SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE: Form 990, tax year 2018

View the entire original 990 at ProPublica ↗

Organization: SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE (EIN 51-0197108)
Tax period: 2018-07-01 to 2019-06-30
Filed: 2020-06-25
IRS object ID: 202011779349301806
Schema version: 2018v3.3
Source: Download XML · Original 990 at ProPublica

Every field in the e-filed return. Faint text is the IRS element name, for citing.

Return header
Form 990
Schedule A
Schedule B
Schedule C
Schedule D
Schedule F
Schedule G
Schedule J
Schedule K
Schedule O
Schedule R

Return header ReturnHeader

Field	Value	IRS element (for citing)
Return	2020-06-25T15:26:41-05:00	ReturnTs
Tax Period End	2019-06-30	TaxPeriodEndDt

Preparer Firm PreparerFirmGrp

Preparer Firm Name PreparerFirmName

Field	Value	IRS element (for citing)
Business Name Line1	ERNST & YOUNG US LLP	BusinessNameLine1Txt

Preparer US Address PreparerUSAddress

Field	Value	IRS element (for citing)
Address Line1	4365 EXECUTIVE DRIVE STE 1600	AddressLine1Txt
City	SAN DIEGO	CityNm
State Abbreviation	CA	StateAbbreviationCd
ZIP	92121	ZIPCd

Field	Value	IRS element (for citing)
Return Type	990	ReturnTypeCd
Tax Period Begin	2018-07-01	TaxPeriodBeginDt

Filer Filer

Field	Value	IRS element (for citing)
EIN	510197108	EIN

Business Name BusinessName

Field	Value	IRS element (for citing)
Business Name Line1	SANFORD BURNHAM PREBYS MEDICAL DISCOVERY	BusinessNameLine1Txt
Business Name Line2	INSTITUTE	BusinessNameLine2Txt

Field	Value	IRS element (for citing)
In Care Of	% LOUIS COFFMAN	InCareOfNm
Business Name Control	SANF	BusinessNameControlTxt
Phone	8586463100	PhoneNum

US Address USAddress

Field	Value	IRS element (for citing)
Address Line1	10901 NORTH TORREY PINES ROAD	AddressLine1Txt
City	LA JOLLA	CityNm
State Abbreviation	CA	StateAbbreviationCd
ZIP	92037	ZIPCd

Business Officer BusinessOfficerGrp

Field	Value	IRS element (for citing)
Person	LOUIS COFFMAN	PersonNm
Person Title	CAO & CFO	PersonTitleTxt
Phone	8586463100	PhoneNum
Signature	2020-06-17	SignatureDt
Discuss With Paid Preparer	Yes (true)	DiscussWithPaidPreparerInd

Preparer Person PreparerPersonGrp

Field	Value	IRS element (for citing)
Preparer Person	JOCELYNE MILLER	PreparerPersonNm
PTIN	P00634378	PTIN
Phone	8585357200	PhoneNum

Filing Security Information FilingSecurityInformation

IP Address IPAddress

Field	Value	IRS element (for citing)
I Pv4 Address	99.132.79.23	IPv4AddressTxt

Field	Value	IRS element (for citing)
Federal Original Submission Id	33008120201775000003	FederalOriginalSubmissionId
Federal Original Submission Id	2020-06-25	FederalOriginalSubmissionIdDt
Filing License Type	P	FilingLicenseTypeCd
At Submission Creation Device Id	DE6C2DF5A9AF955A85F13E615B2394729CA127AA	AtSubmissionCreationDeviceId
At Submission Filing Device Id	36F6D57CE89615FC2EEC8448977178FD35DAD353	AtSubmissionFilingDeviceId

Field	Value	IRS element (for citing)
Tax	2018	TaxYr
Build TS	2020-09-23 17:36:50Z	BuildTS

Form 990 IRS990

Field	Value	IRS element (for citing)
Principal Officer	KRISTIINA VUORI	PrincipalOfficerNm

US Address USAddress

Field	Value	IRS element (for citing)
Address Line1	10901 NORTH TORREY PINES ROAD	AddressLine1Txt
City	LA JOLLA	CityNm
State Abbreviation	CA	StateAbbreviationCd
ZIP	92037	ZIPCd

Field	Value	IRS element (for citing)
Gross Receipts	$267,516,050	GrossReceiptsAmt
Group Return For Affiliates	false	GroupReturnForAffiliatesInd
Organization501c3	Yes (X)	Organization501c3Ind
Website Address	WWW.SBPDISCOVERY.ORG	WebsiteAddressTxt
Type Of Organization Corp	Yes (X)	TypeOfOrganizationCorpInd
Formation	1976	FormationYr
Legal Domicile State	CA	LegalDomicileStateCd
Activity Or Mission	SEE SCHEDULE O	ActivityOrMissionDesc
Voting Members Governing Body	17	VotingMembersGoverningBodyCnt
Voting Members Independent	16	VotingMembersIndependentCnt
Total Employee	911	TotalEmployeeCnt
Total Volunteers	19	TotalVolunteersCnt
Total Gross UBI	$1,353,769	TotalGrossUBIAmt
Net Unrelated Bus Txbl Incm	$0	NetUnrelatedBusTxblIncmAmt
PY Contributions Grants	$113,630,164	PYContributionsGrantsAmt
CY Contributions Grants	$108,300,329	CYContributionsGrantsAmt
PY Program Service Revenue	$1,300,446	PYProgramServiceRevenueAmt
CY Program Service Revenue	$799,803	CYProgramServiceRevenueAmt
PY Investment Income	$6,744,651	PYInvestmentIncomeAmt
CY Investment Income	$11,593,574	CYInvestmentIncomeAmt
PY Other Revenue	$3,651,490	PYOtherRevenueAmt
CY Other Revenue	$2,262,753	CYOtherRevenueAmt
PY Total Revenue	$125,326,751	PYTotalRevenueAmt
CY Total Revenue	$122,956,459	CYTotalRevenueAmt
PY Grants And Similar Paid	$0	PYGrantsAndSimilarPaidAmt
CY Grants And Similar Paid	$0	CYGrantsAndSimilarPaidAmt
PY Benefits Paid To Members	$0	PYBenefitsPaidToMembersAmt
CY Benefits Paid To Members	$0	CYBenefitsPaidToMembersAmt
PY Salaries Comp Emp Bnft Paid	$76,269,756	PYSalariesCompEmpBnftPaidAmt
CY Salaries Comp Emp Bnft Paid	$65,811,734	CYSalariesCompEmpBnftPaidAmt
PY Total Prof Fndrsng Expns	$0	PYTotalProfFndrsngExpnsAmt
CY Total Prof Fndrsng Expns	$0	CYTotalProfFndrsngExpnsAmt
CY Total Fundraising Expense	$1,277,432	CYTotalFundraisingExpenseAmt
PY Other Expenses	$67,249,608	PYOtherExpensesAmt
CY Other Expenses	$120,469,124	CYOtherExpensesAmt
PY Total Expenses	$143,519,364	PYTotalExpensesAmt
CY Total Expenses	$186,280,858	CYTotalExpensesAmt
PY Revenues Less Expenses	-$18,192,613	PYRevenuesLessExpensesAmt
CY Revenues Less Expenses	-$63,324,399	CYRevenuesLessExpensesAmt
Total Assets BOY	$430,760,547	TotalAssetsBOYAmt
Total Assets EOY	$338,796,799	TotalAssetsEOYAmt
Total Liabilities BOY	$149,095,244	TotalLiabilitiesBOYAmt
Total Liabilities EOY	$123,189,379	TotalLiabilitiesEOYAmt
Net Assets Or Fund Balances BOY	$281,665,303	NetAssetsOrFundBalancesBOYAmt
Net Assets Or Fund Balances EOY	$215,607,420	NetAssetsOrFundBalancesEOYAmt
Info In Schedule O Part III	Yes (X)	InfoInScheduleOPartIIIInd
Mission	SEE SCHEDULE O	MissionDesc
Significant New Program Srvc	false	SignificantNewProgramSrvcInd
Significant Change	false	SignificantChangeInd
Expense	$100,125,314	ExpenseAmt
Grant	$0	GrantAmt
Revenue	$1,018,511	RevenueAmt
Desc	SEE SCHEDULE O	Desc
Total Program Service Expenses	$100,125,314	TotalProgramServiceExpensesAmt
Described In Section501c3	Yes (true)	DescribedInSection501c3Ind
Schedule B Required	Yes (true)	ScheduleBRequiredInd
Political Campaign Acty	false	PoliticalCampaignActyInd
Lobbying Activities	Yes (true)	LobbyingActivitiesInd
Subject To Proxy Tax	false	SubjectToProxyTaxInd
Donor Advised Fund	false	DonorAdvisedFundInd
Conservation Easements	false	ConservationEasementsInd
Collections Of Art	false	CollectionsOfArtInd
Credit Counseling	false	CreditCounselingInd
Temp Or Permanent Endowments	Yes (true)	TempOrPermanentEndowmentsInd
Report Land Building Equipment	Yes (true)	ReportLandBuildingEquipmentInd
Report Investments Other Sec	Yes (true)	ReportInvestmentsOtherSecInd
Report Program Related Invst	false	ReportProgramRelatedInvstInd
Report Other Assets	false	ReportOtherAssetsInd
Report Other Liabilities	false	ReportOtherLiabilitiesInd
Include FIN48 Footnote	Yes (true)	IncludeFIN48FootnoteInd
Independent Audit Fincl Stmt	Yes (true)	IndependentAuditFinclStmtInd
Consolidated Audit Fincl Stmt	false	ConsolidatedAuditFinclStmtInd
School Operating	false	SchoolOperatingInd
Foreign Office	Yes (true)	ForeignOfficeInd
Foreign Activities	Yes (true)	ForeignActivitiesInd
More Than5000 K To Org	false	MoreThan5000KToOrgInd
More Than5000 K To Individuals	false	MoreThan5000KToIndividualsInd
Professional Fundraising	false	ProfessionalFundraisingInd
Fundraising Activities	Yes (true)	FundraisingActivitiesInd
Gaming Activities	false	GamingActivitiesInd
Operate Hospital	false	OperateHospitalInd
Grants To Organizations	false	GrantsToOrganizationsInd
Grants To Individuals	false	GrantsToIndividualsInd
Schedule J Required	Yes (true)	ScheduleJRequiredInd
Tax Exempt Bonds	Yes (true)	TaxExemptBondsInd
Invest Tax Exempt Bonds	false	InvestTaxExemptBondsInd
Escrow Account	false	EscrowAccountInd
On Behalf Of Issuer	false	OnBehalfOfIssuerInd
Engaged In Excess Benefit Trans	false	EngagedInExcessBenefitTransInd
PY Excess Benefit Trans	false	PYExcessBenefitTransInd
Loan Outstanding	false	LoanOutstandingInd
Grant To Related Person	false	GrantToRelatedPersonInd
Business Rln With Org Mem	false	BusinessRlnWithOrgMemInd
Business Rln With Fam Mem	false	BusinessRlnWithFamMemInd
Business Rln With Officer Ent	false	BusinessRlnWithOfficerEntInd
Deductible Non Cash Contri	false	DeductibleNonCashContriInd
Deductible Art Contribution	false	DeductibleArtContributionInd
Terminate Operations	false	TerminateOperationsInd
Partial Liquidation	false	PartialLiquidationInd
Disregarded Entity	false	DisregardedEntityInd
Related Entity	Yes (true)	RelatedEntityInd
Related Organization Ctrl Ent	Yes (true)	RelatedOrganizationCtrlEntInd
Transaction With Control Ent	false	TransactionWithControlEntInd
Trnsfr Exmpt Non Chrtbl Rltd Org	false	TrnsfrExmptNonChrtblRltdOrgInd
Activities Conducted Prtshp	false	ActivitiesConductedPrtshpInd
Schedule O Required	Yes (true)	ScheduleORequiredInd
IRP Document	212	IRPDocumentCnt
IRP Document W2 G	0	IRPDocumentW2GCnt
Backup Wthld Compliance	Yes (true)	BackupWthldComplianceInd
Employee	911	EmployeeCnt
Employment Tax Returns Filed	Yes (true)	EmploymentTaxReturnsFiledInd
Unrelated Bus Incm Over Limit	Yes (true)	UnrelatedBusIncmOverLimitInd
Form990 T Filed	Yes (true)	Form990TFiledInd
Foreign Financial Account	false	ForeignFinancialAccountInd
Prohibited Tax Shelter Trans	false	ProhibitedTaxShelterTransInd
Taxable Party Notification	false	TaxablePartyNotificationInd
Nondeductible Contributions	false	NondeductibleContributionsInd
Quid Pro Quo Contributions	Yes (true)	QuidProQuoContributionsInd
Quid Pro Quo Contri Discl	Yes (true)	QuidProQuoContriDisclInd
Form8282 Property Disposed Of	false	Form8282PropertyDisposedOfInd
Rcv Fnds To Pay Prsnl Bnft Cntrct	false	RcvFndsToPayPrsnlBnftCntrctInd
Pay Premiums Prsnl Bnft Cntrct	false	PayPremiumsPrsnlBnftCntrctInd
Indoor Tanning Services	false	IndoorTanningServicesInd
Subj To Tax Rmnrtn Ex Prcht Pymt	false	SubjToTaxRmnrtnExPrchtPymtInd
Subject To Excs Tax Net Invst Inc	false	SubjectToExcsTaxNetInvstIncInd
Info In Schedule O Part VI	Yes (X)	InfoInScheduleOPartVIInd
Governing Body Voting Members	17	GoverningBodyVotingMembersCnt
Independent Voting Member	16	IndependentVotingMemberCnt
Family Or Business Rln	false	FamilyOrBusinessRlnInd
Delegation Of Mgmt Duties	false	DelegationOfMgmtDutiesInd
Change To Org Documents	false	ChangeToOrgDocumentsInd
Material Diversion Or Misuse	false	MaterialDiversionOrMisuseInd
Members Or Stockholders	false	MembersOrStockholdersInd
Election Of Board Members	false	ElectionOfBoardMembersInd
Decisions Subject To Approva	false	DecisionsSubjectToApprovaInd
Minutes Of Governing Body	Yes (true)	MinutesOfGoverningBodyInd
Minutes Of Committees	Yes (true)	MinutesOfCommitteesInd
Officer Mailing Address	false	OfficerMailingAddressInd
Local Chapters	false	LocalChaptersInd
Form990 Provided To Gvrn Body	Yes (true)	Form990ProvidedToGvrnBodyInd
Conflict Of Interest Policy	Yes (true)	ConflictOfInterestPolicyInd
Annual Disclosure Covered Prsn	Yes (true)	AnnualDisclosureCoveredPrsnInd
Regular Monitoring Enfrc	Yes (true)	RegularMonitoringEnfrcInd
Whistleblower Policy	Yes (true)	WhistleblowerPolicyInd
Document Retention Policy	Yes (true)	DocumentRetentionPolicyInd
Compensation Process CEO	Yes (true)	CompensationProcessCEOInd
Compensation Process Other	Yes (true)	CompensationProcessOtherInd
Investment In Joint Venture	false	InvestmentInJointVentureInd
States Where Copy Of Return Is Fld	AL	StatesWhereCopyOfReturnIsFldCd
States Where Copy Of Return Is Fld	AK	StatesWhereCopyOfReturnIsFldCd
States Where Copy Of Return Is Fld	AR	StatesWhereCopyOfReturnIsFldCd
States Where Copy Of Return Is Fld	CA	StatesWhereCopyOfReturnIsFldCd
States Where Copy Of Return Is Fld	CO	StatesWhereCopyOfReturnIsFldCd
States Where Copy Of Return Is Fld	CT	StatesWhereCopyOfReturnIsFldCd
States Where Copy Of Return Is Fld	DC	StatesWhereCopyOfReturnIsFldCd
States Where Copy Of Return Is Fld	FL	StatesWhereCopyOfReturnIsFldCd
States Where Copy Of Return Is Fld	GA	StatesWhereCopyOfReturnIsFldCd
States Where Copy Of Return Is Fld	IL	StatesWhereCopyOfReturnIsFldCd
States Where Copy Of Return Is Fld	KS	StatesWhereCopyOfReturnIsFldCd
States Where Copy Of Return Is Fld	KY	StatesWhereCopyOfReturnIsFldCd
States Where Copy Of Return Is Fld	ME	StatesWhereCopyOfReturnIsFldCd
States Where Copy Of Return Is Fld	MD	StatesWhereCopyOfReturnIsFldCd
States Where Copy Of Return Is Fld	MA	StatesWhereCopyOfReturnIsFldCd
States Where Copy Of Return Is Fld	MI	StatesWhereCopyOfReturnIsFldCd
States Where Copy Of Return Is Fld	MN	StatesWhereCopyOfReturnIsFldCd
States Where Copy Of Return Is Fld	MS	StatesWhereCopyOfReturnIsFldCd
States Where Copy Of Return Is Fld	NH	StatesWhereCopyOfReturnIsFldCd
States Where Copy Of Return Is Fld	NJ	StatesWhereCopyOfReturnIsFldCd
States Where Copy Of Return Is Fld	NM	StatesWhereCopyOfReturnIsFldCd
States Where Copy Of Return Is Fld	NY	StatesWhereCopyOfReturnIsFldCd
States Where Copy Of Return Is Fld	NC	StatesWhereCopyOfReturnIsFldCd
States Where Copy Of Return Is Fld	ND	StatesWhereCopyOfReturnIsFldCd
States Where Copy Of Return Is Fld	OH	StatesWhereCopyOfReturnIsFldCd
States Where Copy Of Return Is Fld	OK	StatesWhereCopyOfReturnIsFldCd
States Where Copy Of Return Is Fld	OR	StatesWhereCopyOfReturnIsFldCd
States Where Copy Of Return Is Fld	PA	StatesWhereCopyOfReturnIsFldCd
States Where Copy Of Return Is Fld	RI	StatesWhereCopyOfReturnIsFldCd
States Where Copy Of Return Is Fld	SC	StatesWhereCopyOfReturnIsFldCd
States Where Copy Of Return Is Fld	TN	StatesWhereCopyOfReturnIsFldCd
States Where Copy Of Return Is Fld	UT	StatesWhereCopyOfReturnIsFldCd
States Where Copy Of Return Is Fld	VA	StatesWhereCopyOfReturnIsFldCd
States Where Copy Of Return Is Fld	WA	StatesWhereCopyOfReturnIsFldCd
States Where Copy Of Return Is Fld	WV	StatesWhereCopyOfReturnIsFldCd
States Where Copy Of Return Is Fld	WI	StatesWhereCopyOfReturnIsFldCd
Upon Request	Yes (X)	UponRequestInd

Books In Care Of Detail BooksInCareOfDetail

Field	Value	IRS element (for citing)
Person	LOUIS COFFMAN	PersonNm
Phone	8586463100	PhoneNum

US Address USAddress

Field	Value	IRS element (for citing)
Address Line1	10901 N Torrey Pines RD	AddressLine1Txt
City	La Jolla	CityNm
State Abbreviation	CA	StateAbbreviationCd
ZIP	92037	ZIPCd

Form990 Part VII Section A Form990PartVIISectionAGrp (28 entries)

TitleTitleTxt	Average Hours Per WeekAverageHoursPerWeekRt	Average Hours Per Week Rltd OrgAverageHoursPerWeekRltdOrgRt	Individual Trustee Or DirectorIndividualTrusteeOrDirectorInd	OfficerOfficerInd	Reportable Comp From OrgReportableCompFromOrgAmt	Reportable Comp From Rltd OrgReportableCompFromRltdOrgAmt	Other CompensationOtherCompensationAmt	Highest Compensated EmployeeHighestCompensatedEmployeeInd	Former Ofcr Director TrusteeFormerOfcrDirectorTrusteeInd
KRISTIINA VUORI MD PHD
PRESIDENT	50.0	0.0	Yes (X)	Yes (X)	$1,010,709	$0	$345,320
DOUGLAS OBENSHAIN
TRUSTEE	1.0	0.0	Yes (X)		$0	$0	$0
DAVID DOWN
TRUSTEE	1.0	0.0	Yes (X)		$0	$0	$0
WILLIAM GERHART
VICE CHAIRMAN	1.0	0.0	Yes (X)	Yes (X)	$0	$0	$0
ALAN GLEICHER
TRUSTEE (PART YEAR)	1.0	0.0	Yes (X)		$0	$0	$0
JEANNE HERBERGER
TRUSTEE	1.0	0.0	Yes (X)		$0	$0	$0
STUART TANZ
TRUSTEE	1.0	0.0	Yes (X)		$0	$0	$0
JAMES JARDON
TRUSTEE	1.0	0.0	Yes (X)		$0	$0	$0
DONALD ROSENBERG
TRUSTEE (PART YEAR)	1.0	0.0	Yes (X)		$0	$0	$0
JAMES MYERS
TRUSTEE	1.0	0.0	Yes (X)		$0	$0	$0
KAZUMI SHIOSAKI
TRUSTEE	1.0	0.0	Yes (X)		$0	$0	$0
PETER SEIDLER
TRUSTEE	1.0	0.0	Yes (X)		$0	$0	$0
ANNA BARKER
TRUSTEE	1.0	0.0	Yes (X)		$0	$0	$0
DANIEL EPSTEIN
TRUSTEE	1.0	0.0	Yes (X)		$0	$0	$0
HENRY NORDOFF
TRUSTEE	1.0	0.0	Yes (X)		$0	$0	$0
JAMES BLAIR
CHAIR	1.0	0.0	Yes (X)	Yes (X)	$0	$0	$0
WILLIAM ROPER
TRUSTEE	1.0	0.0	Yes (X)		$0	$0	$0
MATTHEW BROWNE
TRUSTEE	1.0	0.0	Yes (X)		$0	$0	$0
DAVID SZEKERED
TRUSTEE	1.0	0.0	Yes (X)		$0	$0	$0
KNOX BELL
CORPORATE SECRETARY	2.0	0.0		Yes (X)	$0	$0	$0
GARY CHESSUM
CFO (THRU 7/31/2018)	50.0	0.0		Yes (X)	$218,557	$0	$30,716
LOUIS COFFMAN
CAO & CFO	50.0	0.0		Yes (X)	$207,752	$0	$23,657
GARTH POWIS PHD
CENTER DIRECTOR	50.0	0.0			$504,465	$0	$47,628	Yes (X)
CARL WARE PHD
CENTER DIRECTOR, IIDC	50.0	0.0			$404,789	$0	$47,395	Yes (X)
MICHAEL JACKSON PHD
DRUG DISCOVERY & DEV, SR VP	50.0	0.0			$439,813	$0	$58,021	Yes (X)
RANDAL KAUFMAN PHD
PROGRAM DIRECTOR	50.0	0.0			$360,737	$0	$58,331	Yes (X)
JORGE MOSCAT PHD
PROGRAM DIRECTOR	50.0	0.0			$350,276	$0	$57,743	Yes (X)
PERRY NISEN
FORMER CEO	50.0	0.0			$780,458	$0	$0		Yes (X)

Field	Value	IRS element (for citing)
Total Reportable Comp From Org	$4,277,556	TotalReportableCompFromOrgAmt
Tot Reportable Comp Rltd Org	$0	TotReportableCompRltdOrgAmt
Total Other Compensation	$668,811	TotalOtherCompensationAmt
Indiv Rcvd Greater Than100 K	144	IndivRcvdGreaterThan100KCnt
Former Ofcr Employees Listed	Yes (true)	FormerOfcrEmployeesListedInd
Total Comp Greater Than150 K	Yes (true)	TotalCompGreaterThan150KInd
Compensation From Other Srcs	false	CompensationFromOtherSrcsInd

Contractor Compensation ContractorCompensationGrp (5 entries)

Address Line1ContractorAddress/USAddress/AddressLine1Txt	CityContractorAddress/USAddress/CityNm	State AbbreviationContractorAddress/USAddress/StateAbbreviationCd	ZIPContractorAddress/USAddress/ZIPCd	ServicesServicesDesc	CompensationCompensationAmt
DLA Piper LLP
PO Box 64029	Baltimore	MD	21264	Legal Services	$647,033
Superion LLC
12709 Collection Center Dr	Chicago	IL	60693	Software Development	$461,826
DELOITTE TOUCHE LLP
655 WEST BROADWAY SUITE 400	SAN DIEGO	CA	92101	AUDIT SERVICES	$287,648
Wilson Sonsini Goodrich
PO Box 742866	LOS ANGELES	CA	90074	Legal Services	$249,527
Stealth Partner Group
18940 NOrth Pima Road Suite 210	Scottsdale	AZ	85255	Admin Services	$203,673

Field	Value	IRS element (for citing)
Cntrct Rcvd Greater Than100 K	7	CntrctRcvdGreaterThan100KCnt
Fundraising	$828,901	FundraisingAmt
Government Grants	$68,140,747	GovernmentGrantsAmt
All Other Contributions	$39,330,681	AllOtherContributionsAmt
Noncash Contributions	$4,080	NoncashContributionsAmt
Total Contributions	$108,300,329	TotalContributionsAmt

Program Service Revenue ProgramServiceRevenueGrp

Field	Value	IRS element (for citing)
Desc	SHARED SERVICES REVENUE	Desc
Business	541990	BusinessCd
Total Revenue Column	$799,803	TotalRevenueColumnAmt
Related Or Exempt Func Income	$799,803	RelatedOrExemptFuncIncomeAmt
Unrelated Business Revenue	$0	UnrelatedBusinessRevenueAmt
Exclusion	$0	ExclusionAmt

Field	Value	IRS element (for citing)
Total Program Service Revenue	$799,803	TotalProgramServiceRevenueAmt

Investment Income InvestmentIncomeGrp

Field	Value	IRS element (for citing)
Total Revenue Column	$4,957,099	TotalRevenueColumnAmt
Exclusion	$4,957,099	ExclusionAmt

Incm From Invest Bond Proceeds IncmFromInvestBondProceedsGrp

Field	Value	IRS element (for citing)
Total Revenue Column	$0	TotalRevenueColumnAmt

Royalties Revenue RoyaltiesRevenueGrp

Field	Value	IRS element (for citing)
Total Revenue Column	$971,229	TotalRevenueColumnAmt
Exclusion	$971,229	ExclusionAmt

Gross Rents GrossRentsGrp

Field	Value	IRS element (for citing)
Real	$13,960	RealAmt

Rental Income Or Loss RentalIncomeOrLossGrp

Field	Value	IRS element (for citing)
Real	$13,960	RealAmt
Personal	$0	PersonalAmt

Net Rental Income Or Loss NetRentalIncomeOrLossGrp

Field	Value	IRS element (for citing)
Total Revenue Column	$13,960	TotalRevenueColumnAmt
Exclusion	$13,960	ExclusionAmt

Gross Amount Sales Assets GrossAmountSalesAssetsGrp

Field	Value	IRS element (for citing)
Securities	$150,841,666	SecuritiesAmt

Less Cost Oth Basis Sales Expnss LessCostOthBasisSalesExpnssGrp

Field	Value	IRS element (for citing)
Securities	$144,205,191	SecuritiesAmt

Gain Or Loss GainOrLossGrp

Field	Value	IRS element (for citing)
Securities	$6,636,475	SecuritiesAmt

Net Gain Or Loss Investments NetGainOrLossInvestmentsGrp

Field	Value	IRS element (for citing)
Total Revenue Column	$6,636,475	TotalRevenueColumnAmt
Exclusion	$6,636,475	ExclusionAmt

Field	Value	IRS element (for citing)
Fundraising Gross Income	$59,487	FundraisingGrossIncomeAmt
Contri Rpt Fundraising Event	$828,900	ContriRptFundraisingEventAmt
Fundraising Direct Expenses	$354,400	FundraisingDirectExpensesAmt

Net Incm From Fundraising Evt NetIncmFromFundraisingEvtGrp

Field	Value	IRS element (for citing)
Total Revenue Column	-$294,913	TotalRevenueColumnAmt
Exclusion	-$294,913	ExclusionAmt

Field	Value	IRS element (for citing)
Gaming Gross Income	$0	GamingGrossIncomeAmt
Gaming Direct Expenses	$0	GamingDirectExpensesAmt

Net Income From Gaming NetIncomeFromGamingGrp

Field	Value	IRS element (for citing)
Total Revenue Column	$0	TotalRevenueColumnAmt

Field	Value	IRS element (for citing)
Gross Sales Of Inventory	$0	GrossSalesOfInventoryAmt
Cost Of Goods Sold	$0	CostOfGoodsSoldAmt

Net Income Or Loss NetIncomeOrLossGrp

Field	Value	IRS element (for citing)
Total Revenue Column	$0	TotalRevenueColumnAmt

Other Revenue Misc OtherRevenueMiscGrp (3 entries)

DescDesc	BusinessBusinessCd	Total Revenue ColumnTotalRevenueColumnAmt	Related Or Exempt Func IncomeRelatedOrExemptFuncIncomeAmt	Unrelated Business RevenueUnrelatedBusinessRevenueAmt	ExclusionExclusionAmt
RESEARCH	541700	$1,353,769	$0	$1,353,769	$0
OTHER RESEARCH SUPPORT	541990	$28,816	$28,816	$0	$0
SALE OF REAGENTS	541990	$28,256	$28,256	$0	$0

Miscellaneous Revenue MiscellaneousRevenueGrp

Field	Value	IRS element (for citing)
Total Revenue Column	$161,636	TotalRevenueColumnAmt
Related Or Exempt Func Income	$161,636	RelatedOrExemptFuncIncomeAmt
Exclusion	$0	ExclusionAmt

Field	Value	IRS element (for citing)
Other Revenue Total	$1,572,477	OtherRevenueTotalAmt

Total Revenue TotalRevenueGrp

Field	Value	IRS element (for citing)
Total Revenue Column	$122,956,459	TotalRevenueColumnAmt
Related Or Exempt Func Income	$1,018,511	RelatedOrExemptFuncIncomeAmt
Unrelated Business Revenue	$1,353,769	UnrelatedBusinessRevenueAmt
Exclusion	$12,283,850	ExclusionAmt

Grants To Domestic Orgs GrantsToDomesticOrgsGrp

Field	Value	IRS element (for citing)
Total	$0	TotalAmt
Program Services	$0	ProgramServicesAmt

Grants To Domestic Individuals GrantsToDomesticIndividualsGrp

Field	Value	IRS element (for citing)
Total	$0	TotalAmt
Program Services	$0	ProgramServicesAmt

Foreign Grants ForeignGrantsGrp

Field	Value	IRS element (for citing)
Total	$0	TotalAmt
Program Services	$0	ProgramServicesAmt

Benefits To Members BenefitsToMembersGrp

Field	Value	IRS element (for citing)
Total	$0	TotalAmt
Program Services	$0	ProgramServicesAmt

Comp Current Ofcr Directors CompCurrentOfcrDirectorsGrp

Field	Value	IRS element (for citing)
Total	$1,240,167	TotalAmt
Program Services	$154,502	ProgramServicesAmt
Management And General	$1,085,665	ManagementAndGeneralAmt
Fundraising	$0	FundraisingAmt

Comp Disqual Persons CompDisqualPersonsGrp

Field	Value	IRS element (for citing)
Total	$780,458	TotalAmt
Program Services	$0	ProgramServicesAmt
Management And General	$780,458	ManagementAndGeneralAmt
Fundraising	$0	FundraisingAmt

Other Salaries And Wages OtherSalariesAndWagesGrp

Field	Value	IRS element (for citing)
Total	$49,409,343	TotalAmt
Program Services	$39,978,741	ProgramServicesAmt
Management And General	$8,753,432	ManagementAndGeneralAmt
Fundraising	$677,170	FundraisingAmt

Pension Plan Contributions PensionPlanContributionsGrp

Field	Value	IRS element (for citing)
Total	$3,325,036	TotalAmt
Program Services	$2,636,505	ProgramServicesAmt
Management And General	$632,128	ManagementAndGeneralAmt
Fundraising	$56,403	FundraisingAmt

Other Employee Benefits OtherEmployeeBenefitsGrp

Field	Value	IRS element (for citing)
Total	$8,054,800	TotalAmt
Program Services	$6,589,802	ProgramServicesAmt
Management And General	$1,401,993	ManagementAndGeneralAmt
Fundraising	$63,005	FundraisingAmt

Payroll Taxes PayrollTaxesGrp

Field	Value	IRS element (for citing)
Total	$3,001,930	TotalAmt
Program Services	$2,303,943	ProgramServicesAmt
Management And General	$655,231	ManagementAndGeneralAmt
Fundraising	$42,756	FundraisingAmt

Fees For Services Management FeesForServicesManagementGrp

Field	Value	IRS element (for citing)
Total	$1,084,184	TotalAmt
Program Services	$417,876	ProgramServicesAmt
Management And General	$610,208	ManagementAndGeneralAmt
Fundraising	$56,100	FundraisingAmt

Fees For Services Legal FeesForServicesLegalGrp

Field	Value	IRS element (for citing)
Total	$643,181	TotalAmt
Program Services	$54,570	ProgramServicesAmt
Management And General	$588,611	ManagementAndGeneralAmt
Fundraising	$0	FundraisingAmt

Fees For Services Accounting FeesForServicesAccountingGrp

Field	Value	IRS element (for citing)
Total	$375,420	TotalAmt
Program Services	$0	ProgramServicesAmt
Management And General	$375,420	ManagementAndGeneralAmt
Fundraising	$0	FundraisingAmt

Fees For Services Lobbying FeesForServicesLobbyingGrp

Field	Value	IRS element (for citing)
Total	$1,200	TotalAmt
Program Services	$0	ProgramServicesAmt
Management And General	$1,200	ManagementAndGeneralAmt
Fundraising	$0	FundraisingAmt

Fees For Services Prof Fundraising FeesForServicesProfFundraising

Field	Value	IRS element (for citing)
Total	$0	TotalAmt
Fundraising	$0	FundraisingAmt

Fees For Srvc Invst Mgmnt Fees FeesForSrvcInvstMgmntFeesGrp

Field	Value	IRS element (for citing)
Total	$697,100	TotalAmt
Program Services	$0	ProgramServicesAmt
Management And General	$697,100	ManagementAndGeneralAmt
Fundraising	$0	FundraisingAmt

Fees For Services Other FeesForServicesOtherGrp

Field	Value	IRS element (for citing)
Total	$818,904	TotalAmt
Program Services	$634,526	ProgramServicesAmt
Management And General	$172,704	ManagementAndGeneralAmt
Fundraising	$11,674	FundraisingAmt

Advertising AdvertisingGrp

Field	Value	IRS element (for citing)
Total	$23,974	TotalAmt
Program Services	$0	ProgramServicesAmt
Management And General	$108	ManagementAndGeneralAmt
Fundraising	$23,866	FundraisingAmt

Office Expenses OfficeExpensesGrp

Field	Value	IRS element (for citing)
Total	$6,366,860	TotalAmt
Program Services	$5,663,217	ProgramServicesAmt
Management And General	$654,581	ManagementAndGeneralAmt
Fundraising	$49,062	FundraisingAmt

Information Technology InformationTechnologyGrp

Field	Value	IRS element (for citing)
Total	$1,459,944	TotalAmt
Program Services	$1,107,654	ProgramServicesAmt
Management And General	$314,321	ManagementAndGeneralAmt
Fundraising	$37,969	FundraisingAmt

Royalties RoyaltiesGrp

Field	Value	IRS element (for citing)
Total	$0	TotalAmt
Program Services	$0	ProgramServicesAmt
Management And General	$0	ManagementAndGeneralAmt
Fundraising	$0	FundraisingAmt

Occupancy OccupancyGrp

Field	Value	IRS element (for citing)
Total	$12,201,330	TotalAmt
Program Services	$10,856,400	ProgramServicesAmt
Management And General	$1,273,424	ManagementAndGeneralAmt
Fundraising	$71,506	FundraisingAmt

Travel TravelGrp

Field	Value	IRS element (for citing)
Total	$425,568	TotalAmt
Program Services	$366,755	ProgramServicesAmt
Management And General	$51,894	ManagementAndGeneralAmt
Fundraising	$6,919	FundraisingAmt

Pymt Travel Entrtnmnt Pub Ofcl PymtTravelEntrtnmntPubOfclGrp

Field	Value	IRS element (for citing)
Total	$0	TotalAmt
Program Services	$0	ProgramServicesAmt
Management And General	$0	ManagementAndGeneralAmt
Fundraising	$0	FundraisingAmt

Conferences Meetings ConferencesMeetingsGrp

Field	Value	IRS element (for citing)
Total	$1,046,410	TotalAmt
Program Services	$805,009	ProgramServicesAmt
Management And General	$202,674	ManagementAndGeneralAmt
Fundraising	$38,727	FundraisingAmt

Interest InterestGrp

Field	Value	IRS element (for citing)
Total	$1,919,481	TotalAmt
Program Services	$1,747,687	ProgramServicesAmt
Management And General	$158,933	ManagementAndGeneralAmt
Fundraising	$12,861	FundraisingAmt

Payments To Affiliates PaymentsToAffiliatesGrp

Field	Value	IRS element (for citing)
Total	$0	TotalAmt
Program Services	$0	ProgramServicesAmt
Management And General	$0	ManagementAndGeneralAmt
Fundraising	$0	FundraisingAmt

Depreciation Depletion DepreciationDepletionGrp

Field	Value	IRS element (for citing)
Total	$8,968,041	TotalAmt
Program Services	$8,121,441	ProgramServicesAmt
Management And General	$794,225	ManagementAndGeneralAmt
Fundraising	$52,375	FundraisingAmt

Insurance InsuranceGrp

Field	Value	IRS element (for citing)
Total	$0	TotalAmt
Program Services	$0	ProgramServicesAmt
Management And General	$0	ManagementAndGeneralAmt
Fundraising	$0	FundraisingAmt

Other Expenses OtherExpensesGrp (4 entries)

DescDesc	TotalTotalAmt	Program ServicesProgramServicesAmt	Management And GeneralManagementAndGeneralAmt	FundraisingFundraisingAmt
CONTRIBUTED ASSETS	$65,411,144	$0	$65,411,144	$0
RESEARCH SUPPLIES & SVCS	$10,410,668	$10,410,668	$0	$0
SCIENTIFIC COLLABORATIONS	$8,089,399	$8,089,399	$0	$0
Bad Debt	$222,285	$0	$222,285	$0

All Other Expenses AllOtherExpensesGrp

Field	Value	IRS element (for citing)
Total	$304,031	TotalAmt
Program Services	$186,619	ProgramServicesAmt
Management And General	$40,373	ManagementAndGeneralAmt
Fundraising	$77,039	FundraisingAmt

Total Functional Expenses TotalFunctionalExpensesGrp

Field	Value	IRS element (for citing)
Total	$186,280,858	TotalAmt
Program Services	$100,125,314	ProgramServicesAmt
Management And General	$84,878,112	ManagementAndGeneralAmt
Fundraising	$1,277,432	FundraisingAmt

Total Joint Costs TotalJointCostsGrp

Field	Value	IRS element (for citing)
Total	$0	TotalAmt

Cash Non Interest Bearing CashNonInterestBearingGrp

Field	Value	IRS element (for citing)
BOY	$5,792,608	BOYAmt
EOY	$8,780,651	EOYAmt

Savings And Temp Cash Invst SavingsAndTempCashInvstGrp

Field	Value	IRS element (for citing)
BOY	$13,539,386	BOYAmt
EOY	$2,469	EOYAmt

Pledges And Grants Receivable PledgesAndGrantsReceivableGrp

Field	Value	IRS element (for citing)
BOY	$9,531,085	BOYAmt
EOY	$11,771,097	EOYAmt

Accounts Receivable AccountsReceivableGrp

Field	Value	IRS element (for citing)
BOY	$345,952	BOYAmt
EOY	$470,995	EOYAmt

Receivables From Officers Etc ReceivablesFromOfficersEtcGrp

Field	Value	IRS element (for citing)
BOY	$911,111	BOYAmt
EOY	$0	EOYAmt

Rcvbl From Disqualified Prsn RcvblFromDisqualifiedPrsnGrp

Field	Value	IRS element (for citing)
BOY	$0	BOYAmt
EOY	$0	EOYAmt

Oth Notes Loans Receivable Net OthNotesLoansReceivableNetGrp

Field	Value	IRS element (for citing)
BOY	$693,912	BOYAmt
EOY	$377,300	EOYAmt

Inventories For Sale Or Use InventoriesForSaleOrUseGrp

Field	Value	IRS element (for citing)
BOY	$145,372	BOYAmt
EOY	$45,516	EOYAmt

Prepaid Expenses Defrd Charges PrepaidExpensesDefrdChargesGrp

Field	Value	IRS element (for citing)
BOY	$6,819,615	BOYAmt
EOY	$7,961,896	EOYAmt

Field	Value	IRS element (for citing)
Land Bldg Equip Cost Or Other Bss	$162,402,217	LandBldgEquipCostOrOtherBssAmt
Land Bldg Equip Accum Deprec	$105,290,986	LandBldgEquipAccumDeprecAmt

Land Bldg Equip Basis Net LandBldgEquipBasisNetGrp

Field	Value	IRS element (for citing)
BOY	$125,185,822	BOYAmt
EOY	$57,111,231	EOYAmt

Investments Pub Traded Sec InvestmentsPubTradedSecGrp

Field	Value	IRS element (for citing)
BOY	$247,437,682	BOYAmt
EOY	$218,451,769	EOYAmt

Investments Other Securities InvestmentsOtherSecuritiesGrp

Field	Value	IRS element (for citing)
BOY	$18,047,415	BOYAmt
EOY	$33,823,875	EOYAmt

Investments Program Related InvestmentsProgramRelatedGrp

Field	Value	IRS element (for citing)
BOY	$0	BOYAmt
EOY	$0	EOYAmt

Intangible Assets IntangibleAssetsGrp

Field	Value	IRS element (for citing)
BOY	$0	BOYAmt
EOY	$0	EOYAmt

Other Assets Total OtherAssetsTotalGrp

Field	Value	IRS element (for citing)
BOY	$2,310,587	BOYAmt
EOY	$0	EOYAmt

Total Assets TotalAssetsGrp

Field	Value	IRS element (for citing)
BOY	$430,760,547	BOYAmt
EOY	$338,796,799	EOYAmt

Accounts Payable Accr Expnss AccountsPayableAccrExpnssGrp

Field	Value	IRS element (for citing)
BOY	$16,125,390	BOYAmt
EOY	$15,973,902	EOYAmt

Grants Payable GrantsPayableGrp

Field	Value	IRS element (for citing)
BOY	$0	BOYAmt
EOY	$0	EOYAmt

Deferred Revenue DeferredRevenueGrp

Field	Value	IRS element (for citing)
BOY	$75,065,356	BOYAmt
EOY	$52,727,813	EOYAmt

Tax Exempt Bond Liabilities TaxExemptBondLiabilitiesGrp

Field	Value	IRS element (for citing)
BOY	$57,904,498	BOYAmt
EOY	$54,487,664	EOYAmt

Escrow Account Liability EscrowAccountLiabilityGrp

Field	Value	IRS element (for citing)
BOY	$0	BOYAmt
EOY	$0	EOYAmt

Loans From Officers Directors LoansFromOfficersDirectorsGrp

Field	Value	IRS element (for citing)
BOY	$0	BOYAmt
EOY	$0	EOYAmt

Mortg Notes Pybl Scrd Invst Prop MortgNotesPyblScrdInvstPropGrp

Field	Value	IRS element (for citing)
BOY	$0	BOYAmt
EOY	$0	EOYAmt

Unsecured Notes Loans Payable UnsecuredNotesLoansPayableGrp

Field	Value	IRS element (for citing)
BOY	$0	BOYAmt
EOY	$0	EOYAmt

Other Liabilities OtherLiabilitiesGrp

Field	Value	IRS element (for citing)
BOY	$0	BOYAmt
EOY	$0	EOYAmt

Total Liabilities TotalLiabilitiesGrp

Field	Value	IRS element (for citing)
BOY	$149,095,244	BOYAmt
EOY	$123,189,379	EOYAmt

Field	Value	IRS element (for citing)
Organization Follows SFAS117	Yes (X)	OrganizationFollowsSFAS117Ind

Unrestricted Net Assets UnrestrictedNetAssetsGrp

Field	Value	IRS element (for citing)
BOY	$199,720,438	BOYAmt
EOY	$184,566,051	EOYAmt

Temporarily Rstr Net Assets TemporarilyRstrNetAssetsGrp

Field	Value	IRS element (for citing)
BOY	$67,889,349	BOYAmt
EOY	$16,991,325	EOYAmt

Permanently Rstr Net Assets PermanentlyRstrNetAssetsGrp

Field	Value	IRS element (for citing)
BOY	$14,055,516	BOYAmt
EOY	$14,050,044	EOYAmt

Total Net Assets Fund Balance TotalNetAssetsFundBalanceGrp

Field	Value	IRS element (for citing)
BOY	$281,665,303	BOYAmt
EOY	$215,607,420	EOYAmt

Tot Liab Net Assets Fund Balance TotLiabNetAssetsFundBalanceGrp

Field	Value	IRS element (for citing)
BOY	$430,760,547	BOYAmt
EOY	$338,796,799	EOYAmt

Field	Value	IRS element (for citing)
Reconcilation Revenue Expnss	-$63,324,399	ReconcilationRevenueExpnssAmt
Net Unrlzd Gains Losses Invst	-$2,733,484	NetUnrlzdGainsLossesInvstAmt
Donated Services And Use Fclts	$0	DonatedServicesAndUseFcltsAmt
Investment Expense	$0	InvestmentExpenseAmt
Prior Period Adjustments	$0	PriorPeriodAdjustmentsAmt
Method Of Accounting Accrual	Yes (X)	MethodOfAccountingAccrualInd
Accountant Compile Or Review	false	AccountantCompileOrReviewInd
FS Audited	Yes (true)	FSAuditedInd

FS Audited Basis FSAuditedBasisGrp

Field	Value	IRS element (for citing)
Separate Basis Fincl Stmt	Yes (X)	SeparateBasisFinclStmtInd

Field	Value	IRS element (for citing)
Audit Committee	Yes (true)	AuditCommitteeInd
Federal Grant Audit Required	Yes (true)	FederalGrantAuditRequiredInd
Federal Grant Audit Performed	Yes (true)	FederalGrantAuditPerformedInd

Schedule A IRS990ScheduleA

Field	Value	IRS element (for citing)
Public Organization170	Yes (X)	PublicOrganization170Ind

Gifts Grants Contri Rcvd170 GiftsGrantsContriRcvd170Grp

Field	Value	IRS element (for citing)
Current Tax Year Minus4 Years	$240,798,040	CurrentTaxYearMinus4YearsAmt
Current Tax Year Minus3 Years	$112,703,072	CurrentTaxYearMinus3YearsAmt
Current Tax Year Minus2 Years	$121,777,889	CurrentTaxYearMinus2YearsAmt
Current Tax Year Minus1 Year	$113,630,164	CurrentTaxYearMinus1YearAmt
Current Tax Year	$108,300,329	CurrentTaxYearAmt
Total	$697,209,494	TotalAmt

Tax Rev Levied Orgnztnl Bnft170 TaxRevLeviedOrgnztnlBnft170Grp

Field	Value	IRS element (for citing)
Total	$0	TotalAmt

Govt Furn Srvc Fclts Vl170 GovtFurnSrvcFcltsVl170Grp

Field	Value	IRS element (for citing)
Total	$0	TotalAmt

Total Calendar Year170 TotalCalendarYear170Grp

Field	Value	IRS element (for citing)
Current Tax Year Minus4 Years	$240,798,040	CurrentTaxYearMinus4YearsAmt
Current Tax Year Minus3 Years	$112,703,072	CurrentTaxYearMinus3YearsAmt
Current Tax Year Minus2 Years	$121,777,889	CurrentTaxYearMinus2YearsAmt
Current Tax Year Minus1 Year	$113,630,164	CurrentTaxYearMinus1YearAmt
Current Tax Year	$108,300,329	CurrentTaxYearAmt
Total	$697,209,494	TotalAmt

Field	Value	IRS element (for citing)
Substantial Contributors Tot	$63,750,592	SubstantialContributorsTotAmt
Public Support Total170	$633,458,902	PublicSupportTotal170Amt

Gross Investment Income170 GrossInvestmentIncome170Grp

Field	Value	IRS element (for citing)
Current Tax Year Minus4 Years	$6,992,391	CurrentTaxYearMinus4YearsAmt
Current Tax Year Minus3 Years	$5,532,193	CurrentTaxYearMinus3YearsAmt
Current Tax Year Minus2 Years	$6,303,751	CurrentTaxYearMinus2YearsAmt
Current Tax Year Minus1 Year	$5,346,565	CurrentTaxYearMinus1YearAmt
Current Tax Year	$5,942,288	CurrentTaxYearAmt
Total	$30,117,188	TotalAmt

Unrelated Business Net Incm170 UnrelatedBusinessNetIncm170Grp

Field	Value	IRS element (for citing)
Current Tax Year Minus4 Years	$160,548	CurrentTaxYearMinus4YearsAmt
Current Tax Year Minus3 Years	$52,137	CurrentTaxYearMinus3YearsAmt
Current Tax Year Minus2 Years	$281,883	CurrentTaxYearMinus2YearsAmt
Current Tax Year Minus1 Year	$48,551	CurrentTaxYearMinus1YearAmt
Current Tax Year	$0	CurrentTaxYearAmt
Total	$543,119	TotalAmt

Other Income170 OtherIncome170Grp

Field	Value	IRS element (for citing)
Current Tax Year	$0	CurrentTaxYearAmt
Total	$0	TotalAmt

Field	Value	IRS element (for citing)
Total Support	$727,869,801	TotalSupportAmt
Gross Receipts Rltd Activities	$8,676,314	GrossReceiptsRltdActivitiesAmt
Public Support CY170	0.87029	PublicSupportCY170Pct
Public Support PY170	0.85620	PublicSupportPY170Pct
Thirty Thr Pct Suprt Tests CY170	Yes (X)	ThirtyThrPctSuprtTestsCY170Ind

Schedule B IRS990ScheduleB

Contributor Information ContributorInformationGrp

Field	Value	IRS element (for citing)
Contributor	RESTRICTED	ContributorNum

Contributor Business Name ContributorBusinessName

Field	Value	IRS element (for citing)
Business Name Line1	RESTRICTED	BusinessNameLine1

Contributor US Address ContributorUSAddress

Field	Value	IRS element (for citing)
Address Line1	RESTRICTED	AddressLine1
Address Line2	RESTRICTED	AddressLine2
City	RESTRICTED	City
State	RESTRICTED	State
ZIP Code	RESTRICTED	ZIPCode

Field	Value	IRS element (for citing)
Total Contributions	RESTRICTED	TotalContributionsAmt

Schedule C IRS990ScheduleC

Field	Value	IRS element (for citing)
Total Grassroots Lobbying		TotalGrassrootsLobbyingGrp
Total Direct Lobbying		TotalDirectLobbyingGrp
Total Lobbying Expend		TotalLobbyingExpendGrp
Other Exempt Purpose Expend		OtherExemptPurposeExpendGrp
Total Exempt Purpose Expend		TotalExemptPurposeExpendGrp
Lobbying Nontaxable Amount		LobbyingNontaxableAmountGrp
Grassroots Nontaxable		GrassrootsNontaxableGrp
Tot Lbbyng Grassroot Mns Non Tx		TotLbbyngGrassrootMnsNonTxGrp
Tot Lbby Expend Mns Lbbyng Non Tx		TotLbbyExpendMnsLbbyngNonTxGrp
Volunteers	false	VolunteersInd
Paid Staff Or Management	false	PaidStaffOrManagementInd
Media Advertisements	false	MediaAdvertisementsInd
Media Advertisements	$0	MediaAdvertisementsAmt
Mailings Members	false	MailingsMembersInd
Mailings Members	$0	MailingsMembersAmt
Publications Or Broadcast	false	PublicationsOrBroadcastInd
Publications Or Broadcast	$0	PublicationsOrBroadcastAmt
Grants Other Organizations	false	GrantsOtherOrganizationsInd
Grants Other Organizations	$0	GrantsOtherOrganizationsAmt
Direct Contact Legislators	false	DirectContactLegislatorsInd
Direct Contact Legislators	$0	DirectContactLegislatorsAmt
Rallies Demonstrations	false	RalliesDemonstrationsInd
Rallies Demonstrations	$0	RalliesDemonstrationsAmt
Other Activities	Yes (true)	OtherActivitiesInd
Other Activities	$1,200	OtherActivitiesAmt
Total Lobbying Expenditures	$1,200	TotalLobbyingExpendituresAmt
Not Described Section501c3	false	NotDescribedSection501c3Ind

Supplemental Information Detail SupplementalInformationDetail

Field	Value	IRS element (for citing)
Form And Line Reference	SCHEDULE C, PART II-B, LINE 1I	FormAndLineReferenceDesc
Explanation	Dues to a research and biomedical organization, a portion of which is considered lobbying.	ExplanationTxt

Schedule D IRS990ScheduleD

Field	Value	IRS element (for citing)
Art Public Exhibition Amounts		ArtPublicExhibitionAmountsGrp
Held Works Art		HeldWorksArtGrp

CY Endwmt Fund CYEndwmtFundGrp

Field	Value	IRS element (for citing)
Beginning Year Balance	$29,799,743	BeginningYearBalanceAmt
Contributions	$4,000	ContributionsAmt
Investment Earnings Or Losses	$1,337,873	InvestmentEarningsOrLossesAmt
Other Expenditures	$1,327,075	OtherExpendituresAmt
End Year Balance	$29,814,541	EndYearBalanceAmt

CY Minus1 Yr Endwmt Fund CYMinus1YrEndwmtFundGrp

Field	Value	IRS element (for citing)
Beginning Year Balance	$28,681,314	BeginningYearBalanceAmt
Contributions	$502,000	ContributionsAmt
Investment Earnings Or Losses	$1,841,686	InvestmentEarningsOrLossesAmt
Other Expenditures	$1,225,257	OtherExpendituresAmt
End Year Balance	$29,799,743	EndYearBalanceAmt

CY Minus2 Yr Endwmt Fund CYMinus2YrEndwmtFundGrp

Field	Value	IRS element (for citing)
Beginning Year Balance	$25,987,641	BeginningYearBalanceAmt
Contributions	$530,336	ContributionsAmt
Investment Earnings Or Losses	$3,395,420	InvestmentEarningsOrLossesAmt
Other Expenditures	$1,232,083	OtherExpendituresAmt
End Year Balance	$28,681,314	EndYearBalanceAmt

CY Minus3 Yr Endwmt Fund CYMinus3YrEndwmtFundGrp

Field	Value	IRS element (for citing)
Beginning Year Balance	$26,693,919	BeginningYearBalanceAmt
Contributions	$510,067	ContributionsAmt
Investment Earnings Or Losses	-$3,125	InvestmentEarningsOrLossesAmt
Other Expenditures	$1,213,220	OtherExpendituresAmt
End Year Balance	$25,987,641	EndYearBalanceAmt

CY Minus4 Yr Endwmt Fund CYMinus4YrEndwmtFundGrp

Field	Value	IRS element (for citing)
Beginning Year Balance	$26,870,514	BeginningYearBalanceAmt
Contributions	$920,000	ContributionsAmt
Investment Earnings Or Losses	$36,749	InvestmentEarningsOrLossesAmt
Other Expenditures	$1,133,344	OtherExpendituresAmt
End Year Balance	$26,693,919	EndYearBalanceAmt

Field	Value	IRS element (for citing)
Board Designated Balance EOY	0.32000	BoardDesignatedBalanceEOYPct
Prmnnt Endowment Balance EOY	0.47000	PrmnntEndowmentBalanceEOYPct
Term Endowment Balance EOY	0.21000	TermEndowmentBalanceEOYPct
Endowments Held Unrelated Org	false	EndowmentsHeldUnrelatedOrgInd
Endowments Held Related Org	false	EndowmentsHeldRelatedOrgInd

Land LandGrp

Field	Value	IRS element (for citing)
Investment Cost Or Other Basis	$0	InvestmentCostOrOtherBasisAmt
Other Cost Or Other Basis	$12,758,161	OtherCostOrOtherBasisAmt
Book Value	$12,758,161	BookValueAmt

Buildings BuildingsGrp

Field	Value	IRS element (for citing)
Investment Cost Or Other Basis	$0	InvestmentCostOrOtherBasisAmt
Other Cost Or Other Basis	$86,906,542	OtherCostOrOtherBasisAmt
Depreciation	$54,330,620	DepreciationAmt
Book Value	$32,575,922	BookValueAmt

Field	Value	IRS element (for citing)
Leasehold Improvements		LeaseholdImprovementsGrp

Equipment EquipmentGrp

Field	Value	IRS element (for citing)
Investment Cost Or Other Basis	$0	InvestmentCostOrOtherBasisAmt
Other Cost Or Other Basis	$62,183,549	OtherCostOrOtherBasisAmt
Depreciation	$50,960,366	DepreciationAmt
Book Value	$11,223,183	BookValueAmt

Other Land Buildings OtherLandBuildingsGrp

Field	Value	IRS element (for citing)
Investment Cost Or Other Basis	$0	InvestmentCostOrOtherBasisAmt
Other Cost Or Other Basis	$553,965	OtherCostOrOtherBasisAmt
Book Value	$553,965	BookValueAmt

Field	Value	IRS element (for citing)
Total Book Value Land Buildings	$57,111,231	TotalBookValueLandBuildingsAmt
Financial Derivatives		FinancialDerivativesGrp
Closely Held Equity Interests		CloselyHeldEquityInterestsGrp

Other Securities OtherSecuritiesGrp (3 entries)

DescDesc	Book ValueBookValueAmt	Method ValuationMethodValuationCd
PRIVATE EQUITY LPS	$1,769,079	F
TOTAL RETURN HEDGE FUNDS	$19,525,233	F
SELECT EQUITY FUNDS	$12,529,563	F

Field	Value	IRS element (for citing)
Total Book Value Securities	$33,823,875	TotalBookValueSecuritiesAmt
Federal Income Tax Liability	$0	FederalIncomeTaxLiabilityAmt
Total Liability	$0	TotalLiabilityAmt
Footnote Text	Yes (X)	FootnoteTextInd
Total Rev Etc Audited Fincl Stmt	$119,524,000	TotalRevEtcAuditedFinclStmtAmt
Net Unrealized Gains Invst	-$2,733,484	NetUnrealizedGainsInvstAmt
Revenue Not Reported	-$2,733,484	RevenueNotReportedAmt
Revenue Subtotal	$122,257,484	RevenueSubtotalAmt
Investment Expenses Not Incld	$697,100	InvestmentExpensesNotIncldAmt
Other Revenues Not Included	$1,875	OtherRevenuesNotIncludedAmt
Revenue Not Reported Fincl Stmt	$698,975	RevenueNotReportedFinclStmtAmt
Total Revenue Per Form990	$122,956,459	TotalRevenuePerForm990Amt
Tot Expns Etc Audited Fincl Stmt	$185,582,000	TotExpnsEtcAuditedFinclStmtAmt
Other Expenses Included	$0	OtherExpensesIncludedAmt
Expenses Not Reported	$0	ExpensesNotReportedAmt
Expenses Subtotal	$185,582,000	ExpensesSubtotalAmt
Investment Expenses Not Incld2	$697,100	InvestmentExpensesNotIncld2Amt
Other Expenses Not Included	$1,758	OtherExpensesNotIncludedAmt
Expenses Not Rpt Fincl Stmt	$698,858	ExpensesNotRptFinclStmtAmt
Total Expenses Per Form990	$186,280,858	TotalExpensesPerForm990Amt

Supplemental Information Detail SupplementalInformationDetail (4 entries)

Form And Line ReferenceFormAndLineReferenceDesc	ExplanationExplanationTxt
SCHEDULE D, PART V, LINE 4	INTENDED USES OF THE ORGANIZATION'S ENDOWMENT FUNDS THE INSTITUTE'S ENDOWMENT FUNDS ARE ESTABLISHED FOR VARIOUS PURPOSES: SCIENTIFIC RESEARCH, CEO CHAIR, PRESIDENTIAL CHAIR, CANCER AND NEUROSCIENCE LEADERSHIP CHAIRS, AND UNRESTRICTED AS TO INCOME.
SCHEDULE D, PART X, LINE 2	FIN 48 (ASC 740) FOOTNOTE THE INSTITUTE HAS NO MATERIAL DEFERRED TAX ASSETS OR DEFERRED TAX LIABILITIES RECORDED AS OF JUNE 30, 2019 AND 2018. THE INSTITUTE DID NOT RECOGNIZE A CHANGE IN LIABILITY FOR UNRECOGNIZED TAX BENEFITS (THE DIFFERENCE BETWEEN A TAX POSITION TAKEN, OR EXPECTED TO BE TAKEN, IN A TAX RETURN AND THE BENEFIT RECOGNIZED AND MEASURED IN THE FINANCIAL STATEMENTS). THERE WERE NO LIABILITIES FOR UNRECOGNIZED TAX BENEFITS AT JUNE 30, 2019 AND 2018.
SCHEDULE D, PART XI, LINE 4B	ROUNDING - 1,875
SCHEDULE D, PART XII, LINE 4B	ROUNDING - 1,758

Schedule F IRS990ScheduleF

Account Activities Outside US AccountActivitiesOutsideUSGrp (8 entries)

RegionRegionTxt	EmployeeEmployeeCnt	Type Of Activities ConductedTypeOfActivitiesConductedTxt	Specific Services ProvidedSpecificServicesProvidedTxt	Region Total ExpendituresRegionTotalExpendituresAmt
Europe (Including Iceland and Greenland)	40	Program Services	See Part V	$122,863
East Asia and the Pacific	2	Program Services	See Part V	$24,099
North America	1	Program Services	See Part V	$381
South Asia		Program Services	See Part V	$6,377
Middle East and North Africa		Program Services	See Part V	$3,948
Russia and the Newly Independent States		Program Services	See Part V	$5,417
South America		Program Services	See Part V	$2,682
Central America and the Caribbean		Investments		$17,584,656

Field	Value	IRS element (for citing)
Subtotal Employees	43	SubtotalEmployeesCnt
Total Employee	43	TotalEmployeeCnt
Subtotal Spent	$17,750,423	SubtotalSpentAmt
Total Spent	$17,750,423	TotalSpentAmt
Transfer To Foreign Corp	Yes (true)	TransferToForeignCorpInd
Interest In Foreign Trust	false	InterestInForeignTrustInd
Foreign Corp Ownership	Yes (true)	ForeignCorpOwnershipInd
Passive Foreign Investmest Co	Yes (true)	PassiveForeignInvestmestCoInd
Foreign Partnership	Yes (true)	ForeignPartnershipInd
Boycott Countries	false	BoycottCountriesInd

Supplemental Information Detail SupplementalInformationDetail (3 entries)

Form And Line ReferenceFormAndLineReferenceDesc	ExplanationExplanationTxt
SCHEDULE F, PART I, LINE 3	PROGRAM SERVICE ACTIVITIES SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE DOES NOT MAINTAIN ONGOING OPERATIONS IN FOREIGN JURISDICTIONS. HOWEVER, THE INSTITUTE'S SCIENTISTS DO TRAVEL TO VARIOUS SCIENTIFIC CONFERENCES IN OTHER COUNTRIES TO SHARE THE INSTITUTE'S SCIENTIFIC DISCOVERIES AND TO LEARN FROM OTHER SCIENTISTS ACROSS THE WORLD.
SCHEDULE F, PART I, LINE 3, COLUMN E	TYPE OF SERVICE SPECIFIC PROGRAM SERVICE ACTIVITY IN ALL REGIONS IS AGENTS ATTENDING AND/OR SPEAKING AT SCIENTIFIC CONFERENCES AND COLLABORATIONS.
SCHEDULE F, PART I, LINE 3, COLUMN F	ACCOUNTING METHOD THE ACCRUAL METHOD OF ACCOUNTING WAS USED TO DETERMINE THE AMOUNTS IN PART I, LINE 3, COLUMN F.

Schedule G IRS990ScheduleG

Fundraiser Activity Info FundraiserActivityInfoGrp (2 entries)

ActivityActivityTxt	Fundraiser Control Of FundsFundraiserControlOfFundsInd
ED GILLENWATERS
CONSULTING	false
BLAIR BLUM PARTNERS
CONSULTING	false

Fundraising Event Information FundraisingEventInformationGrp

Field	Value	IRS element (for citing)
Event1	GALA	Event1Nm
Gross Receipts Event1	$645,853	GrossReceiptsEvent1Amt
Charitable Contri Event1	$621,853	CharitableContriEvent1Amt
Gross Revenue Event1	$24,000	GrossRevenueEvent1Amt
Food And Beverage Event1	$65,071	FoodAndBeverageEvent1Amt
Entertainment Event1	$49,648	EntertainmentEvent1Amt
Other Direct Expenses Event1	$71,726	OtherDirectExpensesEvent1Amt
Event2	BRING IT	Event2Nm
Gross Receipts Event2	$242,535	GrossReceiptsEvent2Amt
Charitable Contri Event2	$207,048	CharitableContriEvent2Amt
Gross Revenue Event2	$35,487	GrossRevenueEvent2Amt
Rent Facility Costs Event2	$7,136	RentFacilityCostsEvent2Amt
Food And Beverage Event2	$63,392	FoodAndBeverageEvent2Amt
Entertainment Event2	$6,580	EntertainmentEvent2Amt
Other Direct Expenses Event2	$90,847	OtherDirectExpensesEvent2Amt
Other Events Total	0	OtherEventsTotalCnt
Gross Receipts Total	$888,388	GrossReceiptsTotalAmt
Charitable Contributions Tot	$828,901	CharitableContributionsTotAmt
Gross Revenue Total Events	$59,487	GrossRevenueTotalEventsAmt
Rent Fclty Costs Total Events	$7,136	RentFcltyCostsTotalEventsAmt
Food And Beverage Total Events	$128,463	FoodAndBeverageTotalEventsAmt
Entertainment Total Events	$56,228	EntertainmentTotalEventsAmt
Oth Direct Expnss Total Events	$162,573	OthDirectExpnssTotalEventsAmt
Direct Expense Summary Events	$354,400	DirectExpenseSummaryEventsAmt
Net Income Summary	-$294,913	NetIncomeSummaryAmt

Schedule J IRS990ScheduleJ

Field	Value	IRS element (for citing)
First Class Or Charter Travel	Yes (X)	FirstClassOrCharterTravelInd
Club Dues Or Fees	Yes (X)	ClubDuesOrFeesInd
Written Policy Ref T And E Expnss	Yes (true)	WrittenPolicyRefTAndEExpnssInd
Substantiation Required	Yes (true)	SubstantiationRequiredInd
Compensation Committee	Yes (X)	CompensationCommitteeInd
Independent Consultant	Yes (X)	IndependentConsultantInd
Form990 Of Other Organizations	Yes (X)	Form990OfOtherOrganizationsInd
Written Employment Contract	Yes (X)	WrittenEmploymentContractInd
Compensation Survey	Yes (X)	CompensationSurveyInd
Board Or Committee Approval	Yes (X)	BoardOrCommitteeApprovalInd
Severance Payment	Yes (true)	SeverancePaymentInd
Supplemental Nonqual Rtr Plan	Yes (true)	SupplementalNonqualRtrPlanInd
Equity Based Comp Arrngm	false	EquityBasedCompArrngmInd
Comp Based On Revenue Of Flng Org	false	CompBasedOnRevenueOfFlngOrgInd
Comp Bsd On Rev Related Orgs	false	CompBsdOnRevRelatedOrgsInd
Comp Bsd Net Earns Flng Org	false	CompBsdNetEarnsFlngOrgInd
Comp Bsd Net Earns Rltd Orgs	false	CompBsdNetEarnsRltdOrgsInd
Any Non Fixed Payments	Yes (true)	AnyNonFixedPaymentsInd
Initial Contract Exception	false	InitialContractExceptionInd

Rltd Org Officer Trst Key Empl RltdOrgOfficerTrstKeyEmplGrp (9 entries)

TitleTitleTxt	Base Compensation Filing OrgBaseCompensationFilingOrgAmt	Compensation Based On Rltd OrgsCompensationBasedOnRltdOrgsAmt	Bonus Filing OrganizationBonusFilingOrganizationAmount	Bonus Related OrganizationsBonusRelatedOrganizationsAmt	Other Compensation Filing OrgOtherCompensationFilingOrgAmt	Other Compensation Rltd OrgsOtherCompensationRltdOrgsAmt	Deferred Compensation Flng OrgDeferredCompensationFlngOrgAmt	Deferred Comp Rltd OrgsDeferredCompRltdOrgsAmt	Nontaxable Benefits Filing OrgNontaxableBenefitsFilingOrgAmt	Nontaxable Benefits Rltd OrgsNontaxableBenefitsRltdOrgsAmt	Total Compensation Filing OrgTotalCompensationFilingOrgAmt	Total Compensation Rltd OrgsTotalCompensationRltdOrgsAmt	Comp Report Prior990 Filing OrgCompReportPrior990FilingOrgAmt	Comp Report Prior990 Rltd OrgsCompReportPrior990RltdOrgsAmt
KRISTIINA VUORI MD PHD
PRESIDENT	$758,611	$0	$250,000	$0	$2,098	$0	$327,500	$0	$17,820	$0	$1,356,029	$0	$0	$0
GARY CHESSUM
CFO (THRU 7/31/2018)	$217,139	$0	$0	$0	$1,418	$0	$16,322	$0	$14,394	$0	$249,273	$0	$0	$0
GARTH POWIS PHD
CENTER DIRECTOR	$448,246	$0	$50,000	$0	$6,219	$0	$27,500	$0	$20,128	$0	$552,093	$0	$0	$0
CARL WARE PHD
CENTER DIRECTOR, IIDC	$380,717	$0	$18,902	$0	$5,170	$0	$27,500	$0	$19,895	$0	$452,184	$0	$0	$0
MICHAEL JACKSON PHD
DRUG DISCOVERY & DEV, SR VP	$397,195	$0	$39,395	$0	$3,223	$0	$27,500	$0	$30,521	$0	$497,834	$0	$0	$0
PERRY NISEN
FORMER CEO	$0	$0	$0	$0	$780,458	$0	$0	$0	$0	$0	$780,458	$0	$0	$0
LOUIS COFFMAN
CAO & CFO	$205,559	$0	$0	$0	$2,193	$0	$14,063	$0	$9,594	$0	$231,409	$0	$0	$0
RANDAL KAUFMAN PHD
PROGRAM DIRECTOR	$355,774	$0	$0	$0	$4,963	$0	$27,500	$0	$30,831	$0	$419,068	$0	$0	$0
JORGE MOSCAT PHD
PROGRAM DIRECTOR	$345,940	$0	$0	$0	$4,336	$0	$27,500	$0	$30,243	$0	$408,019	$0	$0	$0

Supplemental Information Detail SupplementalInformationDetail (4 entries)

Form And Line ReferenceFormAndLineReferenceDesc	ExplanationExplanationTxt
FORM 990, SCHEDULE J, PART I, LINE 1A	FIRST CLASS TRAVEL FIRST CLASS TRAVEL IS GENERALLY NOT PERMITTED, EXCEPT UNDER VERY LIMITED AND RARE CIRCUMSTANCES AND CONDITIONS, SUCH AS A MEDICAL CONDITION REQUIREMENT AND URGENT CIRCUMSTANCES. THIS WAS NOT TREATED AS TAXABLE COMPENSATION. HEALTH OR SOCIAL CLUB DUES HEALTH OR SOCIAL CLUB DUES ARE NEGOTIATED IN THE HIRING PROCESS FOR CERTAIN EMPLOYEES. THE AMOUNTS WERE TREATED AS TAXABLE COMPENSATION.
FORM 990, SCHEDULE J, PART I, LINE 4A	DURING THE YEAR THE ORGANIZATION PAID SEVERANCE UNDER A CONFIDENTIAL SEVERANCE AGREEMENT TO ONE INDIVIDUAL.
FORM 990, SCHEDULE J, PART I, LINE 4B	SUPPLEMENTAL NONQUALIFIED RETIREMENT PLAN THE PARTICIPANT OF THE 457(F) DEFERRED COMPENSATION PLAN IS KRISTIINA VUORI. VESTING OCCURS THE EARLIEST OF 04/01/20, OR INVOLUNTARY TERMINATION WITHOUT CAUSE, OR PARTICIPANT'S RESIGNATION FOR GOOD CAUSE, OR THE DATE OF TERMINATION OF THE PLAN. DISTRIBUTION IS A ONE-TIME LUMP SUM PAYMENT UPON VESTING OF 100% OF THE VALUE OF THE PARTICIPANT'S INVESTMENT (COMPRISED OF INSTITUTE CONTRIBUTIONS TO THE CORPUS PLUS ANY INVESTMENT GAINS OR LOSSES THEREON).
FORM 990, SCHEDULE J, PART I, LINE 7	NON-FIXED PAYMENTS SOME SENIOR EXECUTIVES HAVE EMPLOYMENT AGREEMENTS STIPULATING A BONUS WILL BE PAID TO THEM PROVIDED CERTAIN GOALS OR ACCOMPLISHMENTS ARE ACHIEVED.

Schedule K IRS990ScheduleK

Tax Exempt Bonds Issues TaxExemptBondsIssuesGrp

Field	Value	IRS element (for citing)
Bond Reference	A	BondReferenceCd

Issuer Name IssuerName

Field	Value	IRS element (for citing)
Business Name Line1	COUNTY OF SAN DIEGO	BusinessNameLine1Txt

Field	Value	IRS element (for citing)
Bond Issuer EIN	956000934	BondIssuerEIN
CUSIP	79742YAQ5	CUSIPNum
Bond Issued	2015-11-12	BondIssuedDt
Issue Price	$61,963,256	IssuePriceAmt
Purpose	SEE PART VI	PurposeDesc
Defeased	false	DefeasedInd
On Behalf Of Issuer	false	OnBehalfOfIssuerInd
Pool Financing	false	PoolFinancingInd

Tax Exempt Bonds Proceeds TaxExemptBondsProceedsGrp

Field	Value	IRS element (for citing)
Bond Reference	A	BondReferenceCd
Retired	$0	RetiredAmt
Bond Defeased	$11,658,870	BondDefeasedAmt
Total Proceeds	$61,963,256	TotalProceedsAmt
In Reserve Fund	$0	InReserveFundAmt
Capitalized Interest	$0	CapitalizedInterestAmt
Refunding Escrow	$50,015,000	RefundingEscrowAmt
Issuance Costs From Proceeds	$289,386	IssuanceCostsFromProceedsAmt
Credit Enhancement	$0	CreditEnhancementAmt
Working Capital Expenditures	$0	WorkingCapitalExpendituresAmt
Capital Expenditures	$0	CapitalExpendituresAmt
Other Spent Proceeds	$0	OtherSpentProceedsAmt
Unspent	$0	UnspentAmt
Substantial Completion	2015	SubstantialCompletionYr
Refunding Tax Exempt Bonds	Yes (true)	RefundingTaxExemptBondsInd
Refunding Taxable Bonds	false	RefundingTaxableBondsInd
Final Allocation Made	Yes (true)	FinalAllocationMadeInd
Adequate Books And Rec Maint	Yes (true)	AdequateBooksAndRecMaintInd

Tax Exempt Bonds Private Bus Use TaxExemptBondsPrivateBusUseGrp

Field	Value	IRS element (for citing)
Bond Reference	A	BondReferenceCd
Owning Bond Financed Property	false	OwningBondFinancedPropertyInd
Any Lease Arrangements	Yes (true)	AnyLeaseArrangementsInd
Mgmt Contract Bond Fincd Prop	Yes (true)	MgmtContractBondFincdPropInd
Engage Bond Counsel Contracts	Yes (true)	EngageBondCounselContractsInd
Any Research Agreements	Yes (true)	AnyResearchAgreementsInd
Engage Bond Counsel Research	Yes (true)	EngageBondCounselResearchInd
Private Bus Use By Others	0.01590	PrivateBusUseByOthersPct
Total Private Business Use	0.01590	TotalPrivateBusinessUsePct
Bond Iss Meet Prvt Sec Pymt Test	false	BondIssMeetPrvtSecPymtTestInd
Change In Use Bond Financed Prop	false	ChangeInUseBondFinancedPropInd
Remedial Action Taken	false	RemedialActionTakenInd
Procs Nonqualified Bond Remdtd	Yes (true)	ProcsNonqualifiedBondRemdtdInd

Tax Exempt Bonds Arbitrage TaxExemptBondsArbitrageGrp

Field	Value	IRS element (for citing)
Bond Reference	A	BondReferenceCd
Form8038 T Filed	false	Form8038TFiledInd
Rebate Not Due Yet	Yes (true)	RebateNotDueYetInd
Exception To Rebate	false	ExceptionToRebateInd
No Rebate Due	false	NoRebateDueInd
Variable Rate Issue	Yes (true)	VariableRateIssueInd
Hedge Identified In Bks And Rec	false	HedgeIdentifiedInBksAndRecInd

Hedge Provider Name HedgeProviderName

Field	Value	IRS element (for citing)
Business Name Line1	0	BusinessNameLine1Txt

Field	Value	IRS element (for citing)
Gross Proceeds Invested In GIC	false	GrossProceedsInvestedInGICInd

GIC Provider Name GICProviderName

Field	Value	IRS element (for citing)
Business Name Line1	0	BusinessNameLine1Txt

Field	Value	IRS element (for citing)
Gross Proceeds Invested	false	GrossProceedsInvestedInd
Written Proc To Monitor Reqs	Yes (true)	WrittenProcToMonitorReqsInd

Procedures Corrective Action ProceduresCorrectiveActionGrp

Field	Value	IRS element (for citing)
Bond Reference	A	BondReferenceCd
Procedures Corrective Action	Yes (true)	ProceduresCorrectiveActionInd

Supplemental Information Detail SupplementalInformationDetail (2 entries)

Form And Line ReferenceFormAndLineReferenceDesc	ExplanationExplanationTxt
SCHEDULE K, PART I, ROW A, COLUMN (F)	REFINANCE 2006 AND 2012 BONDS WITH ISSUE DATES OF 02/01/2006 AND 11/15/2012, RESPECTIVELY.
SCHEDULE K, PART I, ROW A	FOR THE BOND ISSUES LISTED IN PART I, THE ALTERNATIVE PERIOD USED FOR THE REPORTING REQUIREMENTS IN THIS SECTION IS THE TWELVE MONTHS ENDED DECEMBER 31, 2018.

Schedule O IRS990ScheduleO

Supplemental Information Detail SupplementalInformationDetail (7 entries)

Form And Line ReferenceFormAndLineReferenceDesc	ExplanationExplanationTxt
FORM 990, PART I, LINE 1 & PART III, LINE 1	ORGANIZATIONS MISSION SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE CONDUCTS WORLD-CLASS, COLLABORATIVE RESEARCH DEDICATED TO FINDING CURES FOR HUMAN DISEASE, IMPROVING THE QUALITY OF LIFE, AND THUS CREATING A LEGACY FOR ITS EMPLOYEES, PARTNERS, DONORS, AND COMMUNITY.
FORM 990, PART III, LINE 4	PROGRAM SERVICE ACCOMPLISHMENTS SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE (SBP) IS AN INDEPENDENT NONPROFIT MEDICAL RESEARCH ORGANIZATION THAT DEDICATED TO UNCOVERING THE ORIGINS OF DISEASE AND LAUNCHING BOLD NEW STRATEGIES LAYING THE FOUNDATION FOR CURES. OUR INSTITUTE HAS DEEP EXPERTISE IN FUNDAMENTAL BIOLOGY AND ONE OF THE MOST COMPREHENSIVE DRUG DISCOVERY CENTERS IN THE NONPROFIT WORLD. CANCER CONQUERING CANCER'S INFAMOUS KRAS MUTATION. KRAS IS ONE OF THE MOST CHALLENGING TARGETS IN CANCER. DESPITE ITS DISCOVERY MORE THAN 60 YEARS AGO, RESEARCHERS STILL STRUGGLE TO BLOCK THE CANCER-CAUSING PROTEIN - EARNING ITS REPUTATION AS "UNDRUGGABLE." GARTH POWIS, D.PHIL., LED RESEARCH IDENTIFYING A PROMISING COMPOUND CALLED PHT-7.3 THAT SHRINKS KRAS TUMORS IN MICE. NEARLY 25% OF ALL HUMAN CANCERS ARE KRAS-POSITIVE. POTENTIAL TARGETED TREATMENT FOR ACUTE MYELOID LEUKEMIA. ACUTE MYELOID LEUKEMIA IS A DEADLY BLOOD CANCER WITH LIMITED TREATMENT OPTIONS. FOR PATIENTS OVER 20 YEARS OLD, THE 5-YEAR SURVIVAL IS APPROXIMATELY 25%. ANI DESHPANDE, PH.D., FOUND THAT BLOCKING A PROTEIN CALLED BMI1 WITH A SPECIFIC COMPOUND PROLONGED SURVIVAL OF MOUSE MODELS OF THE DISEASE. THE COMPOUND IS IN CLINICAL DEVELOPMENT FOR ADVANCED SOLID TUMORS BY PTC THERAPEUTICS. PANCREATIC TUMORS SCAVENGE TO SURVIVE. RAPIDLY GROWING PANCREATIC TUMORS GATHER NUTRIENTS THROUGH A SUPPLY ROUTE CALLED MICROPINOCYTOSIS, WHEREBY SMALL PARTICLES ARE ENGULFED VIA THE CELL MEMBRANE. COSIMO COMMISSO, PH.D., DISCOVERED THAT SOME TUMORS HAVE NATURALLY HIGH LEVELS OF MICROPINOCYTOSIS, WHILE OTHERS CAN DIAL UP OR DOWN NUTRIENT SCAVENGING AS NEEDED DURING DISEASE PROGRESSION. THE RESEARCH ALSO IDENTIFIED MOLECULAR REGULATORS OF THE PROCESS WHICH MAY ULTIMATELY LEAD TO PERSONALIZED TREATMENTS TO STARVE TUMORS. STUDY OFFERS NEW APPROACH TO STARVING TUMORS. FOR YEARS, SCIENTISTS HAVE TRIED TO HALT CANCER BY BLOCKING THE NUTRIENTS THAT TUMORS NEED TO GROW. THESE STRATEGIES HAVE OFTEN FAILED BECAUSE CANCER CELLS ARE CRAFTY-THEY HAVE BACKUP PLANS TO GATHER THE FOOD AND OXYGEN THAT THEY NEED TO SURVIVE. BROOKE EMERLING, PH.D., LED RESEARCH REVEALING AN ALTERNATIVE METABOLIC PATHWAY USED BY CANCER CELLS THAT MAY BE TARGETED TO STARVE TUMORS. TARGETING LONG-SOUGHT CANCER RECEPTOR BECOMES CRYSTAL CLEAR. SCIENTISTS HAVE LONG SOUGHT TO TARGET A RECEPTOR CALLED EPHA2 BECAUSE OF ITS KNOWN ROLE IN CANCER AND OTHER DISORDERS INCLUDING INFLAMMATORY CONDITIONS, NEUROLOGICAL DISORDERS AND INFECTIOUS DISEASES. ELENA PASQUALE, PH.D., PUBLISHED RESEARCH ON THE STRUCTURE OF THE RECEPTOR AND ENGINEERED POWERFUL COMPOUNDS THAT ACTIVATE OR INACTIVATE IT, PAVING THE WAY FOR NEW THERAPIES. HOW PROSTATE CANCER BECOMES TREATMENT RESISTANT. SOME MEN WHO RECEIVE ANTI-ANDROGEN THERAPY FOR PROSTATE CANCER DEVELOP NEUROENDOCRINE PROSTATE CANCER (NEPC)-A DEADLY SUBTYPE WITH NO EFFECTIVE TREATMENT. MARIA DIAZ-MECO, PH.D., LED A STUDY DESCRIBING THE MOLECULAR "SWITCH" THAT DRIVES THIS TRANSFORMATION. THE FINDINGS REVEAL THAT AN FDA-APPROVED DRUG HOLDS POTENTIAL AS AN NEPC TREATMENT, AND NEW THERAPEUTIC AVENUES THAT COULD PREVENT THE TRANSFORMATION FROM OCCURRING. LOSS OF GENES DRIVES DEADLY COLORECTAL CANCERS. SOME COLON POLYPS PROGRESS TO A TREATMENT-RESISTANT CANCER CALLED SERRATED COLORECTAL CANCER. MARIA DIAZ-MECO, PH.D. AND JORGE MOSCAT, PH.D., LED RESEARCH THAT REVEALED TWO GENETIC MARKERS THAT CLEARLY IDENTIFY THE SERRATED SUBGROUP OF COLORECTAL CANCER TUMORS. THE STUDY, PERFORMED IN MICE, ALSO IDENTIFIED TWO DRUGS THAT WERE SUCCESSFUL IN REDUCING THE NUMBER AND SIZE OF THESE TUMORS. THE FINDINGS SUGGEST A POTENTIAL BIOMARKER AND PROMISING TREATMENT APPROACH FOR THIS OFTEN-DEADLY CANCER. DISORDERS OF METABOLISM RESEARCH TO RESTORE INSULIN PRODUCTION IN DIABETES. IF YOU HAVE DIABETES, THERE IS A STRONG CHANCE YOU ARE EITHER ON INSULIN THERAPY NOW OR WILL BE IN THE FUTURE. A NEW STUDY BY FRED LEVINE, M.D., PH.D., FOUND THAT UNDER THE RIGHT CIRCUMSTANCES, INSULIN-MAKING "BETA" CELLS COULD BE REGENERATED IN MICE USING THREE DRUGS. ALTHOUGH MORE RESEARCH IS NEEDED, THE FINDINGS COULD ONE DAY FREE MILLIONS OF PATIENTS FROM DAILY DOSES OF INSULIN. MANNOSE'S UNEXPECTED EFFECTS ON THE MICROBIOME AND WEIGHT GAIN. HUDSON FREEZE, PH.D., PUBLISHED RESEARCH DESCRIBING HOW MICE FED A FATTY DIET AND MANNOSE (A SUGAR) WERE PROTECTED FROM WEIGHT GAIN AND WERE MORE FIT. THE EFFECTS WERE ATTRIBUTED TO CHANGES IN THE GUT MICROBIOME BUT WERE ONLY ATTAINED WHEN THE MICE RECEIVING MANNOSE WERE YOUNG, SUGGESTING THE GUT MICROBIOME IS VERY DYNAMIC EARLY IN LIFE. THE RESEARCH CONFIRMS THE IMPORTANT ROLE OF THE GUT MICROBIOME IN METABOLISM AND MAY LEAD TO NEW THERAPIES FOR TREATING OBESITY.
IMMUNITY	HARNESSING NANOPARTICLES TO FIGHT DRUG-RESISTANT INFECTIONS. ERKKI RUOSLAHTI, M.D., PH.D., CO-AUTHORED A STUDY THAT DESCRIBES THE FIRST EXAMPLE OF AN EFFECTIVE GENE THERAPY APPROACH TO FIGHT LETHAL BACTERIAL INFECTIONS. THE METHOD USES NANOPARTICLES TO TARGET SPECIFIC IMMUNE CELLS TO BOLSTER THE IMMUNE SYSTEM. THE TECHNIQUE WAS SUCCESSFULLY USED AGAINST A LETHAL BACTERIAL INFECTION OF STAPHYLOCOCCUS AUREUS PNEUMONIA IN MICE. NEW INSIGHTS INTO T CELL SURVIVAL. A HEALTHY POOL OF CIRCULATING T CELLS IS ESSENTIAL TO KILL PATHOGENS, MAKE ANTIBODIES, SHUT DOWN THE IMMUNE SYSTEM TO PREVENT UNCONTROLLED INFLAMMATION AND AUTOIMMUNE DISORDERS-AND EVEN FIGHT CANCER. A NEW STUDY BY MAXIMILIANO D'ANGELO, PH.D., IDENTIFIED A NUCLEAR PORE PROTEIN THAT IS CRITICAL FOR THE SURVIVAL OF CIRCULATING T CELLS, PAVING THE WAY FOR POTENTIAL ADVANCES IN IMMUNOTHERAPY. GUT MICROBIOME DIRECTS THE IMMUNE SYSTEM TO FIGHT CANCER. IMMUNOTHERAPY HAS BEEN A SIGNIFICANT BREAKTHROUGH IN CANCER TREATMENT-BUT IT DOESN'T WORK FOR EVERYONE. ZE'EV RONAI, PH.D., LED A WORLDWIDE COLLABORATION DEMONSTRATING A CAUSAL LINK BETWEEN THE GUT MICROBIOME AND THE IMMUNE SYSTEM'S ABILITY TO FIGHT CANCER. THE STUDY IDENTIFIED A COCKTAIL OF 11 BACTERIAL STRAINS THAT ACTIVATE THE IMMUNE SYSTEM AND SLOW THE GROWTH OF MELANOMA IN MICE. THE FINDINGS OPEN NEW RESEARCH AVENUES TO TURN ON ANTI-TUMOR IMMUNITY IN PATIENTS WITH CANCER. PATH TO DEADLY SEPSIS VARIES BY BACTERIAL INFECTION. SEPSIS IS A POTENTIALLY DEADLY CONDITION THAT OCCURS WHEN THE BODY REACTS TO AN INFECTION IN THE BLOODSTREAM. JAMEY MARTH, PH.D., LED RESEARCH SHOWING HOW RESPONSES DURING SEPSIS CAN VARY BASED ON THE PATHOGEN. SEPSIS CAUSED BY SALMONELLA OR E. COLI (GRAM-NEGATIVE BACTERIA) ACTIVATED THE HOST INFLAMMATORY RESPONSE, REDUCING THE LIKELIHOOD OF SURVIVAL. THE FINDINGS SUGGEST THAT BOOSTING ANTI-INFLAMMATORY ENZYMES MAY BE A FIRST-LINE THERAPEUTIC DEFENSE AGAINST THESE TYPES OF INFECTIONS. NEUROSCIENCE ANTIMICROBIAL PROTEIN IMPLICATED IN PARKINSON'S DISEASE. WANDA REYNOLDS, PH.D., MADE A DISCOVERY SHOWING THAT AN IMMUNE SYSTEM PROTEIN THAT USUALLY PROTECTS OUR BODIES FROM PATHOGENS IS ABNORMALLY PRODUCED DURING PARKINSON'S DISEASE. THE DISCOVERY INDICATES THAT DEVELOPING A DRUG THAT BLOCKS THE PROTEIN, CALLED MYELOPEROXIDASE, MAY HELP PEOPLE WITH PARKINSON'S DISEASE. ALS RESEARCH REVEALS NEW AVENUE FOR THERAPEUTICS DISCOVERY. AMYOTROPHIC LATERAL SCLEROSIS (ALS, OFTEN REFERRED TO AS LOU GEHRIG'S DISEASE) IS CAUSED BY LOSS OF MOTOR NEURONS IN THE BRAIN AND SPINAL CORD, WHICH LEADS TO GRADUAL MUSCLE DECLINE. HUAXI XU, PH.D., REVEALED THAT A PROTEIN CALLED MEMBRALIN PLAYS A KEY ROLE IN ALS AND IDENTIFIED A MEMBRALIN-BOOSTING GENE THERAPY THAT EXTENDED THE LIFE OF MICE WITH ALS-LIKE SYMPTOMS. ADDITIONAL RESEARCH AND CLINICAL TRIALS MAY ADVANCE THE APPROACH TO TREAT PATIENTS WITH THE DISEASE. MUSCLE DISCOVERY MAY OPEN NEW TREATMENT PATHS FOR ALS. LORENZO PURI, M.D., LED RESEARCH SHOWING HOW THE CELLS NEEDED TO HEAL OUR MUSCLES-CALLED FIBRO-ADIPOGENIC PROGENITORS (FAPS)-HAVE A DARK SIDE. IN NEURODEGENERATIVE DISEASES, SUCH AS ALS (LOU GEHRIG'S DISEASE), FAPS SIGNAL THE IMMUNE SYSTEM TO GO INTO OVERDRIVE, CAUSING MUSCLE WASTING AND SCARRING. BLOCKING FAP'S SIGNAL IN MOUSE MODELS OF ALS STOPPED MUSCLE WASTING AND SCARRING, SUGGESTING A NEW APPROACH TO TREAT THE DISEASE. DNA RECOMBINATION IN THE BRAIN LINKED TO ALZHEIMER'S DISEASE. JEROLD CHUN, M.D., PH.D., PUBLISHED BREAKTHROUGH RESEARCH DESCRIBING HOW GENE RECOMBINATION TAKES PLACE IN NORMAL BRAINS-BUT GOES AWRY IN ALZHEIMER'S DISEASE. GENE RECOMBINATION REQUIRES AN ENZYME CALLED REVERSE TRANSCRIPTASE, THE SAME TYPE OF ENZYME USED BY THE HIV VIRUS TO INFECT CELLS. THE FINDINGS PROVIDE SCIENTIFIC RATIONALE FOR CLINICALLY TESTING THE ANTIRETROVIRAL DRUGS THAT HAVE BEEN USED SAFELY FOR YEARS IN HIV PATIENTS AS AN ALZHEIMER'S THERAPY. CHILDREN'S HEALTH BOOSTING MUSCLE STEM CELLS TO TREAT MUSCULAR DYSTROPHY. LYING WITHIN OUR MUSCLES ARE STEM CELLS, INVISIBLE ENGINES THAT DRIVE THE TISSUE'S GROWTH AND REPAIR. ALESSANDRA SACCO, PH.D., UNCOVERED SPECIFIC CELL PROTEINS THAT REGULATE HOW MUSCLE STEM CELLS DECIDE WHETHER TO SELF-RENEW OR DIFFERENTIATE-AN INSIGHT THAT COULD LEAD TO MUSCLE-BOOSTING THERAPEUTICS FOR MUSCULAR DYSTROPHIES OR AGE-RELATED MUSCLE DECLINE. TRANSLATIONAL MEDICINE NEW STRATEGIC INITIATIVE WITH WARF THERAPEUTICS. THE INSTITUTE FORMALIZED A RESEARCH COLLABORATION AGREEMENT WITH WARF THERAPEUTICS-A PROGRAM OF THE WISCONSIN ALUMNI RESEARCH FOUNDATION ESTABLISHED IN 2018 TO TRANSLATE PROMISING BIOMEDICAL DISCOVERIES FROM THE UNIVERSITY OF WISCONSIN-MADISON INTO NOVEL MEDICINES. UNDER THE TERMS OF THE 5-YEAR AGREEMENT, WARF AND UW SCIENTISTS WILL WORK WITH THE PREBYS CENTER TO TRANSITION CLINICALLY RELEVANT TARGETS TO EARLY-STAGE DRUG DISCOVERY PROJECTS. ELI LILLY COLLABORATION ADVANCES TO PHASE 1 CLINICAL TRIAL. THE FIRST HEALTHY SUBJECT WAS DOSED IN A PHASE 1 CLINICAL TRIAL EVALUATING LY3361237, A BIOLOGIC THAT INHIBITS INFLAMMATION BY ACTIVATING AN IMMUNE CHECKPOINT RECEPTOR. THE SBP RESEARCH TEAM, LED BY CARL WARE, PH.D., PROVIDED DEEP FOUNDATIONAL SCIENTIFIC KNOWLEDGE FOR THE COMPOUND THAT MAY BENEFIT PATIENTS WITH IMMUNOLOGICAL DISORDERS SUCH AS LUPUS, PSORIASIS AND RHEUMATOID ARTHRITIS. THE COLLABORATION WITH ELI LILLY WAS FORMED IN 2015. MAYO CLINIC DRUG DISCOVERY COLLABORATION. THE COLLABORATION BETWEEN SBP AND THE MAYO CLINIC CONTINUES TO ADVANCE PROJECTS AIMED AT SPEEDING THE TRANSLATION OF SCIENTIFIC DISCOVERIES INTO POTENTIAL NEW DRUGS. BOTH INSTITUTIONS HAVE COLLABORATED ON MORE THAN 65 PROJECTS THAT HAVE GARNERED MORE THAN $11.3M IN GRANT FUNDING FROM NIH. THE COLLABORATION'S JOINT STEERING COMMITTEE LAST MET IN DECEMBER 2018 AND SELECTED THREE NEW PROJECTS - FOCUSED ON ALZHEIMER'S DISEASE, BREAST CANCER AND POLYCYSTIC KIDNEY DISEASE - TO ADD TO ITS GROWING PORTFOLIO. MAYO CLINIC INVESTIGATORS WILL PARTNER WITH THE PREBYS CENTER TO JOINTLY DEVELOP PRELIMINARY DATA PACKAGES SUITABLE FOR COMPETITIVE NIH DRUG DISCOVERY GRANT APPLICATIONS. SAN DIEGO ALZHEIMER'S COLLABORATION4CURE (C4C) INITIATIVE. ALZHEIMER'S SAN DIEGO, MRS. DARLENE SHILEY, COUNTY SUPERVISOR DIANE JACOB AND MAYOR KEVIN FAULCONER ALL REAFFIRMED THEIR COMMITMENT TO THE C4C INITIATIVE (TO FUND LOCAL ALZHEIMER'S DRUG DISCOVERY RESEARCH) BY PLEDGING ADDITIONAL FUNDING FOR A 4TH ROUND OF PROPOSALS. SBP'S PREBYS CENTER HAS BEEN INVOLVED SINCE ITS INCEPTION AND HAS BEEN PROUD TO SERVE AS THE DESIGNATED DRUG DISCOVERY CENTER FOR AWARDED PROPOSALS. IN OCTOBER 2018, THE PREBYS CENTER TEAM SHARED THAT THEY HAVE IDENTIFIED AN INHIBITOR THAT BINDS TO A MUTANT FORM OF THE PROTEIN TREM-2. TREM-2 IS THOUGHT TO PLAY A PROTECTIVE ROLE AGAINST ALZHEIMER'S DISEASE AND MUTATIONS IN TREM-2 INCREASE THE RISK OF ALZHEIMER'S DISEASE. THIS RESEARCH IS FUNDED BY A $1.3M GRANT FROM NIH. ELIMINATING HIV ONCE AND FOR ALL. ANTIRETROVIRAL THERAPIES HAVE MADE IT POSSIBLE FOR PEOPLE TO LIVE WITH HIV FOR DECADES. HOWEVER, SMALL RESERVOIRS OF HIV LIVE IN CELLS, LYING DORMANT AND GOING UNDETECTED BY THE IMMUNE SYSTEM. IF RETROVIRAL THERAPY IS DISCONTINUED, THE VIRUS REAWAKENS TO PRODUCE MORE VIRUSES AND INFECT CELLS. WITH SUPPORT FROM THE INSTITUTE'S TRANSLATIONAL SCIENCE INITIATIVE, THE LABORATORY OF SUMIT CHANDA, PH.D. WILL BE WORKING TO ADVANCE A COMPOUND DESIGNED TO REACTIVATE LATENT HIV-INFECTED CELLS SO THEY CAN BE KILLED OFF ONCE AND FOR ALL-A "SHOCK AND KILL" STRATEGY. FUNDING WILL SUPPORT STUDIES OF THE COMPOUND IN AN IN VIVO NON-HUMAN PRIMATE MODEL OF HIV LATENCY. SBP TECHNOLOGY ADVANCES TO PHASE 1 CLINICAL TRIAL. ANTI-CANCER TECHNOLOGY DEVELOPED IN THE LAB OF ERKKI RUOSLAHTI, M.D., PH.D., ADVANCED TO A PHASE 1 CLINICAL TRIAL FOR PANCREATIC CANCER. THE TECHNOLOGY HAS BEEN USED TO CREATE CEND-1, A COMPOUND DESIGNED TO IMPROVE THE EFFICACY OF ANTI-CANCER DRUGS. CEND-1 IS CO-ADMINISTERED WITH ANTI-CANCER DRUGS TO ENHANCE THEIR TUMOR PENETRATION, THEREBY IMPROVING EFFICACY OF THE THERAPY AND MINIMIZING TOXICITY. CEND-1 IS EXCLUSIVELY LICENSED TO DRUGCENDR, INC. COLLABORATING WITH USC. SBP'S PREBYS CENTER FINALIZED A RESEARCH COLLABORATION AGREEMENT WITH DR. JOHN CARPTEN OF USC. THE WORK FOCUSES ON COMPLETING A HIGH-THROUGHPUT SCREEN OF SBP'S CHEMICAL LIBRARIES IN SEARCH OF PROTOTYPE CHEMICALS, WHICH COULD BE DEVELOPED INTO TREATMENTS FOR BREAST CANCER. PROGRESS TOWARD NEW CANCER THERAPEUTICS. SBP'S PREBYS CENTER PRESENTED AT THE NCI CHEMICAL BIOLOGY CONSORTIUM (CBC) STEERING COMMITTEE MEETING TO REPORT ON THE RAPID PROGRESS OF TWO SBP-ORIGINATED PROJECTS ON EMERGENT CANCER TARGETS. THE PROJECTS, LED BY JORGE MOSCAT, PH.D. AND MARIA DIAZ-MECO, PH.D., AND NICHOLAS COSFORD, PH.D. AND LUTZ TAUTZ, PH.D., HAVE SO FAR GARNERED $2.5M IN FUNDING FROM CBC. BOTH PROJECTS EMPLOY KEY HIGH-THROUGHPUT SCREENING TECHNOLOGY THAT THE PREBYS CENTER HAS PARTICULAR EXPERTISE WITH AND THAT ENABLED THE IDENTIFICATION OF NOVEL COMPOUNDS WITH DISTINCT IMPROVEMENTS OVER CURRENT COMPETITOR COMPOUNDS.
FORM 990, PART VI, LINE 11B	PROCESS USED BY MANAGEMENT AND/OR GOVERNING BODY TO REVIEW FORM 990 THE 990 IS PREPARED BY THE FINANCE DEPARTMENT. IT IS REVIEWED BY THE INSTITUTE'S TAX ADVISORS, SELECTED MEMBERS OF MANAGEMENT INCLUDING THE CFO AND AUDIT COMMITTEE AND PROVIDED TO MEMBERS OF THE BOARD PRIOR TO FILING.
FORM 990, PART VI, LINE 12C	DESCR OF PROCESS TO MONITOR TRANSACTIONS FOR CONFLICT OF INTEREST CONFLICT OF INTEREST STATEMENTS ARE GIVEN TO MANAGEMENT STAFF AND PRINCIPAL INVESTIGATORS ON A PERIODIC BASIS TO REPORT ON CONFLICTS OR LACK OF CONFLICTS. THE STATEMENTS ARE REVIEWED ANNUALLY BY THE SENIOR DIRECTOR, INTELLECTUAL PROPERTY AND THE SENIOR DIRECTOR, SPONSORED RESEARCH, WITH A SUMMARY OF THE REVIEW PROVIDED TO THE CFO. AN ASSESSMENT IS MADE AS TO WHETHER A CONFLICT CAN BE MANAGED BY THE EXISTING DEPARTMENTS AND PRACTICES. CONFLICTS ARE BROUGHT TO THE BOARD OF TRUSTEES ON AN AS NEEDED BASIS. CONFLICTS AND POTENTIAL CONFLICTS THAT INVOLVE THE CEO OR THE PRESIDENT ARE BROUGHT TO THE BOARD OF TRUSTEES TO ADDRESS ANY ACTUAL OR POTENTIAL POSSIBILITY THAT THE DESIGNATED REVIEWERS (I.E., SENIOR DIRECTOR, INTELLECTUAL PROPERTY AND THE SENIOR DIRECTOR, SPONSORED RESEARCH, AND THE CFO) COULD BE PRESSURED TO MAKE BIASED DECISIONS IN MANAGING CONFLICTS INVOLVING THE CEO OR PRESIDENT. AS TO RESTRICTIONS IMPOSED: THE INSTITUTE WILL EMPLOY THE MECHANISM THAT IS THE BEST FIT WITH THE FACTS AND CIRCUMSTANCES OF ANY IDENTIFIED CONFLICT OF INTEREST. METHODS TO MANAGE POTENTIAL CONFLICTS/ENFORCEMENT MECHANISM: REVIEWING MANAGEMENT IS RESPONSIBLE FOR MANAGING, REDUCING, OR ELIMINATING REAL OR POTENTIAL CONFLICTS OF INTEREST. EXAMPLES OF CONDITIONS OR RESTRICTIONS THAT MIGHT BE IMPOSED TO MANAGE, REDUCE, OR ELIMINATE CONFLICTS OF INTERESTS INCLUDE: -PUBLIC DISCLOSURE OF SIGNIFICANT FINANCIAL INTERESTS -MONITORING OF RESEARCH BY INDEPENDENT REVIEWERS -MODIFICATION OF THE RESEARCH PLAN -DISQUALIFICATION FROM PARTICIPATION IN THE PORTION OF FUNDED RESEARCH THAT COULD BE AFFECTED BY SIGNIFICANT FINANCIAL INTEREST -DIVESTITURE OF SIGNIFICANT FINANCIAL INTERESTS -SEVERANCE OF RELATIONSHIPS THAT CREATE ACTUAL OR POTENTIAL CONFLICTS -REVIEW OF COMMERCIAL SPONSORED RESEARCH AGREEMENTS FOR SCIENTIFIC MERIT BY THE PROGRAM PLANNING COMMITTEE -REMOVAL OF AN AFFECTED PARTY FROM NEGOTIATION WITH A COMPANY WITH WHICH HE/SHE HAS SIGNIFICANT FINANCIAL INTEREST.
FORM 990, PART VI, LINES 15A & 15B	PROCESS FOR DETERMINING COMPENSATION COMPENSATION FOR THE CEO, THE PRESIDENT, CHIEF FINANCIAL OFFICER, AND OTHER KEY EMPLOYEES IS ESTABLISHED ACCORDING TO INSTITUTE POLICIES WHICH ARE DESIGNED TO MEET THE IRS STANDARD FOR "REBUTTABLE PRESUMPTION OF REASONABLENESS". THE COMPENSATION COMMITTEE OF THE BOARD OF TRUSTEES, CONSISTING OF FOUR INDEPENDENT TRUSTEES, REVIEWS COMPARABILITY DATA PROVIDED BY AN INDEPENDENT EXTERNAL CONSULTANT THAT INCORPORATES AND EVALUATES INSTITUTE DATA AND THAT OF COMPARABLE ORGANIZATIONS AND MARKETS FROM WHICH THE INSTITUTE DRAWS ITS EXECUTIVE TALENT. UTILIZING THIS INFORMATION, THE COMPENSATION COMMITTEE, WHICH TYPICALLY SEEKS TO ESTABLISH COMPENSATION BETWEEN THE 50TH AND THE 75TH PERCENTILE OF THE COMPARABILITY DATA, MAKES A DETERMINATION WHETHER THE PROPOSED COMPENSATION IS REASONABLE. THE COMPENSATION COMMITTEE HAS BEEN DELEGATED AUTHORITY BY THE BOARD OF TRUSTEES TO REVIEW AND APPROVE COMPENSATION OF ALL POSITIONS EXCEPT FOR THE CEO. THE CEOS COMPENSATION PACKAGE IS REVIEWED AND APPROVED INITIALLY BY THE COMPENSATION COMMITTEE AND THEN GOES TO THE EXECUTIVE COMMITTEE FOR FINAL APPROVAL. THE COMPENSATION COMMITTEE CONTEMPORANEOUSLY AND ADEQUATELY DOCUMENTS THE BASIS FOR ITS DETERMINATION AND RECOMMENDATION TO THE EXECUTIVE COMMITTEE. IF APPROVED BY THE EXECUTIVE COMMITTEE, THE CEO COMPENSATION PACKAGE IS THEN IMPLEMENTED AND SUCH DOCUMENTATION IS KEPT IN THE WRITTEN AND ELECTRONIC RECORDS OF THE BOARD OF TRUSTEES. THE PROCESS WAS LAST COMPLETED ON JUNE 6, 2018 FOR THE FOLLOWING POSITIONS: 1) PRESIDENT 2) CFO 3) VP BUSINESS DEVELOPMENT 4) VP PHILANTHROPY 5) SVP DRUG DISCOVERY & DEVELOPMENT 6) CANCER CENTER DIRECTOR/PROFESSOR 7) INFECTIOUS & INFLAMMATORY DISEASE CENTER DIRECTOR/PROFESSOR
FORM 990, PART VI, LINE 19	PROCESS FOR MAKING DOCUMENTS AVAILABLE TO THE PUBLIC DOCUMENTS ARE AVAILABLE UPON REQUEST.

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