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      <CompensationSurveyInd>X</CompensationSurveyInd>
      <BoardOrCommitteeApprovalInd>X</BoardOrCommitteeApprovalInd>
      <SeverancePaymentInd>0</SeverancePaymentInd>
      <SupplementalNonqualRtrPlanInd>0</SupplementalNonqualRtrPlanInd>
      <EquityBasedCompArrngmInd>0</EquityBasedCompArrngmInd>
      <CompBasedOnRevenueOfFlngOrgInd>0</CompBasedOnRevenueOfFlngOrgInd>
      <CompBsdOnRevRelatedOrgsInd>0</CompBsdOnRevRelatedOrgsInd>
      <CompBsdNetEarnsFlngOrgInd>0</CompBsdNetEarnsFlngOrgInd>
      <CompBsdNetEarnsRltdOrgsInd>0</CompBsdNetEarnsRltdOrgsInd>
      <AnyNonFixedPaymentsInd>0</AnyNonFixedPaymentsInd>
      <InitialContractExceptionInd>0</InitialContractExceptionInd>
      <SupplementalInformationDetail>
        <FormAndLineReferenceDesc>FORM 990 PART VII, SECTION A, QUESTION 5</FormAndLineReferenceDesc>
        <ExplanationTxt>DAVID JOHNSON, WHO IS BOTH DIRECTOR AND OFFICER OF IBRI, ALSO IS THE PRESIDENT AND CEO OF CICP FOUNDATION, INC. AS NOTED IN AN EARLIER RESPONSE, CICP FOUNDATION PROVIDE EARLY STAGE OPERATIONAL SUPPORT AND OVERSIGHT AT NO COST TO IBRI.</ExplanationTxt>
      </SupplementalInformationDetail>
    </IRS990ScheduleJ>
    <IRS990ScheduleO documentId="RetDoc1044400001">
      <SupplementalInformationDetail>
        <FormAndLineReferenceDesc>FORM 990, PART VI, SECTION A, LINE 3</FormAndLineReferenceDesc>
        <ExplanationTxt>CICP FOUNDATION, INC. THROUGH ITS BIOCROSSROADS STAFF, PROVIDED EARLY STAGE OPERATIONAL SUPPORT AND OVERSIGHT AT NO COST TO IBRI. INDIVIDUALS INVOLVED IN SUCH SUPPORT INCLUDED BOTH BIOCROSSROADS EMPLOYEES AND OUTSIDE CONSULTANTS PAID FOR BY CICP FOUNDATION.</ExplanationTxt>
      </SupplementalInformationDetail>
      <SupplementalInformationDetail>
        <FormAndLineReferenceDesc>FORM 990, PART VI, SECTION B, LINE 11</FormAndLineReferenceDesc>
        <ExplanationTxt>IBRI'S TAX RETURN WAS PREPARED BY AN INDEPENDENT ACCOUNTING FIRM AND REVIEWED BY IBRI'S LEGAL COUNSEL. THEN A SUBSTANTIALLY COMPLETED FORM WAS PRESENTED TO THE FULL BOARD OF DIRECTORS FOR REVIEW AND COMMENT PRIOR TO ITS FILING WITH THE INTERNAL REVENUE SERVICE.</ExplanationTxt>
      </SupplementalInformationDetail>
      <SupplementalInformationDetail>
        <FormAndLineReferenceDesc>FORM 990, PART VI, SECTION B, LINE 12C</FormAndLineReferenceDesc>
        <ExplanationTxt>IT IS THE POLICY OF THE BOARD OF DIRECTORS OF IBRI THAT IBRI'S DIRECTORS, OFFICERS, AND EMPLOYEES CARRY OUT THEIR RESPECTIVE ROLES WITH IBRI IN A FASHION THAT AVOIDS ACTUAL, POTENTIAL, OR PERCEIVED CONFLICTS</ExplanationTxt>
      </SupplementalInformationDetail>
      <SupplementalInformationDetail>
        <FormAndLineReferenceDesc>FORM 990, PART VI, SECTION B, LINE 15</FormAndLineReferenceDesc>
        <ExplanationTxt>COMPARABILITY DATA IS USED IN MAKING COMPENSATION DECISIONS MOVING FORWARD.</ExplanationTxt>
      </SupplementalInformationDetail>
      <SupplementalInformationDetail>
        <FormAndLineReferenceDesc>FORM 990, PART VI, SECTION C, LINE 19</FormAndLineReferenceDesc>
        <ExplanationTxt>IBRI HAS A COMMUNITY ENGAGEMENT COMMITTEE THAT MEETS THROUGHOUT THE YEAR FOR MATTERS RELATING TO THE ORGANIZATION INCLUDING GOVERNANCE. POLICIES ARE AVAILABLE ON THE WEBSITE. ANNUAL TAX RETURNS ARE AVAILABLE FROM THE COMPANY UPON WRITTEN REQUEST.</ExplanationTxt>
      </SupplementalInformationDetail>
    </IRS990ScheduleO>
  </ReturnData>
</Return>