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        <NontaxableBenefitsFilingOrg>11812</NontaxableBenefitsFilingOrg>
        <NontaxableBenefitsRelatedOrgs>0</NontaxableBenefitsRelatedOrgs>
        <TotalCompensationFilingOrg>472121</TotalCompensationFilingOrg>
        <TotalCompensationRelatedOrgs>0</TotalCompensationRelatedOrgs>
        <CompReportPrior990FilingOrg>0</CompReportPrior990FilingOrg>
        <CompReportPrior990RelatedOrgs>0</CompReportPrior990RelatedOrgs>
      </Form990ScheduleJPartII>
      <Form990ScheduleJPartIII>
        <ReturnReference>Part I, Line 1a</ReturnReference>
        <Explanation>The Scripps Research Institute travel policies permit business class travel on flights of more than three hours. First class travel is permitted on smaller aircraft if business class travel is not offered on these long-haul flights. TSRI's trustees serve without compensation. However, upon request, TSRI will reimburse trustees for the cost of accompanied travel if such reimbursement is necessary to obtain trustee participation at the meetings. Finally, TSRI has two campuses; one in La Jolla, CA and one in Jupiter, Florida. The President and CEO maintains a house in both locations. A housing allowance is provided for one of those locations.</Explanation>
      </Form990ScheduleJPartIII>
      <Form990ScheduleJPartIII>
        <ReturnReference>Part I, Line 4b:</ReturnReference>
        <Explanation>Richard Lerner, M.D. participated in a deferred compensation plan. No payments were made during the year. Total TSRI liability at 9/30/2010 was $5,636,000. Douglas Bingham participated in a supplemental executive retirement plan. No payments were made during the year. Liability at 9/30/2010 was $1,450,000.</Explanation>
      </Form990ScheduleJPartIII>
    </IRS990ScheduleJ>
    <IRS990ScheduleK documentId="RetDoc1053100001">
      <Form990ScheduleKPartI>
        <IssuerName>
          <BusinessNameLine1>See Schedule O</BusinessNameLine1>
        </IssuerName>
        <IssuerEIN>630304653</IssuerEIN>
        <CUSIPNumber>13033WRC9</CUSIPNumber>
        <DateIssued>2005-02-23</DateIssued>
        <IssuePrice>39547350</IssuePrice>
        <DescriptionOfPurpose>See Schedule O</DescriptionOfPurpose>
        <Defeased>0</Defeased>
        <OnBehalfOfIssuer>0</OnBehalfOfIssuer>
      </Form990ScheduleKPartI>
      <Form990ScheduleKPartII>
        <TotalProceeds>39547350</TotalProceeds>
        <AmountDefeased>22905721</AmountDefeased>
        <IssuanceCostsFromProceeds>641629</IssuanceCostsFromProceeds>
        <CapitalExpenditures>16000000</CapitalExpenditures>
        <YearOfSubstCompletion>2005</YearOfSubstCompletion>
        <CurrentRefunding>1</CurrentRefunding>
        <AdvanceRefunding>0</AdvanceRefunding>
        <FinalAllocationMade>1</FinalAllocationMade>
        <AdequateBooksAndRecdsMaintaind>1</AdequateBooksAndRecdsMaintaind>
      </Form990ScheduleKPartII>
      <Form990ScheduleKPartIII>
        <OwningBondFinancedProperty>0</OwningBondFinancedProperty>
        <AnyLeaseArrangements>0</AnyLeaseArrangements>
        <MngmentCntrctBondFinancdPrprty>0</MngmentCntrctBondFinancdPrprty>
        <AnyResearchAgreements>0</AnyResearchAgreements>
        <BondCounselRoutinelyEngaged>0</BondCounselRoutinelyEngaged>
        <PostIssuanceComplianceProcdrs>1</PostIssuanceComplianceProcdrs>
      </Form990ScheduleKPartIII>
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        <Form8038TFiled>0</Form8038TFiled>
        <VariableRateIssue>0</VariableRateIssue>
        <HedgeIdentifiedInBooksAndRecds>0</HedgeIdentifiedInBooksAndRecds>
        <GrossProceedsInvestedInGIC>0</GrossProceedsInvestedInGIC>
        <GrossProceedsInvested>0</GrossProceedsInvested>
        <ExceptionToRebate>1</ExceptionToRebate>
      </Form990ScheduleKPartIV>
    </IRS990ScheduleK>
    <IRS990ScheduleL documentId="RetDoc1042800001">
      <Form990ScheduleLPartIV>
        <NameOfInterestedPerson>
          <NameBusiness>
            <BusinessNameLine1>See Schedule O</BusinessNameLine1>
          </NameBusiness>
        </NameOfInterestedPerson>
        <SharingOfRevenues>0</SharingOfRevenues>
      </Form990ScheduleLPartIV>
    </IRS990ScheduleL>
    <IRS990ScheduleM documentId="RetDoc1042900001">
      <SecuritiesPubliclyTraded>
        <NonCashCheckbox>X</NonCashCheckbox>
        <NumberOfContributions>4</NumberOfContributions>
        <NoncashContribsRptdF990>138476</NoncashContribsRptdF990>
        <MethodOfDeterminingRevenues>Cost/selling price</MethodOfDeterminingRevenues>
      </SecuritiesPubliclyTraded>
      <AnyPropertyThatMustBeHeld>0</AnyPropertyThatMustBeHeld>
      <ReviewProcessUnusualNCGifts>1</ReviewProcessUnusualNCGifts>
      <ThirdPartiesUsed>1</ThirdPartiesUsed>
      <Form990ScheduleMPartII>
        <Identifier>Third Party Use:</Identifier>
        <ReturnReference>Part I, Line 32b:</ReturnReference>
        <Explanation>Shares of stock gifted to TSRI are transferred into our brokerage account at Morgan Stanley Smith Barney and they in turn sell the shares and wire the stock proceeds to TSRI.</Explanation>
      </Form990ScheduleMPartII>
      <Form990ScheduleMPartII>
        <Identifier>Non Reporting of Revenue:</Identifier>
        <ReturnReference>Part I, Line 33:</ReturnReference>
        <Explanation>2 stock gifts, for a total of $138,476, were given to be applied against pledges. They were applied against a pledge receivable rather than revenue.</Explanation>
      </Form990ScheduleMPartII>
    </IRS990ScheduleM>
    <IRS990ScheduleO documentId="RetDoc1044400001">
      <GeneralExplanation>
        <Identifier>Form 990, Part VI, Section A, line 2</Identifier>
        <Explanation>TSRI Board of Trustee members Claudia S. Luttrell and Mark S. Skaggs have a family relationship. Dr. Richard Lerner and Dr. Phillip Frost have a business relationship. Dr. Richard Lerner and Gerald Cohn have a business relationship. Dr. Lawrence Horowitz, Mark Pearson, Ralph Shapiro, Richard Elkus and Louis Gonda have a business relationship with each other.</Explanation>
      </GeneralExplanation>
      <GeneralExplanation>
        <Identifier>Form 990, Part VI, Section B, line 11</Identifier>
        <Explanation>On June 28, 2011, the Audit Committee reviewed a draft of the Form 990 (including all supplemental schedules.) This review included a presentation of the statements by the Chief Financial Officer with particular emphasis on disclosures about governance and about transactions involving interested persons. The 990 will be provided to the full Board of Trustees prior to filing.</Explanation>
      </GeneralExplanation>
      <GeneralExplanation>
        <Identifier>Form 990, Part VI, Section B, line 12c</Identifier>
        <Explanation>TSRI's Conflict of Interest Policy covers all scientific employees, key employees, officers and trustees. It is administered by the Professional Affairs Committee of the Board of Trustees. The conflict of interest policy complies with the requirements of other oversight bodies such as the NIH. All transactions involving potential or actual conflicted persons are brought before the Professional Affairs Committee which, after examination of all relevant information, may do one of the following: 1. Approve the transaction subject to a conflict mitigation plan 2. Disapprove the transaction 3. Request additional information Further, there is an anonymous "hot line" where all employees are invited to disclose information of a broad nature, including potential or perceived conflicts of interest. Once approved by the Professional Affairs Committee, transactions involving officers are brought to the Board of Trustees for final review and approval.</Explanation>
      </GeneralExplanation>
      <GeneralExplanation>
        <Identifier>Form 990, Part VI, Section B, line 15</Identifier>
        <Explanation>The Board of Trustees annually approves the compensation for the President; and, on a bi-annual basis the Board's Compensation Committee (CC) selects and engages an outside compensation consultant. This would be done less than bi-annually only if there have been material changes in the Institute or the President's responsibilities. The consultant meets with the VP of HR to ensure it has complete and accurate information regarding the Institute and scope of executive responsibility. The consultant determines peer institutions for inclusion in a compensation survey. The consultant conducts a compensation review using specialized and published surveys, and submits a written opinion to the CC in accordance with the provisions of Section 53.4958-6(c)(2) and satisfies the professional advice requirements of Section 53.4958-1(d)(iii) of the Income Tax Regulations. After the consultant presents the survey to the CC, the CC reviews the executive performance as communicated from the Executive Committee of the Board of Trustees. The CC reviews executive travel, business expenses, and Outside Professional Activities Disclosure. The CC then makes an independent recommendation to the Board of Trustees on executive compensation, which must be approved by the Board of Trustees. Affected trustees abstain from participation in this process.</Explanation>
      </GeneralExplanation>
      <GeneralExplanation>
        <Identifier>Form 990, Part VI, Section C, line 19</Identifier>
        <Explanation>Governing documents and conflict of interest policies are not available to the public at this time. The financial statements are available on the TSRI web-site and are filed with the State of Florida by the Scripps Florida Funding Corporation. The statements are provided to bond holders through TSRI's dissemination agent. The annual information return is provided upon request.</Explanation>
      </GeneralExplanation>
      <GeneralExplanation>
        <Explanation>Form 990, Schedule K, Part I (A) Issuer Name: California Infrastructure and Economic Development Bank (F) Description of Purpose: 1. To acquire the Immunology building and to refinance the 1994 Arnold and Muriel Beckman Chemistry building construction bonds 2. To pay for a portion of the issuance cost of both issues 3. To pay for capitalized interest on the bonds during the construction period</Explanation>
      </GeneralExplanation>
      <GeneralExplanation>
        <Explanation>Form 990, Schedule R, Part II: TSRI and The Skaggs Institute for Research ceased to be related organizations during the year ended September 30, 2010, but was included as a related organization herein to be consistent with the Skaggs form 990 filing.</Explanation>
      </GeneralExplanation>
      <GeneralExplanation>
        <Identifier>Form 990, Schedule L, part IV</Identifier>
        <Explanation>a. Paul Herrling, Trustee b. Employee of Novartis and a director of Novartis affiliate, The Novartis Institute for Functional Genomics (GNF) c. $8.7 million in payments from Novartis or GNF d. Licensing &amp; faculty recruitment agreements and equipment usage e. NO</Explanation>
      </GeneralExplanation>
      <GeneralExplanation>
        <Identifier>Form 990, Schedule L, part IV</Identifier>
        <Explanation>a. Richard A. Lerner, M.D., President &amp; CEO b. TSRI President &amp; CEO c. $389,000 d. Licensing Agreement e. NO</Explanation>
      </GeneralExplanation>
      <GeneralExplanation>
        <Identifier>Form 990, Schedule L, part IV</Identifier>
        <Explanation>a. Brent Eastman, M.D., Trustee b. Key Employee of Scripps Health c. Cost of services paid to Scripps Health d. $2,494,095 e. No</Explanation>
      </GeneralExplanation>
      <GeneralExplanation>
        <Identifier>Form 990, Schedule L, Additional Information</Identifier>
        <Explanation>PHILLIP FROST, M.D. IS A TRUSTEE OF TSRI AND IS A SIGNIFICANT SHAREHOLDER IN OPKO HEALTH, INC. ("OPKO"). OPKO IS A HEALTH CARE COMPANY FOCUSED ON THE DEVELOPMENT OF PHARMACEUTICALS, HAS A USE LICENSE WITH TSRI, AND MAY BE INVOLVED IN BUSINESS TRANSACTIONS WITH TSRI IN THE FUTURE. RICHARD A. LERNER, M.D. IS THE PRESIDENT AND CEO OF TSRI. DR. LERNER SERVES AS CHAIRMAN ON ONE OF THE SCIENTIFIC ADVISORY BOARD OF PFIZER, INC. HE IS UNCOMPENSATED FOR HIS SERVICES TO PFIZER. TSRI AND PFIZER, INC. ARE PARTIES TO A COLLABORATIVE RESERACH AGREEMENT CURRENTLY IN PLACE. IN ADDITION, DR. LERNER SERVES ON THE BOARD OF DIRECTORS AND IS THE CHAIR OF THE COMPENSATION COMMITTEE OF OPKO. OPKO'S RELATIONSHIP WITH TSRI IS EXPLAINED ABOVE. Several interested persons have equity positions held in the ordinary course of business, in companies with which TSRI does business including Thermo Fisher, Merck Serono, Pfizer, Teva Pharmaceuticals, Fidelity Management and Research and Marsh Risk and Insurance Services.</Explanation>
      </GeneralExplanation>
      <GeneralExplanation>
        <Identifier>FORM 990, PART VII, SECTION B:</Identifier>
        <Explanation>TSRI patents many of its discoveries. For most of those discoveries, the cost of these patents is recovered from third parties pursuant to the terms of the underlying license.</Explanation>
      </GeneralExplanation>
    </IRS990ScheduleO>
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          <BusinessNameLine1>the skaggs institute for research</BusinessNameLine1>
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        <AddressUS>
          <AddressLine1>ALSAM Foundation 6190 S Moffat Farm</AddressLine1>
          <City>Salt Lake City</City>
          <State>UT</State>
          <ZIPCode>841210000</ZIPCode>
        </AddressUS>
        <EIN>870549234</EIN>
        <PrimaryActivities>Grant Making</PrimaryActivities>
        <LegalDomicileState>UT</LegalDomicileState>
        <ExemptCodeSection>section 501(c)(3)</ExemptCodeSection>
        <PublicCharityStatus>Private Foundation</PublicCharityStatus>
      </Form990ScheduleRPartII>
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      <GiftGrantOrCapContrToOtherOrg>0</GiftGrantOrCapContrToOtherOrg>
      <GiftGrantOrCapContrFrOtherOrg>1</GiftGrantOrCapContrFrOtherOrg>
      <LoansOrGuaranteesToOtherOrg>0</LoansOrGuaranteesToOtherOrg>
      <LoansOrGuaranteesFromOtherOrg>0</LoansOrGuaranteesFromOtherOrg>
      <SaleOfAssetsToOtherOrg>0</SaleOfAssetsToOtherOrg>
      <PurchaseOfAssetsFromOtherOrg>0</PurchaseOfAssetsFromOtherOrg>
      <ExchangeOfAssets>0</ExchangeOfAssets>
      <RentalOfFacilitiesToOtherOrgs>0</RentalOfFacilitiesToOtherOrgs>
      <RentalOfFacilitiesFrOtherOrgs>0</RentalOfFacilitiesFrOtherOrgs>
      <PerformOfServicesForOtherOrgs>0</PerformOfServicesForOtherOrgs>
      <PerformOfServicesByOtherOrgs>0</PerformOfServicesByOtherOrgs>
      <SharingOfFacilities>0</SharingOfFacilities>
      <SharingOfPaidEmployees>0</SharingOfPaidEmployees>
      <ReimbursementPaidToOtherOrg>0</ReimbursementPaidToOtherOrg>
      <ReimbursementPaidByOtherOrg>0</ReimbursementPaidByOtherOrg>
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          <BusinessNameLine1>The Skaggs Institute for Research</BusinessNameLine1>
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        <AmountInvolved>1988240</AmountInvolved>
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