CYSTINOSIS RESEARCH FOUNDATION: Form 990, tax year 2024

View the entire original 990 at ProPublica ↗

Organization: CYSTINOSIS RESEARCH FOUNDATION (EIN 32-0067668)
Tax period: 2024-07-01 to 2025-06-30
Filed: 2026-01-14
IRS object ID: 202630149349300928
Schema version: 2024v5.2
Source: Download XML · Original 990 at ProPublica

Every field in the e-filed return. Faint text is the IRS element name, for citing.

Return header
Form 990
Schedule A
Schedule D
Schedule F
Schedule G
Schedule I
Schedule L
Schedule O

Return header ReturnHeader

Field	Value	IRS element (for citing)
Return	2026-01-14T15:56:37-08:00	ReturnTs
Tax Period End	2025-06-30	TaxPeriodEndDt

Preparer Firm PreparerFirmGrp

Field	Value	IRS element (for citing)
Preparer Firm EIN	954489850	PreparerFirmEIN

Preparer Firm Name PreparerFirmName

Field	Value	IRS element (for citing)
Business Name Line1	Montgomery Glick & Company	BusinessNameLine1Txt

Preparer US Address PreparerUSAddress

Field	Value	IRS element (for citing)
Address Line1	23801 Calabasas Rd Ste 103	AddressLine1Txt
City	Calabasas	CityNm
State Abbreviation	CA	StateAbbreviationCd
ZIP	91302	ZIPCd

Field	Value	IRS element (for citing)
Return Type	990	ReturnTypeCd
Tax Period Begin	2024-07-01	TaxPeriodBeginDt

Filer Filer

Field	Value	IRS element (for citing)
EIN	320067668	EIN

Business Name BusinessName

Field	Value	IRS element (for citing)
Business Name Line1	CYSTINOSIS RESEARCH FOUNDATION	BusinessNameLine1Txt

Field	Value	IRS element (for citing)
Business Name Control	CYST	BusinessNameControlTxt
Phone	9492237610	PhoneNum

US Address USAddress

Field	Value	IRS element (for citing)
Address Line1	19200 VON KARMAN AVENUE 920	AddressLine1Txt
City	IRVINE	CityNm
State Abbreviation	CA	StateAbbreviationCd
ZIP	92612	ZIPCd

Business Officer BusinessOfficerGrp

Field	Value	IRS element (for citing)
Person	GEOFFREY STACK	PersonNm
Person Title	Trustee	PersonTitleTxt
Signature	2026-01-14	SignatureDt
Discuss With Paid Preparer	Yes (true)	DiscussWithPaidPreparerInd

Field	Value	IRS element (for citing)
IRS Responsible Prty Info Curr	Yes (true)	IRSResponsiblePrtyInfoCurrInd

Preparer Person PreparerPersonGrp

Field	Value	IRS element (for citing)
Preparer Person	PETER MONTGOMERY	PreparerPersonNm
PTIN	P01209820	PTIN
Phone	8189996967	PhoneNum

Field	Value	IRS element (for citing)
Tax	2024	TaxYr
Build TS	2025-03-06 01:10:19Z	BuildTS

Form 990 IRS990

US Address USAddress

Field	Value	IRS element (for citing)
Address Line1	19200 VON KARMAN AVENUE 920	AddressLine1Txt
City	IRVINE	CityNm
State Abbreviation	CA	StateAbbreviationCd
ZIP	92612	ZIPCd

Field	Value	IRS element (for citing)
Gross Receipts	$3,229,152	GrossReceiptsAmt
Group Return For Affiliates	false	GroupReturnForAffiliatesInd
Organization501c3	Yes (X)	Organization501c3Ind
Website Address	www.cystinosisresearch.org	WebsiteAddressTxt
Type Of Organization Corp	Yes (X)	TypeOfOrganizationCorpInd
Formation	2003	FormationYr
Legal Domicile State	CA	LegalDomicileStateCd
Activity Or Mission	Cystinosis Research Foundation's (CRF) mission is to support bench, clinical, and translational research to find better treatments and a cure for cystinosis. CRF is dedicated to funding research that will improve the quality of life for those with cystinosis and to find a cure for this devastating disease.	ActivityOrMissionDesc
Voting Members Governing Body	17	VotingMembersGoverningBodyCnt
Voting Members Independent	17	VotingMembersIndependentCnt
Total Employee	1	TotalEmployeeCnt
Total Volunteers	5	TotalVolunteersCnt
Total Gross UBI	$0	TotalGrossUBIAmt
PY Contributions Grants	$2,739,787	PYContributionsGrantsAmt
CY Contributions Grants	$2,445,467	CYContributionsGrantsAmt
CY Program Service Revenue	$0	CYProgramServiceRevenueAmt
PY Investment Income	$447,518	PYInvestmentIncomeAmt
CY Investment Income	$731,957	CYInvestmentIncomeAmt
CY Other Revenue	$0	CYOtherRevenueAmt
PY Total Revenue	$3,187,305	PYTotalRevenueAmt
CY Total Revenue	$3,177,424	CYTotalRevenueAmt
PY Grants And Similar Paid	$3,106,189	PYGrantsAndSimilarPaidAmt
CY Grants And Similar Paid	$2,203,637	CYGrantsAndSimilarPaidAmt
CY Benefits Paid To Members	$0	CYBenefitsPaidToMembersAmt
PY Salaries Comp Emp Bnft Paid	$67,946	PYSalariesCompEmpBnftPaidAmt
CY Salaries Comp Emp Bnft Paid	$78,493	CYSalariesCompEmpBnftPaidAmt
CY Total Prof Fndrsng Expns	$0	CYTotalProfFndrsngExpnsAmt
CY Total Fundraising Expense	$171,371	CYTotalFundraisingExpenseAmt
PY Other Expenses	$983,077	PYOtherExpensesAmt
CY Other Expenses	$1,155,877	CYOtherExpensesAmt
PY Total Expenses	$4,157,212	PYTotalExpensesAmt
CY Total Expenses	$3,438,007	CYTotalExpensesAmt
PY Revenues Less Expenses	-$969,907	PYRevenuesLessExpensesAmt
CY Revenues Less Expenses	-$260,583	CYRevenuesLessExpensesAmt
Total Assets BOY	$10,415,384	TotalAssetsBOYAmt
Total Assets EOY	$10,029,960	TotalAssetsEOYAmt
Total Liabilities BOY	$2,669,293	TotalLiabilitiesBOYAmt
Total Liabilities EOY	$2,507,429	TotalLiabilitiesEOYAmt
Net Assets Or Fund Balances BOY	$7,746,091	NetAssetsOrFundBalancesBOYAmt
Net Assets Or Fund Balances EOY	$7,522,531	NetAssetsOrFundBalancesEOYAmt
Mission	CRF is committed to finding a cure through an aggressively funded research agenda. CRF awards research grants bi-annually to accelerate the research process and to ensure that there is never a gap in funding new, cutting-edge research projects. CRF is dedicated to improving the quality of life for cystinosis patients and to finding better treatments, including a cure, for our adults and children living with cystinosis.	MissionDesc
Significant New Program Srvc	false	SignificantNewProgramSrvcInd
Significant Change	false	SignificantChangeInd
Expense	$3,072,586	ExpenseAmt
Desc	EDUCATIONThe Cystinosis Research Foundation is dedicated to educating the cystinosis community, the public and the medical community about cystinosis to ensure early diagnosis and immediate and proper treatment.NATALIES WISHNatalies wish, To have my disease go away forever, was the driving force and inspiration that led to the establishment of the Cystinosis Research Foundation (CRF) in 2003. We knew at that moment that we needed to make every effort to make Natalies wish and the wish of others with cystinosis a reality.HISTORY AND RESEARCHCystinosis is a rare, metabolic, genetic disease that afflicts approximately 2,500 children and adults worldwide. CRF is increasingly focused on funding clinical and translational research which is crucial to finding new treatments and a cure for cystinosis. CRF is committed to prioritizing and aggressively supporting research that has the potential to significantly improve the quality of life for children and adults with cystinosis. RESEARCH GIVES US HOPEWe firmly believe that funding and supporting research gives our community hope for a brighter future for those living with cystinosis. Hope allows us to live with cystinosis until the day a cure is found. Since 2003, the Cystinosis Research Foundation (CRF) has raised over $73 million and has become the worlds leading fund provider of cystinosis research. CRF has strategically and aggressively invested millions of dollars into the CRF research program creating a thriving and collaborative global research community that has changed the course of cystinosis. From the beginning, all CRF operating costs have been privately underwritten, so 100 percent of all donations received by CRF go to support cystinosis research. CRF HAS CREATED A CONTINUOUS CYCLE OF RESEARCH STUDIES BY SEEKING NEW RESEARCH APPLICATIONS TWICE A YEAR. We are pleased to announce that during the 12-month period ending June 30, 2025, CRF announced seven new grantS, AND GRANT PAYMENTS totaling $2,326,589,TO bring us that much closer to better treatments and a cure. RESEARCH PROGRESSFROM THE START OF THE FOUNDATION, WE HAVE UNDERSTOOD THAT FUNDING BASIC AND BENCH RESEARCH WAS important to understanding the cystinosis. Over the years, as discoveries were made in the lab, CRF began funding clinical research, and now we are translating the DATA FROM the clinical studies To the patients. Our strategy of providing seed money to talented researchers has been successful. Our first project involved funding researchers who were focused on a new treatment. CRF provided grants that funded every bench and clinical trial that led to the discovery of a delayed-release form of the life-saving medication for cystinosis. That medication, Procysbi was approved by the FDA on April 30, 2013, and is considered the most significant advancement in the treatment of cystinosis in 30 years. In 2007, CRF began funding Dr. Stphanie Cherqui, at UC San Diego who was focused on stem cell and gene therapy research. As a direct result of CRFs early and continuous funding, in December 2018, the FDA approved a clinical trial to assess the efficacy and safety of a stem cell and gene therapy treatment for cystinosis patients. In October 2019, the first cystinosis patient received the stem cell gene therapy treatment. In 2020, two patients received the therapy. In November 2021, the fourth patient received the treatment and in March 2022, the fifth patient received the treatment. The sixth and final patient in Phase I/II of the clinical trial was treated in October 2022. THE GRANTS AWARDED TO DR. CHERQUI FOR HER STEM CELL WORK HAVE BEEN LEVERAGED BY MULTI-MILLION-DOLLAR GRANTS FROM OTHER FUNDING AGENCIES. IF THIS TREATMENT WORKS, IT COULD STOP THE PROGRESSION OF CYSTINOSIS OR BE THE CURE FOR CYSTINOSIS.Since cystinosis is a systemic disease and affects every cell, CRF has targeted multiple areas of research including kidney disease, muscle wasting, neurological issues, corneal cystinosis, and stem cell and gene therapy, all with the goal of finding better treatments and a cure for cystinosis. CRF RESEARCH LEADS TO NEW DISCOVERIES IN OTHER MORE PREVALENT DISEASESAlthough CRF is focused on cystinosis research, discoveries made by CRF-funded researchers are being applied to other diseases including Friedreichs ataxia, Danon disease, Alzheimers disease, and other genetic and systemic diseases like cystinosis. As a result, breakthroughs initially aimed at helping the cystinosis community are now offering potential benefits to patients affected by other debilitating diseases. By advancing understanding of the underlying mechanisms of cystinosis, we have identified potential treatments that are relevant to other disease communities, creating pathways to cures for their communities. We are changing lives and giving hope to people far beyond the cystinosis community.CRF FAMILIES AND PARTNERSThe Cystinosis Research Foundation has witnessed tremendous growth over the years as cystinosis families have joined our fundraising efforts. Cystinosis families from all over the world have embraced the cystinosis cause and have enthusiastically raised funds to support cystinosis research through CRF. Their commitment to research has not only raised significant funds for research, but also created a strong and united global community of action. We have found strength in numbers and our joint effort gives us a renewed sense of community and purpose.DAY OF HOPE CONFERENCEEach year the Cystinosis Research Foundation hosts the Day of Hope Family Conference. In 2025, 59 families from around the world gathered to share their stories, hopes, and dreams and to build life-long friendships. Leading CRF-funded researchers attended the conference and updated the cystinosis community on their research progress including progress on gene and stem cell therapies, novel eye research, and neurological research. The conference educates cystinosis families about current and ongoing research and offers them hope that brighter days are ahead for cystinosis patients. CURE CYSTINOSIS INTERNATIONAL REGISTRYLaunched in April 2012, the Cure Cystinosis International Registry (CCIR) is an important program in the cystinosis community. The registry tracks patients natural history data, collects data about current treatments, identifies known and unknown medical complications, and collects information about quality-of-life issues. The CCIR is a central hub of information for the global community. The deidentified patient data from the registry can be shared with cystinosis clinicians, researchers, and scientists who are pursuing research focused on better treatments and a cure for cystinosis. Today, more than 171 cystinosis patients have registered with CCIR. CRF INTERNATIONAL RESEARCH SYMPOSIUMCRFs International Research Symposium is held every two years and is a highlight for cystinosis researchers. Attendees are CRF-funded researchers and scientists from around the world. Approximately 60 cystinosis experts from leading international universities and research institutions are invited to give presentations about their work. Attendees share their research progress and are encouraged to form collaborations to accelerate the research process. The symposium has solidified the global research community and created a synergistic research community working in partnership with CRF.	Desc
Total Program Service Expenses	$3,072,586	TotalProgramServiceExpensesAmt
Described In Section501c3	Yes (true)	DescribedInSection501c3Ind
Schedule B Required	false	ScheduleBRequiredInd
Political Campaign Acty	false	PoliticalCampaignActyInd
Lobbying Activities	false	LobbyingActivitiesInd
Subject To Proxy Tax	false	SubjectToProxyTaxInd
Donor Advised Fund	false	DonorAdvisedFundInd
Conservation Easements	false	ConservationEasementsInd
Collections Of Art	false	CollectionsOfArtInd
Credit Counseling	false	CreditCounselingInd
Donor Rstr Or Quasi Endowments	false	DonorRstrOrQuasiEndowmentsInd
Report Land Building Equipment	Yes (true)	ReportLandBuildingEquipmentInd
Report Investments Other Sec	false	ReportInvestmentsOtherSecInd
Report Program Related Invst	false	ReportProgramRelatedInvstInd
Report Other Assets	false	ReportOtherAssetsInd
Report Other Liabilities	Yes (true)	ReportOtherLiabilitiesInd
Include FIN48 Footnote	false	IncludeFIN48FootnoteInd
Independent Audit Fincl Stmt	Yes (true)	IndependentAuditFinclStmtInd
Consolidated Audit Fincl Stmt	false	ConsolidatedAuditFinclStmtInd
School Operating	false	SchoolOperatingInd
Foreign Office	false	ForeignOfficeInd
Foreign Activities	Yes (true)	ForeignActivitiesInd
More Than5000 K To Org	Yes (true)	MoreThan5000KToOrgInd
More Than5000 K To Individuals	false	MoreThan5000KToIndividualsInd
Professional Fundraising	false	ProfessionalFundraisingInd
Fundraising Activities	Yes (true)	FundraisingActivitiesInd
Gaming Activities	false	GamingActivitiesInd
Operate Hospital	false	OperateHospitalInd
Grants To Organizations	Yes (true)	GrantsToOrganizationsInd
Grants To Individuals	false	GrantsToIndividualsInd
Schedule J Required	false	ScheduleJRequiredInd
Tax Exempt Bonds	false	TaxExemptBondsInd
Engaged In Excess Benefit Trans	false	EngagedInExcessBenefitTransInd
PY Excess Benefit Trans	false	PYExcessBenefitTransInd
Loan Outstanding	false	LoanOutstandingInd
Grant To Related Person	false	GrantToRelatedPersonInd
Business Rln With Org Mem	false	BusinessRlnWithOrgMemInd
Business Rln With Fam Mem	false	BusinessRlnWithFamMemInd
Business Rln With35 Ctrl Ent	false	BusinessRlnWith35CtrlEntInd
Deductible Non Cash Contri	false	DeductibleNonCashContriInd
Deductible Art Contribution	false	DeductibleArtContributionInd
Terminate Operations	false	TerminateOperationsInd
Partial Liquidation	false	PartialLiquidationInd
Disregarded Entity	false	DisregardedEntityInd
Related Entity	false	RelatedEntityInd
Related Organization Ctrl Ent	false	RelatedOrganizationCtrlEntInd
Trnsfr Exmpt Non Chrtbl Rltd Org	false	TrnsfrExmptNonChrtblRltdOrgInd
Activities Conducted Prtshp	false	ActivitiesConductedPrtshpInd
Schedule O Required	Yes (true)	ScheduleORequiredInd
IRP Document	9	IRPDocumentCnt
IRP Document W2 G	0	IRPDocumentW2GCnt
Backup Wthld Compliance	Yes (true)	BackupWthldComplianceInd
Employee	1	EmployeeCnt
Employment Tax Returns Filed	Yes (true)	EmploymentTaxReturnsFiledInd
Unrelated Bus Incm Over Limit	false	UnrelatedBusIncmOverLimitInd
Foreign Financial Account	false	ForeignFinancialAccountInd
Prohibited Tax Shelter Trans	false	ProhibitedTaxShelterTransInd
Taxable Party Notification	false	TaxablePartyNotificationInd
Nondeductible Contributions	false	NondeductibleContributionsInd
Quid Pro Quo Contributions	false	QuidProQuoContributionsInd
Form8282 Property Disposed Of	false	Form8282PropertyDisposedOfInd
Form8282 Filed	0	Form8282FiledCnt
Rcv Fnds To Pay Prsnl Bnft Cntrct	false	RcvFndsToPayPrsnlBnftCntrctInd
Pay Premiums Prsnl Bnft Cntrct	false	PayPremiumsPrsnlBnftCntrctInd
Form8899 Filedind	false	Form8899Filedind
Form1098 C Filed	false	Form1098CFiledInd
Indoor Tanning Services	false	IndoorTanningServicesInd
Subj To Tax Rmnrtn Ex Prcht Pymt	false	SubjToTaxRmnrtnExPrchtPymtInd
Subject To Excs Tax Net Invst Inc	false	SubjectToExcsTaxNetInvstIncInd
Info In Schedule O Part VI	Yes (X)	InfoInScheduleOPartVIInd
Governing Body Voting Members	17	GoverningBodyVotingMembersCnt
Independent Voting Member	17	IndependentVotingMemberCnt
Family Or Business Rln	Yes (true)	FamilyOrBusinessRlnInd
Delegation Of Mgmt Duties	false	DelegationOfMgmtDutiesInd
Change To Org Documents	false	ChangeToOrgDocumentsInd
Material Diversion Or Misuse	false	MaterialDiversionOrMisuseInd
Members Or Stockholders	false	MembersOrStockholdersInd
Election Of Board Members	false	ElectionOfBoardMembersInd
Decisions Subject To Approva	false	DecisionsSubjectToApprovaInd
Minutes Of Governing Body	Yes (true)	MinutesOfGoverningBodyInd
Minutes Of Committees	Yes (true)	MinutesOfCommitteesInd
Officer Mailing Address	false	OfficerMailingAddressInd
Local Chapters	false	LocalChaptersInd
Form990 Provided To Gvrn Body	Yes (true)	Form990ProvidedToGvrnBodyInd
Conflict Of Interest Policy	Yes (true)	ConflictOfInterestPolicyInd
Annual Disclosure Covered Prsn	Yes (true)	AnnualDisclosureCoveredPrsnInd
Regular Monitoring Enfrc	Yes (true)	RegularMonitoringEnfrcInd
Whistleblower Policy	Yes (true)	WhistleblowerPolicyInd
Document Retention Policy	Yes (true)	DocumentRetentionPolicyInd
Compensation Process CEO	false	CompensationProcessCEOInd
Compensation Process Other	false	CompensationProcessOtherInd
Investment In Joint Venture	false	InvestmentInJointVentureInd
States Where Copy Of Return Is Fld	CA	StatesWhereCopyOfReturnIsFldCd
Own Website	Yes (X)	OwnWebsiteInd
Other Website	Yes (X)	OtherWebsiteInd
Upon Request	Yes (X)	UponRequestInd

Books In Care Of Detail BooksInCareOfDetail

Field	Value	IRS element (for citing)
Person	GEOFFREY STACK	PersonNm
Phone	9497565959	PhoneNum

US Address USAddress

Field	Value	IRS element (for citing)
Address Line1	19200 VON KARMAN AVENUE STE 920	AddressLine1Txt
City	IRVINE	CityNm
State Abbreviation	CA	StateAbbreviationCd
ZIP	92612	ZIPCd

Field	Value	IRS element (for citing)
No Listed Persons Compensated	Yes (X)	NoListedPersonsCompensatedInd

Form990 Part VII Section A Form990PartVIISectionAGrp (17 entries)

TitleTitleTxt	Average Hours Per WeekAverageHoursPerWeekRt	Average Hours Per Week Rltd OrgAverageHoursPerWeekRltdOrgRt	Individual Trustee Or DirectorIndividualTrusteeOrDirectorInd	OfficerOfficerInd	Reportable Comp From OrgReportableCompFromOrgAmt	Reportable Comp From Rltd OrgReportableCompFromRltdOrgAmt	Other CompensationOtherCompensationAmt
NANCY J STACK
CHAIR - TRUSTEE	40.00	0.00	Yes (X)	Yes (X)	$0	$0	$0
GEOFFREY STACK
VICE CHAIR-TTEE	0.00	0.00	Yes (X)	Yes (X)	$0	$0	$0
DONALD L SOLSBY
TREASURER - TTE	2.00	0.00	Yes (X)	Yes (X)	$0	$0	$0
MARCU ALEXANDER
Trustee	0.00	0.00	Yes (X)		$0	$0	$0
STEPHANIE CHERQUI PHD
Trustee	0.00	0.00	Yes (X)		$0	$0	$0
BRUCE CRAIR
Trustee	0.00	0.00	Yes (X)		$0	$0	$0
JILL EMERSON CPA
Trustee	0.00	0.00	Yes (X)		$0	$0	$0
DENICE FLERCHINGER
Trustee	0.00	0.00	Yes (X)		$0	$0	$0
CLAY EMERSON PHD PE CFM
Trustee	0.00	0.00	Yes (X)		$0	$0	$0
ANGELA KIRCHOFF
Trustee	0.00	0.00	Yes (X)		$0	$0	$0
STEPHEN L JENKINS
Trustee	0.00	0.00	Yes (X)		$0	$0	$0
DAVID W MOSSMAN
Trustee	0.00	0.00	Yes (X)		$0	$0	$0
KEVIN PARTINGTON
Trustee	0.00	0.00	Yes (X)		$0	$0	$0
TERESA PARTINGTON
Trustee	0.00	0.00	Yes (X)		$0	$0	$0
KRISTEN MURRAY
Trustee	0.00	0.00	Yes (X)		$0	$0	$0
BRIAN STURGIS
Trustee	0.00	0.00	Yes (X)		$0	$0	$0
BARBARA KULYK
Trustee	0.00	0.00	Yes (X)		$0	$0	$0

Field	Value	IRS element (for citing)
Indiv Rcvd Greater Than100 K	0	IndivRcvdGreaterThan100KCnt
Former Ofcr Employees Listed	false	FormerOfcrEmployeesListedInd
Total Comp Greater Than150 K	false	TotalCompGreaterThan150KInd
Compensation From Other Srcs	false	CompensationFromOtherSrcsInd
Cntrct Rcvd Greater Than100 K	0	CntrctRcvdGreaterThan100KCnt
Fundraising	$350,606	FundraisingAmt
All Other Contributions	$2,094,861	AllOtherContributionsAmt
Total Contributions	$2,445,467	TotalContributionsAmt
Total Program Service Revenue	$0	TotalProgramServiceRevenueAmt

Investment Income InvestmentIncomeGrp

Field	Value	IRS element (for citing)
Total Revenue Column	$783,685	TotalRevenueColumnAmt
Related Or Exempt Func Income	$783,685	RelatedOrExemptFuncIncomeAmt

Incm From Invest Bond Proceeds IncmFromInvestBondProceedsGrp

Field	Value	IRS element (for citing)
Total Revenue Column	$0	TotalRevenueColumnAmt

Royalties Revenue RoyaltiesRevenueGrp

Field	Value	IRS element (for citing)
Total Revenue Column	$0	TotalRevenueColumnAmt

Net Rental Income Or Loss NetRentalIncomeOrLossGrp

Field	Value	IRS element (for citing)
Total Revenue Column	$0	TotalRevenueColumnAmt

Less Cost Oth Basis Sales Expnss LessCostOthBasisSalesExpnssGrp

Field	Value	IRS element (for citing)
Securities	$51,728	SecuritiesAmt

Gain Or Loss GainOrLossGrp

Field	Value	IRS element (for citing)
Securities	-$51,728	SecuritiesAmt

Net Gain Or Loss Investments NetGainOrLossInvestmentsGrp

Field	Value	IRS element (for citing)
Total Revenue Column	-$51,728	TotalRevenueColumnAmt
Related Or Exempt Func Income	-$51,728	RelatedOrExemptFuncIncomeAmt

Field	Value	IRS element (for citing)
Contri Rpt Fundraising Event	$350,606	ContriRptFundraisingEventAmt

Net Incm From Fundraising Evt NetIncmFromFundraisingEvtGrp

Field	Value	IRS element (for citing)
Total Revenue Column	$0	TotalRevenueColumnAmt

Net Income From Gaming NetIncomeFromGamingGrp

Field	Value	IRS element (for citing)
Total Revenue Column	$0	TotalRevenueColumnAmt

Net Income Or Loss NetIncomeOrLossGrp

Field	Value	IRS element (for citing)
Total Revenue Column	$0	TotalRevenueColumnAmt

Field	Value	IRS element (for citing)
Other Revenue Total	$0	OtherRevenueTotalAmt

Total Revenue TotalRevenueGrp

Field	Value	IRS element (for citing)
Total Revenue Column	$3,177,424	TotalRevenueColumnAmt
Related Or Exempt Func Income	$731,957	RelatedOrExemptFuncIncomeAmt

Grants To Domestic Orgs GrantsToDomesticOrgsGrp

Field	Value	IRS element (for citing)
Total	$1,766,737	TotalAmt
Program Services	$1,766,737	ProgramServicesAmt

Grants To Domestic Individuals GrantsToDomesticIndividualsGrp

Field	Value	IRS element (for citing)
Total	$0	TotalAmt

Foreign Grants ForeignGrantsGrp

Field	Value	IRS element (for citing)
Total	$436,900	TotalAmt
Program Services	$436,900	ProgramServicesAmt

Benefits To Members BenefitsToMembersGrp

Field	Value	IRS element (for citing)
Total	$0	TotalAmt

Comp Current Ofcr Directors CompCurrentOfcrDirectorsGrp

Field	Value	IRS element (for citing)
Total	$0	TotalAmt

Comp Disqual Persons CompDisqualPersonsGrp

Field	Value	IRS element (for citing)
Total	$0	TotalAmt

Other Salaries And Wages OtherSalariesAndWagesGrp

Field	Value	IRS element (for citing)
Total	$72,607	TotalAmt
Program Services	$69,318	ProgramServicesAmt
Management And General	$3,289	ManagementAndGeneralAmt

Pension Plan Contributions PensionPlanContributionsGrp

Field	Value	IRS element (for citing)
Total	$0	TotalAmt

Other Employee Benefits OtherEmployeeBenefitsGrp

Field	Value	IRS element (for citing)
Total	$0	TotalAmt

Payroll Taxes PayrollTaxesGrp

Field	Value	IRS element (for citing)
Total	$5,886	TotalAmt
Program Services	$5,303	ProgramServicesAmt
Management And General	$583	ManagementAndGeneralAmt

Fees For Services Management FeesForServicesManagementGrp

Field	Value	IRS element (for citing)
Total	$0	TotalAmt

Fees For Services Legal FeesForServicesLegalGrp

Field	Value	IRS element (for citing)
Total	$13,039	TotalAmt
Program Services	$13,039	ProgramServicesAmt

Fees For Services Accounting FeesForServicesAccountingGrp

Field	Value	IRS element (for citing)
Total	$91,943	TotalAmt
Program Services	$13,188	ProgramServicesAmt
Management And General	$67,486	ManagementAndGeneralAmt
Fundraising	$11,269	FundraisingAmt

Fees For Services Lobbying FeesForServicesLobbyingGrp

Field	Value	IRS element (for citing)
Total	$0	TotalAmt

Fees For Services Prof Fundraising FeesForServicesProfFundraising

Field	Value	IRS element (for citing)
Total	$0	TotalAmt

Fees For Srvc Invst Mgmnt Fees FeesForSrvcInvstMgmntFeesGrp

Field	Value	IRS element (for citing)
Total	$0	TotalAmt

Fees For Services Other FeesForServicesOtherGrp

Field	Value	IRS element (for citing)
Total	$0	TotalAmt

Advertising AdvertisingGrp

Field	Value	IRS element (for citing)
Total	$34,524	TotalAmt
Program Services	$5,183	ProgramServicesAmt
Fundraising	$29,341	FundraisingAmt

Office Expenses OfficeExpensesGrp

Field	Value	IRS element (for citing)
Total	$0	TotalAmt

Information Technology InformationTechnologyGrp

Field	Value	IRS element (for citing)
Total	$0	TotalAmt

Royalties RoyaltiesGrp

Field	Value	IRS element (for citing)
Total	$0	TotalAmt

Occupancy OccupancyGrp

Field	Value	IRS element (for citing)
Total	$0	TotalAmt

Travel TravelGrp

Field	Value	IRS element (for citing)
Total	$0	TotalAmt

Pymt Travel Entrtnmnt Pub Ofcl PymtTravelEntrtnmntPubOfclGrp

Field	Value	IRS element (for citing)
Total	$0	TotalAmt

Conferences Meetings ConferencesMeetingsGrp

Field	Value	IRS element (for citing)
Total	$0	TotalAmt

Interest InterestGrp

Field	Value	IRS element (for citing)
Total	$0	TotalAmt

Payments To Affiliates PaymentsToAffiliatesGrp

Field	Value	IRS element (for citing)
Total	$0	TotalAmt

Depreciation Depletion DepreciationDepletionGrp

Field	Value	IRS element (for citing)
Total	$8,786	TotalAmt

Insurance InsuranceGrp

Field	Value	IRS element (for citing)
Total	$16,114	TotalAmt
Program Services	$16,114	ProgramServicesAmt

Other Expenses OtherExpensesGrp (4 entries)

DescDesc	TotalTotalAmt	Program ServicesProgramServicesAmt	FundraisingFundraisingAmt	Management And GeneralManagementAndGeneralAmt
EDUCATION	$521,329	$521,329
MAGAZINE	$156,655	$123,787	$32,868
WEBSITE	$96,554	$24,139	$28,966	$43,449
OUTSIDE SERVICES	$88,864	$64,500	$18,000	$6,364

All Other Expenses AllOtherExpensesGrp

Field	Value	IRS element (for citing)
Total	$128,069	TotalAmt
Program Services	$13,049	ProgramServicesAmt
Management And General	$64,093	ManagementAndGeneralAmt
Fundraising	$50,927	FundraisingAmt

Total Functional Expenses TotalFunctionalExpensesGrp

Field	Value	IRS element (for citing)
Total	$3,438,007	TotalAmt
Program Services	$3,072,586	ProgramServicesAmt
Management And General	$185,264	ManagementAndGeneralAmt
Fundraising	$171,371	FundraisingAmt

Cash Non Interest Bearing CashNonInterestBearingGrp

Field	Value	IRS element (for citing)
EOY	$0	EOYAmt

Savings And Temp Cash Invst SavingsAndTempCashInvstGrp

Field	Value	IRS element (for citing)
BOY	$5,144,486	BOYAmt
EOY	$4,442,951	EOYAmt

Pledges And Grants Receivable PledgesAndGrantsReceivableGrp

Field	Value	IRS element (for citing)
EOY	$0	EOYAmt

Accounts Receivable AccountsReceivableGrp

Field	Value	IRS element (for citing)
EOY	$0	EOYAmt

Receivables From Officers Etc ReceivablesFromOfficersEtcGrp

Field	Value	IRS element (for citing)
EOY	$0	EOYAmt

Rcvbl From Disqualified Prsn RcvblFromDisqualifiedPrsnGrp

Field	Value	IRS element (for citing)
EOY	$0	EOYAmt

Oth Notes Loans Receivable Net OthNotesLoansReceivableNetGrp

Field	Value	IRS element (for citing)
EOY	$0	EOYAmt

Inventories For Sale Or Use InventoriesForSaleOrUseGrp

Field	Value	IRS element (for citing)
EOY	$0	EOYAmt

Prepaid Expenses Defrd Charges PrepaidExpensesDefrdChargesGrp

Field	Value	IRS element (for citing)
BOY	$48,476	BOYAmt
EOY	$12,937	EOYAmt

Field	Value	IRS element (for citing)
Land Bldg Equip Cost Or Other Bss	$152,621	LandBldgEquipCostOrOtherBssAmt
Land Bldg Equip Accum Deprec	$152,621	LandBldgEquipAccumDeprecAmt

Land Bldg Equip Basis Net LandBldgEquipBasisNetGrp

Field	Value	IRS element (for citing)
BOY	$17,123	BOYAmt
EOY	$0	EOYAmt

Investments Pub Traded Sec InvestmentsPubTradedSecGrp

Field	Value	IRS element (for citing)
BOY	$5,140,525	BOYAmt
EOY	$5,540,997	EOYAmt

Investments Other Securities InvestmentsOtherSecuritiesGrp

Field	Value	IRS element (for citing)
EOY	$0	EOYAmt

Investments Program Related InvestmentsProgramRelatedGrp

Field	Value	IRS element (for citing)
EOY	$0	EOYAmt

Intangible Assets IntangibleAssetsGrp

Field	Value	IRS element (for citing)
EOY	$0	EOYAmt

Other Assets Total OtherAssetsTotalGrp

Field	Value	IRS element (for citing)
BOY	$64,774	BOYAmt
EOY	$33,075	EOYAmt

Total Assets TotalAssetsGrp

Field	Value	IRS element (for citing)
BOY	$10,415,384	BOYAmt
EOY	$10,029,960	EOYAmt

Accounts Payable Accr Expnss AccountsPayableAccrExpnssGrp

Field	Value	IRS element (for citing)
BOY	$31,780	BOYAmt
EOY	$27,965	EOYAmt

Grants Payable GrantsPayableGrp

Field	Value	IRS element (for citing)
BOY	$2,572,904	BOYAmt
EOY	$2,445,953	EOYAmt

Other Liabilities OtherLiabilitiesGrp

Field	Value	IRS element (for citing)
BOY	$64,609	BOYAmt
EOY	$33,511	EOYAmt

Total Liabilities TotalLiabilitiesGrp

Field	Value	IRS element (for citing)
BOY	$2,669,293	BOYAmt
EOY	$2,507,429	EOYAmt

Field	Value	IRS element (for citing)
Organization Follows FASB117	Yes (X)	OrganizationFollowsFASB117Ind

No Donor Restriction Net Assets NoDonorRestrictionNetAssetsGrp

Field	Value	IRS element (for citing)
BOY	$7,746,091	BOYAmt
EOY	$7,522,531	EOYAmt

Total Net Assets Fund Balance TotalNetAssetsFundBalanceGrp

Field	Value	IRS element (for citing)
BOY	$7,746,091	BOYAmt
EOY	$7,522,531	EOYAmt

Tot Liab Net Assets Fund Balance TotLiabNetAssetsFundBalanceGrp

Field	Value	IRS element (for citing)
BOY	$10,415,384	BOYAmt
EOY	$10,029,960	EOYAmt

Field	Value	IRS element (for citing)
Reconcilation Revenue Expnss	-$260,583	ReconcilationRevenueExpnssAmt
Net Unrlzd Gains Losses Invst	$37,023	NetUnrlzdGainsLossesInvstAmt
Method Of Accounting Accrual	Yes (X)	MethodOfAccountingAccrualInd
Accountant Compile Or Review	false	AccountantCompileOrReviewInd
FS Audited	Yes (true)	FSAuditedInd

FS Audited Basis FSAuditedBasisGrp

Field	Value	IRS element (for citing)
Separate Basis Fincl Stmt	Yes (X)	SeparateBasisFinclStmtInd

Field	Value	IRS element (for citing)
Audit Committee	Yes (true)	AuditCommitteeInd
Federal Grant Audit Required	false	FederalGrantAuditRequiredInd

Schedule A IRS990ScheduleA

Field	Value	IRS element (for citing)
Public Organization170	Yes (X)	PublicOrganization170Ind

Gifts Grants Contri Rcvd170 GiftsGrantsContriRcvd170Grp

Field	Value	IRS element (for citing)
Current Tax Year Minus4 Years	$3,658,065	CurrentTaxYearMinus4YearsAmt
Current Tax Year Minus3 Years	$2,921,004	CurrentTaxYearMinus3YearsAmt
Current Tax Year Minus2 Years	$2,894,123	CurrentTaxYearMinus2YearsAmt
Current Tax Year Minus1 Year	$2,739,787	CurrentTaxYearMinus1YearAmt
Current Tax Year	$2,445,467	CurrentTaxYearAmt
Total	$14,658,446	TotalAmt

Tax Rev Levied Orgnztnl Bnft170 TaxRevLeviedOrgnztnlBnft170Grp

Field	Value	IRS element (for citing)
Total	$0	TotalAmt

Govt Furn Srvc Fclts Vl170 GovtFurnSrvcFcltsVl170Grp

Field	Value	IRS element (for citing)
Total	$0	TotalAmt

Total Calendar Year170 TotalCalendarYear170Grp

Field	Value	IRS element (for citing)
Current Tax Year Minus4 Years	$3,658,065	CurrentTaxYearMinus4YearsAmt
Current Tax Year Minus3 Years	$2,921,004	CurrentTaxYearMinus3YearsAmt
Current Tax Year Minus2 Years	$2,894,123	CurrentTaxYearMinus2YearsAmt
Current Tax Year Minus1 Year	$2,739,787	CurrentTaxYearMinus1YearAmt
Current Tax Year	$2,445,467	CurrentTaxYearAmt
Total	$14,658,446	TotalAmt

Field	Value	IRS element (for citing)
Substantial Contributors Tot	$0	SubstantialContributorsTotAmt
Public Support Total170	$14,658,446	PublicSupportTotal170Amt

Gross Investment Income170 GrossInvestmentIncome170Grp

Field	Value	IRS element (for citing)
Current Tax Year Minus4 Years	$151,448	CurrentTaxYearMinus4YearsAmt
Current Tax Year Minus3 Years	$668,443	CurrentTaxYearMinus3YearsAmt
Current Tax Year Minus2 Years	$360,852	CurrentTaxYearMinus2YearsAmt
Current Tax Year Minus1 Year	$447,518	CurrentTaxYearMinus1YearAmt
Current Tax Year	$731,957	CurrentTaxYearAmt
Total	$2,360,218	TotalAmt

Unrelated Business Net Incm170 UnrelatedBusinessNetIncm170Grp

Field	Value	IRS element (for citing)
Total	$0	TotalAmt

Other Income170 OtherIncome170Grp

Field	Value	IRS element (for citing)
Total	$0	TotalAmt

Field	Value	IRS element (for citing)
Total Support	$17,018,664	TotalSupportAmt
Public Support CY170	0.86130	PublicSupportCY170Pct
Public Support PY170	0.89690	PublicSupportPY170Pct
Thirty Thr Pct Suprt Tests CY170	Yes (X)	ThirtyThrPctSuprtTestsCY170Ind

Schedule D IRS990ScheduleD

Leasehold Improvements LeaseholdImprovementsGrp

Field	Value	IRS element (for citing)
Other Cost Or Other Basis	$8,874	OtherCostOrOtherBasisAmt
Depreciation	$7,429	DepreciationAmt
Book Value	$1,445	BookValueAmt

Equipment EquipmentGrp

Field	Value	IRS element (for citing)
Other Cost Or Other Basis	$96,912	OtherCostOrOtherBasisAmt
Depreciation	$105,247	DepreciationAmt
Book Value	-$8,335	BookValueAmt

Other Land Buildings OtherLandBuildingsGrp

Field	Value	IRS element (for citing)
Other Cost Or Other Basis	$46,835	OtherCostOrOtherBasisAmt
Depreciation	$39,945	DepreciationAmt
Book Value	$6,890	BookValueAmt

Other Liabilities Org OtherLiabilitiesOrgGrp

Field	Value	IRS element (for citing)
Desc	LEASE LIABILITY-OPERATING	Desc
Amt	$33,511	Amt

Field	Value	IRS element (for citing)
Total Liability	$33,511	TotalLiabilityAmt
Total Rev Etc Audited Fincl Stmt	$3,177,424	TotalRevEtcAuditedFinclStmtAmt
Revenue Subtotal	$3,177,424	RevenueSubtotalAmt
Total Revenue Per Form990	$3,177,424	TotalRevenuePerForm990Amt
Tot Expns Etc Audited Fincl Stmt	$3,438,007	TotExpnsEtcAuditedFinclStmtAmt
Expenses Subtotal	$3,438,007	ExpensesSubtotalAmt
Total Expenses Per Form990	$3,438,007	TotalExpensesPerForm990Amt

Schedule F IRS990ScheduleF

Field	Value	IRS element (for citing)
Grant Records Maintained	Yes (true)	GrantRecordsMaintainedInd

Account Activities Outside US AccountActivitiesOutsideUSGrp (7 entries)

RegionRegionTxt	Type Of Activities ConductedTypeOfActivitiesConductedTxt	Specific Services ProvidedSpecificServicesProvidedTxt	Region Total ExpendituresRegionTotalExpendituresAmt
FRANCE	GRANTS	MEDICAL RESEARCH	$0
ITALY	GRANTS	MEDICAL RESEARCH	$86,900
SWITZERLAND	GRANTS	MEDICAL RESEARCH	$350,000
GERMANY	GRANTS	MEDICAL RESEARCH	$0
NEW ZEALAND	GRANTS	MEDICAL RESEARCH	$0
ISRAEL	GRANTS	MEDICAL RESEARCH	$0
CANADA	GRANTS	MEDICAL RESEARCH	$0

Field	Value	IRS element (for citing)
Subtotal Spent	$436,900	SubtotalSpentAmt
Total Spent	$436,900	TotalSpentAmt

Grants To Org Outside US GrantsToOrgOutsideUSGrp (5 entries)

Purpose Of GrantPurposeOfGrantTxt	Manner Of Cash DisbursementMannerOfCashDisbursementTxt
MEDICAL RESEARCH	WIRE TRANSF
MEDICAL RESEARCH	WIRE TRANSF
MEDICAL RESEARCH	WIRE TRANSF
MEDICAL RESEARCH	WIRE TRANSF
MEDICAL RESEARCH	WIRE TRANSF

Field	Value	IRS element (for citing)
Total501c3 Org	5	Total501c3OrgCnt
Transfer To Foreign Corp	false	TransferToForeignCorpInd
Interest In Foreign Trust	false	InterestInForeignTrustInd
Foreign Corp Ownership	false	ForeignCorpOwnershipInd
Passive Foreign Investmest Co	false	PassiveForeignInvestmestCoInd
Foreign Partnership	false	ForeignPartnershipInd
Boycott Countries	false	BoycottCountriesInd

Schedule G IRS990ScheduleG

Field	Value	IRS element (for citing)
Email Solicitations	Yes (X)	EmailSolicitationsInd
Special Fundraising Events	Yes (X)	SpecialFundraisingEventsInd
Agrmt Prof Fundraising Acty	false	AgrmtProfFundraisingActyInd
Licensed States	CA	LicensedStatesCd

Fundraising Event Information FundraisingEventInformationGrp

Field	Value	IRS element (for citing)
Event1	ANNUAL FUNDRAISER - SEE NOTE (4)	Event1Nm
Gross Receipts Event1	$350,606	GrossReceiptsEvent1Amt
Charitable Contri Event1	$350,606	CharitableContriEvent1Amt
Gross Receipts Total	$350,606	GrossReceiptsTotalAmt
Charitable Contributions Tot	$350,606	CharitableContributionsTotAmt

Schedule I IRS990ScheduleI

Field	Value	IRS element (for citing)
Grant Records Maintained	Yes (true)	GrantRecordsMaintainedInd

Recipient Table RecipientTable (7 entries)

Address Line1USAddress/AddressLine1Txt	CityUSAddress/CityNm	State AbbreviationUSAddress/StateAbbreviationCd	ZIPUSAddress/ZIPCd	Recipient EINRecipientEIN	Cash GrantCashGrantAmt	Non Cash AssistanceNonCashAssistanceAmt	Purpose Of GrantPurposeOfGrantTxt
HARVARD MEDICAL SCHOOL
25 SHATTUCK STREET	BOSTON	MA	02115	042103580	$75,000	$0	MEDICAL RESEARCH
HARVARD UNIVERSITY CAMBRIDGE
MASSACHUSETTS HALL	CAMBRIDGE	MA	02138	042103580	$150,000	$0	MEDICAL RESEARCH
MASSACHUSETTS GENERAL HOSPITA
55 FRUIT ST	BOSTON	MA	02114	041564655	$465,595	$0	MEDICAL RESEARCH
STANFORD UNIVERSITY
326 GALVEZ STREET	STANFORD	CA	94305	941156365	$245,000	$0	MEDICAL RESEARCH
THE SCRIPPS INSTITUTE
10550 N TORREY PINES ROAD	LA JOLLA	CA	92037	330435954	$450,000	$0	MEDICAL RESEARCH
UNIV OF CA-IRVINE
1027 W PELTASON DR	IRVINE	CA	92617	943067788	$117,938	$0	MEDICAL RESEARCH
UNIVERSITY OF CALIFORNIA SD
9500 GILMAN DRIVE DEPT 0935	LA JOLLA	CA	92093	956006144	$263,204	$0	MEDICAL RESEARCH

Field	Value	IRS element (for citing)
Total501c3 Org	3	Total501c3OrgCnt
Total Other Org	4	TotalOtherOrgCnt

Schedule L IRS990ScheduleL

Bus Tr Involve Interested Prsn BusTrInvolveInterestedPrsnGrp

Name Of Interested NameOfInterested

Field	Value	IRS element (for citing)
Person	ZOE SOLSBY	PersonNm

Field	Value	IRS element (for citing)
Relationship Description	WIFE OF OFFICER	RelationshipDescriptionTxt
Transaction	COMPENSATION	TransactionDesc
Sharing Of Revenues	false	SharingOfRevenuesInd

Supplemental Information Detail SupplementalInformationDetail

Field	Value	IRS element (for citing)
Form And Line Reference	Schedule L, Part V Supplemental Information	FormAndLineReferenceDesc
Explanation	SEE NOTE 1 TO SCHEDULE L	ExplanationTxt

Schedule O IRS990ScheduleO

Supplemental Information Detail SupplementalInformationDetail (6 entries)

Form And Line ReferenceFormAndLineReferenceDesc	ExplanationExplanationTxt
Form 990, Part VI, Section A, Line 2	TRUSTEES, GEOFFREY AND NANCY STACK,ARE HUSBAND AND WIFE. BOARD MEMBERS, KEVIN AND TERESA PARTINGTON, ARE HUSBAND AND WIFE.BOARD MEMBERS, JILL AND CLAY EMERSON, ARE HUSBAND AND WIFE
Form 990, Part VI, Section B, Line 11b	FORM 990 IS REVIEWED BY BOARD OF DIRECTORS PRIOR TO FILING. AUDITORS FOR THE FOUNDATION HAVE REVIEWED THE RETURN AND PROVIDED COMMENTS TO THE TAX PREPARER.
Form 990, Part VI, Section B, Line 12c	BOARD REVIEWS POSSIBLE CONFLICTS ON AN AS NEEDED BASIS AND DISCUSSES RESOLUTIONS AT BOARD MEETINGS
Form 990, Part VI, Section C, Line 19	CRF MAINTAINS THE GOVERNING DOCUMENTS, POLICIES AND PROCEDURES AND FINANCIAL STATEMENTS AT ITS OFFICES IN IRVINE, CALIFORNIA. COPIES OF THESE DOCUMENTS ARE AVAILABLE TO THE PUBLIC UPON REQUEST. OUR FORM 990 IS POSTED ON OUR WEBSITE AND ON GUIDESTAR ON THE INTERNET.
Statement Note 1	NOTE (1) - SCHEDULE L - PART IVNOTE (1)TRUSTEE DONALD SOLSBY'S WIFE, ZOE SOLSBY, IS A CONSULTANT TO THE FOUNDATION. MRS. SOLSBY RECEIVED COMPENSATION OF APPROXIMATELY $84,000 FOR THE YEAR ENDED JUNE 30,2025.
Statement Note 2	NOTE (2) - FUNDRAISERSSCHEDULE G - PART II FUNDRAISERS - THE FOUNDATION HOLDS AN ANNUAL NATALIE'S WISH ONLINE FUNDRAISER DURING THE MONTH OF APRIL. INCOME FROM THE FUNDRAISER IS IN THE FORM OF CHARITABLE CONTRIBUTIONS. THERE ARE NO DIRECT COSTS FOR THE FUNDRAISER.