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        <ProgramServices>4536</ProgramServices>
        <ManagementAndGeneral>9725</ManagementAndGeneral>
      </FeesForServicesInvstMgmntFees>
      <FeesForServicesOther>
        <Total>140881</Total>
        <ProgramServices>140881</ProgramServices>
      </FeesForServicesOther>
      <Advertising>
        <Total>4022</Total>
        <ProgramServices>4022</ProgramServices>
      </Advertising>
      <OfficeExpenses>
        <Total>81010</Total>
        <ProgramServices>77945</ProgramServices>
        <ManagementAndGeneral>3065</ManagementAndGeneral>
      </OfficeExpenses>
      <InformationTechnology>
        <Total>41673</Total>
        <ProgramServices>33283</ProgramServices>
        <ManagementAndGeneral>8390</ManagementAndGeneral>
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      <ConferencesMeetings>
        <Total>431930</Total>
        <ProgramServices>425939</ProgramServices>
        <ManagementAndGeneral>5991</ManagementAndGeneral>
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      <Insurance>
        <Total>11400</Total>
        <ProgramServices>5671</ProgramServices>
        <ManagementAndGeneral>5729</ManagementAndGeneral>
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      <OtherExpenses>
        <Description>PRESIDENT'S FUND</Description>
        <Total>32363</Total>
        <ProgramServices>9299</ProgramServices>
        <ManagementAndGeneral>23064</ManagementAndGeneral>
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      <OtherExpenses>
        <Description>CREDIT CARD AND BANK FE</Description>
        <Total>21221</Total>
        <ManagementAndGeneral>21221</ManagementAndGeneral>
      </OtherExpenses>
      <OtherExpenses>
        <Description>OTHER BUSINESS FEES AND</Description>
        <Total>18521</Total>
        <ProgramServices>17829</ProgramServices>
        <ManagementAndGeneral>692</ManagementAndGeneral>
      </OtherExpenses>
      <OtherExpenses>
        <Description>COUNCIL AND COMMITTEES</Description>
        <Total>17956</Total>
        <ManagementAndGeneral>17956</ManagementAndGeneral>
      </OtherExpenses>
      <OtherExpenses>
        <Description>MISCELLANEOUS</Description>
        <Total>13121</Total>
        <ProgramServices>10564</ProgramServices>
        <ManagementAndGeneral>2557</ManagementAndGeneral>
      </OtherExpenses>
      <AllOtherExpenses>
        <Total>21202</Total>
        <ProgramServices>15678</ProgramServices>
        <ManagementAndGeneral>5524</ManagementAndGeneral>
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      <TotalFunctionalExpenses>
        <Total>1193710</Total>
        <ProgramServices>847766</ProgramServices>
        <ManagementAndGeneral>345944</ManagementAndGeneral>
        <Fundraising>0</Fundraising>
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      <CashNonInterestBearing>
        <BOY>86967</BOY>
        <EOY>72557</EOY>
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      <SavingsAndTempCashInvestments>
        <BOY>36363</BOY>
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        <EOY>15528</EOY>
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        <EOY>23425</EOY>
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        <EOY>1467890</EOY>
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        <EOY>1579400</EOY>
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        <BOY>45386</BOY>
        <EOY>35267</EOY>
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        <BOY>111991</BOY>
        <EOY>117530</EOY>
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      <TotalLiabilities>
        <BOY>157377</BOY>
        <EOY>152797</EOY>
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      <FollowSFAS117>X</FollowSFAS117>
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        <BOY>1350089</BOY>
        <EOY>1117998</EOY>
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      <TemporarilyRestrictedNetAssets>
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        <EOY>268605</EOY>
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      <PermanentlyRestrictedNetAssets>
        <BOY>40000</BOY>
        <EOY>40000</EOY>
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      <TotalNetAssetsFundBalances>
        <BOY>1641712</BOY>
        <EOY>1426603</EOY>
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      <TotalLiabNetAssetsFundBalances>
        <BOY>1799089</BOY>
        <EOY>1579400</EOY>
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      <InfoInScheduleOPartXI>X</InfoInScheduleOPartXI>
      <ReconcilationRevenueExpenses>-236816</ReconcilationRevenueExpenses>
      <ReconcilationOtherChanges>21707</ReconcilationOtherChanges>
      <InfoInScheduleOPartXII>X</InfoInScheduleOPartXII>
      <MethodOfAccountingAccrual>X</MethodOfAccountingAccrual>
      <AccountantCompileOrReview>0</AccountantCompileOrReview>
      <FSAudited>1</FSAudited>
      <AuditCommittee>1</AuditCommittee>
      <FinancialStatementSeparate>X</FinancialStatementSeparate>
      <FederalGrantAuditRequired>0</FederalGrantAuditRequired>
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      <PubliclySupportedOrg509a2>X</PubliclySupportedOrg509a2>
      <GiftsGrantsContribReceived509>
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        <CurrentTaxYearMinus3Years>375684</CurrentTaxYearMinus3Years>
        <CurrentTaxYearMinus2Years>274805</CurrentTaxYearMinus2Years>
        <CurrentTaxYearMinus1Year>260773</CurrentTaxYearMinus1Year>
        <CurrentTaxYear>233253</CurrentTaxYear>
        <Total>1470874</Total>
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      <GrossReceiptsFromAdmissions>
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        <CurrentTaxYearMinus3Years>783829</CurrentTaxYearMinus3Years>
        <CurrentTaxYearMinus2Years>1417623</CurrentTaxYearMinus2Years>
        <CurrentTaxYearMinus1Year>1071802</CurrentTaxYearMinus1Year>
        <CurrentTaxYear>591756</CurrentTaxYear>
        <Total>5017681</Total>
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      <Total509>
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        <CurrentTaxYearMinus3Years>1159513</CurrentTaxYearMinus3Years>
        <CurrentTaxYearMinus2Years>1692428</CurrentTaxYearMinus2Years>
        <CurrentTaxYearMinus1Year>1332575</CurrentTaxYearMinus1Year>
        <CurrentTaxYear>825009</CurrentTaxYear>
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      <AmtsRecdFromDisqualPersons>
        <Total>0</Total>
      </AmtsRecdFromDisqualPersons>
      <AmtsFromSubstContributors>
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        <CurrentTaxYearMinus2Years>6509</CurrentTaxYearMinus2Years>
        <CurrentTaxYearMinus1Year>5975</CurrentTaxYearMinus1Year>
        <CurrentTaxYear>16858</CurrentTaxYear>
        <Total>51264</Total>
      </AmtsFromSubstContributors>
      <SupportFromDQPsEtc>
        <CurrentTaxYearMinus3Years>21922</CurrentTaxYearMinus3Years>
        <CurrentTaxYearMinus2Years>6509</CurrentTaxYearMinus2Years>
        <CurrentTaxYearMinus1Year>5975</CurrentTaxYearMinus1Year>
        <CurrentTaxYear>16858</CurrentTaxYear>
        <Total>51264</Total>
      </SupportFromDQPsEtc>
      <PublicSupportTotal509>6437291</PublicSupportTotal509>
      <GrossInvestmentIncome509>
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        <CurrentTaxYearMinus2Years>52512</CurrentTaxYearMinus2Years>
        <CurrentTaxYearMinus1Year>65318</CurrentTaxYearMinus1Year>
        <CurrentTaxYear>50056</CurrentTaxYear>
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      <InvestmentIncomeAndUBTI>
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        <CurrentTaxYearMinus3Years>66249</CurrentTaxYearMinus3Years>
        <CurrentTaxYearMinus2Years>52512</CurrentTaxYearMinus2Years>
        <CurrentTaxYearMinus1Year>65318</CurrentTaxYearMinus1Year>
        <CurrentTaxYear>50056</CurrentTaxYear>
        <Total>301795</Total>
      </InvestmentIncomeAndUBTI>
      <OtherIncome509>
        <CurrentTaxYearMinus4Years>6149</CurrentTaxYearMinus4Years>
        <CurrentTaxYearMinus3Years>3101</CurrentTaxYearMinus3Years>
        <CurrentTaxYearMinus2Years>1451</CurrentTaxYearMinus2Years>
        <CurrentTaxYearMinus1Year>4607</CurrentTaxYearMinus1Year>
        <CurrentTaxYear>7050</CurrentTaxYear>
        <Total>22358</Total>
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      <TotalSupportTotal>
        <CurrentTaxYearMinus4Years>1552839</CurrentTaxYearMinus4Years>
        <CurrentTaxYearMinus3Years>1228863</CurrentTaxYearMinus3Years>
        <CurrentTaxYearMinus2Years>1746391</CurrentTaxYearMinus2Years>
        <CurrentTaxYearMinus1Year>1402500</CurrentTaxYearMinus1Year>
        <CurrentTaxYear>882115</CurrentTaxYear>
        <Total>6812708</Total>
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      <PublicSupportPercentage509>0.94490</PublicSupportPercentage509>
      <PriorYearSupportPercentage>0.94830</PriorYearSupportPercentage>
      <InvestmentIncomePercentage>0.04430</InvestmentIncomePercentage>
      <PriorYrInvestIncomePercentage>0.04250</PriorYrInvestIncomePercentage>
      <ThirtyThreePercntTestsCY509>X</ThirtyThreePercntTestsCY509>
    </IRS990ScheduleA>
    <IRS990ScheduleB documentId="RetDoc1234500001">
      <ContributorInfo>
        <ContributorNumber>RESTRICTED</ContributorNumber>
        <ContributorNameBusiness>
          <BusinessNameLine1>RESTRICTED</BusinessNameLine1>
        </ContributorNameBusiness>
        <ContributorAddressUS>
          <AddressLine1>RESTRICTED</AddressLine1>
          <AddressLine2>RESTRICTED</AddressLine2>
          <City>RESTRICTED</City>
          <State>RESTRICTED</State>
          <ZIPCode>RESTRICTED</ZIPCode>
        </ContributorAddressUS>
        <AggregateContributions>RESTRICTED</AggregateContributions>
      </ContributorInfo>
    </IRS990ScheduleB>
    <IRS990ScheduleD documentId="RetDoc1040000001">
      <CurrentYear>
        <BeginningOfYearBalance>443564</BeginningOfYearBalance>
        <Contributions>20</Contributions>
        <InvestmentEarningsOrLosses>30202</InvestmentEarningsOrLosses>
        <OtherExpenditures>7696</OtherExpenditures>
        <EndOfYearBalance>466090</EndOfYearBalance>
      </CurrentYear>
      <CurrentYearMinus1Year>
        <BeginningOfYearBalance>345999</BeginningOfYearBalance>
        <Contributions>23557</Contributions>
        <InvestmentEarningsOrLosses>82348</InvestmentEarningsOrLosses>
        <OtherExpenditures>8340</OtherExpenditures>
        <EndOfYearBalance>443564</EndOfYearBalance>
      </CurrentYearMinus1Year>
      <CurrentYearMinus2Years>
        <BeginningOfYearBalance>376445</BeginningOfYearBalance>
        <Contributions>9668</Contributions>
        <InvestmentEarningsOrLosses>-38196</InvestmentEarningsOrLosses>
        <OtherExpenditures>1918</OtherExpenditures>
        <EndOfYearBalance>345999</EndOfYearBalance>
      </CurrentYearMinus2Years>
      <BoardDesignatedEOYBalance>0.33000</BoardDesignatedEOYBalance>
      <PermanentEndowmentEOYBalance>0.09000</PermanentEndowmentEOYBalance>
      <TermEndowmentEOYBalance>0.58000</TermEndowmentEOYBalance>
      <EndowmentsHeldByUnrelatedOrgs>0</EndowmentsHeldByUnrelatedOrgs>
      <EndowmentsHeldByRelatedOrgs>0</EndowmentsHeldByRelatedOrgs>
      <TotalOfBookValueLandBuildings>0</TotalOfBookValueLandBuildings>
      <TotalRevenue>956894</TotalRevenue>
      <TotalExpenses>1193710</TotalExpenses>
      <ExcessOrDeficitForYear>-236816</ExcessOrDeficitForYear>
      <NetUnrealizedGLOnInvestments>21707</NetUnrealizedGLOnInvestments>
      <TotalAdjustments>21707</TotalAdjustments>
      <ExcessOrDeficitPerFS>-215109</ExcessOrDeficitPerFS>
      <TotRevenueEtcAuditedFinclStmt>978601</TotRevenueEtcAuditedFinclStmt>
      <NetUnrealizedGainsInvestments>21707</NetUnrealizedGainsInvestments>
      <RevenueNotRptdF990>21707</RevenueNotRptdF990>
      <RevenueSubtotal>956894</RevenueSubtotal>
      <RevenueNotRptdOnFinStmt>0</RevenueNotRptdOnFinStmt>
      <TotalRevenuePerForm990>956894</TotalRevenuePerForm990>
      <TotExpensesEtcAuditedFinclStmt>1193710</TotExpensesEtcAuditedFinclStmt>
      <ExpensesNotRptdF990>0</ExpensesNotRptdF990>
      <ExpensesSubtotal>1193710</ExpensesSubtotal>
      <ExpensesNotRptdOnFinStmt>0</ExpensesNotRptdOnFinStmt>
      <TotalExpensesPerForm990>1193710</TotalExpensesPerForm990>
      <Form990ScheduleDPartXIV>
        <Identifier>DESCRIPTION OF INTENDED USE OF ENDOWMENT FUNDS:</Identifier>
        <ReturnReference>PART V, LINE 4:</ReturnReference>
        <Explanation>THE TEMPORARILY RESTRICTED FUNDS ARE RESTRICTED BY THE DONOR AND ARE RELEASED FROM RESTRICTION UPON SATISFACTION OF THE RESTRICTION BY THE SOCIETY. THE PERMANENTLY RESTRICTED FUNDS ARE RESTRICTED IN PERPETUITY BY THE DONOR. EARNINGS ON THE FUNDS ARE THEN RESTRICTED FOR THE PURPOSE DESIGNATED BY THE DONOR AND ARE RELEASED FROM RESTRICTION UPON SATISFACTION OF THE RESTRICTION BY THE SOCIETY.</Explanation>
      </Form990ScheduleDPartXIV>
    </IRS990ScheduleD>
    <IRS990ScheduleF documentId="RetDoc1040500001">
      <GrantRecordsMaintained>1</GrantRecordsMaintained>
      <AcctsActvsOutUSTable>
        <Region>MIDDLE EAST AND NORTH AFRICA</Region>
        <NumberOfOffices>0</NumberOfOffices>
        <NumberOfEmployees>0</NumberOfEmployees>
        <TypeOfActivitiesConducted>GRANTS TO RECIPIENTS</TypeOfActivitiesConducted>
        <TotalExpenditures>1140</TotalExpenditures>
      </AcctsActvsOutUSTable>
      <AcctsActvsOutUSTable>
        <Region>EUROPE (INCLUDING ICELAND &amp; GREENLAND)</Region>
        <NumberOfOffices>0</NumberOfOffices>
        <NumberOfEmployees>0</NumberOfEmployees>
        <TypeOfActivitiesConducted>GRANTS TO RECIPIENTS</TypeOfActivitiesConducted>
        <TotalExpenditures>3050</TotalExpenditures>
      </AcctsActvsOutUSTable>
      <AcctsActvsOutUSTable>
        <Region>SOUTH ASIA</Region>
        <NumberOfOffices>0</NumberOfOffices>
        <NumberOfEmployees>0</NumberOfEmployees>
        <TypeOfActivitiesConducted>GRANTS TO RECIPIENTS</TypeOfActivitiesConducted>
        <TotalExpenditures>3350</TotalExpenditures>
      </AcctsActvsOutUSTable>
      <AcctsActvsOutUSTable>
        <Region>SUB-SAHARAN AFRICA</Region>
        <NumberOfOffices>0</NumberOfOffices>
        <NumberOfEmployees>0</NumberOfEmployees>
        <TypeOfActivitiesConducted>GRANTS TO RECIPIENTS</TypeOfActivitiesConducted>
        <TotalExpenditures>2460</TotalExpenditures>
      </AcctsActvsOutUSTable>
      <SubtotalNumberOfEmployees>0</SubtotalNumberOfEmployees>
      <ContNumberOfEmployees>0</ContNumberOfEmployees>
      <TotalNumberOfEmployees>0</TotalNumberOfEmployees>
      <SubtotalAmountSpent>10000</SubtotalAmountSpent>
      <ContAmountSpent>0</ContAmountSpent>
      <TotalAmountSpent>10000</TotalAmountSpent>
      <GrantsToIndOutsideUS>
        <TypeOfAssistance>TRAVEL GRANT</TypeOfAssistance>
        <Region>EUROPE (INCLUDING ICELAND &amp; GREENLAND)</Region>
        <NumberOfRecipients>5</NumberOfRecipients>
        <AmountOfCashGrant>3050</AmountOfCashGrant>
        <MannerOfCashDisbursement>CHECK OR WIRE TRANSFER</MannerOfCashDisbursement>
      </GrantsToIndOutsideUS>
      <GrantsToIndOutsideUS>
        <TypeOfAssistance>TRAVEL GRANT</TypeOfAssistance>
        <Region>MIDDLE EAST AND NORTH AFRICA</Region>
        <NumberOfRecipients>2</NumberOfRecipients>
        <AmountOfCashGrant>1140</AmountOfCashGrant>
        <MannerOfCashDisbursement>CHECK OR WIRE TRANSFER</MannerOfCashDisbursement>
        <AmountOfNonCashAssistance>0</AmountOfNonCashAssistance>
      </GrantsToIndOutsideUS>
      <GrantsToIndOutsideUS>
        <TypeOfAssistance>TRAVEL GRANT</TypeOfAssistance>
        <Region>SOUTH ASIA</Region>
        <NumberOfRecipients>3</NumberOfRecipients>
        <AmountOfCashGrant>3350</AmountOfCashGrant>
        <MannerOfCashDisbursement>CHECK OR WIRE TRANSFER</MannerOfCashDisbursement>
        <AmountOfNonCashAssistance>0</AmountOfNonCashAssistance>
      </GrantsToIndOutsideUS>
      <GrantsToIndOutsideUS>
        <TypeOfAssistance>TRAVEL GRANT</TypeOfAssistance>
        <Region>SUB-SAHARAN AFRICA</Region>
        <NumberOfRecipients>1</NumberOfRecipients>
        <AmountOfCashGrant>2460</AmountOfCashGrant>
        <MannerOfCashDisbursement>CHECK OR WIRE TRANSFER</MannerOfCashDisbursement>
        <AmountOfNonCashAssistance>0</AmountOfNonCashAssistance>
      </GrantsToIndOutsideUS>
      <TransferToForeignCorp>0</TransferToForeignCorp>
      <InterestInForeignTrust>0</InterestInForeignTrust>
      <OwnForeignCorp>0</OwnForeignCorp>
      <PassiveForeignInvestCo>0</PassiveForeignInvestCo>
      <ForeignPartnership>0</ForeignPartnership>
      <BoycottCountries>0</BoycottCountries>
      <Form990ScheduleFPartV>
        <Identifier>PROCEDURE FOR MONITORING GRANTS OUTSIDE THE U.S.:</Identifier>
        <Explanation>SCHEDULE F, PART I, LINE 2: TRAVEL GRANT RECIPIENTS HAVE TO APPLY AND THE MEMBERSHIP COMMITTEE MAKES THE DECISION ON WHOM TO AWARD THE TRAVEL GRANTS TO. THE AWARDS ARE MONITORED BY THE STAFF OF ISSX. IF A RECIPIENT IS FOUND TO NOT HAVE FULFILLED THE ELIGIBILITY CRITERIA, THE AWARD WILL BE CANCELLED AND/OR FORFEITED.</Explanation>
      </Form990ScheduleFPartV>
    </IRS990ScheduleF>
    <IRS990ScheduleO documentId="RetDoc1044400001">
      <GeneralExplanation>
        <Identifier>FORM 990, PART VI, SECTION A, LINE 3</Identifier>
        <Explanation>THE SOCIETY HAS CONTRACTED WITH SMITHBUCKLIN TO PERFORM ALL MANAGEMENT FUNCTIONS.</Explanation>
      </GeneralExplanation>
      <GeneralExplanation>
        <Identifier>FORM 990, PART VI, SECTION A, LINE 6</Identifier>
        <Explanation>ISSX IS A MEMBERSHIP ORGANIZATION FOR ANYONE ENGAGED IN RESEARCH IN XENOBIOTICS, OR IN THE ADMINISTRATION AND/OR REGULATION OF SUCH RESEARCH, OR ANYONE WHO EXPRESSES A SCIENTIFIC INTEREST IN THE FIELD WILL BE ELIGIBLE FOR MEMBERSHIP. THERE WILL BE NO RESTRICTIONS BECAUSE OF PLACE OF BIRTH, RESIDENCE, NATIONALITY, SEX, RACE OR CREED. MEMBERSHIP CATEGORIES ARE SET FORTH IN THE BY-LAWS.</Explanation>
      </GeneralExplanation>
      <GeneralExplanation>
        <Identifier>FORM 990, PART VI, SECTION A, LINE 7A</Identifier>
        <Explanation>ELECTED COUNCILORS: THERE SHALL BE A MINIMUM OF THREE (3) AND MAXIMUM OF ELEVEN (11) COUNCILORS WITH THE ACTUAL NUMBER OF COUNCILORS TO BE DETERMINED BY THE COUNCIL THROUGH A COUNCIL RESOLUTION. SEVEN COUNCILORS SHALL BE ELECTED ON A BIENNIAL BASIS TO SERVE 2-YEAR TERMS. COUNCILORS MAY SERVE NO MORE THAN TWO SUCCESSIVE 2-YEAR TERMS BUT MAY SERVE ADDITIONAL TERMS AFTER AN ABSENCE FROM COUNCIL MEMBERSHIP OF AT LEAST 1 YEAR.</Explanation>
      </GeneralExplanation>
      <GeneralExplanation>
        <Identifier>FORM 990, PART VI, SECTION B, LINE 11</Identifier>
        <Explanation>THE CLIENT MANAGER PERFORMS AN INITIAL REVIEW AND THE EXECUTIVE DIRECTOR PERFORMS A FINAL REVIEW BEFORE EMAILING A COPY TO THE COUNCIL PRIOR TO FILING.</Explanation>
      </GeneralExplanation>
      <GeneralExplanation>
        <ReturnReference>FORM 990, PART VI, SECTION B, LINE 12C</ReturnReference>
        <Explanation>IN CONNECTION WITH ANY ACTUAL OR POSSIBLE CONFLICT OF INTEREST, AN INTERESTED PERSON MUST DISCLOSE THE EXISTENCE OF THE FINANCIAL INTEREST AND BE GIVEN THE OPPORTUNITY TO DISCLOSE ALL MATERIAL FACTS TO THE COUNCIL MEMBERS AND MEMBERS OF COMMITTEES WITH GOVERNING BOARD DELEGATED POWERS CONSIDERING THE PROPOSED TRANSACTION OR ARRANGEMENT. THE REMAINING COUNCIL MEMBERS SHALL DECIDE IF A CONFLICT OF INTEREST EXISTS. AFTER DISCLOSURE OF THE FINANCIAL INTEREST AND ALL MATERIAL FACTS, AND AFTER ANY DISCUSSION WITH THE INTERESTED PERSON, HE/SHE SHALL LEAVE THE COUNCIL MEETING WHILE THE DETERMINATION OF A CONFLICT OF INTEREST IS DISCUSSED AND VOTED UPON.</Explanation>
      </GeneralExplanation>
      <GeneralExplanation>
        <ReturnReference>FORM 990, PART VI, SECTION C, LINE 19</ReturnReference>
        <Explanation>THE GOVERNING DOCUMENTS, POLICIES, AND FINANCIAL STATEMENTS ARE AVAILABLE TO THE PUBLIC UPON REQUEST.</Explanation>
      </GeneralExplanation>
      <GeneralExplanation>
        <Identifier>CHANGES IN NET ASSETS OR FUND BALANCES:</Identifier>
        <ReturnReference>FORM 990, PART XI, LINE 5:</ReturnReference>
        <Explanation>NET UNREALIZED GAINS ON INVESTMENTS: 21,707.</Explanation>
      </GeneralExplanation>
      <GeneralExplanation>
        <Identifier>OVERSIGHT OF AUDITOR</Identifier>
        <ReturnReference>FORM 990, PART XII, LINE 2C</ReturnReference>
        <Explanation>THE SOCIETY HAS AN AUDIT COMMITTEE WHICH ASSUMES RESPONSIBILITY FOR OVERSIGHT AND SELECTION OF THE INDEPENDENT AUDITOR.</Explanation>
      </GeneralExplanation>
    </IRS990ScheduleO>
  </ReturnData>
</Return>