2013-06-28T12:16:15-05:00 2012-12-31 042571780 ALEXANDER ARONSON FINNING & CO PC 21 EAST MAIN STREET WESTBORO MA 01581 990 2012-01-01 043462719 ALS THERAPY DEVELOPMENT FOUNDATION INC D/B/A ALS THERAPY DEVELOPMENT INSTITUTE ALST 6174417200 300 TECHNOLOGY SQUARE NO 400 CAMBRIDGE MA 02139 STEVE PERRIN 6174417200 2013-06-26 1 JEFFREY CICOLINI CPA P00837468 5083669100 2013-06-25 2012 2016-02-24 21:20:13Z STEVE PERRIN 300 TECHNOLOGY SQUARE NO 400 CAMBRIDGE MA 02139 12445369 0 1 X WWW.ALS.NET X 1999 MA ALS TDI FOLLOWS THE U.S. GAAP STANDARDS FOR ACCOUNTING FOR UNCERTAINTY IN INCOME TAXES, WHICH REQUIRES ALS TDI TO REPORT ANY UNCERTAIN TAX POSITIONS AND TO ADJUST ITS FINANCIAL STATEMENTS FOR THE IMPACT THEREOF. AS OF DECEMBER 31, 2012, ALS TDI DETERMINED THAT IT HAD NO MATERIAL UNRECOGNIZED TAX BENEFITS TO REPORT. ALS TDI FILES INFORMATION RETURNS IN THE UNITED STATES FEDERAL AND VARIOUS STATE JURISDICTIONS. THESE RETURNS ARE GENERALLY SUBJECT TO EXAMINATION BY INTERNAL REVENUE SERVICE AND THE RESPECTIVE STATE TAX AUTHORITIES FOR THE LAST THREE YEARS. 13 12 57 625 0 0 6444164 11018319 743150 273960 15882 70907 782346 205876 7985542 11569062 0 0 0 0 3712121 4426612 0 0 829167 4018958 5279615 7731079 9706227 254463 1862835 5421510 7256370 675469 647494 4746041 6608876 X OUR MISSION IS TO IDENTIFY VIABLE TARGETS FOR THERAPY DEVELOPMENT AND EXPEDITIOUSLY MANAGE THE CREATION OF THOSE TREATMENTS THAT WILL ARREST THE SUFFERING OF TODAY'S ALS PATIENTS. 0 0 8449928 273960 THE ALS THERAPY DEVELOPMENT INSTITUTE SUCCESSFULLY SCREENED A TOTAL OF 20 POTENTIAL TREATMENTS FOR ALS IN 2012. IN FEBRUARY 2012 IT ANNOUNCED A NEW LEAD CANDIDATE IN TDI-132 (GILENYA) AND RAISED $1 MILLION IN 2012 FOR CLINICAL TRIAL TO OCCUR IN 2013. IN MARCH IT MOVED TO THE LARGEST RESEARCH FACILITY IN CAMBRIDGE, MASSACHUSETTS, ADDING ALMOST 10,000 SQ/FT TO ITS LABORATORIES WHICH ENABLED IT TO INCREASE ITS IN VIVO AND IN VITRO VALIDATION CAPABILITIES GREATLY. THE INSTITUTE ENTERED INTO AND COMPLETED SIGNIFICANT ADDITIONAL EXPERIMENTS AS PART OF A RESEARCH AGREEMENT WITH BIOGEN IDEC AND UCB PHARMA ON SECOND CANDIDATE THERAPEUTIC KNOWN AS TDI-846. ALS TDI ALSO ENTERED INTO PARTNERSHIP WITH SWISS BIOTECH, NUEROTUNE AG, ON POTENTIAL TREATMENTS FOR ALS AND A PARTNERSHIP WITH DUTCH BIOTECH, REGENESANCE BV, ON POTENTIAL TREATMENTS FOR ALS; BOTH IN MAY 2012. THE INSTITUTE ALSO COMPLETED THE CHARACTERIZATION PROJECT OF BALOH TDP-43 MOUSE MODEL OF NEURODEGENERATION AS WELL AS THE LOA MOUSE, AND IN-LICENSED TWO ADDITIONAL MODELS FOR FURTHER STUDY. 8449928 1 1 0 1 0 0 0 0 0 0 1 0 0 0 0 1 1 0 0 0 0 0 0 0 1 0 0 0 0 1 0 0 0 0 0 0 0 0 1 0 0 0 0 0 0 0 0 1 27 0 1 57 1 0 0 0 0 0 1 1 0 0 0 0 X 13 12 1 0 0 0 0 0 0 1 1 0 0 1 1 1 1 1 1 1 1 0 AZ CA IL IN X X X INSOURCE SERVICES INC 7812351490 148 LINDEN STREET WELLESLEY MA 02482 DR STANLEY H APPEL MD 2.50 X 0 0 0 ALEXANDER CAPPELLO 2.50 X 0 0 0 SPIROS JAMAS EDD 2.50 X 0 0 0 KEITH MELANSON 2.50 X 0 0 0 LESLIE D MICHELSON 2.50 X 0 0 0 JOHN B HEYWOOD PHD 2.50 X 0 0 0 AUGIE NIETO 2.50 X X 0 0 0 ROB RODIN 2.50 X 0 0 0 JOHN SUTHERLAND 2.50 X 0 0 0 STEVEN PERRIN 40.00 X X 384252 0 17781 JAMES ALLEN HEYWOOD 2.50 X 0 0 0 THEODORE REICH JD CPA 2.50 X X 0 0 0 STEVEN FOWLER 2.50 X 0 0 0 ALAN GILL 40.00 X 153000 0 17591 JOHN LINCECUM 40.00 X 145961 0 14459 BASHAR AL-NAKHALA 40.00 X 121900 0 17513 VLADIMIR MOROZOV 40.00 X 120750 0 16214 PATRICIA TANKSI 40.00 X 170000 0 7352 1095863 0 90910 6 0 1 0 INSOURCE SERVICES INC PO BOX 427 NEWTON UPPER FALLS MA 02464 BOOKKEEPING & FINANCE & HR & IT 346714 THE RICHMOND GROUP 77 MAIN ST HOPKINTON MA 01748 LEASEHOLD IMPROVEMENTS 272010 J DAVID GLADSTONE INSTITUTE 1650 OWENS ST SAN FRANCISCO CA 94158 CONTRACT RESEARCH - SCIENCE 195308 CAPITOL PARTNERS INC 1101 17TH STREET NW SUITE 202 WASHINGTON DC MD 20036 LEGISLATIVE SUPPORT 138913 4 2830576 8187743 109842 11018319 PHARMECEUTICAL CONTRAC 541700 273960 273960 273960 70907 70907 1082183 2830576 876307 205876 205876 11569062 273960 0 276783 402033 344295 13992 43746 3369977 2886004 117281 366692 30811 26502 1049 3260 337166 289182 10099 37885 286625 246606 8982 31037 115898 115898 27839 27839 585906 362618 19903 203385 110649 106117 1467 3065 245283 213771 5898 25614 1760471 1677601 77045 5825 160359 134846 3056 22457 125822 114863 1723 9236 7569 7569 237294 202999 7462 26833 TESTING AND LAB EXPENSE 1770809 1770809 MISCELLANEOUS 75226 20772 10071 44383 PROGRAM SUPPLIES 39521 34479 5042 DUES AND SUBSCRIPTIONS 16969 10895 325 5749 9706227 8449928 427132 829167 1393910 2482395 1750374 1044907 1515000 2981555 239120 49000 58276 65452 2320928 1763938 376351 556990 324 50500 76071 37655 0 5421510 7256370 511289 596889 164180 50605 675469 647494 X 4746041 4527321 0 2081555 4746041 6608876 5421510 7256370 1862835 0 X X 0 1 X 1 0 X 10863117 8455858 6927606 6444164 8936764 41627509 10863117 8455858 6927606 6444164 8936764 41627509 3372844 38254665 55426 48591 30729 15882 70907 221535 463548 310601 704819 782346 205876 2467190 44316234 148000 0.86320 0.90080 X RESTRICTED RESTRICTED RESTRICTED RESTRICTED RESTRICTED RESTRICTED RESTRICTED RESTRICTED 34728 34728 9671499 9706227 635311 158828 0 0 559008 521962 536554 635311 2252835 3379253 45000 50645 37902 34728 168275 139752 130491 134139 158828 563210 844815 375683 55571 320112 1945245 1708367 236878 556990 X 11593922 24860 24860 11569062 0 11569062 9731087 24860 24860 9706227 0 9706227 DESCRIPTION OF UNCERTAIN TAX POSITIONS UNDER FIN 48: PART X, LINE 2: ALS TDI FOLLOWS THE U.S. GAAP STANDARDS FOR ACCOUNTING FOR UNCERTAINTY IN INCOME TAXES, WHICH REQUIRES ALS TDI TO REPORT ANY UNCERTAIN TAX POSITIONS AND TO ADJUST ITS FINANCIAL STATEMENTS FOR THE IMPACT THEREOF. AS OF DECEMBER 31, 2012, ALS TDI DETERMINED THAT IT HAD NO MATERIAL UNRECOGNIZED TAX BENEFITS TO REPORT. ALS TDI FILES INFORMATION RETURNS IN THE UNITED STATES FEDERAL AND MASSACHUSETTS STATE JURISDICTIONS. THESE RETURNS ARE GENERALLY SUBJECT TO EXAMINATION BY INTERNAL REVENUE SERVICE, MASSACHUSETTS, CALIFORNIA, INDIANA, ILLINOIS, AND MICHIGAN TAX AUTHORITIES FOR THE LAST THREE YEARS. TRI STATE TREK 498069 466899 31170 31483 106636 WHITS COAT AFFAIR 481883 263233 218650 77111 16205 88 2932807 2100444 832363 644872 3912759 2830576 1082183 108594 767713 876307 205876 X 1 1 X X X X 0 0 0 0 0 0 0 0 0 STEVEN PERRIN 384252 0 0 0 0 0 0 0 17781 0 402033 0 0 0 ALAN GILL 153000 0 0 0 0 0 0 0 17591 0 170591 0 0 0 JOHN LINCECUM 145961 0 0 0 0 0 0 0 14459 0 160420 0 0 0 PATRICIA TANKSI 170000 0 0 0 0 0 0 0 7352 0 177352 0 0 0 PART I, LINE 1A THE CEO HAS VERBAL AUTHORIZATION TO FLY FIRST CLASS AT HIS DESCRETION. IN GENERAL, HE ONLY FLIES FIRST CLASS WHEN THE FLIGHT IS LONGER THAN 5 1/2 HRS. X 6 3300 SELLING PRICE X 4 24577 SELLING PRICE X DISCOUNTED INVOICE 9 19335 SELLING PRICE X AUCTION ITEMS 56 25124 SELLING PRICE X FUNDRAISING SUPPLIES 11 34318 SELLING PRICE X OTHER 3 3188 SELLING PRICE 0 1 0 FORM 990, PART VI, SECTION A, LINE 2 JAMES HEYWOOD, BOARD MEMBER (AND FORMER CEO), IS THE SON OF JOHN HEYWOOD, MEMBER OF THE BOARD OF DIRECTORS. FORM 990, PART VI, SECTION B, LINE 11 FORM 990 IS REVIEWED BY THE CHIEF FINANCIAL OFFICER AND THEN APPROVED BY THE BOARD OF DIRECTORS. FORM 990, PART VI, SECTION B, LINE 12C ALS TDI HAS A WRITTEN CONFLICT OF INEREST POLICY WHICH REQUIRES ANNUAL SIGNOFFS BY OFFICERS, DIRECTORS AND KEY EMPLOYEES. FORM 990, PART VI, SECTION B, LINE 15 THE PROCESS TO DETERMINE THE COMPENSATION OF THE PRESIDENT WAS LAST UNDERTAKEN AT THE END OF 2010 INTO EARLY 2011. THE PROCESS CONSISTED OF EVALUATING COMPARABLE DATA FOR FUNCTIONALLY SIMILAR POSITIONS AT SIMILAR ORGANIZATIONS, ALONG WITH THE REVIEW AND APPROVAL BY THE EXECUTIVE COMPENSATION COMMITTEE OF THE BOARD OF DIRECTORS WHICH IS COMPRISED OF INDEPENDENT MEMBERS. APPROVALS AND DISCUSSIONS WERE FORMALLY DOCUMENTED BY MEETING MINUTES FOR PRESENATION TO THE FULL BOARD FOR APPROVAL. QUESTION 15B: THE PROCESS TO ESTABLISH COMPENSATION OF OTHER OFFICERS AND KEY EMPLOYEES IS COMPLETED ON AN ANNUAL BASIS BY EVALUATING COMPARABLE DATA FOR FUNCTIONALLY SIMILAR POSITIONS AT SIMILAR ORGANIZATIONS, PRESENTING RECOMMENDATIONS TO THE EXECUTIVE COMPENSATION COMMITTEE OF THE BOARD OF DIRECTORS WHICH IS COMPRISED OF INDEPENDENT MEMBERS AND DOCUMENTING SUCH DISCUSSIONS IN THE BOARD MINUTES. FORM 990, PART VI, SECTION C, LINE 19 GOVERNING DOCUMENTS, CONFLICT OF INTEREST POLICY AND FINANCIAL STATEMENTS ARE MADE AVAILABLE ON THE ORGANIZATION'S WEB SITE. FINANCIAL STATEMENTS ARE ALSO AVAILABLE BY MAIL UPON REQUEST. FORM 990, PART XII, LINE 2C: DURING 2012, THE ORGANIZATION DID NOT CHANGE THE WAY IN WHICH ITS COMMITTEE ASSUMES RESPONSIBILITY FOR OVERSIGHT OF THE AUDIT, ITS FINANCIAL STATEMENTS AND SELECTION OF AN INDEPENDENT ACOUNTANT.