2012-05-15T13:13:35-05:00 2011-12-31 042571780 ALEXANDER ARONSON FINNING & CO PC 21 EAST MAIN STREET WESTBORO MA 01581 990 2011-01-01 043462719 ALS THERAPY DEVELOPMENT FOUNDATION INC D/B/A ALS THERAPY DEVELOPMENT INSTITUTE ALST 6174417200 300 TECHNOLOGY SQUARE NO 400 CAMBRIDGE MA 02139 STEVE PERRIN 6174417200 2012-05-14 1 JEFFREY CICOLINI CPA P00837468 5083669100 2012-05-14 2011 2016-02-24 21:20:13Z X STEVE PERRIN 300 TECHNOLOGY SQUARE NO 400 CAMBRIDGE MA 02139 9539628 0 1 X WWW.ALS.NET X 1999 MA ALS TDI FOLLOWS THE U.S. GAAP STANDARDS FOR ACCOUNTING FOR UNCERTAINTY IN INCOME TAXES, WHICH REQUIRES ALS TDI TO REPORT ANY UNCERTAIN TAX POSITIONS AND TO ADJUST ITS FINANCIAL STATEMENTS FOR THE IMPACT THEREOF. AS OF DECEMBER 31, 2011, ALS TDI DETERMINED THAT IT HAD NO MATERIAL UNRECOGNIZED TAX BENEFITS TO REPORT. ALS TDI FILES INFORMATION RETURNS IN THE UNITED STATES FEDERAL AND VARIOUS STATE JURISDICTIONS. THESE RETURNS ARE GENERALLY SUBJECT TO EXAMINATION BY INTERNAL REVENUE SERVICE AND THE RESPECTIVE STATE TAX AUTHORITIES FOR THE LAST THREE YEARS. 12 9 56 900 0 0 6927606 6444164 0 743150 30729 15882 704819 782346 7663154 7985542 0 0 0 0 3720298 3712121 0 0 766753 3718935 4018958 7439233 7731079 223921 254463 5578935 5421510 1087357 675469 4491578 4746041 X OUR MISSION IS TO IDENTIFY VIABLE TARGETS FOR THERAPY DEVELOPMENT AND EXPEDITIOUSLY MANAGE THE CREATION OF THOSE TREATMENTS THAT WILL ARREST THE SUFFERING OF TODAY'S ALS PATIENTS. 0 0 6701511 743150 ALS TDI EXECUTED MORE THAN 45 DIFFERENT PROGRAMS IN 2011 ON A VARIETY OF DIFFERENT TARGETS THAT IT IDENTIFIED TO BE HIGHLY RELEVANT TO ALS DISEASE PROGRESSION. THESE PROGRAMS MOVED THROUGH VARIOUS POINTS OF THE DRUG DEVELOPMENT PIPELINE; FROM HIT OPTIMIZATION, IN VITRO ASSAY DEVELOPMENT AND VALIDATION, TO IN VIVO PHAMACOKINETICS AND PHARMACODYNAMICS, THROUGH EFFICACY STUDIES IN ALS ANIMAL MODELS. TWO OF THESE PROJECTS, TDI 846 AND TDI 132, WERE IDENTIFIED AS LEAD CANDIDATE THERAPEUTICS AND POSITIONED BY THE INSTITUTE FOR CLINICAL DEVELOPMENT. TDI 846 WAS PARTNERED WITH BIOGEN IDEC AND UCB PHARMA IN DECEMBER FOR CLINICAL DEVELOPMENT. TDI 132 WAS SLATED FOR ADVANCEMENT TO THE CLINIC INDEPENDENTLY IN 2012 AS WELL. THE INSTITUTE ALSO LAUNCHED A NEW WEBSITE IN 2012 WHICH INCREASED ITS SCIENTIFIC TRANSPARENCY, UPDATED ITS ONLINE ALS FORUM, AND CREATED A NEW ONLINE JOURNAL CALLED ALS TODAY WRITTEN BY SCIENTIFIC JOURNALISTS. IT COLLABORATED WITH MORE THAN A DOZEN ACADEMIC AND INDUSTRIAL PARTNERS ON THERAPEUTIC-AIMED PROJECTS. THESE AND OTHER ENDEAVORS LED BY ALS TDI WERE CRUCIAL ELEMENTS OF ADVANCING ITS MISSION TO DISCOVER AND DEVELOP EFFECTIVE TREATMENTS FOR ALS PATIENTS TODAY AS SOON AS POSSIBLE. 6701511 1 1 0 1 0 0 0 0 0 0 1 0 0 0 0 1 1 0 0 0 0 0 0 0 1 0 0 0 0 1 0 0 0 0 0 0 0 0 1 0 0 0 0 0 0 0 0 0 1 10 0 1 56 1 0 0 0 0 0 1 1 0 0 0 0 X 12 9 1 0 0 0 0 0 0 1 1 0 0 1 1 1 1 1 1 1 1 0 AZ CA IL IN X X X INSOURCE SERVICES INC 7812351490 148 LINDEN STREET WELLESLEY MA 02482 DR STANLEY H APPEL MD 2.50 X 0 0 0 ALEXANDER CAPPELLO 2.50 X 0 0 0 SPIROS JAMAS EDD 2.50 X 0 0 0 KEITH MELANSON 2.50 X 0 0 0 LESLIE D MICHELSON 2.50 X 0 0 0 JOHN B HEYWOOD PHD 2.50 X 0 0 0 AUGIE NIETO 2.50 X X 0 0 0 ROB RODIN 2.50 X 0 0 0 JOHN SUTHERLAND 2.50 X 0 0 0 STEVEN PERRIN 40.00 X X X 370604 0 17799 JAMES HEYWOOD 2.50 X 0 0 0 THEODORE REICH JD CPA 2.50 X X 0 0 0 ALAN GILL 40.00 X 149815 0 16829 JOHN LINCECUM 40.00 X 145962 0 14223 BASHAR AL-NAKHALA 40.00 X 121900 0 16751 VLADIMIR MOROZOV 40.00 X 120750 0 15642 FERNANDO VIEIRA 40.00 X 120723 0 15209 1029754 0 96453 6 0 1 0 INSOURCE SERVICES INC PO BOX 427 NEWTON UPPER FALLS MA 02464 BOOKKEEPING & FINANCE & HR & IT 343329 CAPITOL PARTNERS INC 1101 17TH STREET NW SUITE 202 WASHINGTON DC MD 20036 LEGISLATIVE SUPPORT 151610 2 1765475 119167 4559522 110063 6444164 PHARMECEUTICAL CONTRAC 541700 743150 743150 743150 15882 15882 2336432 1765475 1554086 782346 782346 7985542 743150 0 798228 388403 342230 11228 34945 2709250 2388373 76646 244231 25781 22923 701 2157 337357 294157 14075 29125 251330 221999 7196 22135 49959 49959 32768 32768 616591 353388 20820 242383 73514 69113 1559 2842 255383 218553 7753 29077 802268 757773 9951 34544 76768 48446 2089 26233 128906 109021 226 19659 22407 22407 380208 335376 10693 34139 TESTING AND LAB EXPENSE 1464919 1464919 MISCELLANEOUS 64463 8178 11997 44288 DUES AND SUBSCRIPTIONS 29983 27210 1778 995 PROGRAM SUPPLIES 20821 17445 3376 7731079 6701511 262815 766753 2534395 1393910 2088835 1750374 1515000 27393 239120 185240 58276 2181884 1805533 688611 376351 4840 324 11966 50500 37655 37655 5578935 5421510 710091 511289 377266 164180 1087357 675469 X 4491578 4746041 4491578 4746041 5578935 5421510 254463 0 X X 0 1 1 X 0 X 8055008 10863117 8455858 6927606 6444164 40745753 8055008 10863117 8455858 6927606 6444164 40745753 1488569 39257184 47936 55426 48591 30729 15882 198564 375625 463548 310601 704819 782346 2636939 43581256 1265250 0.90080 0.90500 X RESTRICTED RESTRICTED RESTRICTED RESTRICTED RESTRICTED RESTRICTED RESTRICTED RESTRICTED 37902 37902 7693177 7731079 536554 134139 0 0 665247 559008 521962 536554 2282771 3424157 46320 45000 50645 37902 179867 166312 139752 130491 134139 570694 856041 11389 11389 0 2165052 1788701 376351 5443 5443 0 376351 7985542 7731079 254463 254463 7997504 11962 11962 7985542 0 7985542 7743041 11962 11962 7731079 0 7731079 DESCRIPTION OF UNCERTAIN TAX POSITIONS UNDER FIN 48: PART X: ALS TDI FOLLOWS THE U.S. GAAP STANDARDS FOR ACCOUNTING FOR UNCERTAINTY IN INCOME TAXES, WHICH REQUIRES ALS TDI TO REPORT ANY UNCERTAIN TAX POSITIONS AND TO ADJUST ITS FINANCIAL STATEMENTS FOR THE IMPACT THEREOF. AS OF DECEMBER 31, 2011, ALS TDI DETERMINED THAT THEY HAD NO MATERIAL UNRECOGNIZED TAX BENEFITS TO REPORT. ALS TDI FILES INFORMATION RETURNS IN THE UNITED STATES FEDERAL AND MASSACHUSETTS STATE JURISDICTIONS. THESE RETURNS ARE GENERALLY SUBJECT TO EXAMINATION BY INTERNAL REVENUE SERVICE, MASSACHUSETTS, CALIFORNIA, INDIANA, ILLINOIS, AND MICHIGAN TAX AUTHORITIES FOR THE LAST THREE YEARS. TRI STATE TREK 572841 572841 91407 62187 COREY REICH GALA 500768 500768 28872 658 85 3028298 1765475 1262823 1370962 4101907 1765475 2336432 120279 1433807 1554086 782346 X 1 1 X X 0 0 0 0 0 0 0 0 0 STEVEN PERRIN 320604 0 50000 0 0 0 0 0 17799 0 388403 0 0 0 ALAN GILL 149815 0 0 0 0 0 0 0 16829 0 166644 0 0 0 JOHN LINCECUM 145962 0 0 0 0 0 0 0 14223 0 160185 0 0 0 PART I, LINE 1A THE CSO IS ALLOWED TO FLY BUSINESS CLASS OR FIRST CLASS WHEN FLYING COAST TO COAST. X 4 5775 SELLING PRICE X 5 1801 SELLING PRICE X DISCOUNTED INVOICE 6 3381 SELLING PRICE X AUCTION ITEMS 217 64915 SELLING PRICE X OTHER GOODS AND SUPPLIES 8 28919 SELLING PRICE X FUNDRAISING SUPPLIES 27 5272 SELLING PRICE 0 1 0 FORM 990, PART VI, SECTION A, LINE 2 JAMES HEYWOOD, BOARD MEMBER (AND FORMER CEO), IS THE SON OF JOHN HEYWOOD, MEMBER OF THE BOARD OF DIRECTORS. FORM 990, PART VI, SECTION B, LINE 11 FORM 990 IS REVIEWED BY THE CHIEF FINANCIAL OFFICER AND THEN APPROVED BY THE BOARD OF DIRECTORS. FORM 990, PART VI, SECTION B, LINE 12C ALS TDI HAS A WRITTEN CONFLICT OF INEREST POLICY WHICH REQUIRES ANNUAL SIGNOFFS BY OFFICERS, DIRECTORS AND KEY EMPLOYEES. FORM 990, PART VI, SECTION B, LINE 15 THE PROCESS TO DETERMINE THE COMPENSATION OF THE PRESIDENT WAS LAST UNDERTAKEN AT THE END OF 2010 INTO EARLY 2011. THE PROCESS CONSISTED OF EVALUATING COMPARABLE DATA FOR FUNCTIONALLY SIMILAR POSITIONS AT SIMILAR ORGANIZATIONS, ALONG WITH THE REVIEW AND APPROVAL BY THE EXECUTIVE COMPENSATION COMMITTEE OF THE BOARD OF DIRECTORS WHICH IS COMPRISED OF INDEPENDENT MEMBERS. APPROVALS AND DISCUSSIONS WERE FORMALLY DOCUMENTED BY MEETING MINUTES FOR PRESENATION TO THE FULL BOARD FOR APPROVAL. QUESTION 15B: THE PROCESS TO ESTABLISH COMPENSATION OF OTHER OFFICERS AND KEY EMPLOYEES IS COMPLETED ON AN ANNUAL BASIS BY EVALUATING COMPARABLE DATA FOR FUNCTIONALLY SIMILAR POSITIONS AT SIMILAR ORGANIZATIONS, PRESENTING RECOMMENDATIONS TO THE EXECUTIVE COMPENSATION COMMITTEE OF THE BOARD OF DIRECTORS WHICH IS COMPRISED OF INDEPENDENT MEMBERS AND DOCUMENTING SUCH DISCUSSIONS IN THE BOARD MINUTES. FORM 990, PART VI, SECTION C, LINE 19 GOVERNING DOCUMENTS, CONFLICT OF INTEREST POLICY AND FINANCIAL STATEMENTS ARE MADE AVAILABLE ON THE ORGANIZATION'S WEB SITE. FINANCIAL STATEMENTS ARE ALSO AVAILABLE BY MAIL UPON REQUEST. FORM 990, PART XII, LINE 2C: DURING 2011, THE ORGANIZATION DID NOT CHANGE THE WAY IN WHICH ITS COMMITTEE ASSUMES RESPONSIBILITY FOR OVERSIGHT OF THE AUDIT, ITS FINANCIAL STATEMENTS AND SELECTION OF AN INDEPENDENT ACOUNTANT.