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        <ReturnReference>SCHEDULE C PART II-A</ReturnReference>
        <Explanation>CITY OF HOPE NATIONAL MEDICAL CENTER APPLIED FOR A SECTION 501(H) ELECTION ON FORM 5768 IN THE YEAR ENDED SEPTEMBER 30, 1995. THIS ELECTION HAS NOT BEEN REVOKED SUBSEQUENT TO THIS APPLICATION. THE CITY OF HOPE NATIONAL MEDICAL CENTER INCURRED in-house expenditures of $220,100 and DIRECT LOBBYING EXPENDITURES IN THE AMOUNT OF $323,609 DURING FISCAL YEAR 2010. 2010 Summary of Lobbying Activities: City of Hope lobbied on the following provisions: HR 2109 Childhood Cancer Survivorship Research and Quality of Life Act of 2009. (All Provisions) Staff provided expertise, advice and advocacy on legislation. HR 3200 America's Affordable Health Choices Act of 2009 (Provisions to specific Medicare reimbursement, 340 B discount drug program, access to clinical trials, Medicare advisory board). Staff provided expertise, advice and advocacy on legislation. S. 1679, the Affordable Health Choices Act to the Senate (Provisions specific to Medicare reimbursement, 340 B discount drug program, access to clinical trials, &amp; Medicare advisory board). Staff provided expertise, advice and advocacy on legislation. FY11 Federal Funding levels for National Institutes of Health (NIH) and National Cancer Institute (NCI). Staff provided expertise, advice and advocacy on legislation. FY11 House and Senate Defense Appropriations Funding -medical research. Staff provided information and requests for funding. HR 3326 FY10 Defense Appropriations bill (Provisions relating to medical research). Staff provided information and requests for funding. H.R. 3590 Patient Protection and Affordable Care Act (provisions relating to 340 B drug program, outpatient payment for PPS exempt cancer centers, and access to clinical trials). Staff provided expertise, advice and advocacy on legislation. H.R. 3962 Affordable Health Care for America Act (provisions relating to 340 B drug program, outpatient payment for PPS exempt cancer centers, and access to clinical trials). Staff provided expertise, advice and advocacy on legislation. H.R. 4872 the Reconciliation Act of 2010 (provisions relating to 340 B drug program). Staff provided expertise, advice and advocacy on legislation. FY11 Senate and House Labor, HHS, and Education bill (provisions relating to community health programs). Staff provided expertise, advice and advocacy on legislation. H.R. 4213 The American Jobs and Closing Tax Loopholes Act of 2010 (provisions relating to 340 B drug program, outpatient payment for PPS exempt cancer centers, and access to clinical trials). Staff provided expertise, advice and advocacy on legislation. At the California state level, City of Hope lobbied on the following: AB 52 (Portantino) extends the date by which the Department of Public Health is required to establish the Umbilical Cord Blood Collection Program. Staff provided expertise, advice and advocacy on legislation. AB 56 (Portantino) requires health insurers to provide coverage for mammography upon provider referral and requires health plans and health insurers to notify subscribers or policyholders of recommended timelines for testing. Staff provided expertise, advice and advocacy on legislation. AB 113 (Portantino) provides that health care service plan contracts and individual and group policies of health insurance, issued, amended, delivered, or renewed on or after a specified date, shall be deemed to provide coverage for mammographies for screening or diagnostic purposes upon referral of a participating nurse practitioner, certified nurse-midwife, physician assistant, or physician. Staff provided expertise, advice and advocacy on legislation. AB 542 (Feuer) requires the Department of Managed Health Care to adopt regulations establishing uniform policies and practices governing the nonpayment of hospitals for substantiated adverse events. Staff provided expertise, and advice on legislation. AB 549 (Furutani) creates an interim clinical director license for Ph.D graduates. Staff provided expertise, advice and advocacy on legislation. AB 1383 (Jones) establishes a provider fee on hospitals, matches a portion of revenues collected from the fee with federal funds in the Medi-Cal program at an enhanced match. Staff advocated in support of legislation. AB 1640 (Evans) requires the medical director and the director of nursing of a hospital to annually report adverse events and hospital acquired conditions to its governing board. Staff provided expertise and advocacy on legislation. AB 1653 (Jones) modifies the formulas used in calculating the quality assurance fee imposed on hospitals. Staff advocated in support of legislation. SB 289 (Ducheny) requires owners of hospital buildings that are classified as nonconforming to include additional information in statutorily required reports due to the Office of Statewide Health Planning and Development. Staff provided expertise and advice on legislation. SB 364 (Florez) Prohibits an officer, director, or member of a governing board of a general acute care hospital designated by the National Cancer Institute as a comprehensive cancer center, and that accepts state funds, from holding a position as an officer, director, or member of the board, or a similar position, of a specified corporation. Staff collaborated with hospitals and organizations to advocate against provisions in the bill. AB 1733 (Hill) requires the Governor to create, within the Office of the Governor, the position of Director of California Biotechnology Retention and Recruitment. It makes the director responsible for serving as an informational resource for biotechnology, life science, and medical companies. Staff advocated in support of legislation. AB 2477 (Jones) Provides that the continuous eligibility period shall be from the date of determination of eligibility to the earlier of either the end of a 12-month period following the eligibility determination or the date the child exceeds 19 years of age. Staff advocated in support of legislation. SB 1237 (Padilla) requires hospitals and clinics using computed tomography CT X-ray systems for human use to record the dose of radiation produced during the administration of CT X-ray examination. Staff provided expertise, and advice on legislation. THE FOLLOWING ARE THE MEMBERS OF THE AFFILIATED GROUP: CITY OF HOPE (HAS NOT MADE A 501(H) ELECTION) 1500 EAST DUARTE ROAD, DUARTE, CA 91010 EIN = 95-3435919 GRASSROOTS LOBBYING AMOUNT = NONE TOTAL LOBBYING EXPENDITURES = NONE OTHER EXEMPT PURPOSE EXPENDITURES = $218,420,482 TOTAL EXEMPT PURPOSE EXPENDITURES = $218,420,482 LOBBYING NONTAXABLE AMOUNT = NONE GRASSROOTS NONTAXABLE AMOUNT = NONE TOTAL GRASSROOTS LESS NONTAXABLE AMOUNT = NONE TOTAL EXPENDITURES LESS NONTAXABLE AMOUNT = NONE SHARE OF EXCESS LOBBYING EXPENDITURES = NONE BECKMAN RESEARCH INSTITUTE OF THE CITY OF HOPE (HAS NOT MADE A 501(H) ELECTION) 1450 EAST DUARTE ROAD DUARTE, CA 91010 EIN = 95-3432210 GRASSROOTS LOBBYING AMOUNT = NONE TOTAL LOBBYING EXPENDITURES = NONE OTHER EXEMPT PURPOSE EXPENDITURES = $218,916,343 TOTAL EXEMPT PURPOSE EXPENDITURES = $218,916,343 LOBBYING NONTAXABLE AMOUNT = NONE GRASSROOTS NONTAXABLE AMOUNT = NONE TOTAL GRASSROOTS LESS NONTAXABLE AMOUNT = NONE TOTAL EXPENDITURES LESS NONTAXABLE AMOUNT = NONE SHARE OF EXCESS LOBBYING EXPENDITURES = NONE</Explanation>
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        <Explanation>CITY OF HOPE NATIONAL MEDICAL CENTER HAS ENDOWMENT FUNDS THAT ARE AVAILABLE TO FUND FUTURE RESEARCH, CAPITAL AND EXPANSION NEEDS AS DETERMINED BY MANAGEMENT AND THE BOARD OF DIRECTORS.</Explanation>
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        <AnnualCommunityBenefitExpln>The community benefit data for City of Hope National Medical Center appears in the City of Hope Community Benefit report.</AnnualCommunityBenefitExpln>
        <CostingMethodUsed>The amounts reported in this section were determined using cost accounting methodology which captures the true cost of treating patients. These amounts include both direct and indirect costs.</CostingMethodUsed>
        <ShortfallAsCommunityBenefit>In addition to being a NCI-designated Comprehensive Cancer Center, City of Hope is a founding member of the National Comprehensive Cancer Network (NCCN), an alliance of 21 of the nation's leading cancer centers that defines and sets national standards for cancer care - standards that are made available to patients and physicians. NCCN member institutions advance cancer prevention, screening, diagnosis and treatment through excellence in basic and clinical research. City of Hope and other NCCN partners enhance the effectiveness and efficiency of cancer care delivery through the ongoing collection, synthesis and analysis of outcome data. Given the institution's focus on cancer and higher incidence of cancer among adults 65 and older, City of Hope treats a high proportion of Medicare patients. That fact, combined with the high cost of complex cancer care, means that City of Hope bears significant unreimbursed Medicare expenses. Recognizing City of Hope's extraordinary contributions to cancer care, research education and population health, the organization's Medicare shortfall should be considered a community benefit. Costing Methodology Used: Medicare cost is based on the Medicare Cost Report which combines routine and ancillary costs. The calculation of the cost for ancillary services is based on a ratio of cost to charges and routine services are based on direct routine costs, allocated based on the Medicare patient days as a percent of the total patient days.</ShortfallAsCommunityBenefit>
        <DebtCollectionPolicy>Patient accounts are not sent to collection without giving patients adequate time to be evaluated or re-evaluated and to develop alternative payment arrangements. Patient accounts will not be sent to collection pending completion of financial counseling. A patient will be given notice at least seven business days before his or her file is sent to a collection agency. Neither the City of Hope National Medical Center ("the Medical Center") nor its third party collection vendors will use wage garnishment or liens on primary residences as a means of collecting unpaid hospital bills from patients who are eligible for any form of charity care under the Charity Care Policy. All agencies used for collection are advised of the Medical Center's policy in writing, and this "Charity Care Policy" is incorporated by reference in collection contracts with such agencies. The Medical Center receives written assurances from these agencies that they will adhere to the Medical Center's standards.</DebtCollectionPolicy>
        <NeedsAssessment>City of Hope National Medical Center ("City of Hope") completed its last triennial community health needs assessment in 2010. Primary data was collected through telephone interviews with community representatives who were knowledgeable about cancer-related needs in City of Hope's community. Interviews completed reflected a cross-section of the community and included schools, government agencies, mental health agencies, community hospitals, advocacy organizations and organizations focused on serving individuals impacted by cancer. A total of 62 interviews were completed. To develop a demographic and health status profile of the community, data was gathered from such sources as the US Census Bureau, the American Cancer Society, the CA Department of Health Services and the LA County Department of Health Services.</NeedsAssessment>
        <PatientEducationAssistance>Patients and persons who may be billed for patient care are informed about their eligibility for assistance by City of Hope patient financial counselors prior to their first appointment. In addition, clinical social workers assess patients' need for assistance with housing, transportation, obtaining medications, other financial support and eligibility for state and federal programs during their initial meetings with patients and families. Social workers and other City of Hope staff refer to a City of Hope resources coordinator, who helps patients and family apply for assistance and access community resources. In addition, information about medical care for those who cannot afford to pay is contained in the letter sent to all new patients prior to their first visit, and is posted near the new patient check-in desk and is included in the guide provided to every new outpatient. City of Hope patients and their families can also learn about financial counseling and other resources through the institution's Patient and Family Orientation Class and Financial Tips and Tools Workshop. Both of these programs are offered in English and Spanish to every new patient. Individual counseling is offered to patients in other languages. In June 2009, City of Hope introduced SupportScreen, a handheld, touch-screen technology that enables patients to answer questions about their psychological, emotional, physical, rehabilitative, social and financial concerns, so that staff can help patients address potential problems and barriers to care. The system enables staff to promptly follow up with patients who are significantly concerned about financial issues and want more information or someone to talk to about assistance and resources.</PatientEducationAssistance>
        <CommunityInformation>While City of Hope's research advances treatment worldwide, our primary service area covers the four Southern California counties of Los Angeles, Orange, San Bernardino and Riverside. More than 4 million people reside in City of Hope's primary service area. City of Hope is located in the city of Duarte, which prides itself as the "City of Health." Duarte is a richly diverse community with a population of 21,742 located in the San Gabriel Valley in northeast Los Angeles County. City of Hope and Duarte have worked together to improve health in the community for many years, as demonstrated by our long-term collaboration on the Duarte Health Cities and Community of Promise projects. Duarte was part of the original group of ten cities selected in 1989 to participate in the California Health Cities Project. Over the years, the City of Duarte has engaged in a wide array of Healthy Cities activities ranging from bicycle and pedestrian safety to inter-generational mentoring and nutrition and physical activity, City of Hope has been a partner in the Duarte Healthy Cities project since the inception of the California Healthy Cities initiative. City of Hope partners with the City of Duarte, local businesses, and community-based organizations in the Community of Promise Project. Duarte's Promise is part of America's Promise, a national, volunteer-based initiative to support youth development. "Communities of promise" are broadly defined as community-wide alliances working toward a common goal of delivering five promises known to have a significant impact on the lives of youth. Those promises are: an on-going relationship with a caring adult, safe places and structured activities during school hours, a healthy start, marketable skills through effective education and community service opportunities. With more than 4,000 employees, City of Hope is the largest employer in Duarte. In addition to generating a high volume and wide array of job opportunities, City of Hope participates in the Duarte Unified School District's Regional Occupational Program, through which the organization employs area youth and helps them develop marketable skills. Many program alumni are today working at City of Hope. Other community programs aimed at local youth are Groundhog Job Shadow Day and Science Field Day. Groundhog Job Shadow Day enables local high school students to explore career options and gain practical insights into the workplace. Science Field Day provides biology students from Duarte High School with an interactive learning experience focused on basic science research. City of Hope contributes further to the local economy by generating substantial revenue for restaurants and other businesses in the Duarte area.</CommunityInformation>
        <CommunityBuildingActivities>As one of the nation's 40 National Cancer Institute-designated Comprehensive Cancer Centers, City of Hope integrates basic, clinical, prevention, disease control and population research and serves a vital role in its community. At any given time, City of Hope conducts more than 300 clinical trials, involving 25 percent of its patients, demonstrating its commitment to bringing new, more effective treatments to patients. The national average is less than 5 percent. City of Hope offers an extensive array of programs and services that serve students, postdoctoral trainees, physicians, nurses, other health-care professionals and the public. Hospital facilities serve as vital sites for clinical training and as venues for professional medical conferences, meetings and training sessions. City of Hope offers numerous hands-on internships, fellowships and residencies for health professionals in a broad array of areas including cancer genetics, bone marrow transplantation, molecular epidemiology, pharmacy, clinical nutrition and hospital administration. Program alumni go on to provide health care in our communities. City of Hope's Department of Continuing Medical Education, in collaboration with City of Hope faculty, offers extramural, local, regional and national medical education programs. Local conferences are offered to fulfill the educational requirements of physicians at City of Hope and in surrounding communities, and education also is offered online. Monthly programs on advances in cancer prevention, diagnosis, treatment, and other continuing education topics are sponsored jointly with Santa Teresita Hospital in Duarte. Those monthly sessions are aimed at health-care professionals who treat underserved populations in the San Gabriel Valley. City of Hope also collaborates with the American Cancer Society to offer professional education programs that support enrollment of underserved minorities in clinical trials. Technical assistance provided to government agencies and community organizations, contributions to the research literature and leadership of community boards are a few examples of the many non-quantified community benefits contributed by City of Hope. In addition, City of Hope holds regular community forums in which City of Hope experts discuss diseases and treatments and take questions from the public. They also address contemporary issues in health care. City of Hope's board of directors is composed of prominent leaders in the community, business arena and philanthropic world. Coalition Building -- Represents participation by City of Hope program evaluators/health educators in meetings of the West San Gabriel Valley Health Council. The goal of that coalition is to advance the health of our community by promoting program sharing and collaboration among hospitals and community-based organizations in the West San Gabriel Valley.</CommunityBuildingActivities>
        <OtherInformation>City of Hope offers an extensive array of programs and services for students, post-doctoral trainees, physicians, pharmacists, nurses and other healthcare professionals. Numerous fellowships and residencies are offered, ranging from the Cancer Genetics Fellowship Program to the Hematology/Bone Marrow Transplantation Fellowship to the Pharmacy Clerkship and Residency programs. Support from City of Hope Medical Center is integral to all of these programs. Hospital staff contribute their expertise as mentors and presenters. Hospital facilities serve as vital sites for clinical training and as venues for conferences.</OtherInformation>
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        <Identifier>QUESTIONS REGARDING COMPENSATION</Identifier>
        <ReturnReference>SCHEDULE J PART 1</ReturnReference>
        <Explanation>MICHAEL FRIEDMAN, M.D. IS PROVIDED A HOUSING ALLOWANCE WHICH HAS BEEN INCLUDED IN OTHER REPORTABLE COMPENSATION. MICHAEL FRIEDMAN, M.D. IS PROVIDED WITH SOCIAL CLUB MEMBERSHIPS FOR WHICH DETAILED BUSINESS RECEIPTS MUST BE SUBMITTED INDICATING THE BUSINESS PURPOSES ASSOCIATED WITH SERVICES AND THE PERSONAL USE ASSOCIATED WITH SERVICES. HE IS NOT REIMBURSED FOR THE PERSONAL PORTION OF THESE SERVICES. The amount of social club dues included in other reportable compensation column B(iii) was $429 during the year ended December 31, 2009. LINE 4A SEVERANCE PAY JAMES MISER, M.D. WAS PAID A GUARANTEED SEPARATION PAYMENT TOTALING $187,500 DURING the year ended December 31, 2009. LINE 4B PARTICIPATION IN NON-QUALIFIED 457(F) PLAN CITY OF HOPE NATIONAL MEDICAL CENTER HAS AN EXECUTIVE SUPPLEMENTAL ACCUMULATION PLAN THAT IS A NON-QUALIFIED SECTION 457(F) PLAN. THE PLAN WAS EFFECTIVE SEPTEMBER 30, 2007 AND IS DESIGNED TO PROVIDE EACH DESIGNATED EMPLOYEE WITH DEFERRED COMPENSATION. THE PLAN IS MAINTAINED FOR A SELECT GROUP OF MANAGEMENT OR HIGHLY COMPENSATED EMPLOYEES. THE PLAN VESTS AFTER THREE (3) YEARS AND THE VESTED TOTALS ARE INCLUDED IN SCHEDULE J PART II, COLUMN "OTHER REPORTABLE COMPENSATION (B)(iii)." PRIOR TO VESTING THE ANNUAL AMOUNTS ARE INCLUDED IN SCHEDULE J PART II COLUMN "DEFERRED COMPENSATION (C)." DURING the year ended December 31, 2009 THE FOLLOWING DISTRIBUTIONS WERE MADE FROM THE 457(F) PLAN TO THE FOLLOWING PARTICIPANTS: DEBRA FIELDS $3,403 GREGORY SCHETINA $5,970 MICHAEL FRIEDMAN, MD $20,947 MICHAEL JENSEN $3,301 ROBERT STONE $4,454 VIRGINIA OPIPARE $41,777 THESE AMOUNTS HAVE BEEN INCLUDED IN TAXABLE INCOME IN SCHEDULE J. LINE 7 CITY OF HOPE NATIONAL MEDICAL CENTER EXECUTIVES AND SOME KEY EMPLOYEES ARE ELIGIBLE TO RECEIVE INCENTIVE COMPENSATION TIED TO FIVE (5) KEY INDICATORS. THE KEY INDICATORS ARE BOTH FINANCIAL AND NON-FINANCIAL, AND THE POTENTIAL INCENTIVE COMPENSATION IS BASED ON A WEIGHTED AVERAGE AMONG ALL indicators and is paid as a percentage of each individual participant's base compensation. Based upon an individual's goals and performance during the year, the potential payout for any participant can be modified up or down 20%. The incentive compensation paid during this tax year has been reported in Schedule J, Column B(ii).</Explanation>
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        <Identifier>BEN HOROWITZ</Identifier>
        <ReturnReference>Form 990, Part VII</ReturnReference>
        <Explanation>MR. BEN HOROWITZ IS A NON-VOTING, HONORARY MEMBER OF THE CITY OF HOPE BOARD OF DIRECTORS. HE IS ALSO A BOARD MEMBER OF THE CITY OF HOPE NATIONAL MEDICAL CENTER AND THE BECKMAN RESEARCH INSTITUTE OF THE CITY OF HOPE. MR. HOROWITZ WAS PRESIDENT AND CHIEF EXECUTIVE OFFICER OF THE CITY OF HOPE FROM 1953 TO 1986. UPON HIS RETIREMENT, THE BOARD VOTED HIM A MONTHLY RETIREMENT BENEFIT IN RECOGNITION OF HIS EXTRAORDINARY LONG-TERM CONTRIBUTIONS TO THE CITY OF HOPE. MR. HOROWITZ WAS PAID $121,667 IN CALENDAR YEAR 2009 IN CONNECTION WITH A GRAND-FATHERED PRE-1986 DEFERRED COMPENSATION PLAN. THIS AMOUNT IS INCLUDED IN SCHEDULE J REPORTABLE COMPENSATION. THIS STIPEND IS UNRELATED TO THE FACT THAT SUBSEQUENT TO HIS RETIREMENT HE WAS ELECTED TO THE BOARD OF DIRECTORS OF THE MEDICAL CENTER AND BECKMAN RESEARCH INSTITUTE.</Explanation>
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        <IssuerEIN>943130123</IssuerEIN>
        <DateIssued>2006-05-26</DateIssued>
        <IssuePrice>60000000</IssuePrice>
        <DescriptionOfPurpose>Health Care Facility Construction</DescriptionOfPurpose>
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        <Default>false</Default>
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        <NamePerson>MICHAEL JENSEN</NamePerson>
        <PurposeOfLoan>RETENTION LOAN</PurposeOfLoan>
        <LoanFromOrganization>X</LoanFromOrganization>
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      <GeneralExplanation>
        <Identifier>ORGANIZATION'S MISSION</Identifier>
        <ReturnReference>FORM 990, PART III, LINE 1</ReturnReference>
        <Explanation>CITY OF HOPE [collectively referring to City of Hope, City of Hope National Medical Center, Beckman Research Institute of the City of Hope, and City of Hope Auxiliaries], AN INNOVATIVE BIOMEDICAL RESEARCH, TREATMENT AND EDUCATIONAL INSTITUTION, IS DEDICATED TO THE PREVENTION AND CURE OF CANCER AND OTHER LIFE-THREATENING DISEASES, GUIDED BY A COMPASSIONATE, PATIENT-CENTERED PHILOSOPHY AND SUPPORTED BY A NATIONAL FOUNDATION OF HUMANITARIAN PHILANTHROPY.</Explanation>
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      <GeneralExplanation>
        <Identifier>EXEMPT PURPOSE ACHIEVEMENTS</Identifier>
        <ReturnReference>FORM 990, PART III, Line 4A</ReturnReference>
        <Explanation>PATIENT CARE: The Medical Center provides acute care medical services. Some services are provided through charity care funding for patients meeting financial eligibility and clinical criteria and to persons without insurance or who are underinsured. The Medical Center also subsidizes care for patients covered by Medi-Cal and Medicare programs. All PATIENTS treated at City of Hope BENEFIT FROM THE LATEST TECHNOLOGIES COMBINED WITH A CULTURE OF COMPASSIONATE CARE. The Medical Center's FOCUS ON TRANSLATIONAL MEDICINE HEIGHTENS THE COLLABORATION BETWEEN MEMBERS OF THE CARE TEAM AND RESEARCHERS FROM THROUGHOUT THE ORGANIZATION. EDUCATION AND PROESSIONAL DEVELOPMENT ALSO ARE CORE ACTIVITIES AT CITY OF HOPE National Medical Center. THE SHERI &amp; LES BILLER PATIENT AND FAMILY RESOURCE CENTER SERVES AS THE HUB FOR COMPREHENSIVE ASSISTANCE FOR PATIENTS AND FAMILIES, OFFERING PATIENT EDUCATION, SUPPORT GROUPS, SOCIAL WORK RESOURCES, MIND-BODY THERAPIES AND PATIENT NAVIGATORS TO ASSIST PEOPLE THROUGH DIAGNOSIS, TREATMENT AND RECOVERY. ITS HEALTH-CARE PROFESSIONALS, INCLUDING PSYCHOLOGISTS, PSYCHIATRISTS AND PALLIATIVE CARE PHYSICIANS, PARTNER WITH PATIENTS AND FAMILIES TO ALLEVIATE PAIN AND DISTRESS RELATED TO DISEASE AND TREATMENT. RESEARCH: The Medical Center funds a variety of clinical and laboratory research activities focused on finding cures and treatments for cancer and other life-threatening diseases for which grant and extramural funding is not available. WITH A HISTORY OF SIGNIFICANT CONTRIBUTIONS TO THE FIELD OF DIABETES, CITY OF HOPE National Medical Center IS A NATIONAL CENTER FOR ISLET CELL TRANSPLANTATION - AN EMERGING TREATMENT THAT HAS THE POTENTIAL TO REVERSE TYPE 1 DIABETES. THE Medical Center IS ALSO MAKING MAJOR CONTRIBUTIONS IN THE FIELD OF HIV-AIDS. APPROXIMATELY 25 PERCENT OF CITY OF HOPE National Medical Center PATIENTS ARE ENROLLED IN CLINICAL TRIALS, COMPARED TO THE NATIONAL AVERAGE OF LESS THAN 5 PERCENT. THESE TRIALS PROVIDE PATIENTS WITH ACCESS TO THE NEWEST APPROACHES TO COMBATING DISEASES WHILE HELPING DEVELOP THE TREATMENTS OF TOMORROW. THE MEDICAL CENTER PROVIDES INSTITUTIONALLY-SUPPORTED RESEARCH GRANTS, RESIDENCY AND FELLOWSHIP PROGRAMS AND TRAINING AND CONTINUING EDUCATION FOR PHYSICIANS, NURSES AND HEALTH PROFESSIONALS FROM WITHIN AND OUSIDE OF THE INSTITUTION. FACULTY AND STAFF FROM CITY OF HOPE National Medical Center SERVE ON NATIONAL ORGANIZATIONS AND POLICY AND REGULATORY ADVISORY COMMITTEES. THEY ALSO PROVIDE THEIR EXPERTISE TO REVIEW GRANT APPLICATIONS FOR STATE AND FEDERAL AGENCIES AND SERVE AS MEMBERS OF EDITORIAL BOARDS FOR PROFESSIONAL PUBLICATIONS. PUBLIC INFORMATION AND EDUCATION: The Medical Center conducts medical education programs and public forums to inform and educate the public. CITY OF HOPE National Medical Center IS COMMITTED TO SERVING THE COMMUNITY THROUGH EDUCATION AND SUPPORT SERVICES, CANCER AWARENESS PROGRAMS, HEALTH FAIRS AND EDUCATIONAL FORUMS FOR COMMUNITY GROUPS AND BUSINESSES. The Medical Center's DEPARTMENT OF POPULATION SCIENCES ALSO REACHES OUT AND SEEKS TO REDUCE THE BURDEN OF CANCER ACROSS ALL POPULATIONS THROUGH COLLABORATIVE PROGRAMS IN CARE, RESEARCH AND EDUCATION. THIS DEPARTMENT EXAMINES THE CAUSES AND RISKS OF CANCER AND DISPARITIES IN CANCER OUTCOMES IN VARIOUS POPULATIONS. IT INVESTIGATES GENETIC MARKERS LINKED TO CANCER RISK AND SEEKS TO IMPROVE THE QUALITY OF LIFE FOR CANCER SURVIVORS. THE CENTER FOR CANCER SURVIVORSHIP PROVIDES SPECIALIZED, LONG-TERM FOLLOW-UP CARE FOR CANCER SURVIVORS AND CONDUCTS CRITICAL RESEARCH SHARED WITH OTHER INSTITUTIONS. During fiscal year 2010, the costs associated with providing charity related PATIENT CARE AND RESEARCH for the community totaled $115,954,000.</Explanation>
      </GeneralExplanation>
      <GeneralExplanation>
        <Identifier>AUDITED FINANCIAL STATEMENTS</Identifier>
        <ReturnReference>FORM 990, PART IV, Lines 12 AND PART XI, Line 2C</ReturnReference>
        <Explanation>AUDITED CONSOLIDATED FINANCIAL STATEMENTS ARE ISSUED FOR CITY OF HOPE AND AFFILIATES. THIS AFFILIATED GROUP INCLUDES CITY OF HOPE, CITY OF HOPE AUXILIARIES, GENBASIX, INC, CITY OF HOPE NATIONAL MEDICAL CENTER, ONCOLOGY MANAGEMENT SERVICES, INC. AND BECKMAN RESEARCH INSTITUTE OF THE CITY OF HOPE. NO STAND-ALONE AUDITS ARE PERFORMED OR ISSUED FOR CITY OF HOPE NATIONAL MEDICAL CENTER. THE AUDITED CONSOLIDATED FINANCIAL STATEMENTS ARE REVIEWED ANNUALLY BY THE AUDIT COMMITTEE OF THE BOARD OF DIRECTORS OF CITY OF HOPE BEFORE FINALIZATION AND ISSUANCE.</Explanation>
      </GeneralExplanation>
      <GeneralExplanation>
        <Identifier>GOVERNANCE, MANAGEMENT AND DISCLOSURES</Identifier>
        <ReturnReference>FORM 990, PART VI, Section A</ReturnReference>
        <Explanation>Line 2 One board member, Ben Horowitz, is the father of fellow board member Jody Horowitz Marsh. Jody Horowitz Marsh was a board member for 6 days during the fiscal year ended September 30, 2010. Form 990, Part VI, Line 6 CITY OF HOPE (95-3435919) IS THE SOLE CORPORATE MEMBER OF THE CITY OF HOPE NATIONAL MEDICAL CENTER. Form 990, Part VI, Line 7a THE SOLE CORPORATE MEMBER, CITY OF HOPE, ELECTS DIRECTORS TO THE CITY OF HOPE NATIONAL MEDICAL CENTER. Form 990, Part VI, Line 7b Certain actions may not be undertaken without the prior written approval of the Sole Corporate Member, City of Hope, as specified in the governing documents of the City of Hope National Medical Center (Medical Center), including: borrow money in the name of the Medical Center or utilize property owned by the Medical Center as security for such loans; assign, transfer, pledge, compromise or release any of the claims or debts to the Medical Center except on payment in full, or arbitrate or consent to the arbitration of any dispute or controversy of the Medical Center; make, execute or deliver any assignment for the benefit of creditors, or any bond, confession of judgment, chattel mortgage, security agreement, deed, guaranty, indemnity bond, surety bond, or contract to sell or bill of sale of the property of the Medical Center; acquire, purchase, develop, improve, sell, lease, or mortgage any corporate real estate or any interest therein or enter into any contract for any such purposes; or make any loan, investment, transfer or disposition of any assets of the Medical Center or enter into any contract or incur any liabilities on behalf of the Medical Center other than for fair consideration and in the ordinary course of business relating to its normal daily operation; establish capital and operating budgets or adopt material changes there. The following require governing body approval (as well as the approval of the Sole Corporate Member): the adoption of, or material change in, the mission of the Medical Center; sale or disposition of all or substantially all assets; merger and its principal terms (and any amendment to those terms); dissolution of the corporation; adoption of operating and capital budgets; acquisitions and capital expenditures meeting a certain financial threshold; borrowings, guaranties, loans, and bond issuance meeting a certain financial threshold; creation of a new (or acquisition of a controlling interest in an existing) corporation, partnership or limited liability company; adoption of or amendments to individual corporate investment guidelines.</Explanation>
      </GeneralExplanation>
      <GeneralExplanation>
        <Identifier>POLICIES</Identifier>
        <ReturnReference>FORM 990, PART VI, SECTION B</ReturnReference>
        <Explanation>Line 11 A copy of the Form 990 is reviewed by the audit committee of the Board of Directors of City of Hope, which assists the Board in fulfilling its responsibilities regarding the financial, accounting, and corporate compliance matters of City of Hope National Medical Center. The parent's audit committee also serves as the audit committee of the Medical Center. Additionally, the preparation of the Form 990 is done internally and is reviewed thoroughly with internal leadership, external participants, including Ernst &amp; Young, retained tax counsel and other tax preparers. Prior to filing the City of Hope National Medical Center (95-1683875) Form 990 is made available to voting members of the City of Hope Board for review electronically on-line through City of Hope's intranet web portal. City of Hope is the sole corporate member of City of Hope National Medical Center. Additionally certain members of the City of Hope Board of Directors also serve as Board Members of City of Hope National Medical Center. Form 990, Part VI, Line 12C ALL EMPLOYEES OF CITY OF HOPE AND AFFILIATES, BOARD OF DIRECTORS, BOARD COMMITTEE MEMBERS AND RESEARCH TEAM MEMBERS ARE COVERED BY CITY OF HOPE'S APPLICABLE CONFLICT OF INTEREST POLICIES. DETERMINATIONS AS TO WHETHER A CONFLICT OF INTEREST EXISTS AND REVIEWS OF SUCH DISCLOSURES ARE MADE BY THE CHIEF RISK OFFICER, GENERAL COUNSEL AND, AS APPLICABLE, THE CHAIR OF THE BOARD OR BOARD OF DIRECTORS OR THE RESEARCH CONFLICT OF INTEREST COMMITTEE, BASED UPON THE CATEGORY OF PERSON MAKING THE DISCLOSURE. RESTRICTIONS IMPOSED ON PERSONS WITH A CONFLICT VARY, BASED UPON THE FACTS. RESTRICTIONS MAY INCLUDE: PROHIBITION FROM PARTICIPATING IN THE GOVERNING BODY'S DELIBERATIONS AND VOTING ON A GIVEN TRANSACTION OR SET OF TRANSACTIONS, RECUSAL FROM THE DECISION-MAKING PROCESS RELATING TO BUSINESS TRANSACTIONS (E.G., PURCHASING DECISIONS), AND PROHIBITION FROM PARTICIPATING AS A PRINCIPAL INVESTIGATOR IN RESEARCH, DISCLOSURE OF FINANCIAL INTEREST IN RESEARCH STUDY INFORMED CONSENT FORMS AND PUBLICATIONS. MONITORING TRANSACTIONS FOR CONFLICTS IS DONE THROUGH REQUIRED DISCLOSURES AND UPDATES BY PERSONS COVERED BY THE ORGANIZATION'S CONFLICT OF INTEREST POLICIES AND A CONCURRENT REVIEW OF SUCH DISCLOSURES AGAINST TRANSACTIONS. CITY OF HOPE POLICY PROVIDES FOR DISCIPLINARY ACTION AGAINST PERSONS COVERED BY THE CONFLICT OF INTEREST POLICIES WHO DO NOT COMPLY WITH POLICY REQUIREMENTS. Form 990, Part VI, Lines 15A AND 15B THE EXECUTIVE COMPENSATION AND ORGANIZATION DEVELOPMENT COMMITTEE OF THE BOARD OF DIRECTORS ("COMMITTEE"), PURSUANT TO A DELEGATION OF AUTHORITY FROM THE BOARD OF DIRECTORS, IS RESPONSIBLE FOR SETTING THE COMPENSATION OF THE CEO AND CERTAIN OTHER SENIOR EXECUTIVES. THE DIRECTORS ON THIS COMMITTEE ARE INDEPENDENT, AND DELIBERATION AND DECISION MAKING ARE SUBSTANTIATED IN THE MINUTES OF THE COMMITTEE'S MEETINGS. THE MINUTES ARE REVIEWED AND APPROVED AT THE NEXT MEETING OF THE COMMITTEE. AS PART OF THE DELIBERATION PROCESS, THE COMMITTEE RECEIVES ADVICE FROM AN INDEPENDENT, OUTSIDE COMPENSATION CONSULTANT WITH RESPECT TO EXECUTIVE COMPENSATION, COMPARABLE AND BENCHMARK DATA, AND CURRENT COMPENSATION PHILOSOPHY, STRUCTURE, AND ADMINISTRATION OF THE EXECUTIVE CASH COMPENSATION PROGRAMS AT CITY OF HOPE. The Committee carries out the Board of Directors' overall responsibilities relating to executive compensation. The Committee engages outside consultants and other professionals to assist it in setting compensation programs at City of Hope and its related organizations. The executive compensation philosophy of City of Hope, City of Hope National Medical Center and the Beckman Research Institute of the City of Hope (referred collectively in this note as "City of Hope") is designed to assist City of Hope in attracting and retaining the caliber of executives required to enable City of Hope to achieve the highest levels of community benefit, clincial care, quality research and efficient philanthropic development. The Executive Compensation Committee targets the 50th percentile of base salary and the 75th percentile of total cash of the market in which City of Hope competes for executives. A substantial portion of executive compensation is linked directly to performance goals approved in advance by the Executive Compensation Committee. These goals are tied to the performance of City of Hope, including the attainment of specific business objectives for strategic and financial performance as well as non-financial measures such as patient satisfaction and quality of patient care. As a consequence, performance compensation may vary from year to year. THE COMMITTEE CONDUCTS COMPENSATION REVIEWS ANNUALLY AND THIS WAS LAST COMPLETED ON SEPTEMBER 24, 2010. The compensation programs and ranges for all Officers and Key Employees listed on Form 990, Part VII are reviewed by this Committee.</Explanation>
      </GeneralExplanation>
      <GeneralExplanation>
        <Identifier>DISCLOSURES</Identifier>
        <ReturnReference>FORM 990, PART VI, SECTION C</ReturnReference>
        <Explanation>Line 19 City of Hope National Medical Center's governing documents are not required to be made available to the public, however the organization's articles of incorporation are available from the Secretary of State, its financial statements are available on the City of Hope website, and its CONFLICT OF INTEREST POLICIES ARE AVAILABLE BY WRITTEN REQUEST MADE TO THE CONFLICT OF INTEREST MANAGER.</Explanation>
      </GeneralExplanation>
      <GeneralExplanation>
        <Identifier>HOURS WORKED</Identifier>
        <ReturnReference>FORM 990, Part VII, COLUMN B</ReturnReference>
        <Explanation>FULL TIME EMPLOYEES GENERALLY WORK IN EXCESS OF 40 HOURS PER WEEK WHICH HAS BEEN REFLECTED IN THE COMPENSATION SCHEDULES BY THE ESTIMATES OF 60 HOURS PER WEEK. THE MEMBERS OF THE BOARD OF DIRECTORS ARE NOT COMPENSATED FOR SERVING ON THE BOARD OF DIRECTORS. THE HOURS WORKED FOR EACH Director is an estimate of the time spent preparing for and attending meetings of the Board of Directors and its standing committees. The Board of Directors held 7 regularly scheduled meetings in Fiscal Year 2010. The Committees had varying numbers of meetings in Fiscal Year 2010. THE FOLLOWING INDIVIDUALS HAVE SPLIT THEIR TIME BETWEEN ENTITIES AS INDICATED: MICHAEL A. FRIEDMAN CITY OF HOPE 15 HOURS PER WEEK CITY OF HOPE NATIONAL MEDICAL CENTER 21 HOURS PER WEEK BECKMAN RESEARCH INSTITUTE 24 HOURS PER WEEK VIRGINIA OPIPARE CITY OF HOPE 3 HOURS PER WEEK CITY OF HOPE NATIONAL MEDICAL CENTER 43 HOURS PER WEEK BECKMAN RESEARCH INSTITUTE 14 HOURS PER WEEK ROBERT STONE CITY OF HOPE 3 HOURS PER WEEK CITY OF HOPE NATIONAL MEDICAL CENTER 43 HOURS PER WEEK BECKMAN RESEARCH INSTITUTE 14 HOURS PER WEEK DENNIS F. RUSCH CITY OF HOPE 3 HOURS PER WEEK CITY OF HOPE NATIONAL MEDICAL CENTER 43 HOURS PER WEEK BECKMAN RESEARCH INSTITUTE 14 HOURS PER WEEK Theodore Krontiris CITY OF HOPE 0 HOURS PER WEEK CITY OF HOPE NATIONAL MEDICAL CENTER 0 HOURS PER WEEK BECKMAN RESEARCH INSTITUTE 60 HOURS PER WEEK</Explanation>
      </GeneralExplanation>
      <GeneralExplanation>
        <Identifier>Bond Counsel Engagement</Identifier>
        <ReturnReference>Schedule K, Part III, line 3c</ReturnReference>
        <Explanation>The organization has inside counsel experienced with business use restrictions to review management or service contracts or research agreements relating to financed property.</Explanation>
      </GeneralExplanation>
      <GeneralExplanation>
        <Identifier>Loans to/From Interested Persons</Identifier>
        <ReturnReference>SCHEDULE L, PART II</ReturnReference>
        <Explanation>THEODORE KRONTIRIS, M.D., PhD, WAS THE EXECUTIVE VICE PRESIDENT FOR MEDICAL AND SCIENTIFIC AFFAIRS AND CANCER CENTER DIRECTOR. HE RESIGNED THIS POSITION DURING FISCAL YEAR 2008. PRIOR TO THIS, DR. KRONTIRIS WAS RECRUITED IN 1996 TO JOIN THE RESEARCH STAFF OF THE MEDICAL CENTER AS A CONSULTING PHYSICIAN IN THE DEPARTMENT OF HEMATOLOGY. AS PART OF THE RECRUITMENT, THE MEDICAL CENTER MADE A LOAN TO DR. KRONTIRIS TO ASSIST HIM WITH THE COST OF RELOCATING FROM MASSACHUSETTS. DR. KRONTIRIS CONTINUED TO MAKE INTEREST PAYMENTS ON THE LOAN IN 2010. THE INTEREST ONLY LOAN IN THE PRINCIPAL AMOUNT OF $100,000, WAS ISSUED AND IS CARRIED ON THE CITY OF HOPE NATIONAL MEDICAL CENTER'S BOOKS AND BEARS INTEREST AT THE RATE OF 6.68 PERCENT PER ANNUM. THE LOAN IS SECURED BY REAL PROPERTY IN THE STATE OF CALIFORNIA AND IS DUE THE EARLIER OF OCTOBER 2, 2012 OR THE TERMINATION OF DR. KRONTIRIS' EMPLOYMENT. DR. KRONTIRIS CONTINUES TO BE EMPLOYED BY THE BECKMAN RESEARCH INSTITUTE OF THE CITY OF HOPE, A RELATED TAX-EXEMPT ORGANIZATION. Michael Jensen, M.D. was provided with a recruitment retention loan in the principal amount of $500,000. The loan bears interest at 4.61 percent per annum and was secured by real property in the state of California and was due and payable in full within 90 days of when Dr. Jensen terminated his employment with the Center on July 2, 2010. Dr. Jensen continued to make interest payments on this loan in 2010, while the principal is amortized as compensation on Schedule J. Dr. Jensen and the Center are renegotiating the final payment terms of the note while the property securing the note is listed on the market for sale.</Explanation>
      </GeneralExplanation>
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