2025-11-17T18:00:27-06:00 2024-12-31 135565207 KPMG LLP 550 SOUTH HOPE STREET SUITE 1500 LOS ANGELES CA 90071 990 2024-01-01 811669175 CHAN ZUCKERBERG BIOHUB INC CHAN 4155493300 499 ILLINOIS ST SAN FRANCISCO CA 94158 BEN ROH CHIEF FINANACIAL OFFICER 4155493300 2025-11-17 1 0 KATHRYN J OKIMOTO P00746598 2139724000 2025-11-14 2024 2025-03-06 01:10:19Z MARC MALANDRO 499 ILLINOIS ST SAN FRANCISCO CA 94158 99552025 0 X WWW.CZBIOHUB.ORG X 2016 CA CONDUCT CUTTING EDGE MEDICAL RESEARCH 10 6 290 8 0 0 1284038212 92527253 1968367 322389 4264016 6102390 339928 599993 1290610523 99552025 32363671 40383291 0 0 38807920 52472266 0 0 0 36854897 49554468 108026488 142410025 1182584035 -42858000 1479585206 1477092189 44007209 84372192 1435577997 1392719997 X ACCELERATING SCIENCE THROUGH ITS MISSION TO CURE, PREVENT OR MANAGE ALL DISEASES BY THE END OF THE 21ST CENTURY. 0 0 121540906 40383291 322389 IN 2024, THE FOUR RESEARCH INSTITUTES OF CHAN ZUCKERBERG BIOHUB INC ("BIOHUB") MADE SIGNIFICANT ADVANCES IN THE ORGANIZATION'S OVERALL MISSION TO CURE, PREVENT OR MANAGE DISEASE.IN JUNE, RESEARCHERS AT THE CHAN ZUCKERBERG INSTITUTE FOR ADVANCED BIOLOGICAL IMAGING ANNOUNCED THAT THEY HAD SOLVED A MAJOR BOTTLENECK IN THE USE OF THE IMAGING TECHNIQUE KNOWN AS CRYOGENIC ELECTRON TOMOGRAPHY, OR CRYOET. THIS METHOD IS CAPABLE OF CAPTURING DETAILED STRUCTURAL IMAGES OF CELLS AND PROTEINS, BUT THE RESULTING 3D DATASETS, KNOWN AS TOMOGRAMS, MUST BE MANUALLY ANNOTATED, A PAINSTAKING PROCESS THAT CAN TAKE MONTHS, SLOWING THE PACE OF SCIENTIFIC DISCOVERY. BY APPLYING NEW MACHINE LEARNING TOOLS, THE IMAGING INSTITUTE RESEARCHERS AUTOMATICALLY ANNOTATED 13,000 TOMOGRAMS IN JUST THREE-AND-A-HALF DAYS. IN ADDITION, THE INSTITUTE LAUNCHED THE CRYOET DATA PORTAL, AN OPEN ACCESS DATA REPOSITORY THAT CONTAINS ABOUT 16,000 ANNOTATED CRYOET DATASETS IN STANDARDIZED FORMATS. BOTH ACHIEVEMENTS WILL BENEFIT BIOIMAGING SCIENTISTS WORLDWIDE BY ACCELERATING UNDERSTANDING OF THE PROTEINS THAT MAKE UP OUR CELLS.IN A SCIENTIFIC MILESTONE, THE SAN FRANCISCO BIOHUB RESEARCHERS RELEASED "ZEBRAHUB," AN ATLAS OF EARLY ZEBRAFISH DEVELOPMENT. PUBLISHED IN THE JOURNAL CELL IN NOVEMBER, ZEBRAHUB COMBINES STATE-OF-THE-ART 3D MICROSCOPY WITH COMPREHENSIVE GENE-EXPRESSION DATA FOR THE INDIVIDUAL CELLS THAT MAKE UP ZEBRAFISH EMBRYOS. THE MICROSCOPES, GENE-SEQUENCING TECHNIQUES, AND IMAGE ANALYSIS TOOLS USED TO CREATE ZEBRAHUB WERE DESIGNED AND BUILT AT THE BIOHUB. ABOUT 70% OF HUMAN GENES, INCLUDING THOSE INVOLVED IN DISEASES, HAVE COUNTERPARTS IN ZEBRAFISH, SO ZEBRAHUB WILL ACCELERATE DISEASE RESEARCH ACROSS CANCER, HEART DISEASE, AND NEUROLOGICAL DISORDERS PROVIDING FREELY ACCESSIBLE DATA THAT WILL HELP BIOMEDICAL RESEARCHERS WORLDWIDE IDENTIFY NEW TREATMENTS.OCTOBER SAW THE OFFICIAL LAUNCH OF THE NEW YORK BIOHUB, DEVOTED TO CHARACTERIZING AND ENGINEERING THE BEHAVIOR OF OUR IMMUNE CELLS. THESE ENGINEERED CELLS CAN BE ADAPTED TO DETECT SIGNALS THAT PREDICT SEVERAL DISEASES, FROM CANCERS TO ALZHEIMER'S AND PARKINSON'S, AT THEIR EARLIEST STAGES, WHEN THEY ARE EASIER TO TREAT OR PREVENT, AND LONG BEFORE THEY CAN BE DETECTED BY CONVENTIONAL DIAGNOSTIC METHODS. THE NEW YORK BIOHUB ALSO BEGAN CONSTRUCTION OF PERMANENT, STATE-OF-THE-ART LAB SPACE ON COLUMBIA UNIVERSITY'S MANHATTANVILLE CAMPUS, MADE NEW HIRES, AND FUNDED ITS FIRST COHORT OF INVESTIGATORS FROM ITS PARTNER INSTITUTIONS: COLUMBIA UNIVERSITY, THE ROCKEFELLER UNIVERSITY, AND YALE UNIVERSITY.THE TEAM AT CHICAGO BIOHUB TACKLED A LONGSTANDING PROBLEM IN BIOENGINEERING BY BUILDING A FIRST-OF-ITS-KIND IMPLANTABLE SENSOR THAT CAN MONITOR LEVELS OF THE PROTEINS INVOLVED IN INFLAMMATION IN REAL TIME. SENSORS THAT MONITOR GLUCOSE, A SMALL MOLECULE, HAVE REVOLUTIONIZED DIABETES CARE, BUT SCIENTISTS HAVE STRUGGLED TO OBTAIN THE RELIABLE, CONTINUOUS MEASUREMENTS OF PROTEINS ACHIEVED BY THE NEW SENSOR, AS REPORTED IN THE JOURNAL SCIENCE IN DECEMBER. IT HAS BEEN ESTIMATED THAT 50% OF ALL DEATHS ARE RELATED TO INFLAMMATORY CONDITIONS, AND THE NOVEL SENSOR PLACES AN IMPORTANT NEW TOOL IN THE HANDS OF RESEARCHERS TO BETTER UNDERSTAND AND POTENTIALLY PREVENT A RANGE OF DISEASES, FROM NEURODEGENERATION TO CANCER TO HEART DISEASE. 121540906 1 1 0 0 0 0 0 0 0 0 1 0 0 0 1 1 0 1 0 0 1 0 0 0 0 0 0 1 0 1 0 0 0 0 0 0 0 1 0 0 0 0 1 1 1 1 0 0 1 95 0 1 290 1 0 0 0 0 0 0 0 0 0 0 1 0 X 10 6 1 0 0 0 0 1 0 1 1 0 0 1 1 1 1 1 1 1 1 0 CA IL NY OR X THE ORGANIZATION 4155493300 499 ILLINOIS ST SAN FRANCISCO CA 94158 X JOSEPH DERISI DIRECTOR, PRESIDENT CZB SF (KEY EMP) 40.00 0.00 X X 904065 0 61930 STEPHEN QUAKE PRESIDENT & DIRECTOR 10.00 0.00 X X 303006 0 0 CORI BARGMANN DIRECTOR 2.00 0.00 X 0 0 0 MARK ZUCKERBERG DIRECTOR 2.00 41.00 X 0 0 0 MIKE SCHROEPFER DIRECTOR 2.00 0.00 X 0 0 0 PAUL ALIVISATOS DIRECTOR 2.00 0.00 X 0 0 0 PRISCILLA CHAN DIRECTOR 2.00 1.00 X 0 0 0 REID HOFFMAN DIRECTOR 2.00 0.00 X 0 0 0 SAM ALTMAN DIRECTOR 2.00 0.00 X 0 0 0 SAM HAGWOOD DIRECTOR 2.00 0.00 X 0 0 0 MELINDA GRIFFITH SEC (THRU 1/29), COO & COUNS, CZB SF 40.00 0.00 X 733051 0 49159 VICTOR COLUNGA CFO & TREASURER (THRU 6/30) 40.00 0.00 X 316310 0 44320 MARC MALANDRO COO (FROM 1/29) 20.00 0.00 X 0 0 0 SANDY YAO SECRETARY & CLO (FROM 1/29) 20.00 0.00 X 0 0 0 BEN ROH CFO 20.00 0.00 X 0 0 0 ANDREA CALIFANO PRESIDENT, CZB NY 40.00 0.00 X 856238 0 34857 SHANA KELLEY PRESIDENT, CZB CHICAGO 40.00 0.00 X 818795 0 43459 MATTHIAS HAURY COO/ACTING EXECUTIVE DIRECTOR, CZII 40.00 0.00 X 859154 0 31998 CLINTON POTTER FOUNDING TECHNICAL DIRECTOR, CZII 40.00 0.00 X 780004 0 55366 DAVID ANDREW AGARD FOUNDING TECHNICAL DIRECTOR, CZII 40.00 0.00 X 775148 0 57566 BRIDGET CARRAGHER FOUNDING TECHNICAL DIRECTOR, CZII 40.00 0.00 X 782381 0 44059 SANDRA L SCHMID CHIEF SCIENTIFIC OFFICER, CZB SF 40.00 0.00 X 759416 0 44209 7887568 0 466923 173 0 1 0 ZOE LIFE 400 ABERDEEN LLC DBA FULTON LAB 2100 MCKINNEY AVE STE 800 DALLAS TX 75201 CONSTRUCTION 3553298 DOME CONSTRUCTION CORPORATION 393 EAST GRAND AVE SOUTH SAN FRANCISCO CA 94080 CONSTRUCTION 1344815 GARY D NELSON ASSOCIATES INC DBA NELSON 19080 LOMITA AVE SONOMA CA 95476 PROFESSIONAL STAFFING 1200887 ARNOLD & PORTER KAYE SCHOLER LLP 601 MASSACHUSETTS AVE NW WASHINGTON DC 200013743 LEGAL 1167808 KILPATRICK TOWNSEND 1100 PEACHTREE ST NE STE 2800 ATLANTA GA 30309 LEGAL 812186 26 X 131799853 13335337 -52607937 92527253 COLLABORATION FEES 541700 322389 322389 322389 6102390 6102390 492496 492496 OTHER REVENUE 900099 107497 107497 107497 99552025 322389 0 6702383 40383291 40383291 4165190 3748669 416521 37296260 29004359 8291901 4359227 3605825 753402 4134059 3424034 710025 2517530 2088624 428906 2512481 1304432 1208049 752181 752181 3878430 1165508 2712922 759199 166499 592700 4955545 3857193 1098352 19622921 17559414 2063507 1805694 1357581 448113 790851 356217 434634 8205965 7816051 389914 366732 366732 LAB SUPPLIES 5042638 5042638 MARKETING 574507 549794 24713 SUBSCRIPTIONS/LICENSES 287324 110777 176547 142410025 121540906 20869119 0 9095362 12081948 136662084 135469613 1275341448 1201347646 1354066 805950 5427457 3750045 85882470 30301956 29361389 55580514 564098 831423 21779302 67225050 1479585206 1477092189 12127874 6683401 8551517 11082022 23327818 66606769 44007209 84372192 X 156918456 188428962 1278659541 1204291035 1435577997 1392719997 1479585206 1477092189 -42858000 0 X 0 1 X 1 0 X CARLE ILLINOIS COLLEGE OF MEDICINE URBANA IL COLUMBIA UNIVERSITY IRVING MEDICAL CENTER NEW YORK NY LUCILE PACKARD CHILDREN'S HOSPITAL STANFORD PALO ALTO CA NORTHWESTERN MEMORIAL HOSPITAL CHICAGO IL ROCKEFELLER UNIVERSITY HOSPTIAL NEW YORK NY STANFORD UNIVERSITY HOSPITAL PALO ALTO CA UCSF MEDICAL CENTER SAN FRANCISCO CA UNIVERSITY OF CHICAGO MEDICAL CENTER CHICAGO IL YALE NEW HAVEN HOSPITAL NEW HAVEN CT RESTRICTED RESTRICTED RESTRICTED RESTRICTED RESTRICTED RESTRICTED RESTRICTED RESTRICTED 9170698 1458945 7711753 63099421 28843011 34256410 13612351 13612351 55580514 OPERATING LEASE LIABILITIES 66606769 66606769 X 111564510 12012485 12012485 99552025 0 99552025 154422510 12012485 12012485 142410025 0 142410025 PART X, LINE 2: THE INTERNAL REVENUE SERVICE (IRS) HAS DETERMINED THAT BIOHUB IS DESCRIBED IN SECTION 501(C)(3) OF THE INTERNAL REVENUE CODE (THE CODE) AS A MEDICAL RESEARCH ORGANIZATION OPERATED IN CONJUNCTION WITH A HOSPITAL AND SECTION 23701D OF THE CALIFORNIA REVENUE AND TAXATION CODE AND ACCORDINGLY, IS GENERALLY EXEMPT FROM FEDERAL INCOME TAXES UNDER THE PROVISION OF SECTION 501(A) OF THE CODE. BIOHUB HAS NO UNRECOGNIZED TAX BENEFITS OR LIABILITIES AS OF DECEMBER 31, 2024 OR 2023. EUROPE (INCLUDING ICELAND & GREENLAND) 0 0 PROGRAM SERVICES SPEAKING/ATTENDING CONFERENCES 116904 SOUTH AMERICA 0 0 PROGRAM SERVICES SPEAKING/ATTENDING CONFERENCES 32998 NORTH AMERICA 0 0 PROGRAM SERVICES SPEAKING/ATTENDING CONFERENCES 1698 EAST ASIA AND THE PACIFIC 0 0 PROGRAM SERVICES SPEAKING/ATTENDING CONFERENCES 84630 RUSSIA AND NEIGHBORING STATES 0 0 PROGRAM SERVICES SPEAKING/ATTENDING CONFERENCES 14930 SUB-SAHARAN AFRICA 0 0 PROGRAM SERVICES SPEAKING/ATTENDING CONFERENCES 72332 EUROPE (INCLUDING ICELAND & GREENLAND) 0 0 PROGRAM SERVICES CONSULTING SERVICE 100202 EAST ASIA AND THE PACIFIC 0 0 PROGRAM SERVICES CONSULTING SERVICE 1500 0 0 0 0 0 0 425194 0 425194 0 0 0 0 0 0 PART I, LINE 3: EXPENDITURES REPORTED ON LINE 3 ARE EXPENDITURES IN EACH REGION ACCOUNTED FOR UNDER THE ACCRUAL METHOD. 1 NORTHWESTERN UNIVERSITY 633 CLARK ST EVANSTON IL 60208 362167817 501(C)(3) 2826739 0 SCIENTIFIC AND MEDICAL RESEARCH REGENTS OF THE UNIVERSITY OF CALIFORNIA AT BERKELEY 119 CALIFORNIA HALL 5940 BERKELEY CA 94720 946002123 STATE OF CALIFORNIA 5535784 0 SCIENTIFIC AND MEDICAL RESEARCH REGENTS OF THE UNIVERSITY OF CALIFORNIA SAN FRANCISCO 1855 FOLSOM ST STE 425 SAN FRANCISCO CA 94103 946036493 STATE OF CALIFORNIA 12257389 0 SCIENTIFIC AND MEDICAL RESEARCH THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY 485 BROADWAY MAIL CODE 8838 REDWOOD CITY CA 94063 941156365 501(C)(3) 11626018 0 SCIENTIFIC AND MEDICAL RESEARCH THE ROCKEFELLER UNIVERSITY 1230 YORK AVE NEW YORK NY 10065 131624158 501(C)(3) 217471 0 SCIENTIFIC AND MEDICAL RESEARCH THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK 615 WEST 131ST ST MC 8741 NEW YORK NY 10027 135598093 501(C)(3) 1442193 0 SCIENTIFIC AND MEDICAL RESEARCH UNIVERSITY OF CALIFORNIA BERKELEY FOUNDATION 1995 UNIVERSITY AVE STE 401 BERKELEY CA 94704 946090626 501(C)(3) 200000 0 SCIENTIFIC AND MEDICAL RESEARCH UNIVERSITY OF CHICAGO 6054 S DREXEL AVE CHICAGO IL 60637 362177139 501(C)(3) 2868865 0 SCIENTIFIC AND MEDICAL RESEARCH UNIVERSITY OF ILLINOIS FOUNDATION 303 ST MARYS RD CHAMPAIGN IL 61820 376006007 501(C)(3) 2973388 0 SCIENTIFIC AND MEDICAL RESEARCH YALE UNIVERSITY PO BOX 208239 NEW HAVEN CT 06520 060646973 501(C)(3) 434943 0 SCIENTIFIC AND MEDICAL RESEARCH 10 PART I, LINE 2: WITH REGARD TO INVESTIGATOR AWARDS UNDER A MASTER COLLABORATION AGREEMENT WITH PARTNERED UNIVERSITIES, BIOHUB OBLIGATES THE USE OF THE GIFT FUNDS ONLY FOR THE PURPOSE FOR WHICH BIOHUB MAKES THE AWARDS. WE REQUIRE WRITTEN REPORTS CONCERNING THE RESEARCH DONE BY THE RECIPIENTS. THE FUNDS ARE PROVIDED TO THE UNIVERSITIES EMPLOYING THE RECIPIENTS AND THE UNIVERSITIES DISBURSE THE FUNDS ACCORDING TO THEIR POLICIES REGARDING BOTH PROPRIETY AND PROCESS (INCLUDING SUBSTANTIATION). FROM TIME TO TIME, BIOHUB MAY ALSO MAKE SMALL DISCRETIONARY GIFTS FOR RESEARCH AND SIMILAR PURPOSES DIRECTLY TO RECIPIENTS WITHOUT THE NEED FOR A WRITTEN PROPOSAL AND WITH LIMITED AND/OR WITHOUT A POST-GRANT REVIEW BY BIOHUB. X X X 0 0 0 0 0 0 0 1 0 JOSEPH DERISI DIRECTOR, PRESIDENT CZB SF (KEY EMP) 640453 0 260000 0 3612 0 30500 0 31430 0 965995 0 0 0 MATTHIAS HAURY COO/ACTING EXECUTIVE DIRECTOR, CZII 485915 0 364395 0 8844 0 30500 0 1498 0 891152 0 0 0 ANDREA CALIFANO PRESIDENT, CZB NY 605894 0 241200 0 9144 0 30500 0 4357 0 891095 0 0 0 SHANA KELLEY PRESIDENT, CZB CHICAGO 582363 0 234500 0 1932 0 30500 0 12959 0 862254 0 0 0 CLINTON POTTER FOUNDING TECHNICAL DIRECTOR, CZII 547636 0 221700 0 10668 0 30500 0 24866 0 835370 0 0 0 DAVID ANDREW AGARD FOUNDING TECHNICAL DIRECTOR, CZII 542736 0 221700 0 10712 0 30500 0 27066 0 832714 0 0 0 BRIDGET CARRAGHER FOUNDING TECHNICAL DIRECTOR, CZII 550013 0 221700 0 10668 0 30500 0 13559 0 826440 0 0 0 SANDRA L SCHMID CHIEF SCIENTIFIC OFFICER, CZB SF 527863 0 220440 0 11113 0 30500 0 13709 0 803625 0 0 0 MELINDA GRIFFITH SEC (THRU 1/29), COO & COUNS, CZB SF 510912 0 207100 0 15039 0 30500 0 18659 0 782210 0 0 0 VICTOR COLUNGA CFO & TREASURER (THRU 6/30) 221770 0 89583 0 4957 0 30500 0 13820 0 360630 0 0 0 STEPHEN QUAKE PRESIDENT & DIRECTOR 200000 0 101200 0 1806 0 0 0 0 0 303006 0 0 0 PART I, LINE 7 INCENTIVE COMPENSATION WAS PROVIDED TO CERTAIN PERSONS LISTED ON FORM 990, PART VII. INCENTIVE COMPENSATION WAS PAID BASED ON A FIXED PERCENTAGE OF BASE COMPENSATION, PLUS AN ADDITIONAL DISCRETIONARY PERCENTAGE SUBJECT TO BOARD APPROVAL. CHAN ZUCKERBERG INITIATIVE LLC (CZI LLC) CZI LLC IS AN ENTITY MANAGED BY DIRECTORS MARK ZUCKERBERG & PRISCILLA CHAN 456631 RENT AND COMMON AREA MAINTENANCE FEES WERE PAID BY CZI LLC TO BIOHUB. ALL FEES WERE ESTABLISHED AT FAIR MARKET VALUE. 0 FORM 990, PART VI, SECTION A, LINE 2 DIRECTORS PRISCILLA CHAN AND MARK ZUCKERBERG HAVE A FAMILY RELATIONSHIP. FORM 990, PART VI, SECTION A, LINE 7A CHAN ZUCKERBERG INITIATIVE LLC DESIGNATES ALL DIRECTORS OF THE BOARD. FORM 990, PART VI, SECTION B, LINE 11B FORM 990 IS PREPARED BY THE ORGANIZATION'S ACCOUNTING FIRM. A COPY IS PROVIDED TO EACH DIRECTOR AND COUNSEL FOR REVIEW BEFORE BEING FILED. FORM 990, PART VI, SECTION B, LINE 12C THE CONFLICT OF INTEREST POLICY APPLIES TO BIOHUB AND ALL DISREGARDED ENTITIES. EACH COVERED PERSON MUST DISCLOSE IN WRITING TO THE CHIEF CONFLICTS OFFICER EACH OF HIS OR HER CONFLICTS OF INTEREST, INCLUDING FINANCIAL INTERESTS, WHEN THEY JOIN THE COMPANY. TO ENSURE THAT POTENTIAL CONFLICTS OF INTEREST AND CONFLICTS OF COMMITMENT ARE DISCLOSED, EACH COVERED PERSON IS REQUIRED TO UPDATE THEIR DISCLOSURE EACH YEAR AND PERIODICALLY THROUGHOUT THE YEAR AT ANY TIME WHEN HIS OR HER PREVIOUSLY DISCLOSED FINANCIAL INTERESTS CHANGE OR A NEW POTENTIAL CONFLICT OF COMMITMENT OR CONFLICT OF INTEREST ARISES. IN ADDITION, CERTAIN EMPLOYEES AT THE LEVEL OF GROUP OR PLATFORM LEADER OR ABOVE ARE REQUIRED TO FILE UPDATED DISCLOSURE STATEMENTS EACH YEAR. THE BOARD OF DIRECTORS ("THE BOARD") APPROVED THE CONFLICT OF COMMITMENT AND CONFLICT OF INTEREST POLICY FOR THE COMPANY, WHICH OUTLINES THE MECHANISMS FOR IMPLEMENTING THE POLICY. THE BOARD, OR A CONFLICTS COMMITTEE DESIGNATED BY THE BOARD, AND A CHIEF CONFLICTS OFFICER APPOINTED BY THE BOARD IS RESPONSIBLE FOR INTERPRETING BOTH CONFLICTS OF COMMITMENT AND CONFLICTS OF INTEREST UNDER THE POLICY. THE PRIMARY RESPONSIBILITY OF THE CHIEF CONFLICTS OFFICER OR THE CONFLICTS COMMITTEE IS DETERMINING WHETHER A CONFLICT OF COMMITMENT OR CONFLICT OF INTEREST EXISTS AND, IF SO, WHETHER THE PROPOSED ACTIVITY OR THE TRANSACTION OR ARRANGEMENT GIVING RISE TO THE CONFLICT IS IN THE BEST INTERESTS OF BIOHUB AND CAN PROCEED IN A MANNER THAT PROTECTS BIOHUB'S FINANCIAL, SCIENTIFIC AND REPUTATIONAL INTERESTS. WHEN A COVERED PERSON DISCLOSES AN ACTUAL OR POTENTIAL CONFLICT OF COMMITMENT OR CONFLICT OF INTEREST UNDER THIS POLICY, THE CHIEF CONFLICTS OFFICER, THE BOARD, OR THE CONFLICTS COMMITTEE, AS REQUIRED UNDER THE POLICY, WILL FOLLOW THE REVIEW PROCEDURES OUTLINED IN THE POLICY. A COVERED PERSON MAY NOT ENGAGE IN ANY ACTIVITY THAT GIVES RISE TO A CONFLICT OF COMMITMENT OR A CONFLICT OF INTEREST WITHOUT RECEIVING THE APPROVAL(S) REQUIRED IN THIS POLICY. WITH RESPECT TO ANY CONFLICT OF INTEREST, THE COVERED PERSON WILL BE RECUSED FROM ALL DECISIONS INVOLVING THE ACTIVITY GIVING RISE TO THE CONFLICT, AND THE CHIEF CONFLICTS OFFICER, THE BOARD, OR A COMMITTEE DESIGNED BY THE BOARD WILL DETERMINE WHETHER TO PROCEED WITH THE ACTIVITY NOTWITHSTANDING THE CONFLICT. IF THE COVERED PERSON INVOLVED IN THE POTENTIAL OR ACTUAL CONFLICT UNDER REVIEW IS AN OFFICER OR DIRECTOR OF BIOHUB, THE CONFLICT REVIEW PROCEDURES WILL BE PERFORMED BY THE DISINTERESTED MEMBERS OF THE CONFLICTS COMMITTEE, ASSISTED BY THE CHIEF CONFLICTS OFFICER, AND IF REVIEWED BY THE CONFLICTS COMMITTEE, IT MAY REFER THE CONFLICT TO THE DISINTERESTED MEMBERS OF THE BOARD FOR FINAL REVIEW. IF REQUESTED BY THE BOARD OR COMMITTEE, IT MAY BE REFERRED TO OUTSIDE COUNSEL. FORM 990, PART VI, SECTION B, LINE 15 THE BOARD OF DIRECTORS AND EXECUTIVE COMMITTEE OF THE BOARD REVIEW AND APPROVE THE COMPENSATION OF BIOHUB'S CO-PRESIDENTS AND OFFICERS. THE PROCESS INCLUDES A REVIEW OF THE COMPENSATION AGAINST COMPARABILITY DATA SURVEY PROVIDED PERIODICALLY BY AN INDEPENDENT COMPENSATION SERVICE. THE APPROVAL PROCESS IS DOCUMENTED CONTEMPORANEOUSLY. THE MOST RECENT COMPARABILITY DATA STUDY WAS COMPLETED IN 2022. FORM 990, PART VI, SECTION C, LINE 19 THE ORGANIZATION'S GOVERNING DOCUMENTS, CONFLICT OF INTEREST POLICY AND FINANCIAL STATEMENTS ARE MADE AVAILABLE TO THE PUBLIC UPON REQUEST WHEN REQUIRED BY FEDERAL OR STATE LAW. FORM 990, PART VI, SECTION B, LINES 13 & 14: THE WHISTLEBLOWER POLICY AND WRITTEN RETENTION AND DESTRUCTION POLICY APPLY TO BIOHUB AND ALL DISREGARDED ENTITIES. FORM 990, PART VII, SECTION A, COLUMN B: WHERE 40 HOURS IS LISTED AS HOURS OF SERVICE IN RESPECT OF AN INDIVIDUAL, THIS IS BASED ON AN ESTIMATED FULL-TIME WORK WEEK. ACTUAL HOURS DEVOTED BY THE INDIVIDUAL MAY VARY SIGNIFICANTLY, AND MAY EXCEED THE 40 HOUR ESTIMATE. FORM 990, PART VII, SECTION A, LINE 1A(1): NO DIRECTORS OF BIOHUB ARE COMPENSATED IN THEIR CAPACITY AS DIRECTORS. IN 2024 JOSEPH DERISI WAS COMPENSATED IN HIS CAPACITY AS PRESIDENT OF CZ BIOHUB SF LLC, A DISREGARDED ENTITY OF BIOHUB, AND SHOULD BE CLASSIFIED AS A KEY EMPLOYEE OF BIOHUB BASED ON FORM 990 INSTRUCTIONS. AS FORM 990 INSTRUCTIONS DICTATE THAT AN INDIVIDUAL CAN NOT BE REPORTED AS BOTH DIRECTOR AND KEY EMPLOYEE, JOSEPH DERISI IS REPORTED AS AN OFFICER SOLELY TO REFLECT HIS OFFICER POSITION AT THE DISREGARDED ENTITY. FORM 990, PART VII, SECTION A, COLUMN E: COMPENSATION HAS BEEN PAID TO OFFICERS LISTED ON PART VII BY AN ENTITY THAT IS NOT LISTED AS A "RELATED ORGANIZATION" ON SCHEDULE R. ALL SERVICES OF THE OFFICERS WERE DONATED FREE OF CHARGE TO BIOHUB, AND NO DEDUCTION WAS SOUGHT FOR SUCH DONATION. FORM 990, PART VIII, LINE 1: FORM 990 PART VIII LINE 1 REPORTS NEGATIVE CONTRIBUTION REVENUE ON LINE 1F AS A RESULT OF APPLYING THE ACCOUNTING RULES WITH RESPECT TO (I) PRIOR YEAR PLEDGES MADE BY ONE DONOR AND (II) CURRENT YEAR FULFILMENT OF PLEDGES BY A SECOND DONOR-AS PROVIDED FOR UNDER THE PLEDGE AGREEMENT. IN ORDER TO ACCURATELY REPORT ALL DONOR CONTRIBUTIONS, THE TOTAL CONTRIBUTIONS REPORTED ON SCHEDULE B ARE GREATER THAN TOTAL CONTRIBUTION REVENUE ON LINE 1H, RESULTING IN THE PRESENTATION OF NEGATIVE CONTRIBUTION REVENUE. 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OPERATIONALLY THESE ENTITIES DO NOT CONTROL EACH OTHER AND ARE SEPARATELY GOVERNED. FORM 990, SCHEDULE R, PART IV META PLATFORMS INC IS REPORTED AS A "RELATED ORGANIZATION" FOR IRS FORM 990 REPORTING PURPOSES THROUGH ITS COMMON RELATIONSHIP WITH A MANAGER OF CZI LLC'S MEMBER. META AND THE FILING ORGANIZATION ARE OPERATIONALLY UNRELATED AND SEPARATELY GOVERNED. ONE OF THE MANAGERS OF CZI LLC'S MEMBER ALSO HAS A CONTROLLING INTEREST IN SEVERAL PERSONAL PASSIVE INVESTMENT VEHICLES THAT HAVE NO RELATIONSHIP WITH THE ENTITIES REPORTED ON SCHEDULE R.