SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE: Form 990, tax year 2023

View the entire original 990 at ProPublica ↗

Organization: SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE (EIN 51-0197108)
Tax period: 2023-07-01 to 2024-06-30
Filed: 2025-05-09
IRS object ID: 202511299349301756
Schema version: 2023v6.0
Source: Download XML · Original 990 at ProPublica

Every field in the e-filed return. Faint text is the IRS element name, for citing.

Return header
Form 990
Schedule A
Schedule B
Schedule C
Schedule D
Schedule F
Schedule G
Schedule J
Schedule K
Schedule O

Return header ReturnHeader

Field	Value	IRS element (for citing)
Return	2025-05-09T08:40:33+00:00	ReturnTs
Tax Period End	2024-06-30	TaxPeriodEndDt

Preparer Firm PreparerFirmGrp

Field	Value	IRS element (for citing)
Preparer Firm EIN	346565596	PreparerFirmEIN

Preparer Firm Name PreparerFirmName

Field	Value	IRS element (for citing)
Business Name Line1	ERNST & YOUNG US LLP	BusinessNameLine1Txt

Preparer US Address PreparerUSAddress

Field	Value	IRS element (for citing)
Address Line1	2323 VICTORY AVENUE	AddressLine1Txt
City	DALLAS	CityNm
State Abbreviation	TX	StateAbbreviationCd
ZIP	75219	ZIPCd

Field	Value	IRS element (for citing)
Return Type	990	ReturnTypeCd
Tax Period Begin	2023-07-01	TaxPeriodBeginDt

Filer Filer

Field	Value	IRS element (for citing)
EIN	510197108	EIN

Business Name BusinessName

Field	Value	IRS element (for citing)
Business Name Line1	SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE	BusinessNameLine1Txt

Field	Value	IRS element (for citing)
Business Name Control	SANF	BusinessNameControlTxt
Phone	8586463100	PhoneNum

US Address USAddress

Field	Value	IRS element (for citing)
Address Line1	10901 NORTH TORREY PINES ROAD	AddressLine1Txt
City	LA JOLLA	CityNm
State Abbreviation	CA	StateAbbreviationCd
ZIP	92037	ZIPCd

Business Officer BusinessOfficerGrp

Field	Value	IRS element (for citing)
Person	MICHAEL JONES	PersonNm
Person Title	CFO & TREASURER	PersonTitleTxt
Phone	8587955244	PhoneNum
Signature	2025-05-09	SignatureDt
Discuss With Paid Preparer	Yes (true)	DiscussWithPaidPreparerInd

Preparer Person PreparerPersonGrp

Field	Value	IRS element (for citing)
Preparer Person	Patrick Shields	PreparerPersonNm
PTIN	P01508556	PTIN
Phone	2149698000	PhoneNum
Preparation	2025-05-08	PreparationDt

Field	Value	IRS element (for citing)
Tax	2023	TaxYr
Build TS	2025-03-06 01:10:19Z	BuildTS

Form 990 IRS990

Principal Ofcr Business Name PrincipalOfcrBusinessName

Field	Value	IRS element (for citing)
Business Name Line1	David Brenner	BusinessNameLine1Txt

US Address USAddress

Field	Value	IRS element (for citing)
Address Line1	10901 NORTH TORREY PINES ROAD	AddressLine1Txt
City	LA JOLLA	CityNm
State Abbreviation	CA	StateAbbreviationCd
ZIP	92037	ZIPCd

Field	Value	IRS element (for citing)
Gross Receipts	$199,653,255	GrossReceiptsAmt
Group Return For Affiliates	false	GroupReturnForAffiliatesInd
Organization501c3	Yes (X)	Organization501c3Ind
Website Address	WWW.SBPDISCOVERY.ORG	WebsiteAddressTxt
Type Of Organization Corp	Yes (X)	TypeOfOrganizationCorpInd
Formation	1976	FormationYr
Legal Domicile State	CA	LegalDomicileStateCd
Activity Or Mission	SEE SCHEDULE O	ActivityOrMissionDesc
Voting Members Governing Body	16	VotingMembersGoverningBodyCnt
Voting Members Independent	14	VotingMembersIndependentCnt
Total Employee	594	TotalEmployeeCnt
Total Volunteers	16	TotalVolunteersCnt
Total Gross UBI	$1,168,761	TotalGrossUBIAmt
Net Unrelated Bus Txbl Incm	$0	NetUnrelatedBusTxblIncmAmt
PY Contributions Grants	$104,423,511	PYContributionsGrantsAmt
CY Contributions Grants	$107,001,067	CYContributionsGrantsAmt
PY Program Service Revenue	$1,012,265	PYProgramServiceRevenueAmt
CY Program Service Revenue	$669,975	CYProgramServiceRevenueAmt
PY Investment Income	$5,926,237	PYInvestmentIncomeAmt
CY Investment Income	$12,533,478	CYInvestmentIncomeAmt
PY Other Revenue	$5,857,091	PYOtherRevenueAmt
CY Other Revenue	$3,067,961	CYOtherRevenueAmt
PY Total Revenue	$117,219,104	PYTotalRevenueAmt
CY Total Revenue	$123,272,481	CYTotalRevenueAmt
PY Grants And Similar Paid	$0	PYGrantsAndSimilarPaidAmt
CY Grants And Similar Paid	$0	CYGrantsAndSimilarPaidAmt
PY Benefits Paid To Members	$0	PYBenefitsPaidToMembersAmt
CY Benefits Paid To Members	$0	CYBenefitsPaidToMembersAmt
PY Salaries Comp Emp Bnft Paid	$58,193,349	PYSalariesCompEmpBnftPaidAmt
CY Salaries Comp Emp Bnft Paid	$63,300,127	CYSalariesCompEmpBnftPaidAmt
PY Total Prof Fndrsng Expns	$0	PYTotalProfFndrsngExpnsAmt
CY Total Prof Fndrsng Expns	$0	CYTotalProfFndrsngExpnsAmt
CY Total Fundraising Expense	$1,804,005	CYTotalFundraisingExpenseAmt
PY Other Expenses	$45,204,369	PYOtherExpensesAmt
CY Other Expenses	$47,874,465	CYOtherExpensesAmt
PY Total Expenses	$103,397,718	PYTotalExpensesAmt
CY Total Expenses	$111,174,592	CYTotalExpensesAmt
PY Revenues Less Expenses	$13,821,386	PYRevenuesLessExpensesAmt
CY Revenues Less Expenses	$12,097,889	CYRevenuesLessExpensesAmt
Total Assets BOY	$308,605,226	TotalAssetsBOYAmt
Total Assets EOY	$326,353,986	TotalAssetsEOYAmt
Total Liabilities BOY	$65,071,238	TotalLiabilitiesBOYAmt
Total Liabilities EOY	$58,142,392	TotalLiabilitiesEOYAmt
Net Assets Or Fund Balances BOY	$243,533,988	NetAssetsOrFundBalancesBOYAmt
Net Assets Or Fund Balances EOY	$268,211,594	NetAssetsOrFundBalancesEOYAmt
Mission	SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE'S MISSION IS TO ADVANCE THE BIOMEDICAL SCIENCES BY CULTIVATING THE NEXT GENERATION OF SCIENTIFIC LEADERS, PROVIDING MEANINGFUL OPPORTUNITIES FOR RESEARCHERS OF ALL BACKGROUNDS TO LEARN, INNOVATE, AND MAKE BREAKTHROUGH DISCOVERIES THAT IMPROVE HUMAN HEALTH.	MissionDesc
Significant New Program Srvc	false	SignificantNewProgramSrvcInd
Significant Change	false	SignificantChangeInd
Expense	$90,729,383	ExpenseAmt
Grant	$0	GrantAmt
Revenue	$776,452	RevenueAmt
Desc	See Schedule O	Desc
Total Program Service Expenses	$90,729,383	TotalProgramServiceExpensesAmt
Described In Section501c3	Yes (true)	DescribedInSection501c3Ind
Schedule B Required	Yes (true)	ScheduleBRequiredInd
Political Campaign Acty	false	PoliticalCampaignActyInd
Lobbying Activities	Yes (true)	LobbyingActivitiesInd
Donor Advised Fund	false	DonorAdvisedFundInd
Conservation Easements	false	ConservationEasementsInd
Collections Of Art	false	CollectionsOfArtInd
Credit Counseling	false	CreditCounselingInd
Donor Rstr Or Quasi Endowments	Yes (true)	DonorRstrOrQuasiEndowmentsInd
Report Land Building Equipment	Yes (true)	ReportLandBuildingEquipmentInd
Report Investments Other Sec	Yes (true)	ReportInvestmentsOtherSecInd
Report Program Related Invst	false	ReportProgramRelatedInvstInd
Report Other Assets	false	ReportOtherAssetsInd
Report Other Liabilities	Yes (true)	ReportOtherLiabilitiesInd
Include FIN48 Footnote	Yes (true)	IncludeFIN48FootnoteInd
Independent Audit Fincl Stmt	Yes (true)	IndependentAuditFinclStmtInd
Consolidated Audit Fincl Stmt	false	ConsolidatedAuditFinclStmtInd
School Operating	false	SchoolOperatingInd
Foreign Office	false	ForeignOfficeInd
Foreign Activities	Yes (true)	ForeignActivitiesInd
More Than5000 K To Org	false	MoreThan5000KToOrgInd
More Than5000 K To Individuals	false	MoreThan5000KToIndividualsInd
Professional Fundraising	false	ProfessionalFundraisingInd
Fundraising Activities	Yes (true)	FundraisingActivitiesInd
Gaming Activities	false	GamingActivitiesInd
Operate Hospital	false	OperateHospitalInd
Grants To Organizations	false	GrantsToOrganizationsInd
Grants To Individuals	false	GrantsToIndividualsInd
Schedule J Required	Yes (true)	ScheduleJRequiredInd
Tax Exempt Bonds	Yes (true)	TaxExemptBondsInd
Invest Tax Exempt Bonds	false	InvestTaxExemptBondsInd
Escrow Account	false	EscrowAccountInd
On Behalf Of Issuer	false	OnBehalfOfIssuerInd
Engaged In Excess Benefit Trans	false	EngagedInExcessBenefitTransInd
PY Excess Benefit Trans	false	PYExcessBenefitTransInd
Loan Outstanding	false	LoanOutstandingInd
Grant To Related Person	false	GrantToRelatedPersonInd
Business Rln With Org Mem	false	BusinessRlnWithOrgMemInd
Business Rln With Fam Mem	false	BusinessRlnWithFamMemInd
Business Rln With35 Ctrl Ent	false	BusinessRlnWith35CtrlEntInd
Deductible Non Cash Contri	false	DeductibleNonCashContriInd
Deductible Art Contribution	false	DeductibleArtContributionInd
Terminate Operations	false	TerminateOperationsInd
Partial Liquidation	false	PartialLiquidationInd
Disregarded Entity	false	DisregardedEntityInd
Related Entity	false	RelatedEntityInd
Related Organization Ctrl Ent	false	RelatedOrganizationCtrlEntInd
Trnsfr Exmpt Non Chrtbl Rltd Org	false	TrnsfrExmptNonChrtblRltdOrgInd
Activities Conducted Prtshp	false	ActivitiesConductedPrtshpInd
Schedule O Required	Yes (true)	ScheduleORequiredInd
IRP Document	194	IRPDocumentCnt
IRP Document W2 G	0	IRPDocumentW2GCnt
Backup Wthld Compliance	Yes (true)	BackupWthldComplianceInd
Employee	594	EmployeeCnt
Employment Tax Returns Filed	Yes (true)	EmploymentTaxReturnsFiledInd
Unrelated Bus Incm Over Limit	Yes (true)	UnrelatedBusIncmOverLimitInd
Form990 T Filed	Yes (true)	Form990TFiledInd
Foreign Financial Account	false	ForeignFinancialAccountInd
Prohibited Tax Shelter Trans	false	ProhibitedTaxShelterTransInd
Taxable Party Notification	false	TaxablePartyNotificationInd
Nondeductible Contributions	false	NondeductibleContributionsInd
Quid Pro Quo Contributions	Yes (true)	QuidProQuoContributionsInd
Quid Pro Quo Contri Discl	Yes (true)	QuidProQuoContriDisclInd
Form8282 Property Disposed Of	false	Form8282PropertyDisposedOfInd
Rcv Fnds To Pay Prsnl Bnft Cntrct	false	RcvFndsToPayPrsnlBnftCntrctInd
Pay Premiums Prsnl Bnft Cntrct	false	PayPremiumsPrsnlBnftCntrctInd
Form8899 Filedind	false	Form8899Filedind
Form1098 C Filed	false	Form1098CFiledInd
Indoor Tanning Services	false	IndoorTanningServicesInd
Subj To Tax Rmnrtn Ex Prcht Pymt	false	SubjToTaxRmnrtnExPrchtPymtInd
Subject To Excs Tax Net Invst Inc	false	SubjectToExcsTaxNetInvstIncInd
Info In Schedule O Part VI	Yes (X)	InfoInScheduleOPartVIInd
Governing Body Voting Members	16	GoverningBodyVotingMembersCnt
Independent Voting Member	14	IndependentVotingMemberCnt
Family Or Business Rln	false	FamilyOrBusinessRlnInd
Delegation Of Mgmt Duties	false	DelegationOfMgmtDutiesInd
Change To Org Documents	false	ChangeToOrgDocumentsInd
Material Diversion Or Misuse	false	MaterialDiversionOrMisuseInd
Members Or Stockholders	false	MembersOrStockholdersInd
Election Of Board Members	false	ElectionOfBoardMembersInd
Decisions Subject To Approva	false	DecisionsSubjectToApprovaInd
Minutes Of Governing Body	Yes (true)	MinutesOfGoverningBodyInd
Minutes Of Committees	Yes (true)	MinutesOfCommitteesInd
Officer Mailing Address	false	OfficerMailingAddressInd
Local Chapters	false	LocalChaptersInd
Form990 Provided To Gvrn Body	Yes (true)	Form990ProvidedToGvrnBodyInd
Conflict Of Interest Policy	Yes (true)	ConflictOfInterestPolicyInd
Annual Disclosure Covered Prsn	Yes (true)	AnnualDisclosureCoveredPrsnInd
Regular Monitoring Enfrc	Yes (true)	RegularMonitoringEnfrcInd
Whistleblower Policy	Yes (true)	WhistleblowerPolicyInd
Document Retention Policy	Yes (true)	DocumentRetentionPolicyInd
Compensation Process CEO	Yes (true)	CompensationProcessCEOInd
Compensation Process Other	Yes (true)	CompensationProcessOtherInd
Investment In Joint Venture	false	InvestmentInJointVentureInd
States Where Copy Of Return Is Fld	CA	StatesWhereCopyOfReturnIsFldCd
States Where Copy Of Return Is Fld	CO	StatesWhereCopyOfReturnIsFldCd
States Where Copy Of Return Is Fld	CT	StatesWhereCopyOfReturnIsFldCd
States Where Copy Of Return Is Fld	DC	StatesWhereCopyOfReturnIsFldCd
States Where Copy Of Return Is Fld	FL	StatesWhereCopyOfReturnIsFldCd
States Where Copy Of Return Is Fld	GA	StatesWhereCopyOfReturnIsFldCd
States Where Copy Of Return Is Fld	AL	StatesWhereCopyOfReturnIsFldCd
States Where Copy Of Return Is Fld	HI	StatesWhereCopyOfReturnIsFldCd
States Where Copy Of Return Is Fld	IL	StatesWhereCopyOfReturnIsFldCd
States Where Copy Of Return Is Fld	KS	StatesWhereCopyOfReturnIsFldCd
States Where Copy Of Return Is Fld	KY	StatesWhereCopyOfReturnIsFldCd
States Where Copy Of Return Is Fld	ME	StatesWhereCopyOfReturnIsFldCd
States Where Copy Of Return Is Fld	MD	StatesWhereCopyOfReturnIsFldCd
States Where Copy Of Return Is Fld	MA	StatesWhereCopyOfReturnIsFldCd
States Where Copy Of Return Is Fld	MI	StatesWhereCopyOfReturnIsFldCd
States Where Copy Of Return Is Fld	MN	StatesWhereCopyOfReturnIsFldCd
States Where Copy Of Return Is Fld	MS	StatesWhereCopyOfReturnIsFldCd
States Where Copy Of Return Is Fld	MO	StatesWhereCopyOfReturnIsFldCd
States Where Copy Of Return Is Fld	NH	StatesWhereCopyOfReturnIsFldCd
States Where Copy Of Return Is Fld	NJ	StatesWhereCopyOfReturnIsFldCd
States Where Copy Of Return Is Fld	NM	StatesWhereCopyOfReturnIsFldCd
States Where Copy Of Return Is Fld	NY	StatesWhereCopyOfReturnIsFldCd
States Where Copy Of Return Is Fld	NC	StatesWhereCopyOfReturnIsFldCd
States Where Copy Of Return Is Fld	ND	StatesWhereCopyOfReturnIsFldCd
States Where Copy Of Return Is Fld	OH	StatesWhereCopyOfReturnIsFldCd
States Where Copy Of Return Is Fld	OR	StatesWhereCopyOfReturnIsFldCd
States Where Copy Of Return Is Fld	PA	StatesWhereCopyOfReturnIsFldCd
States Where Copy Of Return Is Fld	RI	StatesWhereCopyOfReturnIsFldCd
States Where Copy Of Return Is Fld	SC	StatesWhereCopyOfReturnIsFldCd
States Where Copy Of Return Is Fld	TN	StatesWhereCopyOfReturnIsFldCd
States Where Copy Of Return Is Fld	UT	StatesWhereCopyOfReturnIsFldCd
States Where Copy Of Return Is Fld	VA	StatesWhereCopyOfReturnIsFldCd
States Where Copy Of Return Is Fld	AR	StatesWhereCopyOfReturnIsFldCd
States Where Copy Of Return Is Fld	WI	StatesWhereCopyOfReturnIsFldCd
Other Website	Yes (X)	OtherWebsiteInd
Upon Request	Yes (X)	UponRequestInd

Books In Care Of Detail BooksInCareOfDetail

Business Name BusinessName

Field	Value	IRS element (for citing)
Business Name Line1	MICHAEL JONES	BusinessNameLine1Txt

Field	Value	IRS element (for citing)
Phone	8586463100	PhoneNum

US Address USAddress

Field	Value	IRS element (for citing)
Address Line1	10901 NORTH TORREY PINES RD	AddressLine1Txt
City	LA JOLLA	CityNm
State Abbreviation	CA	StateAbbreviationCd
ZIP	92037	ZIPCd

Form990 Part VII Section A Form990PartVIISectionAGrp (26 entries)

TitleTitleTxt	Average Hours Per WeekAverageHoursPerWeekRt	Average Hours Per Week Rltd OrgAverageHoursPerWeekRltdOrgRt	Individual Trustee Or DirectorIndividualTrusteeOrDirectorInd	OfficerOfficerInd	Reportable Comp From OrgReportableCompFromOrgAmt	Reportable Comp From Rltd OrgReportableCompFromRltdOrgAmt	Other CompensationOtherCompensationAmt	Highest Compensated EmployeeHighestCompensatedEmployeeInd	Former Ofcr Director TrusteeFormerOfcrDirectorTrusteeInd
DAVID BRENNER MD
CEO AND PRESIDENT	50.0	0.0	Yes (X)	Yes (X)	$984,345	$0	$327,443
DONALD B KEARNS MD
VICE CHAIRMAN	1.0	0.0	Yes (X)	Yes (X)	$0	$0	$0
WILLIAM GERHART
CHAIRMAN	1.0	0.0	Yes (X)	Yes (X)	$0	$0	$0
DANIEL J EPSTEIN
TRUSTEE	1.0	0.0	Yes (X)		$0	$0	$0
DAVID L SZEKERES JD
TRUSTEE	1.0	0.0	Yes (X)		$0	$0	$0
DAVID W DOWN
TRUSTEE	1.0	0.0	Yes (X)		$0	$0	$0
DOUGLAS H OBENSHAIN
TRUSTEE	1.0	0.0	Yes (X)		$0	$0	$0
JAMES C BLAIR PHD
TRUSTEE (PART YEAR)	1.0	0.0	Yes (X)		$0	$0	$0
JAMES M MYERS
TRUSTEE (PART YEAR)	1.0	0.0	Yes (X)		$0	$0	$0
KATHERINE CHAPIN
TRUSTEE	1.0	0.0	Yes (X)		$0	$0	$0
KAZUMI SHIOSAKI PHD
TRUSTEE	1.0	0.0	Yes (X)		$0	$0	$0
LONNA J WILLIAMS STOLPER
TRUSTEE	1.0	0.0	Yes (X)		$0	$0	$0
LORI MOORE
TRUSTEE	1.0	0.0	Yes (X)		$0	$0	$0
MICHAEL R CUNNINGHAM
TRUSTEE	1.0	0.0	Yes (X)		$0	$0	$0
NICHOLAS COSFORD
PROFESSOR & TRUSTEE	50.0	0.0	Yes (X)		$244,128	$0	$68,484
STUART A TANZ
TRUSTEE	1.0	0.0	Yes (X)		$0	$0	$0
TED ROTH
TRUSTEE	1.0	0.0	Yes (X)		$0	$0	$0
WILLIAM A ROPER
TRUSTEE	1.0	0.0	Yes (X)		$0	$0	$0
ADRIENNE CROWN JD
GENERAL COUNSEL & SECRETARY	50.0	0.0		Yes (X)	$360,490	$0	$48,673
ROBIN RYAN
CFO & TREASURER	50.0	0.0		Yes (X)	$458,690	$0	$48,299
CARL WARE PHD
CENTER DIRECTOR, IIDC	50.0	0.0			$454,389	$0	$63,702	Yes (X)
KRISTIINA VUORI MD PHD
PROFESSOR	50.0	0.0			$601,208	$0	$60,610	Yes (X)
MICHAEL JACKSON PHD
DRUG DISCOVERY & DEV, SR VP	50.0	0.0			$447,238	$0	$58,573	Yes (X)
RANDAL KAUFMAN PHD
PROGRAM DIRECTOR	50.0	0.0			$402,033	$0	$75,955	Yes (X)
ZE'EV RONAI PHD
CENTER DIRECTOR	50.0	0.0			$497,532	$0	$63,660	Yes (X)
C RANDAL MILLS PHD
FORMER CEO	0.0	0.0			$341,250	$0	$0		Yes (X)

Field	Value	IRS element (for citing)
Total Reportable Comp From Org	$4,791,303	TotalReportableCompFromOrgAmt
Tot Reportable Comp Rltd Org	$0	TotReportableCompRltdOrgAmt
Total Other Compensation	$815,399	TotalOtherCompensationAmt
Indiv Rcvd Greater Than100 K	139	IndivRcvdGreaterThan100KCnt
Former Ofcr Employees Listed	Yes (true)	FormerOfcrEmployeesListedInd
Total Comp Greater Than150 K	Yes (true)	TotalCompGreaterThan150KInd
Compensation From Other Srcs	false	CompensationFromOtherSrcsInd

Contractor Compensation ContractorCompensationGrp (5 entries)

Address Line1ContractorAddress/USAddress/AddressLine1Txt	CityContractorAddress/USAddress/CityNm	State AbbreviationContractorAddress/USAddress/StateAbbreviationCd	ZIPContractorAddress/USAddress/ZIPCd	ServicesServicesDesc	CompensationCompensationAmt
Universal Protection Service LP
PO Box 31001-2374	Pasadena	CA	921102374	Building Security Services	$326,043
Wilson Sonsini Goodrich & Rosati
PO Box 742866	Los Angeles	CA	900742866	Legal Services	$310,415
Deloitte & Touche LLP
PO Box 844708	Dallas	TX	75284	Professional Services	$269,260
JAGGAER LLC
PO BOX 952218	DALLAS	TX	753952218	Procurement Services	$229,200
Constangy Brooks Smith & Porphete LLP
PO Box 102476	Atlanta	GA	303680476	Legal Services	$201,763

Field	Value	IRS element (for citing)
Cntrct Rcvd Greater Than100 K	8	CntrctRcvdGreaterThan100KCnt
Federated Campaigns	$0	FederatedCampaignsAmt
Membership Dues	$0	MembershipDuesAmt
Fundraising	$276,700	FundraisingAmt
Government Grants	$69,821,069	GovernmentGrantsAmt
All Other Contributions	$36,903,298	AllOtherContributionsAmt
Noncash Contributions	$4,101	NoncashContributionsAmt
Total Contributions	$107,001,067	TotalContributionsAmt

Program Service Revenue ProgramServiceRevenueGrp (2 entries)

DescDesc	BusinessBusinessCd	Total Revenue ColumnTotalRevenueColumnAmt	Related Or Exempt Func IncomeRelatedOrExemptFuncIncomeAmt
Shared Services Revenue	541990	$669,975	$669,975
		$0	$0

Total Oth Program Service Rev TotalOthProgramServiceRevGrp

Field	Value	IRS element (for citing)
Total Revenue Column	$0	TotalRevenueColumnAmt
Related Or Exempt Func Income	$0	RelatedOrExemptFuncIncomeAmt
Unrelated Business Revenue	$0	UnrelatedBusinessRevenueAmt
Exclusion	$0	ExclusionAmt

Field	Value	IRS element (for citing)
Total Program Service Revenue	$669,975	TotalProgramServiceRevenueAmt

Investment Income InvestmentIncomeGrp

Field	Value	IRS element (for citing)
Total Revenue Column	$6,757,453	TotalRevenueColumnAmt
Unrelated Business Revenue	$7,850	UnrelatedBusinessRevenueAmt
Exclusion	$6,749,603	ExclusionAmt

Incm From Invest Bond Proceeds IncmFromInvestBondProceedsGrp

Field	Value	IRS element (for citing)
Total Revenue Column	$0	TotalRevenueColumnAmt
Exclusion	$0	ExclusionAmt

Royalties Revenue RoyaltiesRevenueGrp

Field	Value	IRS element (for citing)
Total Revenue Column	$1,515,072	TotalRevenueColumnAmt
Exclusion	$1,515,072	ExclusionAmt

Gross Rents GrossRentsGrp

Field	Value	IRS element (for citing)
Real	$318,300	RealAmt

Less Rental Expenses LessRentalExpensesGrp

Field	Value	IRS element (for citing)
Real	$0	RealAmt

Rental Income Or Loss RentalIncomeOrLossGrp

Field	Value	IRS element (for citing)
Real	$318,300	RealAmt
Personal	$0	PersonalAmt

Net Rental Income Or Loss NetRentalIncomeOrLossGrp

Field	Value	IRS element (for citing)
Total Revenue Column	$318,300	TotalRevenueColumnAmt
Exclusion	$318,300	ExclusionAmt

Gross Amount Sales Assets GrossAmountSalesAssetsGrp

Field	Value	IRS element (for citing)
Securities	$81,702,000	SecuritiesAmt

Less Cost Oth Basis Sales Expnss LessCostOthBasisSalesExpnssGrp

Field	Value	IRS element (for citing)
Securities	$75,925,975	SecuritiesAmt

Gain Or Loss GainOrLossGrp

Field	Value	IRS element (for citing)
Securities	$5,776,025	SecuritiesAmt
Other	$0	OtherAmt

Net Gain Or Loss Investments NetGainOrLossInvestmentsGrp

Field	Value	IRS element (for citing)
Total Revenue Column	$5,776,025	TotalRevenueColumnAmt
Exclusion	$5,776,025	ExclusionAmt

Field	Value	IRS element (for citing)
Fundraising Gross Income	$422,000	FundraisingGrossIncomeAmt
Contri Rpt Fundraising Event	$276,700	ContriRptFundraisingEventAmt
Fundraising Direct Expenses	$454,799	FundraisingDirectExpensesAmt

Net Incm From Fundraising Evt NetIncmFromFundraisingEvtGrp

Field	Value	IRS element (for citing)
Total Revenue Column	-$32,799	TotalRevenueColumnAmt
Exclusion	-$32,799	ExclusionAmt

Other Revenue Misc OtherRevenueMiscGrp (3 entries)

DescDesc	BusinessBusinessCd	Total Revenue ColumnTotalRevenueColumnAmt	Unrelated Business RevenueUnrelatedBusinessRevenueAmt	Related Or Exempt Func IncomeRelatedOrExemptFuncIncomeAmt
Research	541700	$1,160,911	$1,160,911
Equipment Proceeds	541990	$34,563		$34,563
Sale of Reagents	541990	$65,914		$65,914

Miscellaneous Revenue MiscellaneousRevenueGrp

Field	Value	IRS element (for citing)
Total Revenue Column	$6,000	TotalRevenueColumnAmt
Related Or Exempt Func Income	$6,000	RelatedOrExemptFuncIncomeAmt
Unrelated Business Revenue	$0	UnrelatedBusinessRevenueAmt
Exclusion	$0	ExclusionAmt

Field	Value	IRS element (for citing)
Other Revenue Total	$1,267,388	OtherRevenueTotalAmt

Total Revenue TotalRevenueGrp

Field	Value	IRS element (for citing)
Total Revenue Column	$123,272,481	TotalRevenueColumnAmt
Related Or Exempt Func Income	$776,452	RelatedOrExemptFuncIncomeAmt
Unrelated Business Revenue	$1,168,761	UnrelatedBusinessRevenueAmt
Exclusion	$14,326,201	ExclusionAmt

Grants To Domestic Orgs GrantsToDomesticOrgsGrp

Field	Value	IRS element (for citing)
Total	$0	TotalAmt
Program Services	$0	ProgramServicesAmt

Grants To Domestic Individuals GrantsToDomesticIndividualsGrp

Field	Value	IRS element (for citing)
Total	$0	TotalAmt
Program Services	$0	ProgramServicesAmt

Foreign Grants ForeignGrantsGrp

Field	Value	IRS element (for citing)
Total	$0	TotalAmt
Program Services	$0	ProgramServicesAmt

Benefits To Members BenefitsToMembersGrp

Field	Value	IRS element (for citing)
Total	$0	TotalAmt
Program Services	$0	ProgramServicesAmt

Comp Current Ofcr Directors CompCurrentOfcrDirectorsGrp

Field	Value	IRS element (for citing)
Total	$1,465,150	TotalAmt
Program Services	$32,500	ProgramServicesAmt
Management And General	$1,286,400	ManagementAndGeneralAmt
Fundraising	$146,250	FundraisingAmt

Comp Disqual Persons CompDisqualPersonsGrp

Field	Value	IRS element (for citing)
Total	$341,250	TotalAmt
Program Services	$0	ProgramServicesAmt
Management And General	$341,250	ManagementAndGeneralAmt
Fundraising	$0	FundraisingAmt

Other Salaries And Wages OtherSalariesAndWagesGrp

Field	Value	IRS element (for citing)
Total	$47,639,883	TotalAmt
Program Services	$38,317,433	ProgramServicesAmt
Management And General	$8,456,820	ManagementAndGeneralAmt
Fundraising	$865,630	FundraisingAmt

Pension Plan Contributions PensionPlanContributionsGrp

Field	Value	IRS element (for citing)
Total	$3,096,876	TotalAmt
Program Services	$2,417,032	ProgramServicesAmt
Management And General	$625,235	ManagementAndGeneralAmt
Fundraising	$54,609	FundraisingAmt

Other Employee Benefits OtherEmployeeBenefitsGrp

Field	Value	IRS element (for citing)
Total	$7,624,582	TotalAmt
Program Services	$5,886,415	ProgramServicesAmt
Management And General	$1,376,517	ManagementAndGeneralAmt
Fundraising	$361,650	FundraisingAmt

Payroll Taxes PayrollTaxesGrp

Field	Value	IRS element (for citing)
Total	$3,132,386	TotalAmt
Program Services	$2,412,870	ProgramServicesAmt
Management And General	$653,549	ManagementAndGeneralAmt
Fundraising	$65,967	FundraisingAmt

Fees For Services Management FeesForServicesManagementGrp

Field	Value	IRS element (for citing)
Total	$809,508	TotalAmt
Program Services	$273,878	ProgramServicesAmt
Management And General	$453,260	ManagementAndGeneralAmt
Fundraising	$82,370	FundraisingAmt

Fees For Services Legal FeesForServicesLegalGrp

Field	Value	IRS element (for citing)
Total	$928,176	TotalAmt
Program Services	$62,346	ProgramServicesAmt
Management And General	$855,330	ManagementAndGeneralAmt
Fundraising	$10,500	FundraisingAmt

Fees For Services Accounting FeesForServicesAccountingGrp

Field	Value	IRS element (for citing)
Total	$421,627	TotalAmt
Program Services	$0	ProgramServicesAmt
Management And General	$421,627	ManagementAndGeneralAmt
Fundraising	$0	FundraisingAmt

Fees For Services Lobbying FeesForServicesLobbyingGrp

Field	Value	IRS element (for citing)
Total	$1,500	TotalAmt
Program Services	$0	ProgramServicesAmt
Management And General	$1,500	ManagementAndGeneralAmt
Fundraising	$0	FundraisingAmt

Fees For Services Prof Fundraising FeesForServicesProfFundraising

Field	Value	IRS element (for citing)
Total	$0	TotalAmt
Fundraising	$0	FundraisingAmt

Fees For Srvc Invst Mgmnt Fees FeesForSrvcInvstMgmntFeesGrp

Field	Value	IRS element (for citing)
Total	$679,787	TotalAmt
Program Services	$0	ProgramServicesAmt
Management And General	$679,787	ManagementAndGeneralAmt
Fundraising	$0	FundraisingAmt

Fees For Services Other FeesForServicesOtherGrp

Field	Value	IRS element (for citing)
Total	$861,908	TotalAmt
Program Services	$569,281	ProgramServicesAmt
Management And General	$243,903	ManagementAndGeneralAmt
Fundraising	$48,724	FundraisingAmt

Advertising AdvertisingGrp

Field	Value	IRS element (for citing)
Total	$975	TotalAmt
Program Services	$0	ProgramServicesAmt
Management And General	$975	ManagementAndGeneralAmt
Fundraising	$0	FundraisingAmt

Office Expenses OfficeExpensesGrp

Field	Value	IRS element (for citing)
Total	$5,634,672	TotalAmt
Program Services	$5,076,466	ProgramServicesAmt
Management And General	$540,521	ManagementAndGeneralAmt
Fundraising	$17,685	FundraisingAmt

Information Technology InformationTechnologyGrp

Field	Value	IRS element (for citing)
Total	$1,689,633	TotalAmt
Program Services	$1,215,046	ProgramServicesAmt
Management And General	$441,169	ManagementAndGeneralAmt
Fundraising	$33,418	FundraisingAmt

Royalties RoyaltiesGrp

Field	Value	IRS element (for citing)
Total	$0	TotalAmt
Program Services	$0	ProgramServicesAmt
Management And General	$0	ManagementAndGeneralAmt
Fundraising	$0	FundraisingAmt

Occupancy OccupancyGrp

Field	Value	IRS element (for citing)
Total	$6,575,946	TotalAmt
Program Services	$6,149,262	ProgramServicesAmt
Management And General	$401,887	ManagementAndGeneralAmt
Fundraising	$24,797	FundraisingAmt

Travel TravelGrp

Field	Value	IRS element (for citing)
Total	$361,891	TotalAmt
Program Services	$328,382	ProgramServicesAmt
Management And General	$30,749	ManagementAndGeneralAmt
Fundraising	$2,760	FundraisingAmt

Pymt Travel Entrtnmnt Pub Ofcl PymtTravelEntrtnmntPubOfclGrp

Field	Value	IRS element (for citing)
Total	$0	TotalAmt
Program Services	$0	ProgramServicesAmt
Management And General	$0	ManagementAndGeneralAmt
Fundraising	$0	FundraisingAmt

Conferences Meetings ConferencesMeetingsGrp

Field	Value	IRS element (for citing)
Total	$1,004,212	TotalAmt
Program Services	$662,268	ProgramServicesAmt
Management And General	$338,044	ManagementAndGeneralAmt
Fundraising	$3,900	FundraisingAmt

Interest InterestGrp

Field	Value	IRS element (for citing)
Total	$1,151,762	TotalAmt
Program Services	$1,077,703	ProgramServicesAmt
Management And General	$69,682	ManagementAndGeneralAmt
Fundraising	$4,377	FundraisingAmt

Payments To Affiliates PaymentsToAffiliatesGrp

Field	Value	IRS element (for citing)
Total	$0	TotalAmt
Program Services	$0	ProgramServicesAmt
Management And General	$0	ManagementAndGeneralAmt
Fundraising	$0	FundraisingAmt

Depreciation Depletion DepreciationDepletionGrp

Field	Value	IRS element (for citing)
Total	$5,369,141	TotalAmt
Program Services	$5,023,905	ProgramServicesAmt
Management And General	$324,833	ManagementAndGeneralAmt
Fundraising	$20,403	FundraisingAmt

Insurance InsuranceGrp

Field	Value	IRS element (for citing)
Total	$230,910	TotalAmt
Program Services	$0	ProgramServicesAmt
Management And General	$230,910	ManagementAndGeneralAmt
Fundraising	$0	FundraisingAmt

Other Expenses OtherExpensesGrp (4 entries)

DescDesc	TotalTotalAmt	Program ServicesProgramServicesAmt	Management And GeneralManagementAndGeneralAmt	FundraisingFundraisingAmt
RESEARCH SUPPLIES & SVCS	$9,888,051	$9,887,929	$3	$119
SCIENTIFIC COLLABORATIONS	$11,008,033	$11,008,033	$0	$0
RECRUITMENT	$220,928	$151,902	$62,615	$6,411
TUITION FEES	$112,908	$112,908	$0	$0

All Other Expenses AllOtherExpensesGrp

Field	Value	IRS element (for citing)
Total	$922,897	TotalAmt
Program Services	$63,824	ProgramServicesAmt
Management And General	$804,638	ManagementAndGeneralAmt
Fundraising	$54,435	FundraisingAmt

Total Functional Expenses TotalFunctionalExpensesGrp

Field	Value	IRS element (for citing)
Total	$111,174,592	TotalAmt
Program Services	$90,729,383	ProgramServicesAmt
Management And General	$18,641,204	ManagementAndGeneralAmt
Fundraising	$1,804,005	FundraisingAmt

Total Joint Costs TotalJointCostsGrp

Field	Value	IRS element (for citing)
Total	$0	TotalAmt
Program Services	$0	ProgramServicesAmt
Management And General	$0	ManagementAndGeneralAmt
Fundraising	$0	FundraisingAmt

Cash Non Interest Bearing CashNonInterestBearingGrp

Field	Value	IRS element (for citing)
BOY	$3,884,263	BOYAmt
EOY	$3,821,604	EOYAmt

Savings And Temp Cash Invst SavingsAndTempCashInvstGrp

Field	Value	IRS element (for citing)
BOY	$3,005	BOYAmt
EOY	$573	EOYAmt

Pledges And Grants Receivable PledgesAndGrantsReceivableGrp

Field	Value	IRS element (for citing)
BOY	$8,358,514	BOYAmt
EOY	$7,689,710	EOYAmt

Accounts Receivable AccountsReceivableGrp

Field	Value	IRS element (for citing)
BOY	$728,432	BOYAmt
EOY	$525,718	EOYAmt

Receivables From Officers Etc ReceivablesFromOfficersEtcGrp

Field	Value	IRS element (for citing)
BOY	$0	BOYAmt
EOY	$0	EOYAmt

Rcvbl From Disqualified Prsn RcvblFromDisqualifiedPrsnGrp

Field	Value	IRS element (for citing)
BOY	$0	BOYAmt
EOY	$0	EOYAmt

Oth Notes Loans Receivable Net OthNotesLoansReceivableNetGrp

Field	Value	IRS element (for citing)
BOY	$3,332,786	BOYAmt
EOY	$5,645,175	EOYAmt

Inventories For Sale Or Use InventoriesForSaleOrUseGrp

Field	Value	IRS element (for citing)
BOY	$318,694	BOYAmt
EOY	$372,410	EOYAmt

Prepaid Expenses Defrd Charges PrepaidExpensesDefrdChargesGrp

Field	Value	IRS element (for citing)
BOY	$9,710,993	BOYAmt
EOY	$9,857,014	EOYAmt

Field	Value	IRS element (for citing)
Land Bldg Equip Cost Or Other Bss	$168,830,822	LandBldgEquipCostOrOtherBssAmt
Land Bldg Equip Accum Deprec	$117,517,685	LandBldgEquipAccumDeprecAmt

Land Bldg Equip Basis Net LandBldgEquipBasisNetGrp

Field	Value	IRS element (for citing)
BOY	$52,107,305	BOYAmt
EOY	$51,313,137	EOYAmt

Investments Pub Traded Sec InvestmentsPubTradedSecGrp

Field	Value	IRS element (for citing)
BOY	$193,702,694	BOYAmt
EOY	$201,913,843	EOYAmt

Investments Other Securities InvestmentsOtherSecuritiesGrp

Field	Value	IRS element (for citing)
BOY	$35,094,304	BOYAmt
EOY	$44,462,501	EOYAmt

Investments Program Related InvestmentsProgramRelatedGrp

Field	Value	IRS element (for citing)
BOY	$0	BOYAmt

Other Assets Total OtherAssetsTotalGrp

Field	Value	IRS element (for citing)
BOY	$1,364,236	BOYAmt
EOY	$752,301	EOYAmt

Total Assets TotalAssetsGrp

Field	Value	IRS element (for citing)
BOY	$308,605,226	BOYAmt
EOY	$326,353,986	EOYAmt

Accounts Payable Accr Expnss AccountsPayableAccrExpnssGrp

Field	Value	IRS element (for citing)
BOY	$14,782,361	BOYAmt
EOY	$14,624,878	EOYAmt

Deferred Revenue DeferredRevenueGrp

Field	Value	IRS element (for citing)
BOY	$7,432,976	BOYAmt
EOY	$5,645,487	EOYAmt

Tax Exempt Bond Liabilities TaxExemptBondLiabilitiesGrp

Field	Value	IRS element (for citing)
BOY	$39,230,617	BOYAmt
EOY	$34,979,693	EOYAmt

Loans From Officers Directors LoansFromOfficersDirectorsGrp

Field	Value	IRS element (for citing)
BOY	$0	BOYAmt
EOY	$0	EOYAmt

Other Liabilities OtherLiabilitiesGrp

Field	Value	IRS element (for citing)
BOY	$3,625,284	BOYAmt
EOY	$2,892,334	EOYAmt

Total Liabilities TotalLiabilitiesGrp

Field	Value	IRS element (for citing)
BOY	$65,071,238	BOYAmt
EOY	$58,142,392	EOYAmt

Field	Value	IRS element (for citing)
Organization Follows FASB117	Yes (X)	OrganizationFollowsFASB117Ind

No Donor Restriction Net Assets NoDonorRestrictionNetAssetsGrp

Field	Value	IRS element (for citing)
BOY	$183,976,210	BOYAmt
EOY	$200,481,486	EOYAmt

Donor Restriction Net Assets DonorRestrictionNetAssetsGrp

Field	Value	IRS element (for citing)
BOY	$59,557,778	BOYAmt
EOY	$67,730,108	EOYAmt

Total Net Assets Fund Balance TotalNetAssetsFundBalanceGrp

Field	Value	IRS element (for citing)
BOY	$243,533,988	BOYAmt
EOY	$268,211,594	EOYAmt

Tot Liab Net Assets Fund Balance TotLiabNetAssetsFundBalanceGrp

Field	Value	IRS element (for citing)
BOY	$308,605,226	BOYAmt
EOY	$326,353,986	EOYAmt

Field	Value	IRS element (for citing)
Reconcilation Revenue Expnss	$12,097,889	ReconcilationRevenueExpnssAmt
Net Unrlzd Gains Losses Invst	$12,579,717	NetUnrlzdGainsLossesInvstAmt
Other Changes In Net Assets	$0	OtherChangesInNetAssetsAmt
Method Of Accounting Accrual	Yes (X)	MethodOfAccountingAccrualInd
Accountant Compile Or Review	false	AccountantCompileOrReviewInd
FS Audited	Yes (true)	FSAuditedInd

FS Audited Basis FSAuditedBasisGrp

Field	Value	IRS element (for citing)
Separate Basis Fincl Stmt	Yes (X)	SeparateBasisFinclStmtInd

Field	Value	IRS element (for citing)
Audit Committee	Yes (true)	AuditCommitteeInd
Federal Grant Audit Required	Yes (true)	FederalGrantAuditRequiredInd
Federal Grant Audit Performed	Yes (true)	FederalGrantAuditPerformedInd

Schedule A IRS990ScheduleA

Field	Value	IRS element (for citing)
Public Organization170	Yes (X)	PublicOrganization170Ind

Gifts Grants Contri Rcvd170 GiftsGrantsContriRcvd170Grp

Field	Value	IRS element (for citing)
Current Tax Year Minus4 Years	$100,963,692	CurrentTaxYearMinus4YearsAmt
Current Tax Year Minus3 Years	$111,444,313	CurrentTaxYearMinus3YearsAmt
Current Tax Year Minus2 Years	$82,047,252	CurrentTaxYearMinus2YearsAmt
Current Tax Year Minus1 Year	$104,423,511	CurrentTaxYearMinus1YearAmt
Current Tax Year	$107,001,067	CurrentTaxYearAmt
Total	$505,879,835	TotalAmt

Tax Rev Levied Orgnztnl Bnft170 TaxRevLeviedOrgnztnlBnft170Grp

Field	Value	IRS element (for citing)
Total	$0	TotalAmt

Govt Furn Srvc Fclts Vl170 GovtFurnSrvcFcltsVl170Grp

Field	Value	IRS element (for citing)
Total	$0	TotalAmt

Total Calendar Year170 TotalCalendarYear170Grp

Field	Value	IRS element (for citing)
Current Tax Year Minus4 Years	$100,963,692	CurrentTaxYearMinus4YearsAmt
Current Tax Year Minus3 Years	$111,444,313	CurrentTaxYearMinus3YearsAmt
Current Tax Year Minus2 Years	$82,047,252	CurrentTaxYearMinus2YearsAmt
Current Tax Year Minus1 Year	$104,423,511	CurrentTaxYearMinus1YearAmt
Current Tax Year	$107,001,067	CurrentTaxYearAmt
Total	$505,879,835	TotalAmt

Field	Value	IRS element (for citing)
Substantial Contributors Tot	$54,196,231	SubstantialContributorsTotAmt
Public Support Total170	$451,683,604	PublicSupportTotal170Amt

Gross Investment Income170 GrossInvestmentIncome170Grp

Field	Value	IRS element (for citing)
Current Tax Year Minus4 Years	$3,455,907	CurrentTaxYearMinus4YearsAmt
Current Tax Year Minus3 Years	$5,237,546	CurrentTaxYearMinus3YearsAmt
Current Tax Year Minus2 Years	$7,508,720	CurrentTaxYearMinus2YearsAmt
Current Tax Year Minus1 Year	$9,515,640	CurrentTaxYearMinus1YearAmt
Current Tax Year	$8,590,825	CurrentTaxYearAmt
Total	$34,308,638	TotalAmt

Unrelated Business Net Incm170 UnrelatedBusinessNetIncm170Grp

Field	Value	IRS element (for citing)
Current Tax Year Minus4 Years	$0	CurrentTaxYearMinus4YearsAmt
Current Tax Year Minus3 Years	$0	CurrentTaxYearMinus3YearsAmt
Current Tax Year Minus2 Years	$0	CurrentTaxYearMinus2YearsAmt
Current Tax Year Minus1 Year	$0	CurrentTaxYearMinus1YearAmt
Current Tax Year	$0	CurrentTaxYearAmt
Total	$0	TotalAmt

Other Income170 OtherIncome170Grp

Field	Value	IRS element (for citing)
Current Tax Year Minus4 Years	$0	CurrentTaxYearMinus4YearsAmt
Current Tax Year Minus3 Years	$0	CurrentTaxYearMinus3YearsAmt
Current Tax Year Minus2 Years	$0	CurrentTaxYearMinus2YearsAmt
Current Tax Year Minus1 Year	$0	CurrentTaxYearMinus1YearAmt
Current Tax Year	$0	CurrentTaxYearAmt
Total	$0	TotalAmt

Field	Value	IRS element (for citing)
Total Support	$540,188,473	TotalSupportAmt
Gross Receipts Rltd Activities	$5,202,370	GrossReceiptsRltdActivitiesAmt
Public Support CY170	0.8362	PublicSupportCY170Pct
Public Support PY170	0.8870	PublicSupportPY170Pct
Thirty Thr Pct Suprt Tests CY170	Yes (X)	ThirtyThrPctSuprtTestsCY170Ind

Schedule B IRS990ScheduleB

Contributor Information ContributorInformationGrp

Field	Value	IRS element (for citing)
Contributor	RESTRICTED	ContributorNum

Contributor Business Name ContributorBusinessName

Field	Value	IRS element (for citing)
Business Name Line1	RESTRICTED	BusinessNameLine1

Contributor US Address ContributorUSAddress

Field	Value	IRS element (for citing)
Address Line1	RESTRICTED	AddressLine1
Address Line2	RESTRICTED	AddressLine2
City	RESTRICTED	City
State	RESTRICTED	State
ZIP Code	RESTRICTED	ZIPCode

Field	Value	IRS element (for citing)
Total Contributions	RESTRICTED	TotalContributionsAmt

Schedule C IRS990ScheduleC

Field	Value	IRS element (for citing)
Volunteers	false	VolunteersInd
Paid Staff Or Management	false	PaidStaffOrManagementInd
Media Advertisements	false	MediaAdvertisementsInd
Mailings Members	false	MailingsMembersInd
Publications Or Broadcast	false	PublicationsOrBroadcastInd
Grants Other Organizations	false	GrantsOtherOrganizationsInd
Direct Contact Legislators	false	DirectContactLegislatorsInd
Rallies Demonstrations	false	RalliesDemonstrationsInd
Other Activities	Yes (true)	OtherActivitiesInd
Other Activities	$1,500	OtherActivitiesAmt
Total Lobbying Expenditures	$1,500	TotalLobbyingExpendituresAmt
Not Described Section501c3	false	NotDescribedSection501c3Ind

Supplemental Information Detail SupplementalInformationDetail

Field	Value	IRS element (for citing)
Form And Line Reference	Schedule C, Part II-B, Line 1 DETAILED DESCRIPTION OF THE LOBBYING ACTIVITY	FormAndLineReferenceDesc
Explanation	DUES TO AN ASSOCIATION OF INDEPENDENT RESEARCH INSTITUTES, OF WHICH A PORTION IS USED FOR LOBBYING.	ExplanationTxt

Schedule D IRS990ScheduleD

CY Endwmt Fund CYEndwmtFundGrp

Field	Value	IRS element (for citing)
Beginning Year Balance	$21,212,422	BeginningYearBalanceAmt
Contributions	$1,002,100	ContributionsAmt
Investment Earnings Or Losses	$2,217,901	InvestmentEarningsOrLossesAmt
Other Expenditures	$937,725	OtherExpendituresAmt
End Year Balance	$23,494,698	EndYearBalanceAmt

CY Minus1 Yr Endwmt Fund CYMinus1YrEndwmtFundGrp

Field	Value	IRS element (for citing)
Beginning Year Balance	$20,548,272	BeginningYearBalanceAmt
Contributions	$2,825	ContributionsAmt
Investment Earnings Or Losses	$1,615,074	InvestmentEarningsOrLossesAmt
Other Expenditures	$953,749	OtherExpendituresAmt
End Year Balance	$21,212,422	EndYearBalanceAmt

CY Minus2 Yr Endwmt Fund CYMinus2YrEndwmtFundGrp

Field	Value	IRS element (for citing)
Beginning Year Balance	$23,536,441	BeginningYearBalanceAmt
Contributions	$1,805	ContributionsAmt
Investment Earnings Or Losses	-$2,492,894	InvestmentEarningsOrLossesAmt
Other Expenditures	$497,080	OtherExpendituresAmt
End Year Balance	$20,548,272	EndYearBalanceAmt

CY Minus3 Yr Endwmt Fund CYMinus3YrEndwmtFundGrp

Field	Value	IRS element (for citing)
Beginning Year Balance	$19,914,852	BeginningYearBalanceAmt
Contributions	$3,687	ContributionsAmt
Investment Earnings Or Losses	$4,470,604	InvestmentEarningsOrLossesAmt
Other Expenditures	$852,702	OtherExpendituresAmt
End Year Balance	$23,536,441	EndYearBalanceAmt

CY Minus4 Yr Endwmt Fund CYMinus4YrEndwmtFundGrp

Field	Value	IRS element (for citing)
Beginning Year Balance	$29,814,541	BeginningYearBalanceAmt
Contributions	$1,005	ContributionsAmt
Investment Earnings Or Losses	$724,999	InvestmentEarningsOrLossesAmt
Other Expenditures	$10,625,693	OtherExpendituresAmt
End Year Balance	$19,914,852	EndYearBalanceAmt

Field	Value	IRS element (for citing)
Board Designated Balance EOY	0.02	BoardDesignatedBalanceEOYPct
Prmnnt Endowment Balance EOY	0.62	PrmnntEndowmentBalanceEOYPct
Term Endowment Balance EOY	0.36	TermEndowmentBalanceEOYPct
Endowments Held Unrelated Org	false	EndowmentsHeldUnrelatedOrgInd
Endowments Held Related Org	false	EndowmentsHeldRelatedOrgInd

Land LandGrp

Field	Value	IRS element (for citing)
Other Cost Or Other Basis	$12,758,161	OtherCostOrOtherBasisAmt
Book Value	$12,758,161	BookValueAmt

Buildings BuildingsGrp

Field	Value	IRS element (for citing)
Other Cost Or Other Basis	$92,588,616	OtherCostOrOtherBasisAmt
Depreciation	$63,223,124	DepreciationAmt
Book Value	$29,365,492	BookValueAmt

Leasehold Improvements LeaseholdImprovementsGrp

Field	Value	IRS element (for citing)
Other Cost Or Other Basis	$28,337	OtherCostOrOtherBasisAmt
Book Value	$28,337	BookValueAmt

Equipment EquipmentGrp

Field	Value	IRS element (for citing)
Other Cost Or Other Basis	$63,455,708	OtherCostOrOtherBasisAmt
Depreciation	$54,294,561	DepreciationAmt
Book Value	$9,161,147	BookValueAmt

Field	Value	IRS element (for citing)
Total Book Value Land Buildings	$51,313,137	TotalBookValueLandBuildingsAmt

Other Securities OtherSecuritiesGrp (4 entries)

DescDesc	Book ValueBookValueAmt	Method ValuationMethodValuationCd
PRIVATE EQUITY LPS	$12,392,960	F
TOTAL RETURN HEDGE FUNDS	$930,363	F
SELECT EQUITY FUNDS	$25,772,881	F
HC ALTERNATIVE CREDIT OPP	$5,366,297	F

Field	Value	IRS element (for citing)
Total Book Value Securities	$44,462,501	TotalBookValueSecuritiesAmt

Other Liabilities Org OtherLiabilitiesOrgGrp (2 entries)

DescDesc	AmtAmt
OPERATING LEASE LIABILITIES	$752,301
FINANCE LEASE LIABILITIES	$2,140,033

Field	Value	IRS element (for citing)
Total Liability	$2,892,334	TotalLiabilityAmt
Footnote Text	Yes (X)	FootnoteTextInd
Total Rev Etc Audited Fincl Stmt	$136,010,000	TotalRevEtcAuditedFinclStmtAmt
Net Unrealized Gains Invst	$12,579,717	NetUnrealizedGainsInvstAmt
Donated Services And Use Fclts	$837,908	DonatedServicesAndUseFcltsAmt
Other Revenue	$0	OtherRevenueAmt
Revenue Not Reported	$13,417,625	RevenueNotReportedAmt
Revenue Subtotal	$122,592,375	RevenueSubtotalAmt
Investment Expenses Not Incld	$679,787	InvestmentExpensesNotIncldAmt
Other Revenues Not Included	$319	OtherRevenuesNotIncludedAmt
Revenue Not Reported Fincl Stmt	$680,106	RevenueNotReportedFinclStmtAmt
Total Revenue Per Form990	$123,272,481	TotalRevenuePerForm990Amt
Tot Expns Etc Audited Fincl Stmt	$111,333,000	TotExpnsEtcAuditedFinclStmtAmt
Donated Services Use Fclts	$837,908	DonatedServicesUseFcltsAmt
Other Expenses Included	$0	OtherExpensesIncludedAmt
Expenses Not Reported	$837,908	ExpensesNotReportedAmt
Expenses Subtotal	$110,495,092	ExpensesSubtotalAmt
Investment Expenses Not Incld2	$679,787	InvestmentExpensesNotIncld2Amt
Other Expenses Not Included	$612	OtherExpensesNotIncludedAmt
Expenses Not Rpt Fincl Stmt	$680,399	ExpensesNotRptFinclStmtAmt
Total Expenses Per Form990	$111,175,491	TotalExpensesPerForm990Amt

Supplemental Information Detail SupplementalInformationDetail (4 entries)

Form And Line ReferenceFormAndLineReferenceDesc	ExplanationExplanationTxt
Schedule D, Part V, Line 4 Intended uses of endowment funds	INTENDED USES OF THE ORGANIZATION'S ENDOWMENT FUNDS: THE INSTITUTE'S ENDOWMENT FUNDS ARE ESTABLISHED FOR VARIOUS PURPOSES: SCIENTIFIC RESEARCH, CEO CHAIR, PRESIDENTIAL CHAIR, CANCER AND NEUROSCIENCE LEADERSHIP CHAIRS, AND UNRESTRICTED AS TO INCOME.
Schedule D, Part X, Line 2 FIN 48 (ASC 740) footnote	THE INSTITUTE HAS NO MATERIAL DEFERRED TAX ASSETS OR DEFERRED TAX LIABILITIES REOCREDED AS OF JUNE 30, 2024 AND 2023. THE INSTITUTE DID NOT RECOGNIZE A CHANGE IN LIABILITY FOR UNRECOGNIZED TAX BENEFITS (THE DIFFERENCE BETWEEN A TAX POSITION TAKEN, OR EXPECTED TO BE TAKEN, IN A TAX RETURN AND THE BENEFIT RECOGNIZED AND MEASURED IN THE FINANCIAL STATEMENTS). THERE WERE NO LIABILTITIES FOR UNRECOGNIZED TAX BENEFITS AT JUNE 30, 2024 AND 2023.
Schedule D, Part XI, Line 4(b) Other revenues in form 990 not in audited financial statements	ROUNDING - 319
Schedule D, Part XII, Line 4(b) Other expenses in form 990 not in audited financial statements	ROUNDING - 612

Schedule F IRS990ScheduleF

Account Activities Outside US AccountActivitiesOutsideUSGrp (7 entries)

RegionRegionTxt	Type Of Activities ConductedTypeOfActivitiesConductedTxt	Specific Services ProvidedSpecificServicesProvidedTxt	Region Total ExpendituresRegionTotalExpendituresAmt
Europe (Including Iceland and Greenland)	Speaking engagements,Conference Travel	ACTIVITY IN ALL REGIONS IS EMPLOYEES ATTENDING AND/OR SPEAKING AT SCIENTIFIC CONFERENCES AND COLLABORATIONS.	$120,012
East Asia and the Pacific	Speaking engagements,Conference Travel	ACTIVITY IN ALL REGIONS IS EMPLOYEES ATTENDING AND/OR SPEAKING AT SCIENTIFIC CONFERENCES AND COLLABORATIONS.	$15,619
Central America and the Caribbean	Speaking engagements,Conference Travel	ACTIVITY IN ALL REGIONS IS EMPLOYEES ATTENDING AND/OR SPEAKING AT SCIENTIFIC CONFERENCES AND COLLABORATIONS.	$0
South America	Speaking engagements,Conference Travel	ACTIVITY IN ALL REGIONS IS EMPLOYEES ATTENDING AND/OR SPEAKING AT SCIENTIFIC CONFERENCES AND COLLABORATIONS.	$19,964
North America (Canada & Mexico only)	Speaking engagements,Conference Travel	ACTIVITY IN ALL REGIONS IS EMPLOYEES ATTENDING AND/OR SPEAKING AT SCIENTIFIC CONFERENCES AND COLLABORATIONS.	$47
Central America and the Caribbean	Investments		$18,689,620
Middle East and North Africa	Speaking engagements,Conference Travel	ACTIVITY IN ALL REGIONS IS EMPLOYEES ATTENDING AND/OR SPEAKING AT SCIENTIFIC CONFERENCES AND COLLABORATIONS.	$4,743

Field	Value	IRS element (for citing)
Subtotal Offices	0	SubtotalOfficesCnt
Subtotal Employees	0	SubtotalEmployeesCnt
Continuation Total Office	0	ContinuationTotalOfficeCnt
Continuation Total Employee	0	ContinuationTotalEmployeeCnt
Total Office	0	TotalOfficeCnt
Total Employee	0	TotalEmployeeCnt
Subtotal Spent	$18,850,005	SubtotalSpentAmt
Continuation Spent	$0	ContinuationSpentAmt
Total Spent	$18,850,005	TotalSpentAmt
Transfer To Foreign Corp	Yes (true)	TransferToForeignCorpInd
Interest In Foreign Trust	false	InterestInForeignTrustInd
Foreign Corp Ownership	Yes (true)	ForeignCorpOwnershipInd
Passive Foreign Investmest Co	Yes (true)	PassiveForeignInvestmestCoInd
Foreign Partnership	Yes (true)	ForeignPartnershipInd
Boycott Countries	false	BoycottCountriesInd

Supplemental Information Detail SupplementalInformationDetail

Field	Value	IRS element (for citing)
Form And Line Reference	Schedule F, Part I, Line 3 Method used to account for expenditures on org's financial statements	FormAndLineReferenceDesc
Explanation	CENTRAL AMERICA AND THE CARIBBEAN-Accrual,; EAST ASIA AND THE PACIFIC-Accrual; EUROPE (INCLUDING ICELAND AND GREENLAND)-Accrual; MIDDLE EAST AND NORTH AFRICA-Accrual; NORTH AMERICA (CANADA & MEXICO ONLY)-Accrual; SOUTH AMERICA-Accrual	ExplanationTxt

Schedule G IRS990ScheduleG

Fundraising Event Information FundraisingEventInformationGrp

Field	Value	IRS element (for citing)
Event1	Gala	Event1Nm
Gross Receipts Event1	$698,700	GrossReceiptsEvent1Amt
Charitable Contri Event1	$276,700	CharitableContriEvent1Amt
Gross Revenue Event1	$422,000	GrossRevenueEvent1Amt
Food And Beverage Event1	$186,427	FoodAndBeverageEvent1Amt
Entertainment Event1	$23,750	EntertainmentEvent1Amt
Other Direct Expenses Event1	$244,622	OtherDirectExpensesEvent1Amt
Gross Revenue Event2	$0	GrossRevenueEvent2Amt
Gross Revenue Other Events	$0	GrossRevenueOtherEventsAmt
Gross Receipts Total	$698,700	GrossReceiptsTotalAmt
Charitable Contributions Tot	$276,700	CharitableContributionsTotAmt
Gross Revenue Total Events	$422,000	GrossRevenueTotalEventsAmt
Food And Beverage Total Events	$186,427	FoodAndBeverageTotalEventsAmt
Entertainment Total Events	$23,750	EntertainmentTotalEventsAmt
Oth Direct Expnss Total Events	$244,622	OthDirectExpnssTotalEventsAmt
Direct Expense Summary Events	$454,799	DirectExpenseSummaryEventsAmt
Net Income Summary	-$32,799	NetIncomeSummaryAmt

Schedule J IRS990ScheduleJ

Field	Value	IRS element (for citing)
First Class Or Charter Travel	Yes (X)	FirstClassOrCharterTravelInd
Club Dues Or Fees	Yes (X)	ClubDuesOrFeesInd
Written Policy Ref T And E Expnss	Yes (true)	WrittenPolicyRefTAndEExpnssInd
Substantiation Required	Yes (true)	SubstantiationRequiredInd
Compensation Committee	Yes (X)	CompensationCommitteeInd
Independent Consultant	Yes (X)	IndependentConsultantInd
Form990 Of Other Organizations	Yes (X)	Form990OfOtherOrganizationsInd
Written Employment Contract	Yes (X)	WrittenEmploymentContractInd
Compensation Survey	Yes (X)	CompensationSurveyInd
Board Or Committee Approval	Yes (X)	BoardOrCommitteeApprovalInd
Severance Payment	Yes (true)	SeverancePaymentInd
Supplemental Nonqual Rtr Plan	Yes (true)	SupplementalNonqualRtrPlanInd
Equity Based Comp Arrngm	false	EquityBasedCompArrngmInd
Comp Based On Revenue Of Flng Org	false	CompBasedOnRevenueOfFlngOrgInd
Comp Bsd On Rev Related Orgs	false	CompBsdOnRevRelatedOrgsInd
Comp Bsd Net Earns Flng Org	false	CompBsdNetEarnsFlngOrgInd
Comp Bsd Net Earns Rltd Orgs	false	CompBsdNetEarnsRltdOrgsInd
Any Non Fixed Payments	Yes (true)	AnyNonFixedPaymentsInd
Initial Contract Exception	false	InitialContractExceptionInd

Rltd Org Officer Trst Key Empl RltdOrgOfficerTrstKeyEmplGrp (10 entries)

TitleTitleTxt	Base Compensation Filing OrgBaseCompensationFilingOrgAmt	Compensation Based On Rltd OrgsCompensationBasedOnRltdOrgsAmt	Bonus Filing OrganizationBonusFilingOrganizationAmount	Bonus Related OrganizationsBonusRelatedOrganizationsAmt	Other Compensation Filing OrgOtherCompensationFilingOrgAmt	Other Compensation Rltd OrgsOtherCompensationRltdOrgsAmt	Deferred Compensation Flng OrgDeferredCompensationFlngOrgAmt	Deferred Comp Rltd OrgsDeferredCompRltdOrgsAmt	Nontaxable Benefits Filing OrgNontaxableBenefitsFilingOrgAmt	Nontaxable Benefits Rltd OrgsNontaxableBenefitsRltdOrgsAmt	Total Compensation Filing OrgTotalCompensationFilingOrgAmt	Total Compensation Rltd OrgsTotalCompensationRltdOrgsAmt	Comp Report Prior990 Filing OrgCompReportPrior990FilingOrgAmt	Comp Report Prior990 Rltd OrgsCompReportPrior990RltdOrgsAmt
DAVID BRENNER MD
CEO AND PRESIDENT	$974,234	$0	$0	$0	$10,111	$0	$312,500	$0	$14,943	$0	$1,311,788	$0	$0	$0
C RANDAL MILLS PHD
FORMER CEO	$0	$0	$0	$0	$341,250	$0	$0	$0	$0	$0	$341,250	$0	$0	$0
NICHOLAS COSFORD
PROFESSOR & TRUSTEE	$240,544	$0	$0	$0	$3,584	$0	$24,270	$0	$44,214	$0	$312,612	$0	$0	$0
ROBIN RYAN
CFO & TREASURER	$451,617	$0	$0	$0	$7,073	$0	$33,000	$0	$15,299	$0	$506,989	$0	$0	$0
ADRIENNE CROWN JD
GENERAL COUNSEL & SECRETARY	$357,860	$0	$0	$0	$2,630	$0	$33,000	$0	$15,673	$0	$409,163	$0	$0	$0
ZE'EV RONAI PHD
CENTER DIRECTOR	$437,537	$0	$50,000	$0	$9,995	$0	$33,000	$0	$30,660	$0	$561,192	$0	$0	$0
MICHAEL JACKSON PHD
DRUG DISCOVERY & DEV, SR VP	$441,089	$0	$0	$0	$6,149	$0	$33,000	$0	$25,573	$0	$505,811	$0	$0	$0
KRISTIINA VUORI MD PHD
PROFESSOR	$598,654	$0	$0	$0	$2,554	$0	$33,000	$0	$27,610	$0	$661,818	$0	$0	$0
CARL WARE PHD
CENTER DIRECTOR, IIDC	$423,954	$0	$0	$0	$30,435	$0	$33,000	$0	$30,702	$0	$518,091	$0	$0	$0
RANDAL KAUFMAN PHD
PROGRAM DIRECTOR	$386,854	$0	$0	$0	$15,179	$0	$33,000	$0	$42,955	$0	$477,988	$0	$0	$0

Supplemental Information Detail SupplementalInformationDetail (6 entries)

Form And Line ReferenceFormAndLineReferenceDesc	ExplanationExplanationTxt
Schedule J, Part I, Line 1a First-class or charter travel	FIRST CLASS TRAVEL IS GENERALLY NOT PERMITTED, EXCEPT UNDER VERY LIMITED AND RARE CIRCUMSTANCES AND CONDITIONS, SUCH AS A MEDICAL CONDITION REQUIREMENT AND URGENT CIRCUMSTANCES. THIS WAS NOT TREATED AS TAXABLE COMPENSATION.
Schedule J, Part I, Line 1a Health or social club dues or initiation fees	HEALTH OR SOCIAL CLUB DUES ARE NEGOTIATED IN THE HIRING PROCESS FOR CERTAIN EMPLOYEES. THE AMOUNTS WERE TREATED AS TAXABLE COMPENSATION.
Schedule J, Part I, Line 4a Severance or change-of-control payment	C. RANDAL MILLS, PHD RECEIVED $341,250 IN SEVERANCE AS PART OF HIS SEPARATION AGREEMENT.
Schedule J, Part I, Line 4b Supplemental nonqualified retirement plan	A RETENTION BONUS WAS SET UP FOR THE PRESIDENT AND CEO, DR. DAVID BRENNER, WHERE VESTING WILL OCCUR THE EARLIEST OF 09/14/27. DISTRIBUTION IS A ONE-TIME LUMP SUM PAYMENT UPON VESTING.
Schedule J, Part I, Line 7 Non-fixed payments	SOME SENIOR EXECUTIVES HAVE EMPLOYMENT AGREEMENTS STIPULATING A BONUS WILL BE PAID TO THEM PROVIDED CERTAIN GOALS OR ACCOMPLISHMENTS ARE ACHIEVED.
Schedule J, Part II, Column (C) RETIREMENT AND OTHER DEFERRED COMPENSATION	THE AMOUNT REPORTED IN SCHEDULE J, PART II, COLUMN C INCLUDES THE ACCRUAL OF $300,000 FOR THE PRESIDENT & CEO, DR. DAVID BRENNER FOR A RETENTION BONUS DESCRIBED IN PART I. THE AMOUNT IS NOT VESTED AND IS SUBJECT TO SUBSTANTIAL RISK OF FORFEITURE.

Schedule K IRS990ScheduleK

Tax Exempt Bonds Issues TaxExemptBondsIssuesGrp

Field	Value	IRS element (for citing)
Bond Reference	A	BondReferenceCd

Issuer Name IssuerName

Field	Value	IRS element (for citing)
Business Name Line1	COUNTY OF SAN DIEGO	BusinessNameLine1Txt

Field	Value	IRS element (for citing)
Bond Issuer EIN	956000934	BondIssuerEIN
CUSIP	79742YAQ5	CUSIPNum
Bond Issued	2015-11-12	BondIssuedDt
Issue Price	$61,963,256	IssuePriceAmt
Purpose	REFINANCE 2006 AND 2012 BONDS WITH ISSUE DATES OF 02/01/2006 AND 11/15/2012 , RESPECTIVELY.	PurposeDesc
Defeased	false	DefeasedInd
On Behalf Of Issuer	false	OnBehalfOfIssuerInd
Pool Financing	false	PoolFinancingInd

Tax Exempt Bonds Proceeds TaxExemptBondsProceedsGrp

Field	Value	IRS element (for citing)
Bond Reference	A	BondReferenceCd
Retired	$23,210,000	RetiredAmt
Bond Defeased	$0	BondDefeasedAmt
Total Proceeds	$61,963,256	TotalProceedsAmt
In Reserve Fund	$0	InReserveFundAmt
Capitalized Interest	$0	CapitalizedInterestAmt
Refunding Escrow	$0	RefundingEscrowAmt
Issuance Costs From Proceeds	$289,386	IssuanceCostsFromProceedsAmt
Credit Enhancement	$0	CreditEnhancementAmt
Working Capital Expenditures	$0	WorkingCapitalExpendituresAmt
Capital Expenditures	$0	CapitalExpendituresAmt
Other Spent Proceeds	$61,673,870	OtherSpentProceedsAmt
Unspent	$0	UnspentAmt
Substantial Completion	2015	SubstantialCompletionYr
Refunding Tax Exempt Bonds	Yes (true)	RefundingTaxExemptBondsInd
Refunding Taxable Bonds	false	RefundingTaxableBondsInd
Final Allocation Made	Yes (true)	FinalAllocationMadeInd
Adequate Books And Rec Maint	Yes (true)	AdequateBooksAndRecMaintInd

Tax Exempt Bonds Private Bus Use TaxExemptBondsPrivateBusUseGrp

Field	Value	IRS element (for citing)
Bond Reference	A	BondReferenceCd
Owning Bond Financed Property	false	OwningBondFinancedPropertyInd
Any Lease Arrangements	Yes (true)	AnyLeaseArrangementsInd
Mgmt Contract Bond Fincd Prop	Yes (true)	MgmtContractBondFincdPropInd
Engage Bond Counsel Contracts	Yes (true)	EngageBondCounselContractsInd
Any Research Agreements	Yes (true)	AnyResearchAgreementsInd
Engage Bond Counsel Research	Yes (true)	EngageBondCounselResearchInd
Private Bus Use By Others	0.0131	PrivateBusUseByOthersPct
Private Bus Concerning UBI	0.0	PrivateBusConcerningUBIPct
Total Private Business Use	0.0131	TotalPrivateBusinessUsePct
Bond Iss Meet Prvt Sec Pymt Test	false	BondIssMeetPrvtSecPymtTestInd
Change In Use Bond Financed Prop	false	ChangeInUseBondFinancedPropInd
Procs Nonqualified Bond Remdtd	Yes (true)	ProcsNonqualifiedBondRemdtdInd

Tax Exempt Bonds Arbitrage TaxExemptBondsArbitrageGrp

Field	Value	IRS element (for citing)
Bond Reference	A	BondReferenceCd
Form8038 T Filed	false	Form8038TFiledInd
Rebate Not Due Yet	false	RebateNotDueYetInd
Exception To Rebate	Yes (true)	ExceptionToRebateInd
No Rebate Due	false	NoRebateDueInd
Variable Rate Issue	Yes (true)	VariableRateIssueInd
Hedge Identified In Bks And Rec	false	HedgeIdentifiedInBksAndRecInd
Gross Proceeds Invested In GIC	false	GrossProceedsInvestedInGICInd
Gross Proceeds Invested	false	GrossProceedsInvestedInd
Written Proc To Monitor Reqs	Yes (true)	WrittenProcToMonitorReqsInd

Procedures Corrective Action ProceduresCorrectiveActionGrp

Field	Value	IRS element (for citing)
Bond Reference	A	BondReferenceCd
Procedures Corrective Action	Yes (true)	ProceduresCorrectiveActionInd

Supplemental Information Detail SupplementalInformationDetail

Field	Value	IRS element (for citing)
Form And Line Reference	Schedule K, Part V Different Procedures to Undertake Corrective Action	FormAndLineReferenceDesc
Explanation	Issuer name: COUNTY OF SAN DIEGO FOR THE BOND ISSUES LISTED IN PART I, THE ALTERNATIVE PERIOD USED FOR THE REPORTING REQUIREMENTS IN THIS SECTION IS THE TWELVE MONTHS ENDED DECEMBER 31, 2024.	ExplanationTxt

Schedule O IRS990ScheduleO

Supplemental Information Detail SupplementalInformationDetail (11 entries)

Form And Line ReferenceFormAndLineReferenceDesc	ExplanationExplanationTxt
Form 990, Part I, Line 1 MISSION STATEMENT	SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE'S MISSION IS TO ADVANCE THE BIOMEDICAL SCIENCES BY CULTIVATING THE NEXT GENERATION OF SCIENTIFIC LEADERS, PROVIDING MEANINGFUL OPPORTUNITIES FOR RESEARCHERS OF ALL BACKGROUNDS TO LEARN, INNOVATE, AND MAKE BREAKTHROUGH DISCOVERIES THAT IMPROVE HUMAN HEALTH.
Form 990, Part III, Line 4a	Form 990 - Part III, line 4 Program Service Accomplishments Sanford Burnham Prebys is an independent nonprofit medical research organization dedicated to uncovering the origins of disease and launching bold new strategies that lay the foundation for cures. The institute has deep expertise in fundamental biology highlighted by four disease-focused centers, two technology-enabling centers and four cross-cutting themes; stem cells and regenerative medicine; and the Sanford Children's Health Research Center. Cancer Selected published research How a protein component of nuclear pore complexes regulates development of blood cells and may contribute to myeloid disorders. Maximiliano D' Angelo, PhD, et al. Science Advances. June 5, 2024. How tumor stiffness alters immune cell behavior to escape destruction. Kevin Tharp, PhD, and Kelly Kersten, PhD, et al. Nature Cancer. June 3. 2024. Overlooked lipid connected to ancient cellular pathway with links to cancer. Brooke Emerling, PhD, et al. Science Signaling. May 28, 2024. AI tool predicts responses to cancer therapy using information from each cell of the tumor. Sanju Sinha, PhD, et al. Nature Cancer. Apr 18, 2024. What makes a pathogen antibiotic-resistant? Andrei L. Osterman, PhD, et al. npj Antimicrobials and Resistance. Mar 2, 2024. New genome mapping tool may uncover secrets for treating blood cancers. Kristiina Vuori, MD, PhD, et al. Cancers. Jan 18, 2024. The "Eph" system may pave the way for novel cancer therapies. Elena Pasquale, PhD, et al. Nature Reviews Cancer. Nov 27, 2023. "DNA loops" in pediatric brain tumors double relapse risk. Lukas Chavez, PhD, et al. Nature Genetics. Nov 14, 2023. Copycat nutrient leaves pancreatic tumors starving. Cosimo Commisso, PhD, et al. Nature Cancer. Oct 8, 2023. This sugar kills honeybees-it could also help fight cancer. Hudson Freeze, PhD, et al. eLife. July 17, 2023. Cardiovascular and Muscular Diseases Selected published research New genes implicated in deadly heart defect. Rolf Bodmer, PhD, and George Vogler, PhD, et al. eLife. July 17, 2023. Neurologic Diseases Selected published research Tiny brain bubbles carry complete codes. Jerold Chun, MD, PhD, et al. Cell Reports. Apr 23, 2024. Common HIV treatments may aid Alzheimer's disease patients. Jerold Chun, MD, PhD, et al. Pharmaceuticals. Mar 22, 2024. Similarity between vitamin B12 loss and multiple sclerosis revealed. Jerold Chun, MD, et al. Cell Reports. Dec 8, 2023. Inhibiting an enzyme associated with aging could help damaged nerves regrow and restore strength. Yu Xin Wang, PhD, et al. Science Translational Medicine. Oct 11, 2023. Metabolic and Liver Diseases Selected published research A new 3D bioprinted model offers a novel tool to study common liver disease, and perhaps find an effective treatment. David Brenner, MD, et al. American Journal of Pathology. Dec 27, 2023. How liver cells become scarring, and worse. David Brenner, MD, et al. Cellular and Molecular Gastroenterology and Hepatology. Sept 27, 2023. Cross-cutting Themes New roles for autophagy genes in cellular waste management and aging. Malene Hansen, PhD, et al. Nature Aging. Jan 4. 2024. A potential new weapon against a deadly, drug-resistant bacterial pathogen. Andrei Osterman, PhD, et al. Nature. Jan 3, 2024. Study reveals Zika's shape-shifting machinery-and a possible vulnerability. Alexey Terskikh, PhD, et al. PLOS Pathogens. Nov 27, 2023. Selected Awards and Grants Michael Jackson, PhD, and collaborators at Cedars-Sinai have received a four-year, $2.5 million grant from the National Cancer Institute to target the mutant promoter of TERT, which is associated with an increased risk of acute myeloid leukemia. Tim Huang, PhD, was awarded a five-year, $4.3 million grant from the National Institute on Aging to study the potential therapeutic value of SORLA against Alzheimer's disease and related tauopathies. The research is in collaboration with Kevin Yip, PhD. Sanjeev Ranade, PhD, received a three-year, $752,000 award from Additional Ventures to define neural crest regulatory networks and lineages in outflow tract development. Georg Vogler, PhD, was awarded a 3-year, $142,000 grant from the National Aeronautics and Space Administration (NASA) to study the neurological, cardiac and muscular consequences of living in a deep space environment, using the model organism Drosophila melanogaster (fruit fly). Yu Xin Wang, PhD, received a 1-year, $50,000 award from the Department of Health & Human Services (NIH) to study CODEX multiplex immunofluorescence to detect cellular senescence, part of the Cellular Senescence Network initiative. Jerold Chun, MD, PhD, was awarded a 3-year, $660,000 grant from the Larry L. Hillblom Foundation to continue his research into mosaicism and its contribution to age-related neurological disease. Yu Xin Wang, PhD, received a 1-year, $50,000 award from the Department of Health & Human Services (NIH) to study CODEX multiplex immunofluorescence to detect cellular senescence, part of the Cellular Senescence Network initiative David Brenner, MD, received a 5-year, $1.5 million from the NIH and the Department of Health & Human Services to study how collagen fibers and fragments regulate pancreatic cancer metabolism and growth. Nicholas Cosford, PhD, received a 3-year, $500,000 award from Curebound to further pursue the therapeutic potential of ULK1 inhibitor proteins, which have been shown to be a promising biomarker in predicting prognoses and clinical response to cancer treatments. Cosimo Commisso, PhD, received a 1-year, $195,000 award from Curebound to study ion homeostasis as a new drug target for pancreatic cancer treatments. Maximiliano D'Angelo, PhD, received a 2-year, $300,000 Discovery Boost Grant from the American Cancer Society to further his research on how components of nuclear pore complexes (multiprotein channels that act as gatekeepers to the genome) modulate the anti-tumor immune response and might be used as therapeutic targets.
Form 990, Part VI, Line 11b Review of form 990 by governing body	PROCESS USED BY MANAGEMENT AND/OR GOVERNING BODY TO REVIEW FORM 990: THE 990 IS PREPARED BY THE FINANCE DEPARTMENT. IT IS REVIEWED BY THE INSTITUTE'S TAX ADVISORS, SELECTED MEMBERS OF MANAGEMENT INCLUDING THE CFO AND AUDIT COMMITTEE, AND PROVIDED TO MEMBERS OF THE BOARD PRIOR TO FILING.
Form 990, Part VI, Line 12c Conflict of interest policy	DESCRIPTION OF PROCESS TO MONITOR TRANSACTIONS FOR CONFLICT OF INTEREST: SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUE HAS A CONFLICT OF INTEREST POLICY THAT REQUIRES ALL TRUSTEES, PRINCIPAL OFFICERS OR MEMBERS OF A COMMITTEE WITH BOARD DELEGATED POWERS TO ANNUALLY CONFIRM THEIR RECEIPT OF THE CONFLICT OF INTEREST POLICY AND DISCLOSE ANY NEW ASSOCIATIONS OR INTEREST THAT MIGHT POTENTIALLY POSE A CONFLICT. THIS IS A WRITTEN CONFIRMATION THAT SHE OR HE READ AND UNDERSTANDS THE CONFLICT OF INTEREST POLICY, WILL ABIDE BY THE CONFLICT OF INTEREST POLICY AND CERTIFIES DISCLOSURE OF ALL INTERESTS OR RELATIONSHIPS THAT MAY POSE CONFLICTS. NEW TRUSTEES RECEIVE TRAINING REGARDING THE INSTITUTE'S CONFLICT OF INTEREST POLICY, WHICH INCLUDES HOW TO IDENTIFY A CONFLICT OF INTEREST AND HOW TO HANDLE POSSIBLE CONFLICTS OF INTEREST WHEN THEY ARISE. THE COMPLIANCE DEPARTMENT REVIEWS EACH OF THE STATEMENTS AND ASSESSES WHETHER AN ACTUAL OR POTENTIAL CONFLICT OF INTEREST EXISTS AND REFERS THE MATTER TO THE BOARD TO WHETHER THE INDIVIDUAL SHOULD BE PROHIBITED FROM CONSIDERATION OF RELATED ITEMS. ANY TRUSTEE, PRINCIPAL OFFICER OR MEMBER OF A COMMITTEE WITH BOARD DELEGATED POWERS WITH A CONFLICT IN A MATTER REQUIRING ACTION BY THE BOARD ARE PROHIBITED FROM PARTICPATING IN THE BOARD'S DELIBERATIONS AND/OR VOTING ON THE PARTICULAR TRANSACTION OR MATTER IN WHICH HE OR SHE HAS AN INTEREST; AND OTHERWISE REFRAIN FROM EXERTING ANY INFLUENCE TO AFFECT A DECISION. HOWEVER, OTHER MEASURES MAY BE REQUIRED, DEPENDING ON THE NATURE OF AND THE ABILITY TO REASONABLY MANAGE A CONFLICT.
Form 990, Part VI, Line 15a Process to establish compensation of top management official	COMPENSATION FOR THE CEO AND PRESIDENT, CHIEF FINANCIAL OFFICER, AND OTHER KEY EMPLOYEES IS ESTABLISHED ACCORDING TO INSTITUTE POLICIES THAT ARE DESIGNED TO MEET THE IRS STANDARD FOR "REBUTTABLE PRESUMPTION OF REASONABLENESS". THE COMPENSATION COMMITTEE OF THE BOARD OF TRUSTEES, CONSISTING OF AT LEAST THREE INDEPENDENT TRUSTEES, REVIEWS COMPARABILITY DATA AT LEAST EVERY TWO YEARS PROVIDED BY AN INDEPENDENT EXTERNAL CONSULTANT/RESOURCE THAT INCORPORATES AND EVALUATES INSTITUTE DATA AND THAT OF COMPARABLE ORGANIZATIONS AND MARKETS FROM WHICH THE INSTITUTE DRAWS ITS EXECUTIVE TALENT. UTILIZING THIS INFORMATION, THE COMPENSATION COMMITTEE MAKES A DETERMINATION WHETHER THE PROPOSED COMPENSATION IS REASONABLE. THE COMPENSATION COMMITTEE HAS BEEN DELEGATED AUTHORITY BY THE BOARD OF TRUSTEES TO REVIEW AND APPROVE COMPENSATION OF ALL POSITIONS EXCEPT FOR THE CEO. THE CEO'S COMPENSATION PACKAGE IS REVIEWED AND APPROVED INITIALLY BY THE COMPENSATION COMMITTEE AND THEN GOES TO THE EXECUTIVE COMMITTEE FOR FINAL APPROVAL. THE COMPENSATION COMMITTEE CONTEMPORANEOUSLY AND ADEQUATELY DOCUMENTS THE BASIS FOR ITS DETERMINATION AND RECOMMENDATION TO THE EXECUTIVE COMMITTEE. IF APPROVED BY THE EXECUTIVE COMMITTEE, THE CEO COMPENSATION PACKAGE IS THEN IMPLEMENTED AND SUCH DOCUMENTATION IS KEPT IN THE WRITTEN AND ELECTRONIC RECORDS OF THE BOARD OF TRUSTEES. THE PROCESS WAS LAST COMPLETED ON JUNE 27, 2023. THE NEXT REVIEW WILL BE COMPLETED JUNE 2025.
Form 990, Part VI, Line 15b Process to establish compensation of other employees	SEE ABOVE
Form 990, Part VI, Line 19 Required documents available to the public	PROCESS FOR MAKING DOCUMENTS AVAILABLE TO THE PUBLIC: DOCUMENTS ARE AVAILABLE UPON REQUEST AND THE INSTITUTE'S TAX FORM 990 IS AVAILABLE ON CHARITY NAVIGATOR AND GUIDESTAR.
Form 990, Part VIII, Line 11d Other Miscellaneous Revenue	ALL OTHER REVENUE - Total Revenue: 6000, Related or Exempt Function Revenue: 6000, Unrelated Business Revenue: , Revenue Excluded from Tax Under Sections 512, 513, or 514: ;
Schedule F, Part I, Line 3 Program Service Activities	Sanford Burnham Prebys Medical Discovery Institute does not maintain ongoing operations in foreign jurisdictions. However, the Institute's scientists do travel to various scientific conferences in other countries to share the Institute's scientific discoveries, as well as, to learn from other scientists across the world.
Schedule F, Part I, Line 3(e) Type of Service	Specific Program Service Activity in all regions is employees attending and/or speaking at scientific conferences and collaborations.
Schedule F, Part I, Line 3(f) Accounting Method	The accrual method of accounting was used to determine the amounts in Part I, line 3, column F.