VAN ANDEL RESEARCH INSTITUTE: Form 990, tax year 2012
View the entire original 990 at ProPublica ↗
- Organization
- VAN ANDEL RESEARCH INSTITUTE (EIN 52-2000823)
- Tax period
- 2012-12-01 to 2013-11-30
- Filed
- 2014-10-14
- IRS object ID
- 201432879349301913
- Schema version
- 2012v2.1
- Source
- Download XML · Original 990 at ProPublica
Every field in the e-filed return. Faint text is the IRS element name, for citing.
- Return header
- Form 990
- Schedule A
- Schedule B
- Schedule C
- Schedule D
- Schedule F
- Schedule I
- Schedule J
- Schedule K
- Schedule L
- Schedule O
- Schedule R
Return header ReturnHeader
| Field | Value | IRS element (for citing) |
|---|---|---|
| Timestamp | 2014-10-14T16:05:42-05:00 | Timestamp |
| Tax Period End Date | 2013-11-30 | TaxPeriodEndDate |
Preparer Firm PreparerFirm
| Field | Value | IRS element (for citing) |
|---|---|---|
| EIN | 861065772 | EIN |
Preparer Firm Business Name PreparerFirmBusinessName
| Field | Value | IRS element (for citing) |
|---|---|---|
| Business Name Line1 | DELOITTE TAX LLP | BusinessNameLine1 |
Preparer Firm US Address PreparerFirmUSAddress
| Field | Value | IRS element (for citing) |
|---|---|---|
| Address Line1 | 200 RENAISSANCE CENTER STE 3900 | AddressLine1 |
| City | DETROIT | City |
| State | MI | State |
| ZIP Code | 48243 | ZIPCode |
| Field | Value | IRS element (for citing) |
|---|---|---|
| Return Type | 990 | ReturnType |
| Tax Period Begin Date | 2012-12-01 | TaxPeriodBeginDate |
Filer Filer
| Field | Value | IRS element (for citing) |
|---|---|---|
| EIN | 522000823 | EIN |
Name Name
| Field | Value | IRS element (for citing) |
|---|---|---|
| Business Name Line1 | VAN ANDEL RESEARCH INSTITUTE | BusinessNameLine1 |
| Field | Value | IRS element (for citing) |
|---|---|---|
| Name Control | VANA | NameControl |
| Phone | 6162345000 | Phone |
US Address USAddress
| Field | Value | IRS element (for citing) |
|---|---|---|
| Address Line1 | 333 BOSTWICK AVENUE NE | AddressLine1 |
| City | GRAND RAPIDS | City |
| State | MI | State |
| ZIP Code | 49503 | ZIPCode |
Officer Officer
| Field | Value | IRS element (for citing) |
|---|---|---|
| Name | TIMOTHY J MYERS | Name |
| Title | CFO | Title |
| Phone | 6162345368 | Phone |
| Date Signed | 2014-10-14 | DateSigned |
| Authorize Third Party | 1 | AuthorizeThirdParty |
Preparer Preparer
| Field | Value | IRS element (for citing) |
|---|---|---|
| Name | LORI BOYCE | Name |
| PTIN | P00121981 | PTIN |
| Phone | 3133963000 | Phone |
| Field | Value | IRS element (for citing) |
|---|---|---|
| Tax Year | 2012 | TaxYear |
| Build TS | 2015-11-30 17:44:51Z | BuildTS |
Form 990 IRS990
| Field | Value | IRS element (for citing) |
|---|---|---|
| Name Of Principal Officer Person | TIMOTHY J MYERS | NameOfPrincipalOfficerPerson |
Address Principal Officer US AddressPrincipalOfficerUS
| Field | Value | IRS element (for citing) |
|---|---|---|
| Address Line1 | 333 BOSTWICK AVENUE NE | AddressLine1 |
| City | GRAND RAPIDS | City |
| State | MI | State |
| ZIP Code | 49503 | ZIPCode |
| Field | Value | IRS element (for citing) |
|---|---|---|
| Gross Receipts | 64017267 | GrossReceipts |
| Group Return For Affiliates | 0 | GroupReturnForAffiliates |
| Organization501c3 | X | Organization501c3 |
| Web Site | WWW.VAI.ORG | WebSite |
| Type Of Organization Trust | X | TypeOfOrganizationTrust |
| Year Formation | 1996 | YearFormation |
| State Legal Domicile | MI | StateLegalDomicile |
| Activity Or Mission Description | MEDICAL RESEARCH ORGANIZATION | ActivityOrMissionDescription |
| Nbr Voting Members Governing Body | 5 | NbrVotingMembersGoverningBody |
| Nbr Independent Voting Members | 3 | NbrIndependentVotingMembers |
| Total Nbr Employees | 393 | TotalNbrEmployees |
| Total Nbr Volunteers | 0 | TotalNbrVolunteers |
| Total Gross UBI | 267491 | TotalGrossUBI |
| Net Unrelated Business Txbl Income | 41120 | NetUnrelatedBusinessTxblIncome |
| Contributions Grants Prior Year | 57997024 | ContributionsGrantsPriorYear |
| Contributions Grants Current Year | 54068694 | ContributionsGrantsCurrentYear |
| Program Service Revenue Prior Year | 1242591 | ProgramServiceRevenuePriorYear |
| Program Service Revenue CY | 693011 | ProgramServiceRevenueCY |
| Investment Income Prior Year | 333140 | InvestmentIncomePriorYear |
| Investment Income Current Year | 64454 | InvestmentIncomeCurrentYear |
| Other Revenue Prior Year | 10471022 | OtherRevenuePriorYear |
| Other Revenue Current Year | 7773170 | OtherRevenueCurrentYear |
| Total Revenue Prior Year | 70043777 | TotalRevenuePriorYear |
| Total Revenue Current Year | 62599329 | TotalRevenueCurrentYear |
| Grants And Similar Amnts Prior Year | 341390 | GrantsAndSimilarAmntsPriorYear |
| Grants And Similar Amnts CY | 302224 | GrantsAndSimilarAmntsCY |
| Benefits Paid To Members Prior Year | 0 | BenefitsPaidToMembersPriorYear |
| Benefits Paid To Members CY | 0 | BenefitsPaidToMembersCY |
| Salaries Etc Prior Year | 27658068 | SalariesEtcPriorYear |
| Salaries Etc Current Year | 28311621 | SalariesEtcCurrentYear |
| Total Prof Fundrsng Exp Prior Year | 0 | TotalProfFundrsngExpPriorYear |
| Total Prof Fundrsng Exp CY | 0 | TotalProfFundrsngExpCY |
| Total Fundrsng Exp Current Year | 598878 | TotalFundrsngExpCurrentYear |
| Other Expense Prior Year | 40558351 | OtherExpensePriorYear |
| Other Expenses Current Year | 39419946 | OtherExpensesCurrentYear |
| Total Expenses Prior Year | 68557809 | TotalExpensesPriorYear |
| Total Expenses Current Year | 68033791 | TotalExpensesCurrentYear |
| Revenues Less Expenses Prior Year | 1485968 | RevenuesLessExpensesPriorYear |
| Revenues Less Expenses CY | -5434462 | RevenuesLessExpensesCY |
| Total Assets BOY | 267685668 | TotalAssetsBOY |
| Total Assets EOY | 224789773 | TotalAssetsEOY |
| Total Liabilities BOY | 361102589 | TotalLiabilitiesBOY |
| Total Liabilities EOY | 290456167 | TotalLiabilitiesEOY |
| Net Assets Or Fund Balances BOY | -93416921 | NetAssetsOrFundBalancesBOY |
| Net Assets Or Fund Balances EOY | -65666394 | NetAssetsOrFundBalancesEOY |
| Mission Description | MEDICAL RESEARCH ORGANIZATION | MissionDescription |
| Significant New Program Services | 0 | SignificantNewProgramServices |
| Significant Change | 0 | SignificantChange |
| Expense | 3254352 | Expense |
| Revenue | 58261 | Revenue |
| Description | THE PROGRAM FOR BIOSPECIMEN SCIENCE HAS FOCUSED ON THE CHANGE IN BIOLOGICAL PARAMETERS AND QUALITY OF BIOSPECIMENS CAUSED BY COLLECTION, PROCESSING, AND STORAGE PROCEDURES. THIS RESEARCH IDENTIFIES EFFECTS ON THE CELL BIOLOGY THAT MAY BE UNRELATED TO THE DISEASE AND MORE SO CAUSED BY THE MANAGEMENT OF THE BIOSPECIMEN. THE RESULTS CAN BE USED TO DEVELOP BEST PRACTICES IN THE MANAGEMENT OF BIOSPECIMENS AND ULTIMATELY IMPROVE THE QUALITY OF RESEARCH FINDINGS. SCHEDULE O PROVIDES FURTHER INFORMATION REGARDING THIS PROGRAM'S ACCOMPLISHMENTS. | Description |
Activity2 Activity2
| Field | Value | IRS element (for citing) |
|---|---|---|
| Expense | 1775202 | Expense |
| Description | THE LABORATORY OF STRUCTURAL SCIENCES IS FOCUSED ON STUDYING THE STRUCTURES AND FUNCTIONS OF PROTEIN/ LIGAND COMPLEXES THAT PLAY KEY ROLES IN MAJOR HORMONE SIGNALING PATHWAYS. SEE SCHEDULE O FOR FURTHER INFORMATION ABOUT THIS PROGRAM. | Description |
Activity3 Activity3
| Field | Value | IRS element (for citing) |
|---|---|---|
| Expense | 1602052 | Expense |
| Revenue | 55581 | Revenue |
| Description | MET IS OVEREXPRESSED IN MANY TYPES OF HUMAN CANCER AND ITS EXPRESSION CORRELATES WITH AN AGGRESSIVE DISEASE AND POOR PROGNOSIS. SINCE DISCOVERING THE C-MET RECEPTOR TYROSINE KINASE AND ITS LIGAND HEPATOCYTE GROWTH FACTOR (HGF/SF) IN THE 1980'S, THE LAB HAS FOCUSED ON INVESTIGATING THE ROLE THESE MOLECULES PLAY IN MALIGNANT PROGRESSION AND METASTASIS. AS PART OF THE EFFORT TO ENHANCE OUR UNDERSTATING OF THIS SIGNALING SYSTEM, OUR LAB FOCUSES ON THE MECHANISMS RESPONSIBLE FOR TUMOR PROGRESSION WITH THE HYPOTHESIS THAT PHENOTYPIC SWITCHING (E-MT/M-ET) AND CHROMOSOME INSTABILITY CAN DRIVE TUMOR PROGRESSION. WE ALSO DEVELOP AND CHARACTERIZE NOVEL ANIMAL RESEARCH MODELS USED IN PRE-CLINICAL EVALUATION OF NEW INHIBITORS THAT TARGET C-MET IN HUMAN CANCERS. SEE SCHEDULE O FOR FURTHER INFORMATION ABOUT THIS PROGRAM. | Description |
Activity Other ActivityOther
| Field | Value | IRS element (for citing) |
|---|---|---|
| Expense | 37107196 | Expense |
| Grants | 302224 | Grants |
| Revenue | 579169 | Revenue |
| Field | Value | IRS element (for citing) |
|---|---|---|
| Total Of Other Program Service Exp | 37107196 | TotalOfOtherProgramServiceExp |
| Total Of Other Program Service Grnt | 302224 | TotalOfOtherProgramServiceGrnt |
| Total Of Other Program Service Rev | 579169 | TotalOfOtherProgramServiceRev |
| Total Program Service Expense | 43738802 | TotalProgramServiceExpense |
| Described In501 C3 | 1 | DescribedIn501C3 |
| Schedule B Required | 1 | ScheduleBRequired |
| Political Activities | 0 | PoliticalActivities |
| Lobbying Activities | 1 | LobbyingActivities |
| Subject To Proxy Tax | 0 | SubjectToProxyTax |
| Donor Advised Funds | 0 | DonorAdvisedFunds |
| Conservation Easements | 0 | ConservationEasements |
| Collections Of Art | 0 | CollectionsOfArt |
| Credit Counseling | 0 | CreditCounseling |
| Term Or Permanent Endowments | 0 | TermOrPermanentEndowments |
| Report Land Bldg Equip | 1 | ReportLandBldgEquip |
| Report Invest Oth Securities | 0 | ReportInvestOthSecurities |
| Report Prog Rel Invest | 0 | ReportProgRelInvest |
| Report Other Assets | 1 | ReportOtherAssets |
| Report Other Liabilities | 1 | ReportOtherLiabilities |
| Report Fin48 Footnote | 1 | ReportFin48Footnote |
| Independent Audit Financial Stmt | 0 | IndependentAuditFinancialStmt |
| Consolidated Audit Financial Stmt | 1 | ConsolidatedAuditFinancialStmt |
| School | 0 | School |
| Foreign Office | 1 | ForeignOffice |
| Foreign Activities | 1 | ForeignActivities |
| More Than5000 K To Organizations | 0 | MoreThan5000KToOrganizations |
| More Than5000 K To Individuals | 0 | MoreThan5000KToIndividuals |
| Professional Fundraising | 0 | ProfessionalFundraising |
| Fundraising Activities | 0 | FundraisingActivities |
| Gaming | 0 | Gaming |
| Hospital | 0 | Hospital |
| Grants To Organizations | 0 | GrantsToOrganizations |
| Grants To Individuals | 1 | GrantsToIndividuals |
| Schedule J Required | 1 | ScheduleJRequired |
| Tax Exempt Bonds | 1 | TaxExemptBonds |
| Invest Tax Exempt Bonds | 0 | InvestTaxExemptBonds |
| Escrow Account | 0 | EscrowAccount |
| On Behalf Of Issuer | 0 | OnBehalfOfIssuer |
| Excess Benefit Transaction | 0 | ExcessBenefitTransaction |
| Prior Excess Benefit Transaction | 0 | PriorExcessBenefitTransaction |
| Loan To Officer Or DQP | 1 | LoanToOfficerOrDQP |
| Grant To Related Person | 0 | GrantToRelatedPerson |
| Bsnss Rltnshp With Organization | 0 | BsnssRltnshpWithOrganization |
| Bsnss Rltnshp Thru Family Member | 0 | BsnssRltnshpThruFamilyMember |
| Officer Entity With Bsnss Rltnshp | 1 | OfficerEntityWithBsnssRltnshp |
| Deductible Non Cash Contributions | 0 | DeductibleNonCashContributions |
| Deductible Contributions Of Art | 0 | DeductibleContributionsOfArt |
| Terminated | 0 | Terminated |
| Partial Liquidation | 0 | PartialLiquidation |
| Disregarded Entity | 1 | DisregardedEntity |
| Related Entity | 1 | RelatedEntity |
| Related Org Controlled Entity | 1 | RelatedOrgControlledEntity |
| Transaction Related Entity | 1 | TransactionRelatedEntity |
| Transfers To Exempt Non Chrtbl Org | 0 | TransfersToExemptNonChrtblOrg |
| Activities Conducted Partnership | 0 | ActivitiesConductedPartnership |
| Schedule O Required | 1 | ScheduleORequired |
| Number Forms Transmitted With1096 | 107 | NumberFormsTransmittedWith1096 |
| Number W2 G Included | 0 | NumberW2GIncluded |
| Number Of Employees | 393 | NumberOfEmployees |
| Employment Tax Returns Filed | 1 | EmploymentTaxReturnsFiled |
| Unrelated Business Income | 1 | UnrelatedBusinessIncome |
| Form990-T Filed | 1 | Form990-TFiled |
| Foreign Financial Account | 0 | ForeignFinancialAccount |
| Prohibited Tax Shelter Trans | 0 | ProhibitedTaxShelterTrans |
| Taxable Party Notification | 0 | TaxablePartyNotification |
| Non Deductible Contributions | 0 | NonDeductibleContributions |
| Quid Pro Quo Contributions | 0 | QuidProQuoContributions |
| Form8282 Property Disposed Of | 0 | Form8282PropertyDisposedOf |
| Funds To Pay Premiums | 0 | FundsToPayPremiums |
| Premiums Paid | 0 | PremiumsPaid |
| Indoor Tanning Services | 0 | IndoorTanningServices |
| Info In Schedule O Part VI | X | InfoInScheduleOPartVI |
| Nbr Voting Governing Body Members | 5 | NbrVotingGoverningBodyMembers |
| Number Independent Voting Members | 3 | NumberIndependentVotingMembers |
| Family Or Business Relationship | 1 | FamilyOrBusinessRelationship |
| Delegation Of Management Duties | 1 | DelegationOfManagementDuties |
| Changes To Organizing Docs | 0 | ChangesToOrganizingDocs |
| Material Diversion Or Misuse | 0 | MaterialDiversionOrMisuse |
| Members Or Stockholders | 0 | MembersOrStockholders |
| Election Of Board Members | 1 | ElectionOfBoardMembers |
| Decisions Subject To Approval | 0 | DecisionsSubjectToApproval |
| Minutes Of Governing Body | 1 | MinutesOfGoverningBody |
| Minutes Of Committees | 1 | MinutesOfCommittees |
| Officer Mailing Address | 0 | OfficerMailingAddress |
| Local Chapters | 0 | LocalChapters |
| Form990 Provided To Governing Body | 1 | Form990ProvidedToGoverningBody |
| Conflict Of Interest Policy | 1 | ConflictOfInterestPolicy |
| Annual Disclosure Covered Persons | 1 | AnnualDisclosureCoveredPersons |
| Regular Monitoring Enforcement | 1 | RegularMonitoringEnforcement |
| Whistleblower Policy | 1 | WhistleblowerPolicy |
| Document Retention Policy | 1 | DocumentRetentionPolicy |
| Compensation Process CEO | 1 | CompensationProcessCEO |
| Compensation Process Other | 1 | CompensationProcessOther |
| Investment In Joint Venture | 0 | InvestmentInJointVenture |
| States Where Copy Of Return Is Filed | MI | StatesWhereCopyOfReturnIsFiled |
| Upon Request | X | UponRequest |
The Books Are In Care Of TheBooksAreInCareOf
Name Business NameBusiness
| Field | Value | IRS element (for citing) |
|---|---|---|
| Business Name Line1 | TIMOTHY J MYERS CFO | BusinessNameLine1 |
| Field | Value | IRS element (for citing) |
|---|---|---|
| Telephone Number | 6162345368 | TelephoneNumber |
Address US AddressUS
| Field | Value | IRS element (for citing) |
|---|---|---|
| Address Line1 | 333 BOSTWICK AVENUE NE | AddressLine1 |
| City | GRAND RAPIDS | City |
| State | MI | State |
| ZIP Code | 495032518 | ZIPCode |
Form990 Part VII Section A Form990PartVIISectionA (16 entries)
| TitleTitle | Average Hours Per WeekAverageHoursPerWeek | Average Hours Per Week RelatedAverageHoursPerWeekRelated | Individual Trustee Or DirectorIndividualTrusteeOrDirector | OfficerOfficer | Reportable Comp From OrganizationReportableCompFromOrganization | Reportable Comp From Related OrgsReportableCompFromRelatedOrgs | Other CompensationOtherCompensation | Key EmployeeKeyEmployee | Highest Compensated EmployeeHighestCompensatedEmployee | FormerFormer |
|---|---|---|---|---|---|---|---|---|---|---|
| DAVID VAN ANDEL | ||||||||||
| CHAIRMAN / CEO | 36.00 | 17.00 | X | X | 405693 | 0 | 110556 | |||
| DR GEORGE VANDE WOUDE | ||||||||||
| TRUSTEE/ INVESTIGATOR | 50.00 | 0.00 | X | 300227 | 0 | 26410 | ||||
| DR JAMES FAHNER | ||||||||||
| TRUSTEE | 1.00 | 1.00 | X | 10000 | 1000 | 0 | ||||
| DR GARY TARPLEY | ||||||||||
| TRUSTEE | 1.00 | 0.00 | X | 12500 | 0 | 0 | ||||
| DR RALPH WEICHSELBAUM | ||||||||||
| TRUSTEE | 1.00 | 0.00 | X | 0 | 0 | 0 | ||||
| TIMOTHY MYERS | ||||||||||
| CHIEF FINANCIAL OFFICER | 50.00 | 3.00 | X | 231533 | 0 | 70637 | ||||
| DAVID WHITESCARVER | ||||||||||
| SECRETARY/ CHIEF LEGAL OFFICER | 50.00 | 3.00 | X | 303113 | 0 | 92727 | ||||
| DR JANA HALL | ||||||||||
| CHIEF OPERATIONS OFFICER | 50.00 | 3.00 | X | 83527 | 0 | 21390 | ||||
| DR PATRIK BRUNDIN | ||||||||||
| VARI ASSOCIATE DIRECTOR OF RESEARCH | 45.00 | 0.00 | 390092 | 0 | 64030 | X | ||||
| DR H ERIC XU | ||||||||||
| INVESTIGATOR | 45.00 | 0.00 | 283371 | 0 | 54007 | X | ||||
| JOHN BENDER DONE 513 | ||||||||||
| CLINICAL OPERATIONS DIRECTOR | 45.00 | 0.00 | 249080 | 0 | 50158 | X | ||||
| DR GISELLE SHOLLER DONE 613 | ||||||||||
| INVESTIGATOR | 45.00 | 0.00 | 248918 | 0 | 43267 | X | ||||
| DR SCOTT JEWELL | ||||||||||
| INVESTIGATOR | 45.00 | 0.00 | 331418 | 0 | 59268 | X | ||||
| LOVE COLLINS III | ||||||||||
| VICE PRESIDENT OF DEVELOPMENT, COMM., AND MKTG. | 45.00 | 0.00 | 271344 | 0 | 82732 | X | ||||
| DR JEFFREY TRENT DONE 312 | ||||||||||
| PRESIDENT & RESEARCH DIRECTOR | 0.00 | 0.00 | 702479 | 0 | 5632 | X | ||||
| R JACK FRICK DONE 1211 | ||||||||||
| CHIEF ADMINISTRATIVE OFFICER | 0.00 | 0.00 | 273377 | 0 | 0 | X | ||||
| Field | Value | IRS element (for citing) |
|---|---|---|
| Total Reportable Comp From Org | 4096672 | TotalReportableCompFromOrg |
| Total Reportable Comp Frm Rltd Orgs | 1000 | TotalReportableCompFrmRltdOrgs |
| Total Other Compensation | 680814 | TotalOtherCompensation |
| Number Individuals GT100 K | 60 | NumberIndividualsGT100K |
| Formers Listed | 1 | FormersListed |
| Total Comp GT150 K | 1 | TotalCompGT150K |
| Compensation From Other Sources | 0 | CompensationFromOtherSources |
Contractor Compensation ContractorCompensation (5 entries)
| Address Line1AddressOfContractor/AddressUS/AddressLine1 | CityAddressOfContractor/AddressUS/City | StateAddressOfContractor/AddressUS/State | ZIP CodeAddressOfContractor/AddressUS/ZIPCode | Description Of ServicesDescriptionOfServices | CompensationCompensation |
|---|---|---|---|---|---|
| BANK OF AMERICA | |||||
| 100 NORTH TYRON ST | CHARLOTTE | NC | 28202 | CREDIT ENHANCEMENT FEES | 3393605 |
| DK SECURITY INC | |||||
| 5160 FALCONVIEW AVE SE | KENTWOOD | MI | 49512 | SECURITY SERVICES | 363304 |
| HONIGMAN MILLER SCHWARTZ LLC | |||||
| 130 SOUTH FIRST ST 4TH FL | ANN ARBOR | MI | 482263506 | LEGAL/ CONSULTING | 361003 |
| WARNER NORCROSS & JUDD | |||||
| 111 LYON ST 900 OLD KENT | GRAND RAPIDS | MI | 495032487 | LEGAL/ CONSULTING | 210586 |
| CALLAHAN VENTURES LLC | |||||
| 1715 FLOWERS CROSSING | GRAND RAPIDS | MI | 49525 | CONSULTING | 194206 |
| Field | Value | IRS element (for citing) |
|---|---|---|
| Number Of Contractors GT100 K | 20 | NumberOfContractorsGT100K |
| Related Organizations | 43882066 | RelatedOrganizations |
| Government Grants | 7595292 | GovernmentGrants |
| All Other Contributions | 2591336 | AllOtherContributions |
| Total Contributions | 54068694 | TotalContributions |
Program Service Revenue ProgramServiceRevenue
| Field | Value | IRS element (for citing) |
|---|---|---|
| Description | RESEARCH BILLED REV | Description |
| Business Code | 541700 | BusinessCode |
| Total Revenue Column | 693011 | TotalRevenueColumn |
| Related Or Exempt Function Income | 439390 | RelatedOrExemptFunctionIncome |
| Unrelated Business Revenue | 253621 | UnrelatedBusinessRevenue |
| Field | Value | IRS element (for citing) |
|---|---|---|
| Total Program Service Revenue | 693011 | TotalProgramServiceRevenue |
Investment Income InvestmentIncome
| Field | Value | IRS element (for citing) |
|---|---|---|
| Total Revenue Column | 208758 | TotalRevenueColumn |
| Exclusion | $208,758 | ExclusionAmount |
Royalties Revenue RoyaltiesRevenue
| Field | Value | IRS element (for citing) |
|---|---|---|
| Total Revenue Column | 358582 | TotalRevenueColumn |
| Exclusion | $358,582 | ExclusionAmount |
Gross Rents GrossRents
| Field | Value | IRS element (for citing) |
|---|---|---|
| Real | 1227090 | Real |
Less Rental Expenses LessRentalExpenses
| Field | Value | IRS element (for citing) |
|---|---|---|
| Real | 1213702 | Real |
Rental Income Or Loss RentalIncomeOrLoss
| Field | Value | IRS element (for citing) |
|---|---|---|
| Real | 13388 | Real |
Net Rental Income Or Loss NetRentalIncomeOrLoss
| Field | Value | IRS element (for citing) |
|---|---|---|
| Total Revenue Column | 13388 | TotalRevenueColumn |
| Related Or Exempt Function Income | 10230 | RelatedOrExemptFunctionIncome |
| Unrelated Business Revenue | 3158 | UnrelatedBusinessRevenue |
Gross Amount Sales Assets GrossAmountSalesAssets
| Field | Value | IRS element (for citing) |
|---|---|---|
| Other | 59932 | Other |
Less Cost Oth Basis Sales Expenses LessCostOthBasisSalesExpenses
| Field | Value | IRS element (for citing) |
|---|---|---|
| Other | 204236 | Other |
Gain Or Loss GainOrLoss
| Field | Value | IRS element (for citing) |
|---|---|---|
| Other | -144304 | Other |
Net Gain Or Loss Investments NetGainOrLossInvestments
| Field | Value | IRS element (for citing) |
|---|---|---|
| Total Revenue Column | -144304 | TotalRevenueColumn |
| Related Or Exempt Function Income | -144304 | RelatedOrExemptFunctionIncome |
Other Revenue Misc OtherRevenueMisc (3 entries)
| DescriptionDescription | Business CodeBusinessCode | Total Revenue ColumnTotalRevenueColumn | ExclusionExclusionAmount | Unrelated Business RevenueUnrelatedBusinessRevenue |
|---|---|---|---|---|
| REL. PARTY ADMIN SUPPO | 561000 | 7002239 | $7,002,239 | |
| REIMBURSED EXPENSES | 900099 | 313421 | $313,421 | |
| STATE TAX REFUNDS | 900099 | 10712 | 10712 |
Miscellaneous Revenue MiscellaneousRevenue
| Field | Value | IRS element (for citing) |
|---|---|---|
| Total Revenue Column | 74828 | TotalRevenueColumn |
| Exclusion | $74,828 | ExclusionAmount |
| Field | Value | IRS element (for citing) |
|---|---|---|
| Total Other Revenue | 7401200 | TotalOtherRevenue |
Total Revenue TotalRevenue
| Field | Value | IRS element (for citing) |
|---|---|---|
| Total Revenue Column | 62599329 | TotalRevenueColumn |
| Related Or Exempt Function Income | 305316 | RelatedOrExemptFunctionIncome |
| Unrelated Business Revenue | 267491 | UnrelatedBusinessRevenue |
| Exclusion | $7,957,828 | ExclusionAmount |
Grants To Domestic Individuals GrantsToDomesticIndividuals
| Field | Value | IRS element (for citing) |
|---|---|---|
| Total | 302224 | Total |
| Program Services | 302224 | ProgramServices |
Comp Current Officers Directors CompCurrentOfficersDirectors
| Field | Value | IRS element (for citing) |
|---|---|---|
| Total | 1616761 | Total |
| Program Services | 327277 | ProgramServices |
| Management And General | 1289484 | ManagementAndGeneral |
Comp Disqual Persons CompDisqualPersons
| Field | Value | IRS element (for citing) |
|---|---|---|
| Total | 213680 | Total |
| Management And General | 213680 | ManagementAndGeneral |
Other Salaries And Wages OtherSalariesAndWages
| Field | Value | IRS element (for citing) |
|---|---|---|
| Total | 20778216 | Total |
| Program Services | 11714526 | ProgramServices |
| Management And General | 8670213 | ManagementAndGeneral |
| Fundraising | 393477 | Fundraising |
Pension Plan Contributions PensionPlanContributions
| Field | Value | IRS element (for citing) |
|---|---|---|
| Total | 1560210 | Total |
| Program Services | 944516 | ProgramServices |
| Management And General | 590514 | ManagementAndGeneral |
| Fundraising | 25180 | Fundraising |
Other Employee Benefits OtherEmployeeBenefits
| Field | Value | IRS element (for citing) |
|---|---|---|
| Total | 2635984 | Total |
| Program Services | 1592869 | ProgramServices |
| Management And General | 1000215 | ManagementAndGeneral |
| Fundraising | 42900 | Fundraising |
Payroll Taxes PayrollTaxes
| Field | Value | IRS element (for citing) |
|---|---|---|
| Total | 1506770 | Total |
| Program Services | 908912 | ProgramServices |
| Management And General | 572678 | ManagementAndGeneral |
| Fundraising | 25180 | Fundraising |
Fees For Services Legal FeesForServicesLegal
| Field | Value | IRS element (for citing) |
|---|---|---|
| Total | 637795 | Total |
| Program Services | 63251 | ProgramServices |
| Management And General | 574544 | ManagementAndGeneral |
Fees For Services Accounting FeesForServicesAccounting
| Field | Value | IRS element (for citing) |
|---|---|---|
| Total | 128148 | Total |
| Management And General | 128148 | ManagementAndGeneral |
Fees For Services Lobbying FeesForServicesLobbying
| Field | Value | IRS element (for citing) |
|---|---|---|
| Total | 85680 | Total |
| Management And General | 85680 | ManagementAndGeneral |
Fees For Services Other FeesForServicesOther
| Field | Value | IRS element (for citing) |
|---|---|---|
| Total | 2670755 | Total |
| Program Services | 1807905 | ProgramServices |
| Management And General | 862212 | ManagementAndGeneral |
| Fundraising | 638 | Fundraising |
Advertising Advertising
| Field | Value | IRS element (for citing) |
|---|---|---|
| Total | 2522862 | Total |
| Program Services | 51029 | ProgramServices |
| Management And General | 2465373 | ManagementAndGeneral |
| Fundraising | 6460 | Fundraising |
Office Expenses OfficeExpenses
| Field | Value | IRS element (for citing) |
|---|---|---|
| Total | 112947 | Total |
| Program Services | 60195 | ProgramServices |
| Management And General | 52752 | ManagementAndGeneral |
Information Technology InformationTechnology
| Field | Value | IRS element (for citing) |
|---|---|---|
| Total | 402742 | Total |
| Program Services | 149624 | ProgramServices |
| Management And General | 253038 | ManagementAndGeneral |
| Fundraising | 80 | Fundraising |
Occupancy Occupancy
| Field | Value | IRS element (for citing) |
|---|---|---|
| Total | 2265836 | Total |
| Program Services | 1900357 | ProgramServices |
| Management And General | 365479 | ManagementAndGeneral |
Travel Travel
| Field | Value | IRS element (for citing) |
|---|---|---|
| Total | 815559 | Total |
| Program Services | 404647 | ProgramServices |
| Management And General | 397383 | ManagementAndGeneral |
| Fundraising | 13529 | Fundraising |
Conferences Meetings ConferencesMeetings
| Field | Value | IRS element (for citing) |
|---|---|---|
| Total | 165374 | Total |
| Program Services | 108462 | ProgramServices |
| Management And General | 56912 | ManagementAndGeneral |
Interest Interest
| Field | Value | IRS element (for citing) |
|---|---|---|
| Total | 10523660 | Total |
| Program Services | 8634262 | ProgramServices |
| Management And General | 1889398 | ManagementAndGeneral |
Depreciation Depletion DepreciationDepletion
| Field | Value | IRS element (for citing) |
|---|---|---|
| Total | 9314843 | Total |
| Program Services | 7879994 | ProgramServices |
| Management And General | 1434849 | ManagementAndGeneral |
Insurance Insurance
| Field | Value | IRS element (for citing) |
|---|---|---|
| Total | 425107 | Total |
| Program Services | 263367 | ProgramServices |
| Management And General | 161740 | ManagementAndGeneral |
Other Expenses OtherExpenses (4 entries)
| DescriptionDescription | TotalTotal | Program ServicesProgramServices | Management And GeneralManagementAndGeneral | FundraisingFundraising |
|---|---|---|---|---|
| LAB SUPPLIES & SERVICES | 3083328 | 3074127 | 9201 | |
| EQUIPMENT & SOFTWARE | 2206916 | 1093771 | 1113145 | |
| OTHER SCIENTIFIC | 1202105 | 1199506 | 2599 | |
| POSTAGE & SHIPPING | 501746 | 478540 | 22622 | 584 |
All Other Expenses AllOtherExpenses
| Field | Value | IRS element (for citing) |
|---|---|---|
| Total | 2354543 | Total |
| Program Services | 779441 | ProgramServices |
| Management And General | 1484252 | ManagementAndGeneral |
| Fundraising | 90850 | Fundraising |
Total Functional Expenses TotalFunctionalExpenses
| Field | Value | IRS element (for citing) |
|---|---|---|
| Total | 68033791 | Total |
| Program Services | 43738802 | ProgramServices |
| Management And General | 23696111 | ManagementAndGeneral |
| Fundraising | 598878 | Fundraising |
Savings And Temp Cash Investments SavingsAndTempCashInvestments
| Field | Value | IRS element (for citing) |
|---|---|---|
| BOY | 1687416 | BOY |
| EOY | 487783 | EOY |
Pledges And Grants Receivable PledgesAndGrantsReceivable
| Field | Value | IRS element (for citing) |
|---|---|---|
| BOY | 2507373 | BOY |
| EOY | 2496299 | EOY |
Accounts Receivable AccountsReceivable
| Field | Value | IRS element (for citing) |
|---|---|---|
| BOY | 1262403 | BOY |
| EOY | 1841254 | EOY |
Receivables From Officers Etc ReceivablesFromOfficersEtc
| Field | Value | IRS element (for citing) |
|---|---|---|
| EOY | 18355 | EOY |
Other Notes Loans Receivable Net OtherNotesLoansReceivableNet
| Field | Value | IRS element (for citing) |
|---|---|---|
| BOY | 1647915 | BOY |
| EOY | 1596595 | EOY |
Prepaid Expenses Deferred Charges PrepaidExpensesDeferredCharges
| Field | Value | IRS element (for citing) |
|---|---|---|
| BOY | 1153469 | BOY |
| EOY | 1127550 | EOY |
| Field | Value | IRS element (for citing) |
|---|---|---|
| Land Buildings Equipment Basis | 264339993 | LandBuildingsEquipmentBasis |
| Land Bldg Equipment Accum Deprec | 67052323 | LandBldgEquipmentAccumDeprec |
Land Buildings Equipment Basis Net LandBuildingsEquipmentBasisNet
| Field | Value | IRS element (for citing) |
|---|---|---|
| BOY | 203949177 | BOY |
| EOY | 197287670 | EOY |
Investments Other Securities InvestmentsOtherSecurities
| Field | Value | IRS element (for citing) |
|---|---|---|
| BOY | 1431848 | BOY |
| EOY | 943113 | EOY |
Other Assets Total OtherAssetsTotal
| Field | Value | IRS element (for citing) |
|---|---|---|
| BOY | 54046067 | BOY |
| EOY | 18991154 | EOY |
Total Assets TotalAssets
| Field | Value | IRS element (for citing) |
|---|---|---|
| BOY | 267685668 | BOY |
| EOY | 224789773 | EOY |
Accounts Payable Accrued Expenses AccountsPayableAccruedExpenses
| Field | Value | IRS element (for citing) |
|---|---|---|
| BOY | 61769366 | BOY |
| EOY | 26805514 | EOY |
Deferred Revenue DeferredRevenue
| Field | Value | IRS element (for citing) |
|---|---|---|
| BOY | 388625 | BOY |
| EOY | 474750 | EOY |
Tax Exempt Bond Liabilities TaxExemptBondLiabilities
| Field | Value | IRS element (for citing) |
|---|---|---|
| BOY | 221189000 | BOY |
| EOY | 220000000 | EOY |
Other Liabilities OtherLiabilities
| Field | Value | IRS element (for citing) |
|---|---|---|
| BOY | 77755598 | BOY |
| EOY | 43175903 | EOY |
Total Liabilities TotalLiabilities
| Field | Value | IRS element (for citing) |
|---|---|---|
| BOY | 361102589 | BOY |
| EOY | 290456167 | EOY |
| Field | Value | IRS element (for citing) |
|---|---|---|
| Follow SFAS117 | X | FollowSFAS117 |
Unrestricted Net Assets UnrestrictedNetAssets
| Field | Value | IRS element (for citing) |
|---|---|---|
| BOY | -95108778 | BOY |
| EOY | -66813709 | EOY |
Temporarily Restricted Net Assets TemporarilyRestrictedNetAssets
| Field | Value | IRS element (for citing) |
|---|---|---|
| BOY | 1689257 | BOY |
| EOY | 1143715 | EOY |
Permanently Restricted Net Assets PermanentlyRestrictedNetAssets
| Field | Value | IRS element (for citing) |
|---|---|---|
| BOY | 2600 | BOY |
| EOY | 3600 | EOY |
Total Net Assets Fund Balances TotalNetAssetsFundBalances
| Field | Value | IRS element (for citing) |
|---|---|---|
| BOY | -93416921 | BOY |
| EOY | -65666394 | EOY |
Total Liab Net Assets Fund Balances TotalLiabNetAssetsFundBalances
| Field | Value | IRS element (for citing) |
|---|---|---|
| BOY | 267685668 | BOY |
| EOY | 224789773 | EOY |
| Field | Value | IRS element (for citing) |
|---|---|---|
| Info In Schedule O Part XI | X | InfoInScheduleOPartXI |
| Reconcilation Revenue Expenses | -5434462 | ReconcilationRevenueExpenses |
| Reconciliation Unrealized Invest | -201877 | ReconciliationUnrealizedInvest |
| Reconcilation Other Changes | 33386866 | ReconcilationOtherChanges |
| Method Of Accounting Accrual | X | MethodOfAccountingAccrual |
| Accountant Compile Or Review | 0 | AccountantCompileOrReview |
| FS Audited | 1 | FSAudited |
FS Audited Basis FSAuditedBasis
| Field | Value | IRS element (for citing) |
|---|---|---|
| Financial Statement Consolidated | X | FinancialStatementConsolidated |
| Field | Value | IRS element (for citing) |
|---|---|---|
| Audit Committee | 1 | AuditCommittee |
| Federal Grant Audit Required | 1 | FederalGrantAuditRequired |
| Federal Grant Audit Performed | 1 | FederalGrantAuditPerformed |
Schedule A IRS990ScheduleA
| Field | Value | IRS element (for citing) |
|---|---|---|
| Medical Research Org170b1 Aiii | X | MedicalResearchOrg170b1Aiii |
Hospital Name And Address HospitalNameAndAddress (2 entries)
| CityCity | StateState |
|---|---|
| SPECTRUM HEALTH | |
| GRAND RAPIDS | MI |
| MERCY HEALTH SAINT MARY'S | |
| GRAND RAPIDS | MI |
Schedule B IRS990ScheduleB
Contributor Info ContributorInfo
| Field | Value | IRS element (for citing) |
|---|---|---|
| Contributor Number | RESTRICTED | ContributorNumber |
Contributor Name Business ContributorNameBusiness
| Field | Value | IRS element (for citing) |
|---|---|---|
| Business Name Line1 | RESTRICTED | BusinessNameLine1 |
Contributor Address US ContributorAddressUS
| Field | Value | IRS element (for citing) |
|---|---|---|
| Address Line1 | RESTRICTED | AddressLine1 |
| Address Line2 | RESTRICTED | AddressLine2 |
| City | RESTRICTED | City |
| State | RESTRICTED | State |
| ZIP Code | RESTRICTED | ZIPCode |
| Field | Value | IRS element (for citing) |
|---|---|---|
| Aggregate Contributions | RESTRICTED | AggregateContributions |
Schedule C IRS990ScheduleC
Total Grassroots Lobbying TotalGrassrootsLobbying
| Field | Value | IRS element (for citing) |
|---|---|---|
| Filing Organizations Totals | 0 | FilingOrganizationsTotals |
Total Direct Lobbying TotalDirectLobbying
| Field | Value | IRS element (for citing) |
|---|---|---|
| Filing Organizations Totals | 85680 | FilingOrganizationsTotals |
Total Lobbying Expenditures TotalLobbyingExpenditures
| Field | Value | IRS element (for citing) |
|---|---|---|
| Filing Organizations Totals | 85680 | FilingOrganizationsTotals |
Other Exempt Purpose Expenditures OtherExemptPurposeExpenditures
| Field | Value | IRS element (for citing) |
|---|---|---|
| Filing Organizations Totals | 67948111 | FilingOrganizationsTotals |
Total Exempt Purpose Expenditures TotalExemptPurposeExpenditures
| Field | Value | IRS element (for citing) |
|---|---|---|
| Filing Organizations Totals | 68033791 | FilingOrganizationsTotals |
Lobbying Nontaxable LobbyingNontaxableAmount
| Field | Value | IRS element (for citing) |
|---|---|---|
| Filing Organizations Totals | 1000000 | FilingOrganizationsTotals |
Grassroots Nontaxable GrassrootsNontaxableAmount
| Field | Value | IRS element (for citing) |
|---|---|---|
| Filing Organizations Totals | 250000 | FilingOrganizationsTotals |
Tot Lobbying Grassroot Minus Non Tx TotLobbyingGrassrootMinusNonTx
| Field | Value | IRS element (for citing) |
|---|---|---|
| Filing Organizations Totals | 0 | FilingOrganizationsTotals |
Tot Lobby Expend Mns Lobbying Nontx TotLobbyExpendMnsLobbyingNontx
| Field | Value | IRS element (for citing) |
|---|---|---|
| Filing Organizations Totals | 0 | FilingOrganizationsTotals |
Lobbying Nontaxable Amount2 LobbyingNontaxableAmount2
| Field | Value | IRS element (for citing) |
|---|---|---|
| Current Year Minus1 | 1000000 | CurrentYearMinus1 |
| Current Year | 1000000 | CurrentYear |
| Total | 2000000 | Total |
| Field | Value | IRS element (for citing) |
|---|---|---|
| Lobbying Ceiling | $3,000,000 | LobbyingCeilingAmount |
Total Lobbying Expenditures2 TotalLobbyingExpenditures2
| Field | Value | IRS element (for citing) |
|---|---|---|
| Current Year Minus1 | 68133 | CurrentYearMinus1 |
| Current Year | 85680 | CurrentYear |
| Total | 153813 | Total |
Grassroots Nontaxable Amount2 GrassrootsNontaxableAmount2
| Field | Value | IRS element (for citing) |
|---|---|---|
| Current Year Minus1 | 250000 | CurrentYearMinus1 |
| Current Year | 250000 | CurrentYear |
| Total | 500000 | Total |
| Field | Value | IRS element (for citing) |
|---|---|---|
| Grassroots Ceiling | $750,000 | GrassrootsCeilingAmount |
Schedule D IRS990ScheduleD
| Field | Value | IRS element (for citing) |
|---|---|---|
| Endowments Held By Related Orgs | 1 | EndowmentsHeldByRelatedOrgs |
| Are Related Orgs Listed Schedule R | 1 | AreRelatedOrgsListedScheduleR |
Land Land
| Field | Value | IRS element (for citing) |
|---|---|---|
| Other Cost Or Other Basis | 5288315 | OtherCostOrOtherBasis |
| Book Value | 5288315 | BookValue |
Buildings Buildings
| Field | Value | IRS element (for citing) |
|---|---|---|
| Other Cost Or Other Basis | 219569122 | OtherCostOrOtherBasis |
| Depreciation | 37639777 | Depreciation |
| Book Value | 181929345 | BookValue |
Equipment Equipment
| Field | Value | IRS element (for citing) |
|---|---|---|
| Other Cost Or Other Basis | 38253261 | OtherCostOrOtherBasis |
| Depreciation | 29409246 | Depreciation |
| Book Value | 8844015 | BookValue |
Other Land Buildings OtherLandBuildings
| Field | Value | IRS element (for citing) |
|---|---|---|
| Other Cost Or Other Basis | 1229295 | OtherCostOrOtherBasis |
| Depreciation | 3300 | Depreciation |
| Book Value | 1225995 | BookValue |
| Field | Value | IRS element (for citing) |
|---|---|---|
| Total Of Book Value Land Buildings | 197287670 | TotalOfBookValueLandBuildings |
Other Assets OtherAssets (2 entries)
| DescriptionDescription | Book ValueBookValue |
|---|---|
| BOND ISSUANCE COSTS NET OF ACCUMULATED AMORTIZATION | 321154 |
| PLEDGED SECURITIES | 18670000 |
| Field | Value | IRS element (for citing) |
|---|---|---|
| Total Book Value Other Assets | 18991154 | TotalBookValueOtherAssets |
Other Liabilities OtherLiabilities (4 entries)
| DescriptionDescription | AmountAmount |
|---|---|
| ACCRUED POSTRETIREMENT BENEFIT OBLIGATION | $1,511,171 |
| UNREALIZED LOSS ON BOND SWAP | $37,205,987 |
| MSU COLLEGE OF HUMAN MEDICINE- CONTRIBUTION PAYABLE | $4,351,546 |
| CAPITAL LEASE | $107,199 |
| Field | Value | IRS element (for citing) |
|---|---|---|
| Total Of Amounts | 43175903 | TotalOfAmounts |
| Footnote In Part XIII | X | FootnoteInPartXIII |
| Tot Revenue Etc Audited Fincl Stmt | 57231606 | TotRevenueEtcAuditedFinclStmt |
| Net Unrealized Gains Investments | -201877 | NetUnrealizedGainsInvestments |
| Other Revenues | 1847105 | OtherRevenues |
| Revenue Not Rptd F990 | 1645228 | RevenueNotRptdF990 |
| Revenue Subtotal | 55586378 | RevenueSubtotal |
| Other Revenues Not Included | 7012951 | OtherRevenuesNotIncluded |
| Revenue Not Rptd On Fin Stmt | 7012951 | RevenueNotRptdOnFinStmt |
| Total Revenue Per Form990 | 62599329 | TotalRevenuePerForm990 |
| Tot Expenses Etc Audited Fincl Stmt | 29481079 | TotExpensesEtcAuditedFinclStmt |
| Other Expenses Included | -31539761 | OtherExpensesIncluded |
| Expenses Not Rptd F990 | -31539761 | ExpensesNotRptdF990 |
| Expenses Subtotal | 61020840 | ExpensesSubtotal |
| Other Expenses Not Included | 7012951 | OtherExpensesNotIncluded |
| Expenses Not Rptd On Fin Stmt | 7012951 | ExpensesNotRptdOnFinStmt |
| Total Expenses Per Form990 | 68033791 | TotalExpensesPerForm990 |
Form990 Schedule D Part XIII Form990ScheduleDPartXIII (7 entries)
| IdentifierIdentifier | Return ReferenceReturnReference | ExplanationExplanation |
|---|---|---|
| DESCRIPTION OF INTENDED USE OF ENDOWMENT FUNDS: | PART V, LINE 4: | TO SUPPORT THE CORE RESEARCH OF VARI BY SUPPLYING A SOURCE OF INCOME FOR ITS OPERATING EXPENDITURES. |
| DESCRIPTION OF UNCERTAIN TAX POSITIONS UNDER FIN 48: | PART X, LINE 2: | PART X, LINE 1(1) AND LINE 2: THERE ARE NO UNCERTAIN TAX POSITIONS RELATED TO VARI. |
| PART XI, LINE 2D - OTHER ADJUSTMENTS: | RENTAL EXPENSES 1,213,702. CHANGE IN BALANCE SHEET PRESENTATION OF TRANSMED SYSTEMS, INC. 633,403. | |
| PART XI, LINE 4B - OTHER ADJUSTMENTS: | NET ALLOCATED 7,002,239. STATE TAX REFUNDS 10,712. | |
| PART XII, LINE 2D - OTHER ADJUSTMENTS: | GAIN ON SWAP -32,753,463. RENTAL EXPENSES 1,213,702. | |
| PART XII, LINE 4B - OTHER ADJUSTMENTS: | NET ALLOCATED 7,002,239. STATE TAX REFUNDS 10,712. | |
| PART V - THE VAN ANDEL INSTITUTE (A RELATED ORGANIZATION) HOLDS ENDOWMENT FUNDS FOR BOTH VARI AND THE VAN ANDEL EDUCATION INSTITUTE (A RELATED ORGANIZATION) TO FUND OPERATING EXPENSES. PART XI AND XII, LINE 4B: EXPENSE ALLOCATIONS PRESENTED WITHIN REVENUE. |
Schedule F IRS990ScheduleF
| Field | Value | IRS element (for citing) |
|---|---|---|
| Grant Records Maintained | 1 | GrantRecordsMaintained |
Accts Actvs Out US Table AcctsActvsOutUSTable (2 entries)
| RegionRegion | Number Of OfficesNumberOfOffices | Number Of EmployeesNumberOfEmployees | Type Of Activities ConductedTypeOfActivitiesConducted | Specific Services ProvidedSpecificServicesProvided | Total ExpendituresTotalExpenditures |
|---|---|---|---|---|---|
| EAST ASIA & THE PACIFIC | 0 | 1 | PROGRAM SERVICES | RESEARCH COLLABORATION - RESEARCH SERVICES | 321384 |
| EUROPE | 0 | 0 | UNRELATED TRADE OR BUSINESS |
| Field | Value | IRS element (for citing) |
|---|---|---|
| Subtotal Number Of Offices | 0 | SubtotalNumberOfOffices |
| Subtotal Number Of Employees | 1 | SubtotalNumberOfEmployees |
| Cont Number Of Offices | 0 | ContNumberOfOffices |
| Cont Number Of Employees | 0 | ContNumberOfEmployees |
| Total Number Of Offices | 0 | TotalNumberOfOffices |
| Total Number Of Employees | 1 | TotalNumberOfEmployees |
| Subtotal Amount Spent | 321384 | SubtotalAmountSpent |
| Cont Amount Spent | 0 | ContAmountSpent |
| Total Amount Spent | 321384 | TotalAmountSpent |
| Transfer To Foreign Corp | 0 | TransferToForeignCorp |
| Interest In Foreign Trust | 0 | InterestInForeignTrust |
| Own Foreign Corp | 0 | OwnForeignCorp |
| Passive Foreign Invest Co | 0 | PassiveForeignInvestCo |
| Foreign Partnership | 0 | ForeignPartnership |
| Boycott Countries | 0 | BoycottCountries |
Schedule I IRS990ScheduleI
| Field | Value | IRS element (for citing) |
|---|---|---|
| Records Maintained | 1 | RecordsMaintained |
Form990 Schedule I Part III Form990ScheduleIPartIII (2 entries)
| Type Of GrantTypeOfGrant | Number Of RecipientsNumberOfRecipients | Amount Of Cash GrantAmountOfCashGrant | Method Of ValuationMethodOfValuation |
|---|---|---|---|
| GRADUATE STUDENT STIPENDS FOR VAN ANDEL GRADUATE SCHOOL AND MICHIGAN STATE UNIVERSITY STUDENTS | 7 | 235232 | TUITION PAID |
| FOREIGN NATIONAL STUDENT STIPENDS | 10 | 57346 |
Form990 Schedule I Part IV Form990ScheduleIPartIV
| Field | Value | IRS element (for citing) |
|---|---|---|
| Explanation | SCHEDULE I, PART I, LINE 2: STIPENDS ARE PROVIDED TO THE RESEARCH STUDENTS FOR LIVING AND INSURANCE ASSISTANCE. | Explanation |
Schedule J IRS990ScheduleJ
| Field | Value | IRS element (for citing) |
|---|---|---|
| First Class Or Charter Travel | X | FirstClassOrCharterTravel |
| Written Policy Re T And E Expenses | 0 | WrittenPolicyReTAndEExpenses |
| Substantiation Required | 1 | SubstantiationRequired |
| Compensation Committee | X | CompensationCommittee |
| Independent Consultant | X | IndependentConsultant |
| Written Employment Contract | X | WrittenEmploymentContract |
| Compensation Survey | X | CompensationSurvey |
| Board Or Committee Approval | X | BoardOrCommitteeApproval |
| Severance Payment | 1 | SeverancePayment |
| Supplemental Nonqual Retire Plan | 0 | SupplementalNonqualRetirePlan |
| Equity Based Comp Arrangement | 0 | EquityBasedCompArrangement |
| Comp Based On Revenue Of Filing Org | 0 | CompBasedOnRevenueOfFilingOrg |
| Comp Based On Revenue Related Orgs | 0 | CompBasedOnRevenueRelatedOrgs |
| Comp Based Net Earnings Filing Org | 0 | CompBasedNetEarningsFilingOrg |
| Comp Based Net Earnings Relate Orgs | 0 | CompBasedNetEarningsRelateOrgs |
| Any Non Fixed Payments | 1 | AnyNonFixedPayments |
| Initial Contract Exception | 0 | InitialContractException |
Form990 Schedule J Part II Form990ScheduleJPartII (12 entries)
| TitleTitle | Base Compensation Filing OrgBaseCompensationFilingOrg | Comp Based On Related OrgsCompBasedOnRelatedOrgs | Bonus Filing OrgBonusFilingOrg | Bonus Related OrgsBonusRelatedOrgs | Other Compensation Filing OrgOtherCompensationFilingOrg | Other Compensation Related OrgsOtherCompensationRelatedOrgs | Deferred Comp Filing OrgDeferredCompFilingOrg | Deferred Comp Related OrgsDeferredCompRelatedOrgs | Nontaxable Benefits Filing OrgNontaxableBenefitsFilingOrg | Nontaxable Benefits Related OrgsNontaxableBenefitsRelatedOrgs | Total Compensation Filing OrgTotalCompensationFilingOrg | Total Compensation Related OrgsTotalCompensationRelatedOrgs | Comp Report Prior990 Filing OrgCompReportPrior990FilingOrg | Comp Report Prior990 Related OrgsCompReportPrior990RelatedOrgs |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| DAVID VAN ANDEL | ||||||||||||||
| CHAIRMAN / CEO | 300014 | 0 | 85204 | 0 | 20475 | 0 | 110054 | 0 | 502 | 0 | 516249 | 0 | 85204 | 0 |
| DR GEORGE VANDE WOUDE | ||||||||||||||
| TRUSTEE/ INVESTIGATOR | 280755 | 0 | 0 | 0 | 19472 | 0 | 25000 | 0 | 1410 | 0 | 326637 | 0 | 0 | 0 |
| TIMOTHY MYERS | ||||||||||||||
| CHIEF FINANCIAL OFFICER | 194070 | 0 | 37163 | 0 | 300 | 0 | 62163 | 0 | 8474 | 0 | 302170 | 0 | 37163 | 0 |
| DAVID WHITESCARVER | ||||||||||||||
| SECRETARY/ CHIEF LEGAL OFFICER | 258023 | 0 | 25000 | 0 | 20090 | 0 | 84253 | 0 | 8474 | 0 | 395840 | 0 | 25000 | 0 |
| DR PATRIK BRUNDIN | ||||||||||||||
| VARI ASSOCIATE DIRECTOR OF RESEARCH | 374146 | 0 | 0 | 0 | 15946 | 0 | 56263 | 0 | 7767 | 0 | 454122 | 0 | 0 | 0 |
| DR H ERIC XU | ||||||||||||||
| INVESTIGATOR | 267126 | 0 | 15795 | 0 | 450 | 0 | 45533 | 0 | 8474 | 0 | 337378 | 0 | 15795 | 0 |
| JOHN BENDER DONE 513 | ||||||||||||||
| CLINICAL OPERATIONS DIRECTOR | 212707 | 0 | 17393 | 0 | 18980 | 0 | 41685 | 0 | 8473 | 0 | 299238 | 0 | 17393 | 0 |
| DR GISELLE SHOLLER DONE 613 | ||||||||||||||
| INVESTIGATOR | 234395 | 0 | 14223 | 0 | 300 | 0 | 41858 | 0 | 1409 | 0 | 292185 | 0 | 14223 | 0 |
| DR SCOTT JEWELL | ||||||||||||||
| INVESTIGATOR | 265546 | 0 | 64557 | 0 | 1315 | 0 | 50795 | 0 | 8473 | 0 | 390686 | 0 | 31557 | 0 |
| LOVE COLLINS III | ||||||||||||||
| VICE PRESIDENT OF DEVELOPMENT, COMM. | 250054 | 0 | 20000 | 0 | 1290 | 0 | 74259 | 0 | 8473 | 0 | 354076 | 0 | 0 | 0 |
| DR JEFFREY TRENT DONE 312 | ||||||||||||||
| PRESIDENT & RESEARCH DIRECTOR | 456207 | 0 | 210328 | 0 | 35944 | 0 | 5280 | 0 | 352 | 0 | 708111 | 0 | 210000 | 0 |
| R JACK FRICK DONE 1211 | ||||||||||||||
| CHIEF ADMINISTRATIVE OFFICER | 18180 | 0 | 75732 | 0 | 179465 | 0 | 0 | 0 | 0 | 0 | 273377 | 0 | 47748 | 0 |
Form990 Schedule J Part III Form990ScheduleJPartIII (4 entries)
| Return ReferenceReturnReference | ExplanationExplanation |
|---|---|
| PART I, LINE 1A | VARI ALLOWS FOR FIRST-CLASS OR CHARTER TRAVEL FOR OFFICERS AND TRUSTEES. |
| PART I, LINE 1B | A WRITTEN POLICY IS IN PLACE FOR FIRST CLASS/ CHARTER TRAVEL. |
| PART I, LINE 4A | R. JACK FRICK RECEIVED SEVERANCE PAYMENTS OF $169,600 DURING CALENDAR YEAR 2012. |
| PART I, LINE 7 | ALL OFFICERS AND OTHER HIGHLY COMPENSATED EMPLOYEES ARE INCLUDED IN A VARIABLE PAY PLAN BASED ON ACHIEVEMENTS OF THE ORGANIZATION AS WELL AS RESPECTIVE INDIVIDUAL PREDETERMINED GOALS AND OBJECTIVES. |
Schedule K IRS990ScheduleK
Form990 Schedule K Part I Form990ScheduleKPartI
| Field | Value | IRS element (for citing) |
|---|---|---|
| Bond Reference | A | BondReferenceCd |
Issuer Name IssuerName
| Field | Value | IRS element (for citing) |
|---|---|---|
| Business Name Line1 | MICHIGAN STRATEGIC FUND | BusinessNameLine1 |
| Field | Value | IRS element (for citing) |
|---|---|---|
| Issuer EIN | 521417332 | IssuerEIN |
| Date Issued | 2013-04-01 | DateIssued |
| Issue Price | 220000000 | IssuePrice |
| Description Of Purpose | REFUND BOND ISSUE 4/10/08 | DescriptionOfPurpose |
| Defeased | 0 | Defeased |
| On Behalf Of Issuer | 0 | OnBehalfOfIssuer |
| Pool Financing | 0 | PoolFinancing |
Form990 Schedule K Part II Form990ScheduleKPartII
| Field | Value | IRS element (for citing) |
|---|---|---|
| Bond Reference | A | BondReferenceCd |
| Total Proceeds | 220000000 | TotalProceeds |
| Other Spent Proceeds | 220000000 | OtherSpentProceeds |
| Current Refunding | 1 | CurrentRefunding |
| Advance Refunding | 0 | AdvanceRefunding |
| Final Allocation Made | 1 | FinalAllocationMade |
| Adequate Books And Recds Maintaind | 1 | AdequateBooksAndRecdsMaintaind |
Form990 Schedule K Part III Form990ScheduleKPartIII
| Field | Value | IRS element (for citing) |
|---|---|---|
| Bond Reference | A | BondReferenceCd |
| Owning Bond Financed Property | 0 | OwningBondFinancedProperty |
| Any Lease Arrangements | 1 | AnyLeaseArrangements |
| Mngment Cntrct Bond Financd Prprty | 1 | MngmentCntrctBondFinancdPrprty |
| Engage Bond Counsel Contracts | 1 | EngageBondCounselContracts |
| Any Research Agreements | 1 | AnyResearchAgreements |
| Engage Bond Counsel Research | 1 | EngageBondCounselResearch |
| Percentage Of Prvt Business Re UBI | 0.00910 | PercentageOfPrvtBusinessReUBI |
| Total Private Business Use | 0.00910 | TotalPrivateBusinessUse |
| Bond Iss Meet Prvt Security Pay Test | 0 | BondIssMeetPrvtSecurityPayTest |
| Change In Use Bond Financed Prop | 0 | ChangeInUseBondFinancedProp |
| Non Qualified Bond Remed Procdrs | 1 | NonQualifiedBondRemedProcdrs |
Form990 Schedule K Part IV Form990ScheduleKPartIV
| Field | Value | IRS element (for citing) |
|---|---|---|
| Bond Reference | A | BondReferenceCd |
| Form8038 T Filed | 0 | Form8038TFiled |
| Rebate Not Due Yet | 0 | RebateNotDueYet |
| Exception To Rebate | 0 | ExceptionToRebate |
| No Rebate Due | 1 | NoRebateDue |
| Variable Rate Issue | 1 | VariableRateIssue |
| Hedge Identified In Books And Recds | 0 | HedgeIdentifiedInBooksAndRecds |
| Gross Proceeds Invested In GIC | 0 | GrossProceedsInvestedInGIC |
| Gross Proceeds Invested | 0 | GrossProceedsInvested |
| Written Proc To Monitor Reqs | 1 | WrittenProcToMonitorReqs |
Form990 Schedule K Part V Form990ScheduleKPartV
| Field | Value | IRS element (for citing) |
|---|---|---|
| Bond Reference | A | BondReferenceCd |
| Proc To Undertk Corrective Action | 1 | ProcToUndertkCorrectiveAction |
Form990 Schedule K Part VI Form990ScheduleKPartVI
| Field | Value | IRS element (for citing) |
|---|---|---|
| Identifier | SCHEDULE K PART IV, ARBITRAGE, LINE 2C | Identifier |
| Return Reference | DATE REBATE COMPUTATION PERFORMED | ReturnReference |
| Explanation | ISSUER NAME: MICHIGAN STRATEGIC FUND DATE THE REBATE COMPUTATION WAS PERFORMED: 11/30/2013 | Explanation |
Schedule L IRS990ScheduleL
Loan Table LoanTable
| Field | Value | IRS element (for citing) |
|---|---|---|
| Name Person | PATRIK BRUNDIN | NamePerson |
| Relationship With Organization | KEY EMPLOYEE | RelationshipWithOrganization |
| Purpose Of Loan | CONTRACT | PurposeOfLoan |
| Loan From Organization | X | LoanFromOrganization |
| Original Principal | $25,000 | OriginalPrincipalAmount |
| Balance Due | 18355 | BalanceDue |
| Default | 0 | Default |
| Approved By Board | 0 | ApprovedByBoard |
| Written Agreement | 1 | WrittenAgreement |
| Field | Value | IRS element (for citing) |
|---|---|---|
| Total Balance Due | 18355 | TotalBalanceDue |
Form990 Schedule L Part IV Form990ScheduleLPartIV
Name Of Interested Person NameOfInterestedPerson
Name Business NameBusiness
| Field | Value | IRS element (for citing) |
|---|---|---|
| Business Name Line1 | JVAE FOUNDATION | BusinessNameLine1 |
| Field | Value | IRS element (for citing) |
|---|---|---|
| Relationship | COMMON TRUSTEES | Relationship |
| Amount Of Transaction | 177994 | AmountOfTransaction |
| Description Of Transaction | IT CONSULTING/ SERVICES | DescriptionOfTransaction |
| Sharing Of Revenues | 0 | SharingOfRevenues |
Schedule O IRS990ScheduleO
General Explanation GeneralExplanation (12 entries)
| Return ReferenceReturnReference | ExplanationExplanation | IdentifierIdentifier |
|---|---|---|
| FORM 990, PART VI, SECTION A, LINE 2 | VARI AND VAEI SHARE COMMON MANAGEMENT. AS OFFICERS OF VARI, DAVID VAN ANDEL, DR. JANA HALL, TIMOTHY MYERS AND DAVID WHITESCARVER INTERACT AND WORK TOGETHER WITH STEVE TRIEZENBERG, AN OFFICER OF VAEI. | |
| FORM 990, PART VI, SECTION A, LINE 3 | DURING THE FISCAL YEAR, JERRY CALLAHAN, FORMERLY AN INDEPENDENT CONTRACTOR, BECAME A FULL TIME EMPLOYEE (IN JANUARY 2013) AS THE VICE PRESIDENT OF BUSINESS DEVELOPMENT AND EXTRAMURAL ADMINISTRATION. | |
| FORM 990, PART VI, SECTION A, LINE 7A | THE TRUSTEES OF VAN ANDEL INSTITUTE HAVE THE AUTHORITY TO ELECT ONE OR MORE MEMBERS OF VARI'S GOVERNING BODY. | |
| FORM 990, PART VI, SECTION B, LINE 11 | FOLLOWING COMPLETION OF THE FINANCIAL STATEMENT AUDIT, THE FORM 990 IS PREPARED AND REVIEWED BY MANAGEMENT. IT IS THEN CIRCULATED TO THE FULL BOARD FOR REVIEW AND FINAL APPROVAL PRIOR TO FILING WITH THE IRS. | |
| FORM 990, PART VI, SECTION B, LINE 12C | VARI HAS WRITTEN CONFLICT OF INTEREST ("COI") POLICIES AND PROCEDURES (ADMINISTERED BY VAN ANDEL INSTITUTE) WHICH ADMINISTER AND ENFORCE A PROCESS TO IDENTIFY, EVALUATE, AND MANAGE POTENTIAL COIS. THESE POLICIES HAVE BEEN BOARD APPROVED. VAI ADMINISTERS THE COI POLICIES AND PROCEDURES THROUGH TWO COMMITTEES: THE CONFLICTS COMMITTEE ("CC") AND THE INSTITUTIONAL COI COMMITTEE ("ICOIC"). THE COI POLICIES AND PROCEDURES APPLY TO AND SERVE AS A GUIDE FOR EVERYONE IN THE ORGANIZATION. THEY 1) PROVIDE A USEFUL RESOURCE WHEN DEVELOPING ACTIVITIES OR RELATIONSHIPS WITH OUTSIDE ENTITIES OR PERSONS, AND 2) ESTABLISH COMMITTEES TO REVIEW AND MANAGE POTENTIAL COIS AS THEY MAY ARISE. THE CC, CHAIRED BY THE CHIEF LEGAL OFFICER, REQUIRES ANNUAL AND UPDATED DISCLOSURES BY COVERED PERSONS AND REVIEWS AND APPROVES MANAGEMENT PLANS. THE INSTITUTIONAL COI POLICIES AND PROCEDURES SERVE AS A GUIDE FOR MEMBERS OF THE BOARDS OF TRUSTEES AND SENIOR EXECUTIVES. IN THE EVENT A POTENTIAL COI ARISES AT THE BOARD OR SENIOR EXECUTIVE LEVEL, THE ICOIC MEETS TO REVIEW AND DECIDE HOW TO MANAGE SUCH POTENTIAL COIS IN ACCORDANCE WITH THE COI POLICIES AND PROCEDURES. | |
| FORM 990, PART VI, SECTION B, LINE 15 | COMPARABILITY DATA FROM EXPERT THIRD PARTY IS OBTAINED AND REVIEWED BY VAN ANDEL INSTITUTE'S INDEPENDENT COMPENSATION COMMITTEE TO DETERMINE APPROPRIATE COMPENSATION FOR THE CEO, EXECUTIVE MANAGEMENT OFFICIALS, OFFICERS, AND KEY EMPLOYEES, ON BEHALF OF VAN ANDEL RESEARCH INSTITUTE. | |
| FORM 990, PART VI, SECTION C, LINE 19 | THE CONFLICT OF INTEREST POLICY AND FINANCIAL STATEMENTS ARE AVAILABLE TO THE PUBLIC UPON REQUEST. | |
| FORM 990, PART XI, LINE 9: | GAIN ON INTEREST RATE SWAP 32,753,463. CHANGE IN BALANCE SHEET PRESENTATION OF TMS 633,403. | CHANGES IN NET ASSETS OR FUND BALANCES: |
| FORM 990, PART III, LINES 4A-4B | LINE 4A - PROGRAM SERVICE ACTIVITY #1 VARI'S PROGRAM FOR BIOSPECIMEN SCIENCE SUPPORTS SCIENTIFIC RESEARCH AND DISCOVERY BY PROVIDING COMPREHENSIVE BIOSPECIMEN SERVICES FOR VARI SCIENTISTS AND EXTERNAL COLLABORATORS. THE PROGRAM FOR BIOSPECIMEN SCIENCE FOCUSES ON THE CHANGE AND QUALITY OF BIOSPECIMENS CAUSED BY COLLECTION, PROCESSING AND STORAGE PROCEDURES. THE PROGRAM'S RESEARCH IDENTIFIES EFFECTS ON THE CELL BIOLOGY OF SAMPLES THAT MAY BE UNRELATED TO THE DISEASE AND MORE SO CAUSED BY THE MANAGEMENT OF THE BIOSPECIMEN. THE RESULTS CAN BE USED TO DEVELOP BEST PRACTICES IN THE MANAGEMENT OF BIOSPECIMENS AND, ULTIMATELY, IMPROVE THE QUALITY OF RESEARCH FINDINGS. THE PROGRAM FOR BIOSPECIMEN SCIENCE ALSO ENCOMPASSES VARI'S NATIONALLY AND INTERNATIONALLY RECOGNIZED BIOREPOSITORY, WHICH PROVIDES SCIENTIFIC EVALUATION ON THE PATTERNS OF DEGRADATION IN BIOSPECIMENS; DATABASE TRACKING AND MANAGEMENT OF BIOSPECIMEN INVENTORY; PROCUREMENT OF SURGICAL TISSUE AND BIOSPECIMENS FROM PATIENT POPULATIONS; QUALITY CONTROL ASSESSMENT OF OPERATIONS FOR THE COLLECTION AND BANKING OF BIOSPECIMENS; AND BIOSPECIMEN PROJECT MANAGEMENT. VARI'S BIOREPOSITORY ALSO SERVES AS THE NATIONAL CANCER INSTITUTE'S COMPREHENSIVE BIOSPECIMEN RESOURCE FOR THE CANCER HUMAN BIOBANK (CAHUB) AND PROVIDES BIOREPOSITORY SERVICES FOR THE MULTIPLE MYELOMA RESEARCH FOUNDATION (MMRF). THE BIOREPOSITORY HAS COLLECTED AND STORED MORE THAN 30,000 BIOSPECIMENS FOR THESE PROGRAMS, WHICH AID SCIENTISTS IN THEIR RESEARCH BY PROVIDING HUMAN TUMOR SAMPLES IN WHICH TO STUDY GENE EXPRESSION (CAHUB) AND TO CONDUCT MOLECULAR PROFILING OF MULTIPLE MYELOMA (MMRF). CURRENTLY, THE BIOREPOSITORY CONTAINS MORE THAN 5,000 CONSENTED, PROSPECTIVELY PROCURED HUMAN BIOSPECIMENS, INCLUDING TISSUES, AND BLOOD BYPRODUCTS AND THEIR DERIVATIVES FROM MORE THAN 400 PATIENTS. ADDITIONALLY, THE BIOREPOSITORY HOUSES AN EXTENSIVE PARAFFIN BLOCK ARCHIVE OF HUMAN DIAGNOSTIC TISSUES, WHICH CURRENTLY EXCEEDS 900,000 BLOCKS GATHERED FROM ABOUT 250,000 CASES. ACQUISITION OF THESE SAMPLES IS CONDUCTED IN PART BY COLLABORATION WITH WEST MICHIGAN HOSPITALS (INCLUDING SPECTRUM HEALTH). THIS BIOREPOSITORY IS A CRUCIAL RESOURCE FOR SCIENTISTS WITH INSTITUTIONAL REVIEW BOARD (IRB) APPROVAL TO STUDY CANCER AND OTHER HUMAN DISEASES USING STORED BIOSPECIMENS FROM THE BIOREPOSITORY. VARI'S BIOREPOSITORY IS ACCREDITED BY THE COLLEGE OF AMERICAN PATHOLOGISTS (CAP) THROUGH ITS BIOREPOSITORY ACCREDITATION PROGRAM (BAP). ITS ACCREDITATION NUMBER IS 8017856 AND COVERS GENERAL BIOREPOSITORY, GENERAL SPECIMEN PROCESSING, NUCLEIC ACID EXTRACTION, SPECIMEN COLLECTION AND PROCUREMENT, SPECIMEN DISTRIBUTION AND AGREEMENTS, SPECIMEN INFORMATICS, AND SPECIMEN STORAGE. VARI'S BIOREPOSITORY ALSO IS A FOUNDING MEMBER OF THE GREAT LAKES BIOREPOSITORY RESEARCH NETWORK (GLBRN). LINE 4B - PROGRAM SERVICE ACTIVITY #2 THE LABORATORY OF STRUCTURAL SCIENCES FOCUSES ON STUDYING THE STRUCTURES AND FUNCTIONS OF PROTEIN/LIGAND COMPLEXES THAT PLAY KEY ROLES IN MAJOR HORMONE SIGNALING PATHWAYS. THE LABORATORY ALSO EXPLORES STRUCTURAL INFORMATION TO DEVELOP THERAPEUTIC AGENTS FOR TREATING HUMAN DISEASES, INCLUDING CANCER AND DIABETES. THE LAB USES A MULTIDISCIPLINARY APPROACH INCLUDING MOLECULAR AND CELLULAR BIOLOGY, BIOCHEMISTRY, ANIMAL PHYSIOLOGY, AND X-RAY CRYSTALLOGRAPHY. THE LAB'S CURRENT WORK FOCUSES ON THREE AREAS: NUCLEAR HORMONE RECEPTORS, THE MET TYROSINE KINASE RECEPTOR, AND G PROTEIN-COUPLED RECEPTORS (GPCRS). IN ADDITION TO THEIR FUNDAMENTAL ROLES IN BIOLOGY, THESE PROTEINS ARE IMPORTANT DRUG TARGETS. IN THE REALM OF NUCLEAR HORMONE RECEPTORS, THE LAB HAS DETERMINED THE CRYSTAL STRUCTURES OF PEROXISOME PROLIFERATOR-ACTIVATED RECEPTORS (PPAR) LIGAND-BINDING DOMAIN (LBD) BOUND TO MANY DIVERSE LIGANDS. THIS AIDS IN OUR UNDERSTANDING OF THE MOLECULAR BASIS OF LIGAND-MEDIATED SIGNALING BY PPARS. WE FOUND THAT THE CRYSTAL STRUCTURES OF THE RECEPTORS ARE BOUND TO COACTIVATORS OR CO-REPRESSORS, WHICH PROVIDES A FRAMEWORK FOR UNDERSTANDING THE MECHANISMS OF PPAR AGONISTS AND ANTAGONISTS, AND THE RECRUITMENT OF COACTIVATORS AND CO-REPRESSORS. THE LAB ALSO FOUND THAT ANDROGEN RECEPTOR (AR) MUTATIONS IN PROSTATE CANCERS OFTEN RESULTS IN ENHANCED BINDING TO A PARTICULAR COACTIVATOR, SRC-3 (WHICH IS ALSO CALLED "AMPLIFIED IN BREAST CANCER1", OR AIB1). LASTLY, WE FOUND THAT RETINOIC ACID IS A LOW-AFFINITY LIGAND FOR COUP-TF, WHICH IS ONE OF THE MOST CONSERVED NUCLEAR RECEPTORS AND HAS ESSENTIAL ROLES IN ANGIOGENESIS, HEART DEVELOPMENT, CENTRAL NERVOUS SYSTEM ACTIVITY, AND METABOLIC HOMEOSTASIS. FOR THE MET TYROSINE KINASE RECEPTOR, THE LAB HAS ENGINEERED AND DETERMINED THE CRYSTAL STRUCTURE OF THE C-MET LIGAND, HEPATOCYTE GROWTH FACTOR, NK1 AND NK2 VARIANTS. IN REGARD TO G PROTEIN-COUPLED RECEPTORS (GPCRS), WE HAVE DETERMINED CRYSTAL STRUCTURES OF THE LIGAND-BINDING DOMAIN OF THE PTH RECEPTOR AND THE CRF RECEPTOR, AND WE ARE DEVELOPING HORMONE ANALOGS FOR TREATING OSTEOPOROSIS, DEPRESSION, AND DIABETES. ADDITIONALLY, WE ARE DEVELOPING A MAMMALIAN OVEREXPRESSION SYSTEM AND PLAN TO USE IT TO EXPRESS FULL-LENGTH GPCRS FOR CRYSTALLIZATION AND STRUCTURAL STUDIES. THE LAB ALSO STUDIES THE PLANT HORMONE ABSCISIC ACID (ABA) AND ITS ASSOCIATED SIGNALING PATHWAYS, WITH THE STRUCTURES OF ABA RECEPTORS BEING HIGHLIGHTED AS ONE OF TOP 10 SCIENTIFIC BREAKTHROUGHS BY SCIENCE IN 2009. THIS WORK HAS SIGNIFICANT IMPLICATIONS FOR ENHANCING DROUGHT RESISTANCE IN PLANTS. | |
| FORM 990, PART III, LINES 4C-4D | LINE 4C - PROGRAM SERVICE ACTIVITY #3 MET IS OVEREXPRESSED IN MANY TYPES OF HUMAN CANCER AND ITS EXPRESSION CORRELATES WITH AGGRESSIVE DISEASE AND POOR PROGNOSIS (WWW.VAI.ORG/MET). SINCE DISCOVERING THE C-MET RECEPTOR TYROSINE KINASE AND ITS LIGAND HEPATOCYTE GROWTH FACTOR (HGF/SF) IN THE MID-1980S, THE VANDE WOUDE LAB HAS FOCUSED ON INVESTIGATING THE KEY ROLE THESE MOLECULES PLAY IN MALIGNANT PROGRESSION OR THE INVASIVE SPREAD OF THE CANCER FOLLOWED BY METASTATIC COLONIZATION. AS PART OF THE ONGOING EFFORT TO FURTHER ENHANCE OUR UNDERSTATING OF THIS SIGNALING SYSTEM, THE LABORATORY OF MOLECULAR ONCOLOGY FOCUSES ON THE MECHANISMS RESPONSIBLE FOR TUMOR PROGRESSION WITH THE HYPOTHESIS THAT PHENOTYPIC SWITCHING (E-MT/M-ET) AND CHROMOSOME INSTABILITY CAN DRIVE TUMOR PROGRESSION. ADDITIONALLY, WE CONTINUE TO DEVELOP AND CHARACTERIZE NOVEL ANIMAL RESEARCH MODELS THAT ARE USED IN PRECLINICAL EVALUATION OF NEW INHIBITORS THAT TARGET C-MET IN A VARIETY OF HUMAN CANCERS. TUMOR PHENOTYPIC SWITCHING: MECHANISM AND THERAPEUTIC IMPLICATION IN HUMAN CARCINOMAS, CANCER CELLS' ABILITY TO INVADE OTHER TISSUES REQUIRES A BREAKDOWN OF THE JUNCTIONS BETWEEN NEIGHBORING CELLS, A PROCESS CALLED THE EPITHELIAL-TO-MESENCHYMAL TRANSITION (E-MT). EPITHELIAL CELLS LINE BODY CAVITIES, WHILE MESENCHYMAL CELLS ARE CELLS THAT CAN DIFFERENTIATE INTO CELL TYPES SUCH AS BONE, CARTILAGE AND FAT. PARADOXICALLY, METASTATIC CARCINOMAS OFTEN EXHIBIT AN EPITHELIAL PHENOTYPE, LEADING TO THE HYPOTHESIS THAT E-MT IS A TRANSIENT PROCESS INDUCED BY MICROENVIRONMENTAL FACTORS (E.G., THE CONDITIONS THAT SURROUND THE TUMOR). UPON SPREADING TO SECONDARY SITES, MESENCHYMAL CELLS REVERT TO AN EPITHELIAL PHENOTYPE (MESENCHYMAL-TO-EPITHELIAL TRANSITION; M-ET). TYPICALLY, HUMAN CARCINOMA TISSUES AND CELLS EXHIBIT EXTENSIVE DIVERSITY IN BOTH PHENOTYPE (PHYSICAL TRAIT) AND GENOTYPE (GENETIC MAKEUP), SUGGESTING A ROLE FOR GENETIC INSTABILITY IN CELL TYPE DETERMINATION. TO TEST THIS POSSIBILITY, WE HAVE DEVELOPED METHODS TO CONTINUALLY ISOLATE PHENOTYPIC VARIANTS FROM EPITHELIAL OR MESENCHYMAL SUBCLONES OF CARCINOMA CELL LINES. WE HAVE EXPLORED THE SIGNAL PATHWAY UNDERLYING E-MT/M-ET PHENOTYPIC SWITCHING USING SEVERAL APPROACHES, INCLUDING GENE EXPRESSION ANALYSIS, SPECTRAL KARYOTYPING (SKY), AND FLUORESCENT IN SITU HYBRIDIZATION (FISH). WE FOUND THAT CHANGES IN CHROMOSOME CONTENT ARE ASSOCIATED WITH PHENOTYPIC SWITCHING. WE FURTHER SHOWED THAT THESE CHANGES DICTATED THE EXPRESSION OF SPECIFIC GENES, WHICH IN E-MT EVENTS ARE MESENCHYMAL AND IN M-ET EVENTS ARE EPITHELIAL. OUR RESULTS SUGGEST THAT CHROMOSOME INSTABILITY CAN PROVIDE THE DIVERSITY OF GENE EXPRESSION NEEDED FOR TUMOR CELLS TO SWITCH PHENOTYPE. IN VIVO RESEARCH MODELS: MODEL DEVELOPMENT AND PRECLINICAL TREATMENT EVALUATION ANTI-CANCER THERAPY BASED ON BLOCKING THE HGF-MET SIGNALING PATHWAY HAS EMERGED AS AN IMPORTANT GOAL OF PHARMACEUTICAL RESEARCH. ONE OF THE LIMITATIONS OF STUDYING ALTERED MET/HGF/SF SIGNALING IN HUMAN CANCERS IN MOUSE MODELS HAS BEEN THAT THE MOUSE HGF/SF PROTEIN SHOWS LOW AFFINITY FOR HUMAN MET. TO OVERCOME THIS CHALLENGE, OUR LAB DEVELOPED THE TRANSGENIC HUMAN HGF/SCID MOUSE MODEL (HHGFTG-SCID) THAT GENERATES A HUMAN-COMPATIBLE HGF/SF PROTEIN, THUS ALLOWING THE GROWTH OF HUMAN TUMORS (ZHANG ET AL 2005). THIS MODEL HAS BEEN PROVEN AS A VALUABLE PRECLINICAL TOOL FOR IN VIVO STUDY OF MET-DEPENDENT CANCERS AND IS USED TO EVALUATE TREATMENT STRATEGIES THAT AIM TO TARGET THIS PATHWAY (ZHANG ET AL 2010, 2013; XIE ET AL, 2013). FORM 990, PART III, LINE 4D IN 2013, VARI RESEARCHERS FOUND WAYS TO POTENTIALLY DIAGNOSE AND FIGHT SEVERAL DIFFERENT TYPES OF CANCER AND NEURODEGENERATIVE DISEASES. BELOW ARE EXAMPLES OF SIGNIFICANT RESEARCH FINDINGS: - IN 2013 VAI PARTICIPATES IN THE LINKED CLINICAL TRIALS INITIATIVE DESIGNED BY THE CURE PARKINSON'S TRUST TO IDENTIFY NEW TREATMENTS FOR PARKINSON'S DISEASE BY REPURPOSING MEDICATIONS APPROVED TO TREAT OTHER CONDITIONS. - THE VAI'S CENTER FOR NEURODEGENERATIVE SCIENCE DIRECTOR AND COLLEAGUES IN EUROPE SHOWED THAT A MISFOLDED PROTEIN ASSOCIATED WITH PARKINSON'S DISEASE CAN TRAVEL FROM NEURONS IN THE OLFACTORY BULB - ONE OF THE AREAS FIRST IMPACTED BY THE DISEASE - TO OTHER REGIONS. THIS MAY LEAD TO NEW THERAPIES THAT SLOW PROGRESSION OF PARKINSON'S DISEASE. -VAI SCIENTISTS HAVE SHOWN THE INTERACTION BETWEEN MET AND HER2 (ERBB2+) RECEPTORS (TWO IMPORTANT GENES RELATED TO CANCER) IS LINKED TO TUMORS RESISTANT TO TARGETED THERAPIES. - ANXIETY, DEPRESSION AND MIGRAINES VAI SCIENTISTS ALONG WITH COLLEAGUES IN CHINA DISCOVERED THE STRUCTURAL BLUEPRINT THAT WILL AID IN THE DESIGN OF MORE SELECTIVE ACTIVATORS OF SEROTONIN RECEPTORS. SEROTONIN IS A NEUROTRANSMITTER AND ITS RECEPTORS ARE IMPORTANT DRUG TARGETS FOR CONDITIONS SUCH AS ANXIETY, DEPRESSION AND MIGRAINES. - RESEARCH INITIATED IN VAI'S CENTER FOR CANCER AND CELL BIOLOGY AND CONTINUED WITH COLLEAGUES IN THE CENTER FOR SKELETAL DISEASE AND TUMOR METASTASIS HAVE LINKED A DEFICIENCY OF MIG-6, A GENE ASSOCIATED WITH JOINT STABILITY, TO OSTEOARTHRITIS DEVELOPMENT AND THE REGULATION OF CARTILAGE CELLS. THIS WORK COULD LEAD TO DISEASE-MODIFYING TREATMENTS FOR OSTEOARTHRITIS. - VAI SCIENTISTS ARE WORKING TO FURTHER UNDERSTAND A KEY SIGNALING PATHWAY THAT MAY PROVIDE MORE EFFECTIVE TREATMENTS FOR PATIENTS WHOSE PROSTATE CANCER HAS SPREAD TO THEIR BONES. - SCIENTISTS IN VAI'S CENTER FOR SKELETAL DISEASE AND TUMOR METASTASIS HAVE SHOWN THAT A MUTATION OF THE LRP6 GENE CAN LEAD TO SEVERE OSTEOARTHRITIS AND FURTHER CLARIFIES THE ROLES OF THE LRP6 AND LRP5 GENES IN BONE STABILITY. BY USING A GENETIC MODEL, VAI SCIENTISTS WERE ABLE TO ASCERTAIN A CLEAR LINK BETWEEN THE GENES AND THE CELLS RESPONSIBLE FOR THE FORMATION OF BONE. - USING MELANOMA-BASED AVATAR MODELS THAT MIRROR HUMAN TUMOR PROGRESSION, VAI SCIENTISTS IDENTIFIED SEVERAL ACQUIRED DRUG RESISTANCE MECHANISMS TO TARGETED CANCER THERAPIES. THE GROUP ALSO IDENTIFIED A COMBINATION DRUG APPROACH THAT LED TO SUSTAINED REMISSIONS IN A VALIDATED PRE-CLINICAL SYSTEM. - VAI SCIENTISTS HAVE DEVELOPED A NEW METHOD THAT WILL AID IN THE DIAGNOSIS OF PRECANCEROUS CYSTS IN THE PANCREAS, WHICH CAN DEVELOP INTO AN AGGRESSIVE FORM OF CANCER. | |
| FORM 990, PART X, LINE 33 | VARI NET ASSETS ARE CONSIDERED ON A CONSOLIDATED BASIS WITH VAN ANDEL INSTITUTE (VAI), VAN ANDEL EDUCATION INSTITUTE (VAEI), AND THE TRANSLATIONAL GENOMICS RESEARCH INSTITUTE (2012 ONLY), RELATED PARTIES. ON A CONSOLIDATED BASIS, NET ASSETS ARE $1,173,409,000 PER AUDITED FINANCIAL STATEMENTS. THE NEGATIVE NET ASSET BALANCE AT VARI IS DUE TO VAI FUNDING EXPENSES ON A CASH BASIS AND THE UNREALIZED LOSS RECORDED IN ASSOCIATION WITH THE INTEREST RATE SWAP. | |
| FORM 990, PART IX, COLUMN D | FUNDRAISING EXPENSES AT VARI WERE INCURRED TO SUPPORT THE MISSION OF THE RESEARCH INSTITUTE THROUGH DONOR SOLICITATION, GRANT SOLICITATION AND EXTRAMURAL PROPOSAL PREPARATION. |
Schedule R IRS990ScheduleR
Form990 Schedule R Part I Form990ScheduleRPartI (4 entries)
| Address Line1AddressUS/AddressLine1 | CityAddressUS/City | StateAddressUS/State | ZIP CodeAddressUS/ZIPCode | EINEIN | Primary ActivitiesPrimaryActivities | Legal Domicile StateLegalDomicileState | Total IncomeTotalIncome | EOY AssetsEOYAssets | Business Name Line1DirectControllingEntityName/BusinessNameLine1 |
|---|---|---|---|---|---|---|---|---|---|
| VAI INNOVATIONS LLC | |||||||||
| 333 BOSTWICK AVENUE NE | GRAND RAPIDS | MI | 495032518 | 522000823 | LICENSING INTELLECTUAL PROPERTY OF VARI | MI | -628663 | 10174 | VAN ANDEL RESEARCH INSTITUTE |
| VARI INTERNATIONAL | |||||||||
| 333 BOSTWICK AVENUE NE | GRAND RAPIDS | MI | 495032518 | 262615936 | BIOMEDICAL RESEARCH | MI | 32 | 0 | VAN ANDEL RESEARCH INSTITUTE |
| BOSTWICK EVENT MANAGEMENT | |||||||||
| 333 BOSTWICK AVENUE NE | GRAND RAPIDS | MI | 495032518 | 522000823 | EVENT MANAGEMENT | MI | 5866 | 117458 | VAN ANDEL RESEARCH INSTITUTE |
| VARI-CLINXUS LLC (TRANSFERRED 82213) | |||||||||
| 333 BOSTWICK AVENUE NE | GRAND RAPIDS | MI | 495032518 | 274015168 | CLINICAL TRIALS | MI | -331866 | 40161 | VAN ANDEL RESEARCH INSTITUTE |
Form990 Schedule R Part II Form990ScheduleRPartII (3 entries)
| Address Line1AddressUS/AddressLine1 | CityAddressUS/City | StateAddressUS/State | ZIP CodeAddressUS/ZIPCode | EINEIN | Primary ActivitiesPrimaryActivities | Legal Domicile StateLegalDomicileState | Exempt Code SectionExemptCodeSection | Public Charity StatusPublicCharityStatus | Direct Controlling Entity NADirectControllingEntityNA | Controlled OrgControlledOrg | Business Name Line1DirectControllingEntityName/BusinessNameLine1 |
|---|---|---|---|---|---|---|---|---|---|---|---|
| VAN ANDEL INSTITUTE | |||||||||||
| 333 BOSTWICK AVENUE NE | GRAND RAPIDS | MI | 495032518 | 522000820 | SUPPORTING ORGANIZATION FOR VARI AND VAEI | MI | 501(C)(3) | 11C | N/A | 0 | |
| VAN ANDEL EDUCATION INSTITUTE | |||||||||||
| 333 BOSTWICK AVENUE NE | GRAND RAPIDS | MI | 495032518 | 522000824 | OPERATING A SCIENCE EDUCATION PROGRAM | MI | 501(C)(3) | 2 | 1 | VAN ANDEL INSTITUTE | |
| VAN ANDEL INSTITUTE GRADUATE SCHOOL | |||||||||||
| 333 BOSTWICK AVENUE NE | GRAND RAPIDS | ME | 495032518 | 203340886 | OPERATING A GRADUATE SCHOOL | MI | 501(C)(3) | 2 | 1 | VAN ANDEL EDUCATION INSTITUTE | |
Form990 Schedule R Part IV Form990ScheduleRPartIV
Name Of Related Org NameOfRelatedOrg
| Field | Value | IRS element (for citing) |
|---|---|---|
| Business Name Line1 | TRANSMED SYSTEMS INC | BusinessNameLine1 |
Address US AddressUS
| Field | Value | IRS element (for citing) |
|---|---|---|
| Address Line1 | 21170 CANYON OAK WAY | AddressLine1 |
| City | CUPERTINO | City |
| State | CA | State |
| ZIP Code | 95014 | ZIPCode |
| Field | Value | IRS element (for citing) |
|---|---|---|
| EIN | 272358859 | EIN |
| Primary Activity | PERSONALIZED MEDICINE SOFTWARE AND SERVICES | PrimaryActivity |
| Legal Domicile State | DE | LegalDomicileState |
Direct Controlling Entity Name DirectControllingEntityName
| Field | Value | IRS element (for citing) |
|---|---|---|
| Business Name Line1 | VAI INNOVATIONS LLC | BusinessNameLine1 |
| Field | Value | IRS element (for citing) |
|---|---|---|
| Type Of Entity | C | TypeOfEntity |
| Share Of Total Income | -1274453 | ShareOfTotalIncome |
| Share Of EOY Assets | 880871 | ShareOfEOYAssets |
| Percentage Ownership | 0.31930 | PercentageOwnership |
| Controlled Org | 0 | ControlledOrg |
| Field | Value | IRS element (for citing) |
|---|---|---|
| Receipt Of Int Ann Rents Royalties | 1 | ReceiptOfIntAnnRentsRoyalties |
| Gift Grant Or Cap Contr To Other Org | 1 | GiftGrantOrCapContrToOtherOrg |
| Gift Grant Or Cap Contr Fr Other Org | 1 | GiftGrantOrCapContrFrOtherOrg |
| Loans Or Guarantees To Other Org | 0 | LoansOrGuaranteesToOtherOrg |
| Loans Or Guarantees From Other Org | 1 | LoansOrGuaranteesFromOtherOrg |
| Dividends Related Organization | 0 | DividendsRelatedOrganization |
| Sale Of Assets To Other Org | 0 | SaleOfAssetsToOtherOrg |
| Purchase Of Assets From Other Org | 0 | PurchaseOfAssetsFromOtherOrg |
| Exchange Of Assets | 0 | ExchangeOfAssets |
| Rental Of Facilities To Other Orgs | 0 | RentalOfFacilitiesToOtherOrgs |
| Rental Of Facilities Fr Other Orgs | 0 | RentalOfFacilitiesFrOtherOrgs |
| Perform Of Services For Other Orgs | 1 | PerformOfServicesForOtherOrgs |
| Perform Of Services By Other Orgs | 0 | PerformOfServicesByOtherOrgs |
| Sharing Of Facilities | 1 | SharingOfFacilities |
| Sharing Of Paid Employees | 1 | SharingOfPaidEmployees |
| Reimbursement Paid To Other Org | 1 | ReimbursementPaidToOtherOrg |
| Reimbursement Paid By Other Org | 1 | ReimbursementPaidByOtherOrg |
| Other Transfer To Other Org | 1 | OtherTransferToOtherOrg |
| Other Transfer From Other Org | 0 | OtherTransferFromOtherOrg |
Transactions Related Orgs Table TransactionsRelatedOrgsTable (17 entries)
| Transaction TypeTransactionType | Amount InvolvedAmountInvolved | Method Of Amt DeterminationMethodOfAmtDetermination |
|---|---|---|
| VAN ANDEL INSTITUTE | ||
| C | 43882066 | ACTUAL AMOUNT PAID |
| VAN ANDEL INSTITUTE | ||
| E | 18670000 | TOTAL RECORDED |
| VAN ANDEL INSTITUTE | ||
| N | 315668 | ALLOCATION BASED ON SQ. FOOTAGE |
| VAN ANDEL INSTITUTE | ||
| P | 491604 | ACTUAL AMOUNT PAID |
| VAN ANDEL INSTITUTE | ||
| N | 173843 | ALLOCATION BASED ON EFFORT |
| VAN ANDEL INSTITUTE | ||
| O | 1167918 | ALLOCATION BASED ON EFFORT |
| VAN ANDEL EDUCATION INSTITUTE | ||
| P | 75898 | ACTUAL AMOUNT PAID |
| VAN ANDEL EDUCATION INSTITUTE | ||
| Q | 1080055 | ACTUAL AMOUNT RECEIVED |
| VAN ANDEL EDUCATION INSTITUTE | ||
| O | 69920 | APPORTIONED FY13 COMPENSATION |
| VAN ANDEL EDUCATION INSTITUTE | ||
| N | 40815 | ALLOCATION BASED ON EFFORT |
| VAN ANDEL EDUCATION INSTITUTE | ||
| O | 274207 | ALLOCATION BASED ON EFFORT |
| VAN ANDEL INSTITUTE GRADUATE SCHOOL | ||
| N | 19652 | ALLOCATION BASED ON EFFORT |
| VAN ANDEL INSTITUTE GRADUATE SCHOOL | ||
| N | 177563 | ALLOCATION BASED ON SQ. FOOTAGE |
| VAN ANDEL INSTITUTE GRADUATE SCHOOL | ||
| Q | 148148 | ACTUAL AMOUNT RECEIVED |
| VAN ANDEL INSTITUTE GRADUATE SCHOOL | ||
| O | 132025 | ALLOCATION BASED ON EFFORT |
| TRANSMED SYSTEMS INC | ||
| A | 666667 | ACCRUED PER CONTRACT |
| VAN ANDEL INSTITUTE | ||
| Q | 5527150 | ACTUAL AMOUNT PAID |