCE OFFICER (EX-OFFICIO) THE COIC MEETS AT LEAST ONCE PER QUARTER TO, AMONG OTHER THINGS, REVIEW NEWLY IDENTIFIED POTENTIAL OR ACTUAL FCOI, DISCUSS THE ONGOING MONITORING OF EXISTING FCOI, AND ASSESS PROGRESS AND ADHERENCE OF MANAGEMENT PLANS. IN ADDITION, THE COIC MEETS ON AN AD HOC BASIS WHENEVER POTENTIAL FCOI ARE IDENTIFIED. IN THE EVENT OF A FCOI, THE COIC WILL CREATE AND MONITOR A MANAGEMENT PLAN. MANAGEMENT MAY INCLUDE BUT IS NOT LIMITED TO: INVESTIGATOR PUBLIC DISCLOSURE OF FCOI LIMITATIONS REGARDING WORK/ROLE ON A CONFLICTED PROJECT DIVESTITURE OF INTERESTS THE COIC IS AN INDEPENDENT BODY WHICH MAY REPORT, THROUGH THE CHIEF COMPLIANCE OFFICER, CONCERNS TO THE ISB BOARD OF DIRECTORS. THE POLICIES ALSO REQUIRE THAT IF A CONFLICT DOES ARISE, THE COVERED PERSON WILL RECUSE HIMSELF OR HERSELF FROM ANY DISCUSSION OR VOTE ON THE MATTER. FORM 990, PART VI, SECTION B, LINE 15 THE COMPENSATION OF THE INSTITUTE'S PRESIDENT WAS REVIEWED BY A PAID CONSULTANT TO DETERMINE ITS COMPARABILITY TO PREVAILING MARKET CONDITIONS FOR SIMILAR POSITIONS AT OTHER ORGANIZATIONS. THIS STUDY WAS PRESENTED TO AND APPROVED BY THE INSTITUTE'S GOVERNING BOARD OF DIRECTORS. ALSO, THE EMPLOYMENT AGREEMENT FOR THE INSTITUTE'S PRESIDENT WAS REVIEWED AND APPROVED BY THE INSTITUTE'S GOVERNING BOARD OF DIRECTORS. THE REVIEW PROCESS WAS LAST PERFORMED IN JULY 2011, WHEN THE PRESIDENT'S COMPENSATION WAS LAST CHANGED. THE COMPENSATION OF ALL OFFICERS AND KEY EMPLOYEES ARE BASED UPON AND SUBJECT TO APPROVAL OF THE PRESIDENT AND ARE REVIEWED AND APPROVED BY THE BOARD OF DIRECTORS AS NECESSARY. TYPICALLY, THIS IS DONE WHEN SUCH POSITIONS ARE REFILLED DUE TO VACANCIES. THIS REVIEW PROCESS WAS LAST PERFORMED IN DECEMBER 2015. FORM 990, PART VI, SECTION C, LINE 19 THE INSTITUTE'S GOVERNING DOCUMENTS, CONFLICT OF INTEREST POLICY, AND FINANCIAL STATEMENTS ARE NOT MADE READILY AVAILABLE TO THE PUBLIC. THE INSTITUTE'S APPLICATION FOR TAX EXEMPT STATUS AND ITS ANNUAL FORM 990 ARE AVAILABLE FOR PUBLIC INSPECTION AND REVIEW UPON REQUEST.