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      <FactsAndCircumstancesTest>THE FOUNDATION IS OPERATED FOR THE BENEFIT OF THE CANCER THERAPY AND RESEARCH CENTER (CTRC) PROGRAM AT THE UNIVERSITY OF TEXAS HEALTH SCIENCE CENTER. THE FOUNDATION HAS A BOARD WHICH IS REPRESENTATIVE OF THE GENERAL PUBLIC AND IS IN THE PROCESS OF ACTIVELY SOLICITING DONATIONS FROM THE GENERAL PUBLIC. ALL FUNDS RECEIVED BY THE FOUNDATION AND ITS EARNINGS FROM INVESTMENTS ARE UTILIZED FOR THE BENEFIT OF THE GENERAL POPULATION IN THE FIGHT AGAINST CANCER.</FactsAndCircumstancesTest>
      <GeneralExplanation>SCHEDULE A, PART IV, SUPPLEMENTAL INFORMATION: UNTIL DECEMBER 2007, THE ENTITY WAS A SUPPORTING ORGANIZATION OF THE CANCER THERAPY AND RESEARCH CENTER AND IS NOW IN THE TRANSITION TO EXPAND ITS FUND DEVELOPMENT FUNCTION IN SUPPORT OF THE CTRC PROGRAM AT THE UNIVERSITY OF TEXAS HEALTH SCIENCE CENTER.</GeneralExplanation>
    </IRS990ScheduleA>
    <IRS990ScheduleB documentId="RetDoc1234500001">
      <ContributorInfo>
        <ContributorNumber>RESTRICTED</ContributorNumber>
        <ContributorNameBusiness>
          <BusinessNameLine1>RESTRICTED</BusinessNameLine1>
        </ContributorNameBusiness>
        <ContributorAddressUS>
          <AddressLine1>RESTRICTED</AddressLine1>
          <AddressLine2>RESTRICTED</AddressLine2>
          <City>RESTRICTED</City>
          <State>RESTRICTED</State>
          <ZIPCode>RESTRICTED</ZIPCode>
        </ContributorAddressUS>
        <AggregateContributions>RESTRICTED</AggregateContributions>
      </ContributorInfo>
    </IRS990ScheduleB>
    <IRS990ScheduleD documentId="RetDoc1040000001">
      <CurrentYear>
        <BeginningOfYearBalance>21653893</BeginningOfYearBalance>
        <Contributions>500000</Contributions>
        <InvestmentEarningsOrLosses>-613371</InvestmentEarningsOrLosses>
        <GrantsOrScholarships>143294</GrantsOrScholarships>
        <OtherExpenditures>196749</OtherExpenditures>
        <AdministrativeExpenses>118399</AdministrativeExpenses>
        <EndOfYearBalance>21082080</EndOfYearBalance>
      </CurrentYear>
      <CurrentYearMinus1Year>
        <BeginningOfYearBalance>21026492</BeginningOfYearBalance>
        <Contributions>500000</Contributions>
        <InvestmentEarningsOrLosses>562838</InvestmentEarningsOrLosses>
        <GrantsOrScholarships>120558</GrantsOrScholarships>
        <OtherExpenditures>206652</OtherExpenditures>
        <AdministrativeExpenses>108227</AdministrativeExpenses>
        <EndOfYearBalance>21653893</EndOfYearBalance>
      </CurrentYearMinus1Year>
      <CurrentYearMinus2Years>
        <BeginningOfYearBalance>21250912</BeginningOfYearBalance>
        <InvestmentEarningsOrLosses>348180</InvestmentEarningsOrLosses>
        <GrantsOrScholarships>192684</GrantsOrScholarships>
        <OtherExpenditures>280711</OtherExpenditures>
        <AdministrativeExpenses>99205</AdministrativeExpenses>
        <EndOfYearBalance>21026492</EndOfYearBalance>
      </CurrentYearMinus2Years>
      <PermanentEndowmentEOYBalance>1.00000</PermanentEndowmentEOYBalance>
      <EndowmentsHeldByUnrelatedOrgs>1</EndowmentsHeldByUnrelatedOrgs>
      <EndowmentsHeldByRelatedOrgs>0</EndowmentsHeldByRelatedOrgs>
      <TotalOfBookValueLandBuildings>0</TotalOfBookValueLandBuildings>
      <OtherSecurities>
        <Description>BENEFICIAL INTEREST IN PERPETUAL TRUST</Description>
        <BookValue>3789358</BookValue>
        <MethodOfValuation>F</MethodOfValuation>
      </OtherSecurities>
      <OtherSecurities>
        <Description>MUTUAL FUNDS</Description>
        <BookValue>4989694</BookValue>
        <MethodOfValuation>F</MethodOfValuation>
      </OtherSecurities>
      <TotalOfBookValueSecurities>8779052</TotalOfBookValueSecurities>
      <TotalRevenue>3332864</TotalRevenue>
      <TotalExpenses>2887634</TotalExpenses>
      <ExcessOrDeficitForYear>445230</ExcessOrDeficitForYear>
      <NetUnrealizedGLOnInvestments>-2981141</NetUnrealizedGLOnInvestments>
      <TotalAdjustments>-2981141</TotalAdjustments>
      <ExcessOrDeficitPerFS>-2535911</ExcessOrDeficitPerFS>
      <Form990ScheduleDPartXIV>
        <Identifier>DESCRIPTION OF INTENDED USE OF ENDOWMENT FUNDS:</Identifier>
        <ReturnReference>PART V, LINE 4:</ReturnReference>
        <Explanation>ENDOWMENT FUNDS ARE TO BE USED FOR THE SUPPORT OF THE CTRC PROGRAM AT THE UNIVERSITY OF TEXAS HEALTH SCIENCE CENTER. THE INTEREST IN PERPETUAL TRUST IS HELD AND ADMINISTERED BY FROST BANK.</Explanation>
      </Form990ScheduleDPartXIV>
    </IRS990ScheduleD>
    <IRS990ScheduleI documentId="RetDoc1041900001">
      <RecordsMaintained>1</RecordsMaintained>
      <RecipientTable>
        <RecipientNameBusiness>
          <BusinessNameLine1>THE UNIVERSITY OF TEXAS HEALTH SCIENCE CENTER OF SAN ANTONIO (UTHSC)</BusinessNameLine1>
        </RecipientNameBusiness>
        <AddressUS>
          <AddressLine1>4502 MEDICAL DR</AddressLine1>
          <City>SAN ANTONIO</City>
          <State>TX</State>
          <ZIPCode>78229</ZIPCode>
        </AddressUS>
        <EINOfRecipient>741586031</EINOfRecipient>
        <IRCSection>STATE UNIVERSITY</IRCSection>
        <AmountOfCashGrant>2600000</AmountOfCashGrant>
        <PurposeOfGrant>TO ASSIST THE ENTITY WITH THE OPERATION OF THE CTRC PROGRAM AT THE UNIVERSITY OF TX HEALTH SCIENCE CTR.</PurposeOfGrant>
      </RecipientTable>
      <TotalNbrOf501C3AndGovtGrants>1</TotalNbrOf501C3AndGovtGrants>
      <TotalNbrOfOtherOrganizations>0</TotalNbrOfOtherOrganizations>
      <Form990ScheduleIPartIV>
        <Identifier>PROCEDURE FOR MONITORING GRANTS IN THE U.S.:</Identifier>
        <ReturnReference>PART I, LINE 2:</ReturnReference>
        <Explanation>SCHEDULE I, PART I, LINE 2: THE ENTITY IS AFFILIATED WITH THE ORGANIZATION IT SUPPORTS. FUNDS ARE DISTRIBUTED ON A PREDETERMINED BASIS TO SUPPORT THE MISSION AND PROGRAMS OF THE ORGANIZATION. THE ORGANIZATION REQUIRES AN ANNUAL ACCOUNTING AS TO HOW THE FUNDS ARE BEING UTILIZED.</Explanation>
      </Form990ScheduleIPartIV>
    </IRS990ScheduleI>
    <IRS990ScheduleO documentId="RetDoc1044400001">
      <GeneralExplanation>
        <Identifier>FORM 990, PART VI, SECTION B, LINE 11</Identifier>
        <Explanation>A DRAFT OF FORM 990 IS REVIEWED BY LEGAL COUNSEL AND SUBMITTED TO THE CHAIRMAN OF THE BOARD FOR APPROVAL. CHANGES IF NECESSARY ARE MADE BEFORE THE RETURN IS FILED.</Explanation>
      </GeneralExplanation>
      <GeneralExplanation>
        <ReturnReference>FORM 990, PART VI, SECTION B, LINE 12C</ReturnReference>
        <Explanation>THE BOARD REVIEWS ON AN ANNUAL BASIS WITH ITS DIRECTORS WHETHER ANY CONFLICT OF INTEREST EXISTS.</Explanation>
      </GeneralExplanation>
      <GeneralExplanation>
        <Explanation>THE ORGANIZATION DOES NOT HAVE COMPENSATED OFFICERS, DIRECTORS, OR KEY EMPLOYEES.</Explanation>
      </GeneralExplanation>
      <GeneralExplanation>
        <ReturnReference>FORM 990, PART VI, SECTION C, LINE 19</ReturnReference>
        <Explanation>THE ENTITY COMPLIES WITH THE REQUIREMENTS FOR PUBLIC INSPECTION AND MAKES ITS FORM 990 AND RELATED FINANCIAL INFORMATION AND POLICIES AVAILABLE TO THE PUBLIC UPON REQUEST.</Explanation>
      </GeneralExplanation>
      <GeneralExplanation>
        <Identifier>CHANGES IN NET ASSETS OR FUND BALANCES:</Identifier>
        <ReturnReference>FORM 990, PART XI, LINE 5:</ReturnReference>
        <Explanation>NET UNREALIZED LOSSES ON INVESTMENTS: -2,981,141.</Explanation>
      </GeneralExplanation>
    </IRS990ScheduleO>
    <IRS990ScheduleR documentId="RetDoc1043400001">
      <Form990ScheduleRPartI>
        <NameOfDisregardedEntity>
          <BusinessNameLine1>CTRC LLC</BusinessNameLine1>
        </NameOfDisregardedEntity>
        <AddressUS>
          <AddressLine1>7373 BROADWAY ST STE 500</AddressLine1>
          <City>SAN ANTONIO</City>
          <State>TX</State>
          <ZIPCode>78209</ZIPCode>
        </AddressUS>
        <PrimaryActivities>N/A</PrimaryActivities>
        <LegalDomicileState>TX</LegalDomicileState>
        <TotalIncome>0</TotalIncome>
        <EOYAssets>0</EOYAssets>
        <DirectControllingEntityName>
          <BusinessNameLine1>CANCER THERAPY AND RESEARCH CENTER FOUNDATION</BusinessNameLine1>
        </DirectControllingEntityName>
      </Form990ScheduleRPartI>
      <Form990ScheduleRPartII>
        <NameOfDisregardedEntity>
          <BusinessNameLine1>CANCER THERAPY AND RESEARCH CENTER</BusinessNameLine1>
        </NameOfDisregardedEntity>
        <AddressUS>
          <AddressLine1>7373 BROADWAY ST STE 500</AddressLine1>
          <City>SAN ANTONIO</City>
          <State>TX</State>
          <ZIPCode>78209</ZIPCode>
        </AddressUS>
        <EIN>742773755</EIN>
        <PrimaryActivities>HEALTHCARE</PrimaryActivities>
        <LegalDomicileState>TX</LegalDomicileState>
        <ExemptCodeSection>501(C)(3)</ExemptCodeSection>
        <PublicCharityStatus>PUBLIC CHARITY</PublicCharityStatus>
        <ControlledOrg>0</ControlledOrg>
      </Form990ScheduleRPartII>
      <Form990ScheduleRPartII>
        <NameOfDisregardedEntity>
          <BusinessNameLine1>UNIVERSITY OF TEXAS HEALTH SCIENCE CENTER AT SAN ANTONIO</BusinessNameLine1>
        </NameOfDisregardedEntity>
        <AddressUS>
          <AddressLine1>7703 FLOYD CURL DRIVE</AddressLine1>
          <City>SAN ANTONIO</City>
          <State>TX</State>
          <ZIPCode>78229</ZIPCode>
        </AddressUS>
        <EIN>741586031</EIN>
        <PrimaryActivities>HEALTHCARE</PrimaryActivities>
        <LegalDomicileState>TX</LegalDomicileState>
        <ExemptCodeSection>STATE UNIVERSITY</ExemptCodeSection>
        <PublicCharityStatus>GOVERNMENT ENTITY</PublicCharityStatus>
        <ControlledOrg>0</ControlledOrg>
      </Form990ScheduleRPartII>
      <ReceiptOfIntAnnRentsRoyalties>0</ReceiptOfIntAnnRentsRoyalties>
      <GiftGrantOrCapContrToOtherOrg>1</GiftGrantOrCapContrToOtherOrg>
      <GiftGrantOrCapContrFrOtherOrg>0</GiftGrantOrCapContrFrOtherOrg>
      <LoansOrGuaranteesToOtherOrg>0</LoansOrGuaranteesToOtherOrg>
      <LoansOrGuaranteesFromOtherOrg>0</LoansOrGuaranteesFromOtherOrg>
      <SaleOfAssetsToOtherOrg>0</SaleOfAssetsToOtherOrg>
      <PurchaseOfAssetsFromOtherOrg>0</PurchaseOfAssetsFromOtherOrg>
      <ExchangeOfAssets>0</ExchangeOfAssets>
      <RentalOfFacilitiesToOtherOrgs>0</RentalOfFacilitiesToOtherOrgs>
      <RentalOfFacilitiesFrOtherOrgs>0</RentalOfFacilitiesFrOtherOrgs>
      <PerformOfServicesForOtherOrgs>0</PerformOfServicesForOtherOrgs>
      <PerformOfServicesByOtherOrgs>0</PerformOfServicesByOtherOrgs>
      <SharingOfFacilities>0</SharingOfFacilities>
      <SharingOfPaidEmployees>0</SharingOfPaidEmployees>
      <ReimbursementPaidToOtherOrg>0</ReimbursementPaidToOtherOrg>
      <ReimbursementPaidByOtherOrg>0</ReimbursementPaidByOtherOrg>
      <OtherTransferToOtherOrg>0</OtherTransferToOtherOrg>
      <OtherTransferFromOtherOrg>0</OtherTransferFromOtherOrg>
    </IRS990ScheduleR>
  </ReturnData>
</Return>