2011-11-08T16:48:45-06:00 2010-12-31 CLARK NUBER PS 10900 NE 4TH STREET SUITE 1700 BELLEVUE WA 98004 990 2010-01-01 912003593 INSTITUTE FOR SYSTEMS BIOLOGY INST 2067321200 401 TERRY AVENUE N SEATTLE WA 98109 JAMES R LADD 2067321200 2011-11-04 1 SARA ELIZABETH J HYRE 4254544919 2011-11-04 2010 2016-03-07 17:11:31Z X LEROY HOOD 401 TERRY AVENUE N SEATTLE WA 98109 58324658 0 X WWW.SYSTEMSBIOLOGY.ORG X 1999 WA USING THE SCIENCE OF SYSTEMS BIOLOGY TO PREDICT, PREVENT AND CURE DISEASE. 10 9 363 10 20244 19244 29351797 39044471 6754119 17334852 360426 544409 273053 623927 36739395 57547659 0 0 0 0 21086738 24299984 0 0 327034 19232425 26420568 40319163 50720552 -3579768 6827107 38775759 56185035 23729798 34311967 15045961 21873068 X THE INSTITUTE FOR SYSTEMS BIOLOGY IS A NON-PROFIT RESEARCH INSTITUTE FOUNDED IN SEATTLE IN 1999 TO ADVANCE A SYSTEMS (OR HOLISTIC AND CROSS-DISCIPLINARY) APPROACH TO SCIENCE; PERSONALIZED MEDICINE; GLOBAL HEALTH AND ENVIRONMENTAL SUSTAINABILITY; SCIENCE EDUCATION; AND THE PIONEERING AND INVENTION OF BIOLOGICAL AND TECHNOLOGICAL METHODS AND TOOLS. 0 0 26700222 311724 BIOMOLECULAR RESEARCH: INSTITUTE FOR SYSTEMS BIOLOGY SCIENTISTS PUBLISHED MORE THAN 80 RESEARCH PAPERS IN PEER-REVIEWED JOURNALS IN 2010. RESEARCH TOPICS INCLUDED: GENOMICS, MICROFLUIDICS, PROTEOMICS, HIGH-THROUGHPUT COMPUTATION, SYSTEMS BIOLOGY APPLICATIONS, AND BIOINFORMATICS. IN 2009, SCIMAGO RATED THE IMPACT OF ISB'S PAPERS AS NO. 1 IN THE UNITED STATES AND NO. 3 IN THE WORLD. 608916 156026 SCIENCE EDUCATION: ISB'S CENTER FOR INQUIRY SCIENCE (CIS) PROVIDES TRAINING FOR K-12 SCIENCE TEACHERS IN MORE THAN 30 DISTRICTS ACROSS WASHINGTON STATE THAT SERVE 45 PERCENT OF THE TOTAL STUDENT POPULATION IN THE STATE. CIS STAFF HAVE HOSTED MORE THAN 90 PROFESSIONAL DEVELOPMENT SESSIONS, SERVING MORE THAN 900 SCIENCE EDUCATORS OVER THE COURSE OF 150 WORKSHOP DAYS. THIS WORK HAS HELPED INCREASE ACHIEVEMENT SCORES IN THE HIGHEST-NEED DISTRICTS BY NEARLY 30 PERCENT. 11776517 16867102 UNIVERSITY OF LUXEMBOURG (UL) COLLABORATION CONTRACT: THIS IS A FIVE-YEAR PROJECT UTILIZING FUNDS SPENT DOMESTICALLY, IN WHICH THE INSTITUTE WILL: (1) COORDINATE AND PERFORM RESEARCH WORK ON TWO PRIMARY PROJECTS RELATED TO (A) PERSONAL GENOME SEQUENCING AND SYSTEMS GENETICS AND (B) PERSONAL BLOOD PROTEOMICS, RNA, AND PROGENITOR CELL ANALYSIS; (2) ASSIST UL WITH ESTABLISHING AND RECRUITING FACULTY FOR A CENTER FOR SYSTEMS BIOLOGY; (3) TRANSFER KNOWLEDGE ABOUT SYSTEMS BIOLOGY TO UL STAFF THROUGH MENTORING, STAFF EXCHANGES, AND RESEARCH COLLABORATIONS. ACCOMPLISHMENTS IN 2010 INCLUDED: (1) GROUNDBREAKING OF LUXEMBOURG CENTRE FOR SYSTEMS BIOMEDICINE. (2) THE SEQUENCING ANALYSIS OF THE COMPLETE GENOMES OF A FAMILY OF FOUR. (3) ISB SEQUENCED MORE THAN 100 INDIVIDUAL GENOMES IN SIX LARGER FAMILIES. (4) LAUNCHED NEW GENETICS STUDIES INVOLVING DISEASES SUCH AS CONGENITAL HEART DEFECTS, HUNTINGTON'S DISEASE AND, EVENTUALLY, ALZHEIMER'S, EPILEPSY, PARKINSON'S AND SPINAL MUSCULAR ATROPHY. 39085655 1 1 0 1 0 0 0 0 1 1 0 0 0 1 0 1 0 0 0 0 0 0 0 0 0 0 0 0 1 0 0 0 1 0 0 0 0 0 0 0 0 0 1 1 0 0 0 1 100 0 1 363 1 1 1 0 0 0 0 0 0 0 0 0 X 10 9 0 0 0 0 0 0 0 1 0 0 0 1 1 1 1 1 1 1 1 0 WA CA X GARY C STREICHER 2067321227 401 TERRY AVENUE N SEATTLE WA 98109 ROGER PERLMUTTER MD PHD 1.00 X X 0 0 0 GARRY MENZEL PHD 1.00 X 0 0 0 CHARLES L HIRSCH 1.00 X 0 0 0 WILLIAM K BOWES JR 0.50 X 0 0 0 THOMAS J CABLE 1.00 X 0 0 0 LOUIS G LANGE MD PHD 1.00 X X 0 0 0 DAVID A SABEY 1.00 X 0 0 0 MARK ASHIDA 5.00 X 0 0 0 ROBERT T NELSEN 1.00 X 0 0 0 LEROY HOOD PHD 84.00 X X 351443 0 31401 ALAN ADEREM PHD 80.00 X 321303 0 43672 JAMES R LADD 50.00 X 247353 0 36646 CATHRYN CAMPBELL JD PHD 40.00 X 218133 0 29010 SHIRLEY MEINECKE 40.00 X 83841 0 14994 LAURENCE HERRON 50.00 X 205368 0 15891 DAVID GALAS PHD 60.00 X 295843 0 32050 JOHN AITCHISON PHD 50.00 X 256303 0 43360 TIMOTHY GALITSKI PHD 50.00 X 198634 0 38881 ILYA SHMULEVICH PHD 50.00 X 196631 0 38879 DIANE ISONAKA 50.00 X 194760 0 26625 ROBERT MORITZ PHD 50.00 X 180450 0 25147 2750062 0 376556 33 0 1 0 BN BUILDERS 2601 4TH AVENUE SUITE 350 SEATTLE WA 98121 GENERAL CONSTRUCTION 7324994 PERKINS WILL INC 1221 2ND AVENUE SUITE 200 SEATTLE WA 98101 ARCHITECTURAL & ENGINEERING 1053882 MORRISON & FOERSTER LLP 12531 HIGH BLUFF DRIVE SUITE 100 SAN DIEGO CA 92130 LEGAL SERVICES 188753 CLARK NUBER PS 10900 NE 4TH ST SUITE 1700 BELLEVUE WA 98004 ACCOUNTING, AUDIT, & TAX SERVICES 157243 TATUM LLC 601 UNION STREET SUITE 4200-176 SEATTLE WA 98101 MANAGEMENT CONSULTING 116084 8 29558192 9486279 39044471 LUXEMBOURG COLLABORATN 541700 16867152 16867152 LAB AND RESEARCH SRVCS 541700 311674 311674 SCIENCE EDUCATION 541900 156026 156026 17334852 186521 186521 155339 155339 854203 769199 85004 85004 20244 64760 342815 22873 7800 342815 15073 357888 357888 COST REIMBURSEMENTS 900099 383584 383584 383584 57547659 17334852 20244 1148092 1926944 963770 890855 72319 15638291 11497009 4083647 57635 1524654 1111090 408346 5218 3805014 2794900 985611 24503 1405081 995275 400175 9631 378983 5741 373242 511767 9511 502256 186819 186819 93311 93311 339392 339392 111441 22403 88889 149 710857 41135 662955 6767 358086 35009 323077 5473418 4260414 1089896 123108 567005 314214 238189 14602 154338 38238 113844 2256 153574 125716 24107 3751 3190637 2922285 264077 4275 137681 137681 SUPPLIES 5606589 5606430 159 SUBCONTRACTS 4081219 4081219 SHARED SERVICES 2200872 2190073 10799 FELLOWSHIPS 322945 250720 72225 FEDERAL TAXES 3330 3330 1838304 1481111 354532 2661 50720552 39085655 11307863 327034 69620 70450 24073240 24611013 3285333 10253126 381343 1848141 45000 37500 671283 671283 885801 666644 44016346 26855593 8490589 17160753 192270 184845 681280 681280 38775759 56185035 5378460 7173342 7080276 7401564 9908500 9387000 1362562 10350061 23729798 34311967 X 5507661 4764116 866800 8437452 8671500 8671500 15045961 21873068 38775759 56185035 6827107 0 X 0 1 1 X 1 1 X 22406640 27760023 36067112 29351797 39044471 154630043 22406640 27760023 36067112 29351797 39044471 154630043 8585272 146044771 969589 974479 892643 1256885 1075697 5169293 42136 24340 19519 3976 20244 110215 4201 1585 140398 139147 383582 668913 160578464 25571294 0.90950 0.89800 X SCHEDULE A, PART II, LINE 10, EXPLANATION OF OTHER INCOME: COST REIMBURSEMENTS RESTRICTED RESTRICTED RESTRICTED RESTRICTED RESTRICTED RESTRICTED RESTRICTED RESTRICTED 0 0 0 0 0 0 1 93311 0 0 93311 0 8671500 83055 83055 8671500 8671500 161549 161549 8671500 8671500 8671500 1.00000 0 0 13503203 11748714 1754489 20749425 15106879 5642546 9763718 9763718 17160753 DEFERRED RENT PAYABLE 10350061 10350061 57547659 50720552 6827107 0 6827107 57978336 0 57978336 -430677 -430677 57547659 51151229 430677 430677 50720552 0 50720552 DESCRIPTION OF INTENDED USE OF ENDOWMENT FUNDS: PART V, LINE 4: THESE ENDOWMENT FUNDS ARE PLEDGED AS COLLATERAL FOR THE ORGANIZATION'S LONG-TERM DEBT. EARNINGS ON THE ENDOWMENT FUNDS ARE USED TO PARTIALLY FUND PAYMENT OF PRINCIPAL & INTEREST DUE ON THE DEBT. PART XII, LINE 4B - OTHER ADJUSTMENTS: RENTAL EXPENSES NETTED AGAINST REVENUES ON PART VIII -769,199. TENANT REVENUE NETTED WITH EXPENSES ON FINANCIAL STATEMENTS 338,522. PART XIII, LINE 2D - OTHER ADJUSTMENTS: RENTAL EXPENSES NETTED AGAINST REVENUES ON PART VIII 769,199. TENANT REVENUE NETTED WITH EXPENSES ON FINANCIAL STATEMENTS -338,522. X X X X X 1 0 0 0 0 0 0 0 0 LEROY HOOD PHD 350000 0 0 0 1443 0 23968 0 7433 0 382844 0 0 0 ALAN ADEREM PHD 319860 0 0 0 1443 0 24500 0 19172 0 364975 0 0 0 JAMES R LADD 246021 0 0 0 1332 0 24500 0 12146 0 283999 0 0 0 CATHRYN CAMPBELL JD PHD 217002 0 0 0 1131 0 21967 0 7043 0 247143 0 0 0 LAURENCE HERRON 94852 0 0 0 110516 0 9501 0 6390 0 221259 0 0 0 DAVID GALAS PHD 294400 0 0 0 1443 0 24500 0 7550 0 327893 0 0 0 JOHN AITCHISON PHD 247360 0 0 0 8943 0 24319 0 19041 0 299663 0 0 0 TIMOTHY GALITSKI PHD 197401 0 0 0 1233 0 20123 0 18758 0 237515 0 0 0 ILYA SHMULEVICH PHD 195420 0 0 0 1211 0 20121 0 18758 0 235510 0 0 0 DIANE ISONAKA 193650 0 0 0 1110 0 19536 0 7089 0 221385 0 0 0 ROBERT MORITZ PHD 179360 0 0 0 1090 0 18109 0 7038 0 205597 0 0 0 PART I, LINE 4A LAURENCE HERRON - SEPARATION PAYMENT OF $110,000 WHICH INCLUDED SIX MONTHS SEVERANCE AND DISPOSITION OF OTHER BENEFITS. INTEGRATED DIAGNOSTICS INC 2008 OPERATING EXPENSES X 287733 287733 0 1 1 JOHN AITCHISON RELOCATION ASSISTANCE X 75000 37500 0 0 1 INTEGRATED DIAGNOSTICS INC 2009 OPERATING EXPENSES (THRU 8/31/09) X 383550 383550 0 1 1 708783 FORM 990, PART VI, SECTION A, LINE 8B ALL MEETINGS HELD AND WRITTEN ACTIONS TAKEN BY THE INSTITUTE'S BOARD OF DIRECTORS ARE DOCUMENTED CONTEMPORANEOUSLY IN MINUTES. BECAUSE OF THE SMALL SIZE OF THE BOARD OF DIRECTORS AND EVEN SMALLER SIZE OF ITS COMMITTEES, MEETINGS OF BOARD COMMITTEES HELD IN 2010 WERE NOT DOCUMENTED IN MINUTES OR OTHER FORM. FORM 990, PART VI, SECTION B, LINE 11 FORM 990 IS PREPARED WITH ASSISTANCE FROM A PAID PROFESSIONAL ADVISOR BASED ON INFORMATION PREPARED BY STAFF. THE DRAFT RETURN IS REVIEWED IN TURN BY THE DIRECTOR OF FINANCE, THE SENIOR VICE PRESIDENT FOR FINANCE & OPERATIONS, AND THEN BY THE AUDIT COMMITTEE OF THE BOARD OF DIRECTORS BEFORE COMPLETING IT IN FINAL FORM. THE FILING VERSION OF THE RETURN IS DISTRIBUTED ELECTRONICALLY TO ALL BOARD MEMBERS PRIOR TO FILING WITH THE IRS. FORM 990, PART VI, SECTION B, LINE 12C THE CONFLICT OF INTEREST (COI) POLICY APPLIES TO 'COVERED PERSONS', DEFINED AS ANY INSTITUTE (BOARD) DIRECTOR, OFFICER, OR ANY MEMBER OF ANY COMMITTEE OF THE INSTITUTE'S BOARD OF DIRECTORS THAT HAS AUTHORITY TO ACT ON BEHALF OF THE BOARD OF DIRECTORS. EACH COVERED PERSON SHALL PROMPTLY AND FULLY DISCLOSE ALL MATERIAL FACTS OF EVERY ACTUAL OR POTENTIAL CONFLICT OF INTEREST: [A] EXISTING AT THE TIME WHEN HE/SHE BECOMES A COVERED PERSON; [B] THAT ARISES WHILE HE/SHE IS A COVERED PERSON, AT THE TIME SUCH ACTUAL OR POTENTIAL CONFLICT ARISES; AND [C] THROUGH THE ANNUAL CIRCULATION OF THE FIDUCIARY COI QUESTIONNAIRE. THE VICE PRESIDENT OF FINANCE & ADMINSTRATION SHALL DISCLOSE TO THE BOARD OF DIRECTORS ALL CONFLICTS OF INTEREST REPORTED TO HIM OR HER UNDER THIS POLICY. THE BOARD OF DIRECTORS WILL EVALUATE THE DISCLOSURES TO DETERMINE WHETHER THEY INVOLVE ACTUAL CONFLICTS OF INTEREST AND MAY ATTEMPT TO DEVELOP ALTERNATIVES TO REMOVE THE CONFLICT FROM THE SITUATION. FORM 990, PART VI, SECTION B, LINE 15 DURING 2010, THE COMPENSATION OF THE INSTITUTE'S PRESIDENT WAS REVIEWED BY A PAID CONSULTANT TO DETERMINE ITS COMPARABILITY TO PREVAILING MARKET CONDITIONS FOR SIMILAR POSITIONS AT OTHER ORGANIZATIONS. THIS STUDY WAS PRESENTED TO AND APPROVED BY THE INSTITUTE'S GOVERNING BOARD OF DIRECTORS. ALSO THE EMPLOYMENT AGREEMENT FOR THE INSTITUTE'S PRESIDENT WAS REVIEWED AND APPROVED BY THE INSTITUTE'S GOVERNING BOARD OF DIRECTORS. THE COMPENSATION OF THE SCIENCE DIRECTOR, VP OF FINANCE AND VP OF DEVELOPMENT IS BASED UPON THE APPROVAL BY THE PRESIDENT. FORM 990, PART VI, SECTION C, LINE 19 THE INSTITUTE'S GOVERNING DOCUMENTS, CONFLICT OF INTEREST POLICY AND FINANCIAL STATEMENTS ARE NOT MADE READILY AVAILABLE TO THE PUBLIC. THE INSTITUTE'S APPLICATION FOR TAX EXEMPT STATUS AND ITS ANNUAL FORM 990 ARE AVAILABLE FOR PUBLIC INSPECTION AND REVIEW UPON REQUEST. FORM 990, PART I, LINE 6 TEN VOLUNTEERS SERVED AS INDIVIDUAL DIRECTORS ON ISB'S BOARD OF DIRECTORS DURING 2010. P4 MEDICINE INSTITUTE 401 TERRY AVENUE N SEATTLE WA 98109 272079809 PROMOTE COLLABORATIONS TO FOSTER DEVELOPMENT OF P4 MEDICAL APPROACH DE 501(C)(3) LINE 11A, I N/A 0 0 0 0 1 0 0 0 0 1 0 0 0 0 0 0 1 0 0