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      <FollowSFAS117>X</FollowSFAS117>
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      <InfoInScheduleOPartXII>X</InfoInScheduleOPartXII>
      <MethodOfAccountingAccrual>X</MethodOfAccountingAccrual>
      <AccountantCompileOrReview>0</AccountantCompileOrReview>
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      <AuditCommittee>1</AuditCommittee>
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      <FederalGrantAuditRequired>0</FederalGrantAuditRequired>
    </IRS990>
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        <CurrentTaxYearMinus1Year>96994</CurrentTaxYearMinus1Year>
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      <Total509>
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        <CurrentTaxYearMinus1Year>1223661</CurrentTaxYearMinus1Year>
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      <AmtsRecdFromDisqualPersons>
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      <SupportFromDQPsEtc>
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      </SupportFromDQPsEtc>
      <PublicSupportTotal509>3677870</PublicSupportTotal509>
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        <CurrentTaxYearMinus2Years>1071</CurrentTaxYearMinus2Years>
        <CurrentTaxYearMinus1Year>634</CurrentTaxYearMinus1Year>
        <Total>7950</Total>
      </GrossInvestmentIncome509>
      <InvestmentIncomeAndUBTI>
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        <CurrentTaxYearMinus2Years>1071</CurrentTaxYearMinus2Years>
        <CurrentTaxYearMinus1Year>634</CurrentTaxYearMinus1Year>
        <Total>7950</Total>
      </InvestmentIncomeAndUBTI>
      <OtherIncome509>
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        <CurrentTaxYearMinus1Year>233</CurrentTaxYearMinus1Year>
        <CurrentTaxYear>1000</CurrentTaxYear>
        <Total>4358</Total>
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      <TotalSupportTotal>
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      <InvestmentIncomePercentage>0.00220</InvestmentIncomePercentage>
      <ThirtyThreePercntTestsCY509>X</ThirtyThreePercntTestsCY509>
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    <IRS990ScheduleB documentId="RetDoc1234500001">
      <ContributorInfo>
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        <ContributorNameBusiness>
          <BusinessNameLine1>RESTRICTED</BusinessNameLine1>
        </ContributorNameBusiness>
        <ContributorAddressUS>
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          <AddressLine2>RESTRICTED</AddressLine2>
          <City>RESTRICTED</City>
          <State>RESTRICTED</State>
          <ZIPCode>RESTRICTED</ZIPCode>
        </ContributorAddressUS>
        <AggregateContributions>RESTRICTED</AggregateContributions>
      </ContributorInfo>
    </IRS990ScheduleB>
    <IRS990ScheduleD documentId="RetDoc1040000001">
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      <TotalRevenue>887646</TotalRevenue>
      <TotalExpenses>852946</TotalExpenses>
      <ExcessOrDeficitForYear>34700</ExcessOrDeficitForYear>
      <ExcessOrDeficitPerFS>34700</ExcessOrDeficitPerFS>
      <TotRevenueEtcAuditedFinclStmt>887646</TotRevenueEtcAuditedFinclStmt>
      <RevenueNotRptdF990>0</RevenueNotRptdF990>
      <RevenueSubtotal>887646</RevenueSubtotal>
      <RevenueNotRptdOnFinStmt>0</RevenueNotRptdOnFinStmt>
      <TotalRevenuePerForm990>887646</TotalRevenuePerForm990>
      <TotExpensesEtcAuditedFinclStmt>852946</TotExpensesEtcAuditedFinclStmt>
      <ExpensesNotRptdF990>0</ExpensesNotRptdF990>
      <ExpensesSubtotal>852946</ExpensesSubtotal>
      <ExpensesNotRptdOnFinStmt>0</ExpensesNotRptdOnFinStmt>
      <TotalExpensesPerForm990>852946</TotalExpensesPerForm990>
      <Form990ScheduleDPartXIV>
        <Identifier>DESCRIPTION OF UNCERTAIN TAX POSITIONS UNDER FIN 48:</Identifier>
        <ReturnReference>PART X:</ReturnReference>
        <Explanation>THE SOCIETY IS EXEMPT FROM FEDERAL AND STATE INCOME TAXES UNDER SECTION 501(C)(3) OF THE INTERNAL REVENUE CODE. THE SOCIETY IS SUBJECT TO INCOME TAXES ON ITS UNRELATED BUSINESS INCOME. THERE WERE NO TAXES OWED FOR THE YEARS ENDED DECEMBER 31, 2011 AND 2010. THE SOCIETY HAS ADOPTED THE REQUIREMENTS FOR ACCOUNTING FOR UNCERTAIN TAX POSITIONS. THE SOCIETY DETERMINED THAT IT IS NOT REQUIRED TO RECORD A LIABILITY RELATED TO UNCERTAIN TAX POSITIONS FOR THE YEARS ENDED DECEMBER 31, 2011 AND 2010. THE FEDERAL AND STATE TAX RETURNS OF THE SOCIETY FOR 2008, 2009, AND 2010 ARE SUBJECT TO EXAMINATION BY THE INTERNAL REVENUE SERVICE AND STATE TAXING AUTHORITIES, GENERALLY FOR THREE YEARS AFTER THEY WERE FILED.</Explanation>
      </Form990ScheduleDPartXIV>
    </IRS990ScheduleD>
    <IRS990ScheduleI documentId="RetDoc1041900001">
      <RecordsMaintained>1</RecordsMaintained>
      <RecipientTable>
        <RecipientNameBusiness>
          <BusinessNameLine1>THE GENERAL HOSPITAL CORPORATION DBA MASSACHUSETTS GENERAL HOSPITAL</BusinessNameLine1>
        </RecipientNameBusiness>
        <AddressUS>
          <AddressLine1>55 FRUIT STREET</AddressLine1>
          <City>BOSTON</City>
          <State>MA</State>
          <ZIPCode>021142696</ZIPCode>
        </AddressUS>
        <EINOfRecipient>042697983</EINOfRecipient>
        <IRCSection>501(C)(3)</IRCSection>
        <AmountOfCashGrant>50000</AmountOfCashGrant>
        <PurposeOfGrant>ISEH AMGEN FELLOWSHIP</PurposeOfGrant>
      </RecipientTable>
      <Form990ScheduleIPartIII>
        <TypeOfGrant>TRAVEL AWARDS</TypeOfGrant>
        <NumberOfRecipients>22</NumberOfRecipients>
        <AmountOfCashGrant>26000</AmountOfCashGrant>
      </Form990ScheduleIPartIII>
      <Form990ScheduleIPartIII>
        <TypeOfGrant>NEW INVESTIGATOR AWARDS</TypeOfGrant>
        <NumberOfRecipients>4</NumberOfRecipients>
        <AmountOfCashGrant>2750</AmountOfCashGrant>
      </Form990ScheduleIPartIII>
      <Form990ScheduleIPartIV>
        <Identifier>PROCEDURE FOR MONITORING GRANTS IN THE U.S.:</Identifier>
        <ReturnReference>PART I, LINE 2:</ReturnReference>
        <Explanation>SCHEDULE I, PART I, LINE 2: THE TRAVEL AWARDS WERE REQUIRED TO HAVE PROOF THAT THE INDIVIDUAL TRAVELED TO THE CONFERENCE.</Explanation>
      </Form990ScheduleIPartIV>
    </IRS990ScheduleI>
    <IRS990ScheduleO documentId="RetDoc1044400001">
      <GeneralExplanation>
        <ReturnReference>FORM 990, PART VI, SECTION A, LINE 3</ReturnReference>
        <Explanation>THE ORGANIZATION HAS CONTRACTED WITH SMITHBUCKLIN CORPORATION TO PERFORM ALL MANAGEMENT FUNCTIONS.</Explanation>
      </GeneralExplanation>
      <GeneralExplanation>
        <ReturnReference>FORM 990, PART VI, SECTION A, LINE 6</ReturnReference>
        <Explanation>THE ORGANIZATION'S BY-LAWS PROVIDE FOR SIX CATEGORIES OF MEMBERSHIP; ACTIVE, ASSOCIATE, HONORARY, EMERITUS, AFFILIATE AND CORPORATE.</Explanation>
      </GeneralExplanation>
      <GeneralExplanation>
        <ReturnReference>FORM 990, PART VI, SECTION A, LINE 7A</ReturnReference>
        <Explanation>MEMBERS SHALL ELECT BY MAIL THE VICE-PRESIDENT, AND MEMBERS OF THE BOARD OF DIRECTORS TO REPLACE THOSE INDIVIDUALS TERMINATING THEIR TERMS OF OFFICE. THEY MAY ALSO BE REQUESTED TO VOTE ON OTHER MATTERS BROUGHT BEFORE THEM BY THE OFFICERS FOR ISSUES DEEMED TO BE CRUCIAL AND WHICH CANNOT WAIT UNTIL THE NEXT REGULAR MEETING OF THE MEMBERSHIP OR AT A GENERAL MEETING OF THE MEMBERSHIP.</Explanation>
      </GeneralExplanation>
      <GeneralExplanation>
        <ReturnReference>FORM 990, PART VI, SECTION B, LINE 11</ReturnReference>
        <Explanation>THE CLIENT MANAGER PERFORMS AN INITIAL REVIEW AND THE EXECUTIVE DIRECTOR PERFORMS A FINAL REVIEW.</Explanation>
      </GeneralExplanation>
      <GeneralExplanation>
        <ReturnReference>FORM 990, PART VI, SECTION B, LINE 12C</ReturnReference>
        <Explanation>THE PECUNIARY OF PERSONAL INTEREST, DIRECT OR INDIRECT, THROUGH A BUSINESS INTEREST OR AN INVESTMENT OR OF AN IMMEDIATE FAMILY MEMBER SHALL, IF KNOWN TO THE DIRECTOR, BE DEEMED TO BE ALSO THE PECUNIARY OF INTEREST OF THE DIRECTOR. EVERY DECLARATION OF INTEREST AND THE GENERAL NATURE OF THEROF SHALL BE RECORDED IN THE MINUTES OF THE MEETING.</Explanation>
      </GeneralExplanation>
      <GeneralExplanation>
        <ReturnReference>FORM 990, PART VI, SECTION C, LINE 19</ReturnReference>
        <Explanation>THE GOVERNING DOCUMENTS, POLICIES, AND FINANCIAL STATEMENTS ARE AVAILABLE TO THE PUBLIC UPON REQUEST.</Explanation>
      </GeneralExplanation>
      <GeneralExplanation>
        <ReturnReference>FORM 990, PART XI, LINE 2C</ReturnReference>
        <Explanation>THE ORGANIZATION DID NOT CHANGE ITS OVERSIGHT PROCESS DURING THE YEAR.</Explanation>
      </GeneralExplanation>
    </IRS990ScheduleO>
  </ReturnData>
</Return>