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        <NamePerson>Eisenstadt PhD Eric</NamePerson>
        <BaseCompensationFilingOrg>50140</BaseCompensationFilingOrg>
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        <Identifier>SCHEDULE J, PART I, LINE 4A</Identifier>
        <ReturnReference>SEVERANCE PAYMENTS</ReturnReference>
        <Explanation>Eric Eisenstadt received severance payments in the amount of $67,470 during 2010. Schedule J, Part I, Line 7 Description of Non-Fixed Payments The institute provides service awards to its employees for five, ten, fifteen and twenty years of service. In addition, bonuses are paid for performance or other accomplishments. Other reportable compensation includes the employer match for 401(k), third party benefit payments and severance payments.</Explanation>
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    <IRS990ScheduleL documentId="IRS990ScheduleL">
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        <NameOfInterestedPerson>
          <NamePerson>Heather Kowalski</NamePerson>
        </NameOfInterestedPerson>
        <Relationship>spouse of officer/dir</Relationship>
        <AmountOfTransaction>120000</AmountOfTransaction>
        <DescriptionOfTransaction>performance of media services</DescriptionOfTransaction>
        <SharingOfRevenues>false</SharingOfRevenues>
      </Form990ScheduleLPartIV>
      <Form990ScheduleLPartIV>
        <NameOfInterestedPerson>
          <NamePerson>SYNTHETIC GENOMICS</NamePerson>
        </NameOfInterestedPerson>
        <Relationship>See Part V</Relationship>
        <AmountOfTransaction>4023506</AmountOfTransaction>
        <DescriptionOfTransaction>SRA SEQUENCING &amp; RESEARCH</DescriptionOfTransaction>
        <SharingOfRevenues>false</SharingOfRevenues>
      </Form990ScheduleLPartIV>
      <Form990ScheduleLPartV>
        <Identifier>Description of Relationships</Identifier>
        <ReturnReference>Schedule L, Part IV (2)</ReturnReference>
        <Explanation>J. Craig Venter is the CEO of the J. Craig Venter Institute and Synthetic Genomics Inc. He is the Chairman of the J. Craig Venter Institute and a board member of Synthetic Genomics,Inc. He is a shareholder of Synthetic Genomics, Inc. JCVI trustee and employee Hamilton O. Smith is a co-founder, board member, employee and shareholder of Synthetic Genomics, Inc. JCVI trustee and employee Kenneth Nealson is a member of the scientific advisory board of Synthetic Genomics, Inc. and a consultant. JCVI employee Clyde Hutchison is the Chairman of the Scientific Advisory Board of Synthetic Genomics, Inc. and a shareholder of Synthetic Genomics, Inc. In addition, JCVI board members Theodore Danforth, William Harman and Dean Ornish are shareholders of Synthetic Genomics, Inc.</Explanation>
      </Form990ScheduleLPartV>
    </IRS990ScheduleL>
    <IRS990ScheduleM documentId="IRS990ScheduleM">
      <WorksOfArt />
      <ArtHistoricalTreasures />
      <ArtFractionalInterest />
      <BooksAndPublications />
      <ClothingAndHouseholdGoods />
      <CarsAndOtherVehicles />
      <BoatsAndPlanes />
      <IntellectualProperty />
      <SecuritiesPubliclyTraded />
      <SecuritiesCloselyHeldStock>
        <NonCashCheckbox>X</NonCashCheckbox>
        <NumberOfContributions>1</NumberOfContributions>
        <NoncashContribsRptdF990>2658335</NoncashContribsRptdF990>
        <MethodOfDeterminingRevenues>opinions of experts</MethodOfDeterminingRevenues>
      </SecuritiesCloselyHeldStock>
      <SecuritiesPrtnrshpTrustIntrsts />
      <SecuritiesMiscellaneous />
      <QualifiedContribHistStruct />
      <QualifiedContribOther />
      <RealEstateResidential />
      <RealEstateCommercial />
      <RealEstateOther />
      <Collectibles />
      <FoodInventory />
      <DrugsAndMedicalSupplies />
      <Taxidermy />
      <HistoricalArtifacts />
      <ScientificSpecimens />
      <ArchaeologicalArtifacts />
      <NumberOf8283Received>0</NumberOf8283Received>
      <AnyPropertyThatMustBeHeld>false</AnyPropertyThatMustBeHeld>
      <ReviewProcessUnusualNCGifts>false</ReviewProcessUnusualNCGifts>
      <ThirdPartiesUsed>false</ThirdPartiesUsed>
    </IRS990ScheduleM>
    <IRS990ScheduleN documentId="IRS990ScheduleN">
      <LiquidationTable referenceDocumentId="BinaryAttach" />
      <DispositionTable>
        <DescriptionOfAsset>Building/land/land improvements</DescriptionOfAsset>
        <DateOfDistribution>2010-05-03</DateOfDistribution>
        <FMVOfAsset>53000000</FMVOfAsset>
        <MethodOfFMVDetermination>actual cost</MethodOfFMVDetermination>
        <EIN>272389132</EIN>
        <NamePerson>BMR-Medical Center Drive LLC</NamePerson>
        <AddressUS>
          <AddressLine1>9600 Blackwell Road</AddressLine1>
          <City>Rockville</City>
          <State>MD</State>
          <ZIPCode>20850</ZIPCode>
        </AddressUS>
      </DispositionTable>
      <DirectorOfSuccessor2>false</DirectorOfSuccessor2>
      <EmployeeOfSuccessor2>false</EmployeeOfSuccessor2>
      <OwnerOfSuccessor2>false</OwnerOfSuccessor2>
      <ReceiveCompensation2>false</ReceiveCompensation2>
    </IRS990ScheduleN>
    <IRS990ScheduleO documentId="IRS990ScheduleO">
      <GeneralExplanation>
        <Identifier>Description of Other Program Services</Identifier>
        <ReturnReference>Form 990, Part III, Line 4D</ReturnReference>
        <Explanation>With support from various other sources, JCVI conducts research which has uncovered more than six million new genes and thousands of new protein families from organisms found in sea water; sequenced microbial flora found in human environments such as the vagina, oral cavity and human gut; and sequenced a variety of important infectious disease agents, microbial and environmental genomes and plant genomes.</Explanation>
      </GeneralExplanation>
      <GeneralExplanation>
        <Identifier>Description of Relationships</Identifier>
        <ReturnReference>Form 990, Part VI, Question 2</ReturnReference>
        <Explanation>J. Craig Venter is the CEO of the J. Craig Venter Institute, Synthetic Genomics, Inc., and Synthetic Genomics Vaccines, Inc. He is the Chairman of the J. Craig Venter Institute and a board member of Synthetic Genomics, Inc., and Synthetic Genomic Vaccines, Inc. He is a shareholder of Synthetic Genomics, Inc. JCVI trustee and employee Hamilton O. Smith is a co-founder, board member, employee, and shareholder of Synthetic Genomics, Inc. JCVI trustee and employee Kenneth Nealson is a member of the scientific advisory board of Synthetic Genomics, Inc. and a consultant. JCVI employee Clyde Hutchison is the Chairman of the Scientific Advisory Board of Synthetic Genomics, Inc. and a shareholder of Synthetic Genomics, Inc. Erling Norrby is a board member of both the J. Craig Venter Institute and Synthetic Genomics Vaccines, Inc. In addition, JCVI board members Theodore Danforth, William Harman and Dean Ornish are shareholders of Synthetic Genomics, Inc.; and JCVI board members Theodore Danforth and William Harman are shareholders of Synthetic Genomics Vaccines, Inc.</Explanation>
      </GeneralExplanation>
      <GeneralExplanation>
        <Identifier>Describe the Process used by Management &amp;/or Governing Body to Review 990</Identifier>
        <ReturnReference>Form 990, Part VI, Question 11</ReturnReference>
        <Explanation>The Audit Committee of the Board reviewed the Form 990 and the supporting schedules with the CFO and the organization's 990 preparer in detail. A complete copy of the Form 990 and supporting schedules was also provided to the full board for approval and review prior to being filed.</Explanation>
      </GeneralExplanation>
      <GeneralExplanation>
        <Identifier>Policies</Identifier>
        <ReturnReference>Form 990, Part VI, Question 12, 13 and 14</ReturnReference>
        <Explanation>The organization's written conflict of interest, whistleblower, and document retention policies were reviewed by the board during 2010. However, the 2010 Form 990 instructions were released in December 2010 and the organization did not have time for its Board to meet to formally adopt the policies prior to its year end. JCVI monitors compliance of Conflict of Interest policy through an annual solicitation of conflict of interest statement from trustees, officers and employees.</Explanation>
      </GeneralExplanation>
      <GeneralExplanation>
        <Identifier>Offices &amp; Positions for which process was used</Identifier>
        <ReturnReference>Form 990, Part VI, Question 15A and 15B</ReturnReference>
        <Explanation>JCVI uses Mercer, an outside compensation consultant, to provide a list of comparable salaries for the Chief Executive Officer, Directors of Maryland and California, Chief Financial Officer, and General Counsel. These are reviewed by the JCVI Compensation Committee and CEO before a final determination is made.</Explanation>
      </GeneralExplanation>
      <GeneralExplanation>
        <Identifier>Avail of Gov Docs, Conflict of Interest Policy, &amp; Fin Stmts to Gen Public</Identifier>
        <ReturnReference>Form 990, Part VI, Question 19</ReturnReference>
        <Explanation>These documents are not generally made available to the public.</Explanation>
      </GeneralExplanation>
      <GeneralExplanation>
        <Identifier>Average Hours Per Week</Identifier>
        <ReturnReference>Form 990, Part VII, Section A, Column (b)</ReturnReference>
        <Explanation>The following officers and executives routinely work more than 40 hours per week: J. Craig Venter, Robert Strausberg, Robert Friedman, Julie Adelson, Aimee Turner, Leslie Bisignano, Eric Eisenstadt and Karen Nelson. Until December 16, 2010, Kenneth Nealson's average hours per week was 20 hours per week. The remainder of the year he worked an average of 8 hours per week.</Explanation>
      </GeneralExplanation>
      <GeneralExplanation>
        <Identifier>Other Changes in Net Assets or Fund Balance</Identifier>
        <ReturnReference>Part XI, Line 5</ReturnReference>
        <Explanation>Deferred gain on bldg sale amortized over 10 yrs - credit to rent expense $(3,320,641); Net Unrealized gains on investments $2,470,744; Unrelated Business Loss from partnerships of $1,137</Explanation>
      </GeneralExplanation>
    </IRS990ScheduleO>
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          <BusinessNameLine1>Venter Institute Vaccines Inc</BusinessNameLine1>
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          <City>Rockville</City>
          <State>MD</State>
          <ZIPCode>20850</ZIPCode>
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        <EIN>271936205</EIN>
        <PrimaryActivity>research</PrimaryActivity>
        <LegalDomicileState>DE</LegalDomicileState>
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        <ShareOfTotalIncome>0</ShareOfTotalIncome>
        <ShareOfEOYAssets>0</ShareOfEOYAssets>
        <PercentageOwnership>1.00000</PercentageOwnership>
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      <ReceiptOfIntAnnRentsRoyalties>false</ReceiptOfIntAnnRentsRoyalties>
      <GiftGrantOrCapContrToOtherOrg>false</GiftGrantOrCapContrToOtherOrg>
      <GiftGrantOrCapContrFrOtherOrg>false</GiftGrantOrCapContrFrOtherOrg>
      <LoansOrGuaranteesToOtherOrg>false</LoansOrGuaranteesToOtherOrg>
      <LoansOrGuaranteesFromOtherOrg>false</LoansOrGuaranteesFromOtherOrg>
      <SaleOfAssetsToOtherOrg>false</SaleOfAssetsToOtherOrg>
      <PurchaseOfAssetsFromOtherOrg>false</PurchaseOfAssetsFromOtherOrg>
      <ExchangeOfAssets>false</ExchangeOfAssets>
      <RentalOfFacilitiesToOtherOrgs>false</RentalOfFacilitiesToOtherOrgs>
      <RentalOfFacilitiesFrOtherOrgs>false</RentalOfFacilitiesFrOtherOrgs>
      <PerformOfServicesForOtherOrgs>false</PerformOfServicesForOtherOrgs>
      <PerformOfServicesByOtherOrgs>false</PerformOfServicesByOtherOrgs>
      <SharingOfFacilities>false</SharingOfFacilities>
      <SharingOfPaidEmployees>false</SharingOfPaidEmployees>
      <ReimbursementPaidToOtherOrg>false</ReimbursementPaidToOtherOrg>
      <ReimbursementPaidByOtherOrg>false</ReimbursementPaidByOtherOrg>
      <OtherTransferToOtherOrg>false</OtherTransferToOtherOrg>
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