2012-05-15T14:42:31-07:00 2011-06-30 STACK & ASSOCIATES CPAS 600 W BROADWAY STE 3150 SAN DIEGO CA 921010908 990 2010-07-01 330903864 Vaccine Research Institute of San Diego VACC 8585813960 3030 Bunker Hill Street San Diego CA 92109 RICHARD BRANDT 2012-05-15 ROBERT STACK 6192313150 2010 2016-02-24 21:20:13Z X 3160539 false false X www.vrisd.org X CA DEVELOPMENT OF PRODUCTS TO TREAT AND/OR PREVENT VIRAL INFECTIONS & CERTAIN OTHER INFECTIOUS DISEASES. 3 2 26 0 2925657 3135707 0 1042 832 27500 24000 2954199 3160539 337409 450558 0 1430397 1443461 0 0 1240465 1246404 3008271 3140423 -54072 20116 521944 659740 567092 684772 -45148 -25032 X OUR MISSION IS SCIENTIFIC RESEARCH FOCUSING ON DEVELOPMENT OF PREVENTATIVE AND THERAPEUTIC TREATMENTS FOR BOTH INFECTIOUS (MALARIA, HEPATITIS B AND C, AND INFLUENZA) AND NON-INFECTIOUS DISEASES (CANCER AND CARDIOVASCULAR DISEASE). false false 889438 889438 CHRONIC HEPATITIS B INFECTION AND THERAPEUTIC VACCINES.PROGRESS ON CHARACTERIZATION OF A UNIQUE HBEAG-SPECIFIC, DN (DOUBLE NEGATIVE) TREG CELL POLUATION. CLINICAL STUDIES HAVE RECENTLY IMPLICATED REGULATORY T CELLS (TREGS) IN HBV PERSISTENCE. OUR STUDIES IN HBC/HBEAG X TCR-DOUBLE-TG MICE HAVE ALSO IDENTIFIED A NOVEL TREG CELL INDUCED BY THE SECRETORY HBEAG, BUT NOT BY THE HBCAG. SIGNIFICANT PROGRESS ON A CTL-MEDIATED LIVER INJURY MODEL USING GENE ARRAY AND QRT-PCR METHODS. TO EXPLAIN THE EMERGENCE OF HBEAG-NEGATIVE MUTANTS DURING CHRONIC INFECTION, WE HAVE DEVELOPED A MODEL OF LIVER INJURY AND UNEXPECTEDLY THE SAME CTLS TRANSFERRED INTO HBEAG-TG AND HBCAG-TG MICE ELICITED A MORE SEVERE LIVER INJURY OF A LONGER DURATION IN THE HBEAG-TG RECIPIENTS SUGGESTING THAT THE HBEAG-NEGATIVE MUTANT MAY REPRESENT A CTL ESCAPE MUTATION. CONTINUE DEVELOPMENT OF A THERAPEUTIC VACCINE FOR CHRONIC HBV INFECTION USING WHCAG HYBRID VLPS. OUR INNOVATIVE APPROACH IS TO USE THE WHCAG SPECIES VARIANT AS A VACCINE PLATFORM TO DELIVER NEUTRALIZING HBV-PRES B CELL EPITOPES. WE HAVE ALREADY DEMONSTRATED THAT WHCAG-PRES VLPS CIRCUMVENT HBV-SPECIFIC T CELL TOLERANCE. 699935 301484 699935 MALARIA-HYBRID-WHCAG VLPS CARRYING 2 CS-REPEAT B CELL EPITOPES AND 4 CS-NONREPEAT B CELL EPITOPES WERE PRODUCED, PURIFIED AND USED TO IMMUNIZE MICE. ALL CONSTRUCTS ELICITED HIGH LEVES OF ANTI-INSERT ANTIBODIES.THE HYBRID-WHCAG VLPS CARRYING CS-REPEAT B CELL EPITOPES CONFERRED 98.7% PROTECTION AGAINST A 10,000 HYBRID SPOROZOITE CHALLENGE, WHEREAS THE NON-REPEAT B CELL EPITOPES WERE MINIMALLY TO NON-PROTECTIVE. ALTHOUGH ANTI-CS NON-REPEAT ANTIBODIES BOUND DRY SPOROZOITES, VIABLE SPOROZOITES WERE NOT RECOGNIZED BY ANTI-CS NON-REPEAT ANTIBODES. THE CRYPTIC NATURE OF CS-NONREPEAT EPITOMES ON VIABLE SPOROZOITES MAY EXPLAIN HE LACK OF PROTECTION. COMPARING CS-REPEAT B CELL EPITOPES, ANTI-NANP ANTIBODIES WERE MORE PROTECTIVE THAN ANTI-NVDP ANTIBODIES. HUM CD4+ / CD8+ T CELL RECOGNITION SITES WERE ALSO INSERTED ONTO HYBRID-WHCAG VLPS (I.E. UTC, TH.3R, CS.T3) AND A VLP CONSTRUCT CONTAINING ALL 3 WELL CHARACTERIZED T CELL DOMAINS PRIMED MURINE CS-SPECIFIC T CELLS AS WELL AS WHCAG-SPECIFIC T CELLS. 409682 149074 409682 SALMONELLA GENES ASSOCIATED WITH COLOIZATION OF SPECIFIC HOSTS. THIS PROJECT HAS GENERATED A RESOURCE OF MUTANTS IN ALMOST EVERY PROTEIN CODING GENE IN THE PATHOGEN SALMONELLA. THIS RESOURCE IS BEING USED IN RESEARCH LABORATORIES WORLDWIDE TO UNDERSTAND HOW THIS ORGANISM INFECTS HUMANS AND DOMESTIC ANIMALS. BEYOND THE SCOPE OF THIS PROJECT, THE RESOURCE IS NOW ALSO BEING USED TO IMPROVE SALMONELLA AS A VECTOR FOR VACCINES AND FOR DELIVERING CANCER THERAPEUTICS. 839493 839493 2838548 true false false false false false false false false false true false false true true false true false false false false false false false false false false true false true false false false false false false true false false false false false false false false false true true true false false true 2 0 false 26 true false false false false false false false false false false false 0 false false false false false false false false false false false X 3 2 false false false false false false false true true false false false false true true true true true true true false false CA X Richard Brandt 8585813960 3030 Bunker Hill St Suite 203 San Diego CA 92109 TERRY DILLMAN 1.00 X 0 0 0 RICHARD BRANDT 40.00 X X 82846 0 6669 RANDY HORTON 1.00 X 0 0 0 MICHAEL MCCLELLAND 40.00 X X 143784 0 10260 JOYCE JONES 40.00 X X 83868 10154 5498 DAVID R MILICH PHD 40.00 X X 97853 104938 11997 408351 115092 34424 1 false true false 0 2954241 181466 3135707 0 832 832 0 0 24000 24000 24000 24000 0 0 0 0 0 3160539 24832 450558 450558 0 0 0 316726 265376 51350 0 855667 820859 34808 0 271068 251148 19920 0 0 4266 4266 0 0 0 0 81300 65041 16259 8952 8952 0 0 0 610102 488164 121938 5047 5047 0 0 0 0 3088 3088 22569 4514 18055 TELEPHONE 10304 8243 2061 SUPPLIES 232071 220467 11604 G&A 13511 13511 EQUIPMENT REPAIR AND MAINTENAN 13736 13736 DIRECT EXPENSE 224635 224635 16823 11808 5015 3140423 2838548 301875 0 67658 75535 286647 331296 67583 74764 91036 121813 0 0 0 0 0 113319 108058 8350 5261 0 0 0 0 670 51071 521944 659740 154510 182149 74815 74840 337767 427783 567092 684772 X -45148 -25032 -45148 -25032 521944 659740 20116 X false true true X true true X 1682734 1511045 1514979 2925657 3135707 10770122 0 0 1682734 1511045 1514979 2925657 3135707 10770122 0 10770122 309 11261 24003 28542 24833 88948 0 0 10859070 0.99180 0.99020 X 113319 108058 5261 5261 DEPOSITS 51071 51071 UNEARNED REVENUE 391225 DEFERRED RENT 36558 427783 3160539 3140423 20116 20116 3160539 3160539 3160539 3140423 3140423 3140423 Virginia CW University Stranger Hall Box 614 Richmond VA 23298 520595110 501(C)(3) 73549 0 RESEARCH GRANTS TEXAS A&M RESEARCH FD 400 HAVEY MITCHELL PKWAY COLLEGE STATION TX 77845 741238434 501(C)(3) 50119 0 RESEARCH GRANTS OHIO STATE UNIVERSITY 1960 KENNY ROAD COLUMBUS OH 43210 316401599 501(C)(3) 98955 0 RESEARCH GRANTS JOHN HOPKINS UNIV 615 N WOLFE ST STE E3630 BALTIMORE MD 21205 546001758 501(C)(3) 227935 0 RESEARCH GRANTS 4 0 false false false false false false false false false false MICHAEL MCCLELLAND 143784 7032 3228 154044 93276 DAVID R MILICH PHD 97853 104938 7788 4209 109850 104938 181779 MICHAEL MCCLELLAND X 100000 74840 false true true 74840 Form 990, Part VI, Line 19 Form 990, Part VI, Line 19: Other Organization Documents Publicly Available THE ORGANIZATIONAL DOCUMENTS OF THE ORGANIZATION WILL BE AVAILABLE (FOR INSPECTION OR COPYING) AT THE ORGANIZATION'S MAIN OFFICE DURING NORMAL BUSINESS HOURS.THE PUBLIC INSPECTION COPY OF THE ORGANIZATION'S FORM 990, FROM THE PREVIOUS THREE YEARS, WILL BE AVAILABLE (FOR INSPECTION OR COPYING) AT THE ORGANIZATION'S MAIN OFFICE DURING NORMAL BUSINESS HOURS.THE AUDITED FINANCIAL STATEMENTS WILL BE AVAILABLE (FOR INSPECTION OR COPYING) AT THE ORGANIZATION'S MAIN OFFICE DURING NORMAL BUSINESS HOURS.WHEN RESPONDING TO A PUBLIC INSPECTION REQUEST FOR ANY ORGANIZATIONAL DOCUMENT OR FORM 990 BY ANYONE, THE ORGANIZATION SHALL FULFILL SUCH REQUEST IN A TIMELY FASHION WITHOUT INQUIRING AS TO THE REASON FOR THE PUBLIC INSPECTION REQUEST. Form 990, Part VI, Line 15b Form 990, Part VI, Line 15b: Compensation Review and Approval Process for Officers and Key Employees SALARIES NOT TO EXCEED NEW HIRE CAP OF $197,700. SALARY INCREASES ARE VOTED ON BY THE BOARD OF DIRECTORS. Form 990, Part VI, Line 12c Form 990, Part VI, Line 12c: Explanation of Monitoring and Enforcement of Conflicts ALL BOARD MEMBERS MUST FILL OUT AN ANNUAL STATEMENT ON ANY POSSIBLE CONFLICT OF INTEREST. Form 990, Part VI, Line 11 Form 990, Part VI, Line 11: Form 990 Review Process THE CEO REVIEWS THE 990 PRIOR TO FILING. Form 990, Part III, Line 4d Form 990, Part III, Line 4d : Other Program Services Description OTHER PROGRAM SERVICES 4: PASS THROUGH RESEARCH - TEXAS A&M OTHER PROGRAM SERVICES 5: PASS THROUGH RESEARCH - VARIOUS UNIVERSITIES OTHER PROGRAM SERVICES 6: ALL OTHER PROGRAMS VLP BIOTECH INC 10835 ROAD TO THE CURE SUITE 150 SAN DIEGO CA 92121 200425548 BIOTECHNOLOGY CA NA C CORP true false false false false false false false true false false false false false false true false false VLP BIOTECH INC p 116806 Actual Costs VLP BIOTECH INC a 24000 square footage