SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE: Form 990, tax year 2011

View the entire original 990 at ProPublica ↗

Organization: SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE (EIN 51-0197108)
Tax period: 2011-07-01 to 2012-06-30
Filed: 2013-05-14
IRS object ID: 201341349349307729
Schema version: 2011v1.5
Source: Download XML · Original 990 at ProPublica

Every field in the e-filed return. Faint text is the IRS element name, for citing.

Return header
Form 990
Schedule A
Schedule B
Schedule C
Schedule D
Schedule F
Schedule G
Schedule J
Schedule K
Schedule L
Schedule M
Schedule O
Schedule R

Return header ReturnHeader

Field	Value	IRS element (for citing)
Timestamp	2013-05-14T19:46:58-05:00	Timestamp
Tax Period End Date	2012-06-30	TaxPeriodEndDate

Preparer Firm PreparerFirm

Preparer Firm Business Name PreparerFirmBusinessName

Field	Value	IRS element (for citing)
Business Name Line1	ERNST & YOUNG US LLP	BusinessNameLine1

Preparer Firm US Address PreparerFirmUSAddress

Field	Value	IRS element (for citing)
Address Line1	4370 LA JOLLA VILLAGE DR SUITE 500	AddressLine1
City	SAN DIEGO	City
State	CA	State
ZIP Code	92122	ZIPCode

Field	Value	IRS element (for citing)
Return Type	990	ReturnType
Tax Period Begin Date	2011-07-01	TaxPeriodBeginDate

Filer Filer

Field	Value	IRS element (for citing)
EIN	510197108	EIN

Name Name

Field	Value	IRS element (for citing)
Business Name Line1	SANFORD-BURNHAM MEDICAL RESEARCH INSTITUTE	BusinessNameLine1

Field	Value	IRS element (for citing)
In Care Of Name	% GARY F RAISL EDD EVP CAO CFO	InCareOfName
Name Control	SANF	NameControl
Phone	8586463100	Phone

US Address USAddress

Field	Value	IRS element (for citing)
Address Line1	10901 NORTH TORREY PINES ROAD	AddressLine1
City	LA JOLLA	City
State	CA	State
ZIP Code	92037	ZIPCode

Officer Officer

Field	Value	IRS element (for citing)
Name	GARY F RAISL	Name
Title	EVP/CAO/CFO/TREASURER	Title
Date Signed	2013-05-14	DateSigned

Preparer Preparer

Field	Value	IRS element (for citing)
Phone	8585357200	Phone

Field	Value	IRS element (for citing)
Tax Year	2011	TaxYear
Build TS	2016-02-24 21:20:13Z	BuildTS

Form 990 IRS990

Field	Value	IRS element (for citing)
Name Of Principal Officer Person	KRISTIINA VUORI MD PHD	NameOfPrincipalOfficerPerson

Address Principal Officer US AddressPrincipalOfficerUS

Field	Value	IRS element (for citing)
Address Line1	10901 N TORREY PINES ROAD	AddressLine1
City	LA JOLLA	City
State	CA	State
ZIP Code	92037	ZIPCode

Field	Value	IRS element (for citing)
Gross Receipts	174816413	GrossReceipts
Group Return For Affiliates	false	GroupReturnForAffiliates
Organization501c3	X	Organization501c3
Web Site	WWW.SANFORDBURNHAM.ORG	WebSite
Type Of Organization Corporation	X	TypeOfOrganizationCorporation
Year Formation	1976	YearFormation
State Legal Domicile	CA	StateLegalDomicile
Activity Or Mission Description	SEE SCHEDULE O	ActivityOrMissionDescription
Nbr Voting Members Governing Body	21	NbrVotingMembersGoverningBody
Nbr Independent Voting Members	16	NbrIndependentVotingMembers
Total Nbr Employees	1157	TotalNbrEmployees
Total Nbr Volunteers	25	TotalNbrVolunteers
Total Gross UBI	0	TotalGrossUBI
Contributions Grants Prior Year	160093433	ContributionsGrantsPriorYear
Contributions Grants Current Year	156880684	ContributionsGrantsCurrentYear
Program Service Revenue Prior Year	0	ProgramServiceRevenuePriorYear
Program Service Revenue CY	774874	ProgramServiceRevenueCY
Investment Income Prior Year	850375	InvestmentIncomePriorYear
Investment Income Current Year	1048418	InvestmentIncomeCurrentYear
Other Revenue Prior Year	1742249	OtherRevenuePriorYear
Other Revenue Current Year	3393059	OtherRevenueCurrentYear
Total Revenue Prior Year	162686057	TotalRevenuePriorYear
Total Revenue Current Year	162097035	TotalRevenueCurrentYear
Grants And Similar Amnts Prior Year	0	GrantsAndSimilarAmntsPriorYear
Grants And Similar Amnts CY	0	GrantsAndSimilarAmntsCY
Benefits Paid To Members Prior Year	0	BenefitsPaidToMembersPriorYear
Benefits Paid To Members CY	0	BenefitsPaidToMembersCY
Salaries Etc Prior Year	82307396	SalariesEtcPriorYear
Salaries Etc Current Year	82248203	SalariesEtcCurrentYear
Total Prof Fundrsng Exp Prior Year	0	TotalProfFundrsngExpPriorYear
Total Prof Fundrsng Exp CY	196445	TotalProfFundrsngExpCY
Total Fundrsng Exp Current Year	3337433	TotalFundrsngExpCurrentYear
Other Expense Prior Year	78857656	OtherExpensePriorYear
Other Expenses Current Year	75933118	OtherExpensesCurrentYear
Total Expenses Prior Year	161165052	TotalExpensesPriorYear
Total Expenses Current Year	158377766	TotalExpensesCurrentYear
Revenues Less Expenses Prior Year	1521005	RevenuesLessExpensesPriorYear
Revenues Less Expenses CY	3719269	RevenuesLessExpensesCY
Total Assets BOY	321579555	TotalAssetsBOY
Total Assets EOY	316383458	TotalAssetsEOY
Total Liabilities BOY	115088741	TotalLiabilitiesBOY
Total Liabilities EOY	109159237	TotalLiabilitiesEOY
Net Assets Or Fund Balances BOY	206490814	NetAssetsOrFundBalancesBOY
Net Assets Or Fund Balances EOY	207224221	NetAssetsOrFundBalancesEOY
Info In Schedule O Part III	X	InfoInScheduleOPartIII
Mission Description	SEE SCHEDULE O	MissionDescription
Significant New Program Services	false	SignificantNewProgramServices
Significant Change	false	SignificantChange
Expense	133658916	Expense
Grants	0	Grants
Revenue	0	Revenue
Description	SEE SCHEDULE O	Description
Total Program Service Expense	133658916	TotalProgramServiceExpense
Described In501 C3	true	DescribedIn501C3
Schedule B Required	true	ScheduleBRequired
Political Activities	false	PoliticalActivities
Lobbying Activities	true	LobbyingActivities
Subject To Proxy Tax	false	SubjectToProxyTax
Donor Advised Funds	false	DonorAdvisedFunds
Conservation Easements	false	ConservationEasements
Collections Of Art	false	CollectionsOfArt
Credit Counseling	false	CreditCounseling
Term Or Permanent Endowments	true	TermOrPermanentEndowments
Report Land Bldg Equip	true	ReportLandBldgEquip
Report Invest Oth Securities	false	ReportInvestOthSecurities
Report Prog Rel Invest	false	ReportProgRelInvest
Report Other Assets	false	ReportOtherAssets
Report Other Liabilities	false	ReportOtherLiabilities
Report Fin48 Footnote	true	ReportFin48Footnote
Independent Audit Financial Stmt	true	IndependentAuditFinancialStmt
Consolidated Audit Financial Stmt	false	ConsolidatedAuditFinancialStmt
School	false	School
Foreign Office	true	ForeignOffice
Foreign Activities	true	ForeignActivities
More Than5000 K To Organizations	false	MoreThan5000KToOrganizations
More Than5000 K To Individuals	false	MoreThan5000KToIndividuals
Professional Fundraising	true	ProfessionalFundraising
Fundraising Activities	true	FundraisingActivities
Gaming	false	Gaming
Hospital	false	Hospital
Grants To Organizations	false	GrantsToOrganizations
Grants To Individuals	false	GrantsToIndividuals
Schedule J Required	true	ScheduleJRequired
Tax Exempt Bonds	true	TaxExemptBonds
Invest Tax Exempt Bonds	false	InvestTaxExemptBonds
Escrow Account	false	EscrowAccount
On Behalf Of Issuer	false	OnBehalfOfIssuer
Excess Benefit Transaction	false	ExcessBenefitTransaction
Prior Excess Benefit Transaction	false	PriorExcessBenefitTransaction
Loan To Officer Or DQP	true	LoanToOfficerOrDQP
Grant To Related Person	false	GrantToRelatedPerson
Bsnss Rltnshp With Organization	false	BsnssRltnshpWithOrganization
Bsnss Rltnshp Thru Family Member	false	BsnssRltnshpThruFamilyMember
Officer Entity With Bsnss Rltnshp	true	OfficerEntityWithBsnssRltnshp
Deductible Non Cash Contributions	true	DeductibleNonCashContributions
Deductible Contributions Of Art	false	DeductibleContributionsOfArt
Terminated	false	Terminated
Partial Liquidation	false	PartialLiquidation
Disregarded Entity	false	DisregardedEntity
Related Entity	true	RelatedEntity
Related Org Controlled Entity	false	RelatedOrgControlledEntity
Transaction Related Entity	false	TransactionRelatedEntity
Transfers To Exempt Non Chrtbl Org	false	TransfersToExemptNonChrtblOrg
Activities Conducted Partnership	false	ActivitiesConductedPartnership
Schedule O Required	true	ScheduleORequired
Number Forms Transmitted With1096	224	NumberFormsTransmittedWith1096
Number W2 G Included	0	NumberW2GIncluded
Compliance With Backup Witholding	true	ComplianceWithBackupWitholding
Number Of Employees	1157	NumberOfEmployees
Employment Tax Returns Filed	true	EmploymentTaxReturnsFiled
Unrelated Business Income	false	UnrelatedBusinessIncome
Foreign Financial Account	false	ForeignFinancialAccount
Prohibited Tax Shelter Trans	false	ProhibitedTaxShelterTrans
Taxable Party Notification	false	TaxablePartyNotification
Non Deductible Contributions	false	NonDeductibleContributions
Quid Pro Quo Contributions	true	QuidProQuoContributions
Quid Pro Quo Disclosure	true	QuidProQuoDisclosure
Form8282 Property Disposed Of	false	Form8282PropertyDisposedOf
Funds To Pay Premiums	false	FundsToPayPremiums
Premiums Paid	false	PremiumsPaid
Indoor Tanning Services	false	IndoorTanningServices
Info In Schedule O Part VI	X	InfoInScheduleOPartVI
Nbr Voting Governing Body Members	21	NbrVotingGoverningBodyMembers
Number Independent Voting Members	16	NumberIndependentVotingMembers
Family Or Business Relationship	false	FamilyOrBusinessRelationship
Delegation Of Management Duties	false	DelegationOfManagementDuties
Changes To Organizing Docs	false	ChangesToOrganizingDocs
Material Diversion Or Misuse	false	MaterialDiversionOrMisuse
Members Or Stockholders	false	MembersOrStockholders
Election Of Board Members	false	ElectionOfBoardMembers
Decisions Subject To Approval	false	DecisionsSubjectToApproval
Minutes Of Governing Body	true	MinutesOfGoverningBody
Minutes Of Committees	true	MinutesOfCommittees
Officer Mailing Address	false	OfficerMailingAddress
Local Chapters	false	LocalChapters
Form990 Provided To Governing Body	true	Form990ProvidedToGoverningBody
Conflict Of Interest Policy	true	ConflictOfInterestPolicy
Annual Disclosure Covered Persons	true	AnnualDisclosureCoveredPersons
Regular Monitoring Enforcement	true	RegularMonitoringEnforcement
Whistleblower Policy	true	WhistleblowerPolicy
Document Retention Policy	true	DocumentRetentionPolicy
Compensation Process CEO	true	CompensationProcessCEO
Compensation Process Other	true	CompensationProcessOther
Investment In Joint Venture	false	InvestmentInJointVenture
States Where Copy Of Return Is Filed	AK	StatesWhereCopyOfReturnIsFiled
States Where Copy Of Return Is Filed	CA	StatesWhereCopyOfReturnIsFiled
States Where Copy Of Return Is Filed	CT	StatesWhereCopyOfReturnIsFiled
States Where Copy Of Return Is Filed	FL	StatesWhereCopyOfReturnIsFiled
States Where Copy Of Return Is Filed	KS	StatesWhereCopyOfReturnIsFiled
States Where Copy Of Return Is Filed	MD	StatesWhereCopyOfReturnIsFiled
States Where Copy Of Return Is Filed	NJ	StatesWhereCopyOfReturnIsFiled
States Where Copy Of Return Is Filed	NY	StatesWhereCopyOfReturnIsFiled
States Where Copy Of Return Is Filed	PA	StatesWhereCopyOfReturnIsFiled
States Where Copy Of Return Is Filed	VA	StatesWhereCopyOfReturnIsFiled
Upon Request	X	UponRequest

The Books Are In Care Of TheBooksAreInCareOf

Field	Value	IRS element (for citing)
Name Person	GARY F RAISL EDD EVP CAO CFO	NamePerson
Telephone Number	8586463100	TelephoneNumber

Address US AddressUS

Field	Value	IRS element (for citing)
Address Line1	10901 N TORREY PINES ROAD	AddressLine1
City	LA JOLLA	City
State	CA	State
ZIP Code	92037	ZIPCode

Field	Value	IRS element (for citing)
Info In Schedule O Part VII	X	InfoInScheduleOPartVII

Form990 Part VII Section A Form990PartVIISectionA (36 entries)

TitleTitle	Average Hours Per WeekAverageHoursPerWeek	Individual Trustee Or DirectorIndividualTrusteeOrDirector	Reportable Comp From OrganizationReportableCompFromOrganization	Reportable Comp From Related OrgsReportableCompFromRelatedOrgs	Other CompensationOtherCompensation	OfficerOfficer	Highest Compensated EmployeeHighestCompensatedEmployee
LORENZO BERHO
TRUSTEE	1.0	X	0	0	0
ARTHUR BRODY
TRUSTEE	1.0	X	0	0	0
SHEHAN DISSANAYAKE
TRUSTEE	1.0	X	0	0	0
DANIEL EPSTEIN
TRUSTEE	1.0	X	0	0	0
WAIN FISHBURN
TRUSTEE/CHAIRMAN	1.0	X	0	0	0	X
PAULINE FOSTER
TRUSTEE	1.0	X	0	0	0
ALAN GLEICHER
TRUSTEE	1.0	X	0	0	0
DAVID HALE
TRUSTEE	1.0	X	0	0	0
JEANNE HERBERGER
TRUSTEE	1.0	X	0	0	0
BRENT JACOBS
TRUSTEE	1.0	X	0	0	0
JAMES JARDON
TRUSTEE	1.0	X	0	0	0
ROBERT LAUER
TRUSTEE	1.0	X	0	0	0
GREG LUCIER
TRUSTEE	1.0	X	0	0	0
ROBERT MANDELL
TRUSTEE	1.0	X	0	0	0
NICOLAS NIERENBERG
TRUSTEE	1.0	X	0	0	0
DOUGLAS OBENSHAIN
TRUSTEE	1.0	X	0	0	0
PETER PREUSS
TRUSTEE	1.0	X	0	0	0
DUANNE ROTH
TRUSTEE	1.0	X	0	0	0
STUART TANZ
TRUSTEE	1.0	X	0	0	0
JAN TUTTLEMAN
TRUSTEE	1.0	X	0	0	0
ANDREW VITERBI
TRUSTEE	1.0	X	0	0	0
BARBARA WARREN
TRUSTEE	1.0	X	0	0	0
ALLEN WEISS
TRUSTEE	1.0	X	0	0	0
GAYLE WILSON
TRUSTEE	1.0	X	0	0	0
DIANE WINOKUR
TRUSTEE	1.0	X	0	0	0
JOHN C REED MD PHD
CEO	50.0	X	942673	0	427253	X
KRISTIINA VUORI MD PHD
PRESIDENT	50.0	X	757003	0	345887	X
STUART LIPTON MD PHD
CENTER DIRECTOR	50.0	X	464312	0	58415
CARL WARE PHD
CENTER DIRECTOR	50.0	X	359943	0	49600
GARY F RAISL EDD
EVP/CAO/CFO/TREASURER	50.0		511225	0	50559	X
MARGARET DUNBAR JD
SECRETARY/SR DIRECTOR IP	50.0		172085	0	20302	X
DANIEL KELLY MD
SCIENTIFIC DIRECTOR	50.0		487867	0	50968		X
PAUL LAIKIND PHD
SR VP CBO	50.0		468434	0	59835		X
JORGE MOSCAT PHD
PROFESSOR	50.0		282768	0	36499		X
TARIQ RANA PHD
PROGRAM DIRECTOR	50.0		281338	0	45966		X
EDGAR GILLENWATERS
VP EXTERNAL RELATIONS	50.0		272625	0	63366		X

Field	Value	IRS element (for citing)
Total Reportable Comp From Org	5000273	TotalReportableCompFromOrg
Total Reportable Comp Frm Rltd Orgs	0	TotalReportableCompFrmRltdOrgs
Total Other Compensation	1208650	TotalOtherCompensation
Number Individuals GT100 K	128	NumberIndividualsGT100K
Formers Listed	false	FormersListed
Total Comp GT150 K	true	TotalCompGT150K
Compensation From Other Sources	false	CompensationFromOtherSources

Contractor Compensation ContractorCompensation (5 entries)

Address Line1AddressOfContractor/AddressUS/AddressLine1	CityAddressOfContractor/AddressUS/City	StateAddressOfContractor/AddressUS/State	ZIP CodeAddressOfContractor/AddressUS/ZIPCode	Description Of ServicesDescriptionOfServices	CompensationCompensation
DLA PIPER US LLP
PO BOX 64029	BALTIMORE	MD	21264	LEGAL	665449
PABST PATENT GROUP
1545 PEACHTREE ST NE SUITE 320	ATLANTA	GA	30309	LEGAL	588922
JONES DAY
12265 EL CAMINO REAL SUITE 200	SAN DIEGO	CA	92130	LEGAL	309882
DELOITTE TOUCHE
200 SOUTH ORANGE SUITE 1800	ORLANDO	FL	32801	AUDIT	243384
BERMAN PROPERTY MANAGEMENT LLC
100 W LUCERNE CIRCLE SUITE 403	ORLANDO	FL	32801	JANITORIAL	237363

Field	Value	IRS element (for citing)
Number Of Contractors GT100 K	10	NumberOfContractorsGT100K
Fundraising Events	1790026	FundraisingEvents
Government Grants	124523171	GovernmentGrants
All Other Contributions	30567487	AllOtherContributions
Noncash Contributions	1083713	NoncashContributions
Total Contributions	156880684	TotalContributions

Program Service Revenue ProgramServiceRevenue

Field	Value	IRS element (for citing)
Description	SHARED SERVICE REVENUE	Description
Business Code	541900	BusinessCode
Total Revenue Column	774874	TotalRevenueColumn
Related Or Exempt Function Income	774874	RelatedOrExemptFunctionIncome

Field	Value	IRS element (for citing)
Total Program Service Revenue	774874	TotalProgramServiceRevenue

Investment Income InvestmentIncome

Field	Value	IRS element (for citing)
Total Revenue Column	930497	TotalRevenueColumn
Exclusion	$930,497	ExclusionAmount

Income From Invest Bond Proceeds IncomeFromInvestBondProceeds

Field	Value	IRS element (for citing)
Total Revenue Column	44815	TotalRevenueColumn
Exclusion	$44,815	ExclusionAmount

Royalties Revenue RoyaltiesRevenue

Field	Value	IRS element (for citing)
Total Revenue Column	3270214	TotalRevenueColumn
Exclusion	$3,270,214	ExclusionAmount

Gross Rents GrossRents

Field	Value	IRS element (for citing)
Real	156675	Real

Rental Income Or Loss RentalIncomeOrLoss

Field	Value	IRS element (for citing)
Real	156675	Real

Net Rental Income Or Loss NetRentalIncomeOrLoss

Field	Value	IRS element (for citing)
Total Revenue Column	156675	TotalRevenueColumn
Exclusion	$156,675	ExclusionAmount

Gross Amount Sales Assets GrossAmountSalesAssets

Field	Value	IRS element (for citing)
Securities	12275645	Securities

Less Cost Oth Basis Sales Expenses LessCostOthBasisSalesExpenses

Field	Value	IRS element (for citing)
Securities	12202539	Securities

Gain Or Loss GainOrLoss

Field	Value	IRS element (for citing)
Securities	73106	Securities

Net Gain Or Loss Investments NetGainOrLossInvestments

Field	Value	IRS element (for citing)
Total Revenue Column	73106	TotalRevenueColumn
Exclusion	$73,106	ExclusionAmount

Field	Value	IRS element (for citing)
Gross Income Fundraising Events	112366	GrossIncomeFundraisingEvents
Cntrbtns Rprtd Fundraising Events	1790026	CntrbtnsRprtdFundraisingEvents
Fundraising Direct Expenses	516839	FundraisingDirectExpenses

Net Income From Fundraising Events NetIncomeFromFundraisingEvents

Field	Value	IRS element (for citing)
Total Revenue Column	-404473	TotalRevenueColumn
Exclusion	-$404,473	ExclusionAmount

Net Income From Gaming NetIncomeFromGaming

Field	Value	IRS element (for citing)
Total Revenue Column	0	TotalRevenueColumn

Net Income Or Loss NetIncomeOrLoss

Field	Value	IRS element (for citing)
Total Revenue Column	0	TotalRevenueColumn

Other Revenue Misc OtherRevenueMisc (3 entries)

DescriptionDescription	Business CodeBusinessCode	Total Revenue ColumnTotalRevenueColumn	ExclusionExclusionAmount
REAGENTS (BY PRODUCT OF EXEMPT RESEARCH)	541900	200087	$200,087
SYMPOSIUM FEES	541900	84350	$84,350
All other revenue	900099	86206	$86,206

Field	Value	IRS element (for citing)
Total Other Revenue	370643	TotalOtherRevenue

Total Revenue TotalRevenue

Field	Value	IRS element (for citing)
Total Revenue Column	162097035	TotalRevenueColumn
Related Or Exempt Function Income	774874	RelatedOrExemptFunctionIncome
Exclusion	$4,441,477	ExclusionAmount

Grants To Domestic Orgs GrantsToDomesticOrgs

Field	Value	IRS element (for citing)
Total	0	Total

Grants To Domestic Individuals GrantsToDomesticIndividuals

Field	Value	IRS element (for citing)
Total	0	Total

Foreign Grants ForeignGrants

Field	Value	IRS element (for citing)
Total	0	Total

Benefits To Members BenefitsToMembers

Field	Value	IRS element (for citing)
Total	0	Total

Comp Current Officers Directors CompCurrentOfficersDirectors

Field	Value	IRS element (for citing)
Total	3820675	Total
Program Services	2332592	ProgramServices
Management And General	1488083	ManagementAndGeneral

Comp Disqual Persons CompDisqualPersons

Field	Value	IRS element (for citing)
Total	0	Total

Other Salaries And Wages OtherSalariesAndWages

Field	Value	IRS element (for citing)
Total	61993413	Total
Program Services	51424649	ProgramServices
Management And General	8872346	ManagementAndGeneral
Fundraising	1696418	Fundraising

Pension Plan Contributions PensionPlanContributions

Field	Value	IRS element (for citing)
Total	3909187	Total
Program Services	3121685	ProgramServices
Management And General	691364	ManagementAndGeneral
Fundraising	96138	Fundraising

Other Employee Benefits OtherEmployeeBenefits

Field	Value	IRS element (for citing)
Total	8713053	Total
Program Services	7263485	ProgramServices
Management And General	1252448	ManagementAndGeneral
Fundraising	197120	Fundraising

Payroll Taxes PayrollTaxes

Field	Value	IRS element (for citing)
Total	3811875	Total
Program Services	3081173	ProgramServices
Management And General	621288	ManagementAndGeneral
Fundraising	109414	Fundraising

Fees For Services Management FeesForServicesManagement

Field	Value	IRS element (for citing)
Total	1298851	Total
Program Services	1093605	ProgramServices
Management And General	205211	ManagementAndGeneral
Fundraising	35	Fundraising

Fees For Services Legal FeesForServicesLegal

Field	Value	IRS element (for citing)
Total	1566460	Total
Program Services	61955	ProgramServices
Management And General	1504505	ManagementAndGeneral

Fees For Services Accounting FeesForServicesAccounting

Field	Value	IRS element (for citing)
Total	498836	Total
Management And General	498836	ManagementAndGeneral

Fees For Services Lobbying FeesForServicesLobbying

Field	Value	IRS element (for citing)
Total	126038	Total
Management And General	126038	ManagementAndGeneral

Fees For Services Prof Fundraising FeesForServicesProfFundraising

Field	Value	IRS element (for citing)
Total	196445	Total
Fundraising	196445	Fundraising

Fees For Services Invst Mgmnt Fees FeesForServicesInvstMgmntFees

Field	Value	IRS element (for citing)
Total	0	Total

Fees For Services Other FeesForServicesOther

Field	Value	IRS element (for citing)
Total	808701	Total
Program Services	453669	ProgramServices
Management And General	222301	ManagementAndGeneral
Fundraising	132731	Fundraising

Advertising Advertising

Field	Value	IRS element (for citing)
Total	44857	Total
Management And General	6656	ManagementAndGeneral
Fundraising	38201	Fundraising

Office Expenses OfficeExpenses

Field	Value	IRS element (for citing)
Total	9820758	Total
Program Services	9107239	ProgramServices
Management And General	589275	ManagementAndGeneral
Fundraising	124244	Fundraising

Information Technology InformationTechnology

Field	Value	IRS element (for citing)
Total	1741934	Total
Program Services	1238920	ProgramServices
Management And General	495559	ManagementAndGeneral
Fundraising	7455	Fundraising

Royalties Royalties

Field	Value	IRS element (for citing)
Total	0	Total

Occupancy Occupancy

Field	Value	IRS element (for citing)
Total	13817632	Total
Program Services	12302843	ProgramServices
Management And General	1383193	ManagementAndGeneral
Fundraising	131596	Fundraising

Travel Travel

Field	Value	IRS element (for citing)
Total	874746	Total
Program Services	735935	ProgramServices
Management And General	110666	ManagementAndGeneral
Fundraising	28145	Fundraising

Travel Entrtnmnt Public Officials TravelEntrtnmntPublicOfficials

Field	Value	IRS element (for citing)
Total	0	Total

Conferences Meetings ConferencesMeetings

Field	Value	IRS element (for citing)
Total	1477921	Total
Program Services	1058675	ProgramServices
Management And General	362528	ManagementAndGeneral
Fundraising	56718	Fundraising

Interest Interest

Field	Value	IRS element (for citing)
Total	4030913	Total
Program Services	3659666	ProgramServices
Management And General	333356	ManagementAndGeneral
Fundraising	37891	Fundraising

Payments To Affiliates PaymentsToAffiliates

Field	Value	IRS element (for citing)
Total	0	Total

Depreciation Depletion DepreciationDepletion

Field	Value	IRS element (for citing)
Total	19986867	Total
Program Services	17405538	ProgramServices
Management And General	2396889	ManagementAndGeneral
Fundraising	184440	Fundraising

Insurance Insurance

Field	Value	IRS element (for citing)
Total	53377	Total
Management And General	53377	ManagementAndGeneral

Other Expenses OtherExpenses (4 entries)

DescriptionDescription	TotalTotal	Program ServicesProgramServices	Management And GeneralManagementAndGeneral	FundraisingFundraising
Research supplies & services	12684932	12684932
Scientific collaborations	6324867	6324867
Recruitment	349094	181481	53369	114244
Miscellaneous	426334	126007	114129	186198

Total Functional Expenses TotalFunctionalExpenses

Field	Value	IRS element (for citing)
Total	158377766	Total
Program Services	133658916	ProgramServices
Management And General	21381417	ManagementAndGeneral
Fundraising	3337433	Fundraising

Cash Non Interest Bearing CashNonInterestBearing

Field	Value	IRS element (for citing)
BOY	2816447	BOY
EOY	2011199	EOY

Savings And Temp Cash Investments SavingsAndTempCashInvestments

Field	Value	IRS element (for citing)
BOY	9163063	BOY
EOY	7878644	EOY

Pledges And Grants Receivable PledgesAndGrantsReceivable

Field	Value	IRS element (for citing)
BOY	34446878	BOY
EOY	32920556	EOY

Accounts Receivable AccountsReceivable

Field	Value	IRS element (for citing)
BOY	288168	BOY
EOY	230956	EOY

Receivables From Officers Etc ReceivablesFromOfficersEtc

Field	Value	IRS element (for citing)
BOY	942475	BOY
EOY	1142218	EOY

Receivables From Disqual Persons ReceivablesFromDisqualPersons

Field	Value	IRS element (for citing)
BOY	0	BOY
EOY	0	EOY

Other Notes Loans Receivable Net OtherNotesLoansReceivableNet

Field	Value	IRS element (for citing)
BOY	6451607	BOY
EOY	6173667	EOY

Inventories For Sale Or Use InventoriesForSaleOrUse

Field	Value	IRS element (for citing)
BOY	899924	BOY
EOY	629240	EOY

Prepaid Expenses Deferred Charges PrepaidExpensesDeferredCharges

Field	Value	IRS element (for citing)
BOY	8944007	BOY
EOY	8065520	EOY

Field	Value	IRS element (for citing)
Land Buildings Equipment Basis	283732280	LandBuildingsEquipmentBasis
Land Bldg Equipment Accum Deprec	116139261	LandBldgEquipmentAccumDeprec

Land Buildings Equipment Basis Net LandBuildingsEquipmentBasisNet

Field	Value	IRS element (for citing)
BOY	183343497	BOY
EOY	167593019	EOY

Investments Pub Traded Securities InvestmentsPubTradedSecurities

Field	Value	IRS element (for citing)
BOY	70789430	BOY
EOY	86413448	EOY

Investments Other Securities InvestmentsOtherSecurities

Field	Value	IRS element (for citing)
BOY	0	BOY
EOY	0	EOY

Investments Program Related InvestmentsProgramRelated

Field	Value	IRS element (for citing)
BOY	0	BOY
EOY	0	EOY

Intangible Assets IntangibleAssets

Field	Value	IRS element (for citing)
BOY	0	BOY
EOY	0	EOY

Other Assets Total OtherAssetsTotal

Field	Value	IRS element (for citing)
BOY	3494059	BOY
EOY	3324991	EOY

Total Assets TotalAssets

Field	Value	IRS element (for citing)
BOY	321579555	BOY
EOY	316383458	EOY

Accounts Payable Accrued Expenses AccountsPayableAccruedExpenses

Field	Value	IRS element (for citing)
BOY	20655550	BOY
EOY	20849521	EOY

Grants Payable GrantsPayable

Field	Value	IRS element (for citing)
BOY	0	BOY
EOY	0	EOY

Deferred Revenue DeferredRevenue

Field	Value	IRS element (for citing)
BOY	12245663	BOY
EOY	11772199	EOY

Tax Exempt Bond Liabilities TaxExemptBondLiabilities

Field	Value	IRS element (for citing)
BOY	82187528	BOY
EOY	76537517	EOY

Escrow Account Liability EscrowAccountLiability

Field	Value	IRS element (for citing)
BOY	0	BOY
EOY	0	EOY

Loans From Officers Directors LoansFromOfficersDirectors

Field	Value	IRS element (for citing)
BOY	0	BOY
EOY	0	EOY

Mort Notes Pybl Secured Invest Prop MortNotesPyblSecuredInvestProp

Field	Value	IRS element (for citing)
BOY	0	BOY
EOY	0	EOY

Unsecured Notes Loans Payable UnsecuredNotesLoansPayable

Field	Value	IRS element (for citing)
BOY	0	BOY
EOY	0	EOY

Other Liabilities OtherLiabilities

Field	Value	IRS element (for citing)
BOY	0	BOY
EOY	0	EOY

Total Liabilities TotalLiabilities

Field	Value	IRS element (for citing)
BOY	115088741	BOY
EOY	109159237	EOY

Field	Value	IRS element (for citing)
Follow SFAS117	X	FollowSFAS117

Unrestricted Net Assets UnrestrictedNetAssets

Field	Value	IRS element (for citing)
BOY	78809513	BOY
EOY	74517313	EOY

Temporarily Restricted Net Assets TemporarilyRestrictedNetAssets

Field	Value	IRS element (for citing)
BOY	115687533	BOY
EOY	120682803	EOY

Permanently Restricted Net Assets PermanentlyRestrictedNetAssets

Field	Value	IRS element (for citing)
BOY	11993768	BOY
EOY	12024105	EOY

Total Net Assets Fund Balances TotalNetAssetsFundBalances

Field	Value	IRS element (for citing)
BOY	206490814	BOY
EOY	207224221	EOY

Total Liab Net Assets Fund Balances TotalLiabNetAssetsFundBalances

Field	Value	IRS element (for citing)
BOY	321579555	BOY
EOY	316383458	EOY

Field	Value	IRS element (for citing)
Info In Schedule O Part XI	X	InfoInScheduleOPartXI
Reconcilation Revenue Expenses	3719269	ReconcilationRevenueExpenses
Reconcilation Other Changes	-2985862	ReconcilationOtherChanges
Method Of Accounting Accrual	X	MethodOfAccountingAccrual
Accountant Compile Or Review	false	AccountantCompileOrReview
FS Audited	true	FSAudited
Audit Committee	true	AuditCommittee
Financial Statement Separate	X	FinancialStatementSeparate
Federal Grant Audit Required	true	FederalGrantAuditRequired
Federal Grant Audit Performed	true	FederalGrantAuditPerformed

Schedule A IRS990ScheduleA

Field	Value	IRS element (for citing)
Publicly Supported Org170b1 Avi	X	PubliclySupportedOrg170b1Avi

Gifts Grants Contrib Received170 GiftsGrantsContribReceived170

Field	Value	IRS element (for citing)
Current Tax Year Minus4 Years	103328720	CurrentTaxYearMinus4Years
Current Tax Year Minus3 Years	209859230	CurrentTaxYearMinus3Years
Current Tax Year Minus2 Years	150769181	CurrentTaxYearMinus2Years
Current Tax Year Minus1 Year	160093433	CurrentTaxYearMinus1Year
Current Tax Year	156880684	CurrentTaxYear
Total	780931248	Total

Total170 Total170

Field	Value	IRS element (for citing)
Current Tax Year Minus4 Years	103328720	CurrentTaxYearMinus4Years
Current Tax Year Minus3 Years	209859230	CurrentTaxYearMinus3Years
Current Tax Year Minus2 Years	150769181	CurrentTaxYearMinus2Years
Current Tax Year Minus1 Year	160093433	CurrentTaxYearMinus1Year
Current Tax Year	156880684	CurrentTaxYear
Total	780931248	Total

Field	Value	IRS element (for citing)
Amounts Subst Contributors Total	14453736	AmountsSubstContributorsTotal
Public Support Total170	766477512	PublicSupportTotal170

Gross Investment Income170 GrossInvestmentIncome170

Field	Value	IRS element (for citing)
Current Tax Year Minus4 Years	3955763	CurrentTaxYearMinus4Years
Current Tax Year Minus3 Years	1995011	CurrentTaxYearMinus3Years
Current Tax Year Minus2 Years	1354102	CurrentTaxYearMinus2Years
Current Tax Year Minus1 Year	2037946	CurrentTaxYearMinus1Year
Current Tax Year	4402201	CurrentTaxYear
Total	13745023	Total

Other Income170 OtherIncome170

Field	Value	IRS element (for citing)
Current Tax Year Minus4 Years	303840	CurrentTaxYearMinus4Years
Current Tax Year Minus3 Years	286205	CurrentTaxYearMinus3Years
Current Tax Year Minus2 Years	343630	CurrentTaxYearMinus2Years
Current Tax Year Minus1 Year	907754	CurrentTaxYearMinus1Year
Current Tax Year	370643	CurrentTaxYear
Total	2212072	Total

Field	Value	IRS element (for citing)
Total Support	796888343	TotalSupport
Gross Receipts From Admissions Etc	1314412	GrossReceiptsFromAdmissionsEtc
Public Support Pertcentage170	0.96184	PublicSupportPertcentage170
Public Support Pertcent Prior Year	0.97231	PublicSupportPertcentPriorYear
Thirty Three Percnt Tests CY170	X	ThirtyThreePercntTestsCY170

Schedule B IRS990ScheduleB

Contributor Info ContributorInfo

Field	Value	IRS element (for citing)
Contributor Number	RESTRICTED	ContributorNumber

Contributor Name Business ContributorNameBusiness

Field	Value	IRS element (for citing)
Business Name Line1	RESTRICTED	BusinessNameLine1

Contributor Address US ContributorAddressUS

Field	Value	IRS element (for citing)
Address Line1	RESTRICTED	AddressLine1
Address Line2	RESTRICTED	AddressLine2
City	RESTRICTED	City
State	RESTRICTED	State
ZIP Code	RESTRICTED	ZIPCode

Field	Value	IRS element (for citing)
Aggregate Contributions	RESTRICTED	AggregateContributions

Schedule C IRS990ScheduleC

Field	Value	IRS element (for citing)
Total Grassroots Lobbying		TotalGrassrootsLobbying
Total Direct Lobbying		TotalDirectLobbying
Total Lobbying Expenditures		TotalLobbyingExpenditures
Other Exempt Purpose Expenditures		OtherExemptPurposeExpenditures
Total Exempt Purpose Expenditures		TotalExemptPurposeExpenditures
Lobbying Nontaxable		LobbyingNontaxableAmount
Grassroots Nontaxable		GrassrootsNontaxableAmount
Tot Lobbying Grassroot Minus Non Tx		TotLobbyingGrassrootMinusNonTx
Tot Lobby Expend Mns Lobbying Nontx		TotLobbyExpendMnsLobbyingNontx
Volunteers	false	Volunteers
Paid Staff Or Management	false	PaidStaffOrManagement
Media Advertisements	false	MediaAdvertisements
Mailings Members	false	MailingsMembers
Publications Or Broadcast	false	PublicationsOrBroadcast
Grants Other Organizations	false	GrantsOtherOrganizations
Direct Contact Legislators	true	DirectContactLegislators
Direct Contact Legislators	$140,384	DirectContactLegislatorsAmount
Rallies Demonstrations	false	RalliesDemonstrations
Other Activities	true	OtherActivities
Other Activities	$126,038	OtherActivitiesAmount
Total Lobbying Expenditures IIB	266422	TotalLobbyingExpendituresIIB
Not Described In501c3	false	NotDescribedIn501c3

Form990 Schedule C Part IV Form990ScheduleCPartIV

Field	Value	IRS element (for citing)
Identifier	LOBBYING ACTIVITIES	Identifier
Return Reference	SCHEDULE C, PART II-B	ReturnReference
Explanation	LINE 1G - CONTACT AND MEET WITH FEDERAL AND STATE LEGISLATORS AND THEIR STAFF TO SEEK POTENTIAL RESEARCH FUNDING. LINE 1I - DUES TO RESEARCH AND BIOMEDICAL ORGANIZATIONS, A PORTION OF WHICH ARE CONSIDERED LOBBYING. THE INSTITUTE CONTRACTS WITH HURT NORTON AND ASSOCIATES FOR REPRESENTATION IN WASHINGTON, DC, TO INVESTIGATE AND SEEK POTENTIAL FEDERAL RESEARCH FUNDING OPPORTUNITIES OUTSIDE THE TRADITIONAL NIH PROCESS.	Explanation

Schedule D IRS990ScheduleD

Field	Value	IRS element (for citing)
Art Public Exhibition Amts		ArtPublicExhibitionAmts
Held Works Of Art Amts		HeldWorksOfArtAmts

Current Year CurrentYear

Field	Value	IRS element (for citing)
Beginning Of Year Balance	21602848	BeginningOfYearBalance
Contributions	29575	Contributions
Investment Earnings Or Losses	961439	InvestmentEarningsOrLosses
Other Expenditures	1393391	OtherExpenditures
End Of Year Balance	21200471	EndOfYearBalance

Current Year Minus1 Year CurrentYearMinus1Year

Field	Value	IRS element (for citing)
Beginning Of Year Balance	19352544	BeginningOfYearBalance
Contributions	1050000	Contributions
Investment Earnings Or Losses	1656322	InvestmentEarningsOrLosses
Other Expenditures	456018	OtherExpenditures
End Of Year Balance	21602848	EndOfYearBalance

Current Year Minus2 Years CurrentYearMinus2Years

Field	Value	IRS element (for citing)
Beginning Of Year Balance	15181323	BeginningOfYearBalance
Contributions	2983403	Contributions
Investment Earnings Or Losses	1912336	InvestmentEarningsOrLosses
Other Expenditures	724518	OtherExpenditures
End Of Year Balance	19352544	EndOfYearBalance

Current Year Minus3 Years CurrentYearMinus3Years

Field	Value	IRS element (for citing)
Beginning Of Year Balance	17485831	BeginningOfYearBalance
Contributions	55002	Contributions
Investment Earnings Or Losses	-2359510	InvestmentEarningsOrLosses
Other Expenditures	0	OtherExpenditures
End Of Year Balance	15181323	EndOfYearBalance

Field	Value	IRS element (for citing)
Board Designated EOY Balance	0.43280	BoardDesignatedEOYBalance
Permanent Endowment EOY Balance	0.56720	PermanentEndowmentEOYBalance
Endowments Held By Unrelated Orgs	false	EndowmentsHeldByUnrelatedOrgs
Endowments Held By Related Orgs	false	EndowmentsHeldByRelatedOrgs

Land Land

Field	Value	IRS element (for citing)
Other Cost Or Other Basis	25793087	OtherCostOrOtherBasis
Book Value	25793087	BookValue

Buildings Buildings

Field	Value	IRS element (for citing)
Other Cost Or Other Basis	162127121	OtherCostOrOtherBasis
Depreciation	49202842	Depreciation
Book Value	112924279	BookValue

Field	Value	IRS element (for citing)
Leasehold Improvements		LeaseholdImprovements

Equipment Equipment

Field	Value	IRS element (for citing)
Other Cost Or Other Basis	95770521	OtherCostOrOtherBasis
Depreciation	66936419	Depreciation
Book Value	28834102	BookValue

Other Land Buildings OtherLandBuildings

Field	Value	IRS element (for citing)
Other Cost Or Other Basis	41551	OtherCostOrOtherBasis
Depreciation	0	Depreciation
Book Value	41551	BookValue

Field	Value	IRS element (for citing)
Total Of Book Value Land Buildings	167593019	TotalOfBookValueLandBuildings
Federal Income Tax Liability	0	FederalIncomeTaxLiability
Total Of Amounts	0	TotalOfAmounts
Total Revenue	162097035	TotalRevenue
Total Expenses	158377766	TotalExpenses
Excess Or Deficit For Year	3719269	ExcessOrDeficitForYear
Net Unrealized GL On Investments	-1212803	NetUnrealizedGLOnInvestments
Other	-$1,772,466	OtherAmount
Total Adjustments	-2985269	TotalAdjustments
Excess Or Deficit Per FS	734000	ExcessOrDeficitPerFS
Tot Revenue Etc Audited Fincl Stmt	160884000	TotRevenueEtcAuditedFinclStmt
Other Revenues	-1213035	OtherRevenues
Revenue Not Rptd F990	-1213035	RevenueNotRptdF990
Revenue Subtotal	162097035	RevenueSubtotal
Total Revenue Per Form990	162097035	TotalRevenuePerForm990
Tot Expenses Etc Audited Fincl Stmt	160150000	TotExpensesEtcAuditedFinclStmt
Other Expenses Included	1772234	OtherExpensesIncluded
Expenses Not Rptd F990	1772234	ExpensesNotRptdF990
Expenses Subtotal	158377766	ExpensesSubtotal
Total Expenses Per Form990	158377766	TotalExpensesPerForm990

Form990 Schedule D Part XIV Form990ScheduleDPartXIV (5 entries)

IdentifierIdentifier	Return ReferenceReturnReference	ExplanationExplanation
INTENDED USES OF THE ORGANIZATION'S ENDOWMENT FUNDS	SCHEDULE D, PART V, LINE 4	THE INSTITUTE'S ENDOWMENT FUNDS ARE ESTABLISHED FOR VARIOUS PURPOSES: SCIENTIFIC RESEARCH, ALS RESEARCH, CEO CHAIR, PRESIDENTIAL CHAIR, AND UNRESTRICTED AS TO INCOME.
FIN 48 (ASC 740) FOOTNOTE	SCHEDULE D, PART X, LINE 2	THE INSTITUTE HAS NO MATERIAL DEFERRED TAX ASSETS OR DEFERRED TAX LIABILITIES RECORDED AS OF JUNE 30, 2012 AND 2011. THE INSTITUTE DID NOT RECOGNIZE A CHANGE IN LIABILITY FOR UNRECOGNIZED TAX BENEFITS (THE DIFFERENCE BETWEEN A TAX POSITION TAKEN, OR EXPECTED TO BE TAKEN, IN A TAX RETURN AND THE BENEFIT RECOGNIZED AND MEASURED IN THE FINANCIAL STATEMENTS). THE INSTITUTES LIABILITY FOR UNRECOGNIZED TAX BENEFITS WAS $0 AT JUNE 30, 2012 AND 2011.
DETAIL OF AMOUNT	SCHEDULE D, PART XI, LINE 8	UNREALIZED LOSS ON INTEREST RATE SWAP $(1,773,062) ROUNDING $ 596 ------------ $(1,772,466)
DETAIL OF AMOUNT	SCHEDULE D, PART XII, LINE 2D	UNREALIZED LOSS ON INVESTMENTS $(1,212,803) ROUNDING $ (232) ------------ $(1,213,035)
DETAIL OF AMOUNT	SCHEDULE D, PART XIII, LINE 2D	UNREALIZED LOSS ON INTEREST RATE SWAP $ 1,773,062 ROUNDING $ (828) ------------ $ 1,772,234

Schedule F IRS990ScheduleF

Accts Actvs Out US Table AcctsActvsOutUSTable (8 entries)

RegionRegion	Number Of EmployeesNumberOfEmployees	Type Of Activities ConductedTypeOfActivitiesConducted	Total ExpendituresTotalExpenditures
Europe (Including Iceland and Greenland)	63	Agents Attending/Speaking a	173313
East Asia and the Pacific	26	Agents Attending/Speaking a	57647
North America	2	Agents Attending/Speaking a	976
South Asia	3	Agents Attending/Speaking a	576
Middle East and North Africa	4	Agents Attending/Speaking a	7947
Russia and the Newly Independent States	4	Agents Attending/Speaking a	6060
South America	2	Agents Attending/Speaking a	2825
Central America and the Caribbean	7	Agents Attending/Speaking a	18763

Field	Value	IRS element (for citing)
Subtotal Number Of Employees	88	SubtotalNumberOfEmployees
Total Number Of Employees	111	TotalNumberOfEmployees
Subtotal Amount Spent	268107	SubtotalAmountSpent
Total Amount Spent	268107	TotalAmountSpent
Transfer To Foreign Corp	false	TransferToForeignCorp
Interest In Foreign Trust	false	InterestInForeignTrust
Own Foreign Corp	false	OwnForeignCorp
Passive Foreign Invest Co	false	PassiveForeignInvestCo
Foreign Partnership	false	ForeignPartnership
Boycott Countries	false	BoycottCountries

Form990 Schedule F Part V Form990ScheduleFPartV (2 entries)

IdentifierIdentifier	Return ReferenceReturnReference	ExplanationExplanation
SUPPLEMENTAL INFORMATION	SCHEDULE F, PART I, LINE 3	SANFORD-BURNHAM MEDICAL RESEARCH INSTITUTE DOES NOT MAINTAIN ONGOING OPERATIONS IN FOREIGN JURISDICTIONS. HOWEVER, THE INSTITUTE'S SCIENTISTS DO TRAVEL TO VARIOUS SCIENTIFIC CONFERENCES IN OTHER COUNTRIES TO SHARE THE INSTITUTE'S SCIENTIFIC DISCOVERIES, AS WELL AS TO LEARN FROM OTHER SCIENTISTS ACROSS THE WORLD.
ACCOUNTING METHOD	SCHEDULE F, PART I, LINE 3, COLUMN (F)	THE ACCRUAL METHOD OF ACCOUNTING WAS USED TO DETERMINE THE AMOUNTS IN PART I, LINE 3, COLUMN (F)

Schedule G IRS990ScheduleG

Field	Value	IRS element (for citing)
Mail Solicitations	X	MailSolicitations
Email Solicitations	X	EmailSolicitations
Phone Solicitations	X	PhoneSolicitations
In Person Solicitations	X	InPersonSolicitations
Solicitation Of Non Govt Grants	X	SolicitationOfNonGovtGrants
Solicitation Of Govt Grants	X	SolicitationOfGovtGrants
Special Fundraising Events	X	SpecialFundraisingEvents
Agreement Ref Fundraising	true	AgreementRefFundraising

Fundraiser Activity Information FundraiserActivityInformation (2 entries)

Name Of IndividualNameOfIndividual	Address Line1AddressUS/AddressLine1	CityAddressUS/City	StateAddressUS/State	ZIP CodeAddressUS/ZIPCode	ActivityActivity	Fundraiser Control Of FundsFundraiserControlOfFunds	Gross ReceiptsGrossReceipts	Amount Retained By ContractorAmountRetainedByContractor	Net To OrganizationNetToOrganization
JEROLD PANAS LINZY PARTNERS	500 NORTH MICHIGAN AVENUE	CHICAGO	IL	60611	CONSULTING FEE	false	0	142045	0
MICHELLE MONICA GLENN	6135 WOLFSTAR COURT	SAN DIEGO	CA	92122	CONSULTING FEE	false	0	54400	0

Field	Value	IRS element (for citing)
Total Gross Receipts	0	TotalGrossReceipts
Total Retained By Contractors	196445	TotalRetainedByContractors
Total Net To Organization	0	TotalNetToOrganization
Licensed States	AL	LicensedStates
Licensed States	AK	LicensedStates
Licensed States	CA	LicensedStates
Licensed States	CT	LicensedStates
Licensed States	FL	LicensedStates
Licensed States	KS	LicensedStates
Licensed States	LA	LicensedStates
Licensed States	MD	LicensedStates
Licensed States	MA	LicensedStates
Licensed States	NJ	LicensedStates
Licensed States	NY	LicensedStates
Licensed States	PA	LicensedStates
Licensed States	VA	LicensedStates

Events Information EventsInformation

Field	Value	IRS element (for citing)
Name Of Event1	GALA	NameOfEvent1
Gross Receipts Event1	1594891	GrossReceiptsEvent1
Charitable Contributions Event1	1543035	CharitableContributionsEvent1
Gross Revenue Event1	51856	GrossRevenueEvent1
Rent Facility Costs Event1	14180	RentFacilityCostsEvent1
Food And Beverage Event1	55323	FoodAndBeverageEvent1
Entertainment Event1	109370	EntertainmentEvent1
Other Direct Expenses Event1	61298	OtherDirectExpensesEvent1
Name Of Event2	BRING IT	NameOfEvent2
Gross Receipts Event2	243808	GrossReceiptsEvent2
Charitable Contributions Event2	203428	CharitableContributionsEvent2
Gross Revenue Event2	40380	GrossRevenueEvent2
Food And Beverage Event2	41078	FoodAndBeverageEvent2
Entertainment Event2	62053	EntertainmentEvent2
Other Direct Expenses Event2	40642	OtherDirectExpensesEvent2
Total Number Of Other Events	1	TotalNumberOfOtherEvents
Gross Receipts Other Events	63692	GrossReceiptsOtherEvents
Charitable Contrib Other Events	43562	CharitableContribOtherEvents
Gross Revenue Other Events	20130	GrossRevenueOtherEvents
Other Direct Expenses Other Events	132894	OtherDirectExpensesOtherEvents
Gross Receipts Total	1902391	GrossReceiptsTotal
Charitable Contributions Total	1790025	CharitableContributionsTotal
Gross Revenue Total Events	112366	GrossRevenueTotalEvents
Rent Facility Costs Total Events	14180	RentFacilityCostsTotalEvents
Food And Beverage Total Events	96401	FoodAndBeverageTotalEvents
Entertainment Total Events	171423	EntertainmentTotalEvents
Other Direct Expenses Total Events	234834	OtherDirectExpensesTotalEvents
Direct Expense Summary Events	516838	DirectExpenseSummaryEvents
Net Income Summary	-404472	NetIncomeSummary

Schedule J IRS990ScheduleJ

Field	Value	IRS element (for citing)
First Class Or Charter Travel	X	FirstClassOrCharterTravel
Club Dues Or Fees	X	ClubDuesOrFees
Written Policy Re T And E Expenses	true	WrittenPolicyReTAndEExpenses
Substantiation Required	true	SubstantiationRequired
Compensation Committee	X	CompensationCommittee
Independent Consultant	X	IndependentConsultant
Form990 Of Other Organizations	X	Form990OfOtherOrganizations
Written Employment Contract	X	WrittenEmploymentContract
Compensation Survey	X	CompensationSurvey
Board Or Committee Approval	X	BoardOrCommitteeApproval
Severance Payment	false	SeverancePayment
Supplemental Nonqual Retire Plan	true	SupplementalNonqualRetirePlan
Equity Based Comp Arrangement	false	EquityBasedCompArrangement
Comp Based On Revenue Of Filing Org	false	CompBasedOnRevenueOfFilingOrg
Comp Based On Revenue Related Orgs	false	CompBasedOnRevenueRelatedOrgs
Comp Based Net Earnings Filing Org	false	CompBasedNetEarningsFilingOrg
Comp Based Net Earnings Relate Orgs	false	CompBasedNetEarningsRelateOrgs
Any Non Fixed Payments	true	AnyNonFixedPayments
Initial Contract Exception	false	InitialContractException

Form990 Schedule J Part II Form990ScheduleJPartII (11 entries)

Base Compensation Filing OrgBaseCompensationFilingOrg	Comp Based On Related OrgsCompBasedOnRelatedOrgs	Bonus Filing OrgBonusFilingOrg	Bonus Related OrgsBonusRelatedOrgs	Other Compensation Filing OrgOtherCompensationFilingOrg	Other Compensation Related OrgsOtherCompensationRelatedOrgs	Deferred Comp Filing OrgDeferredCompFilingOrg	Deferred Comp Related OrgsDeferredCompRelatedOrgs	Nontaxable Benefits Filing OrgNontaxableBenefitsFilingOrg	Nontaxable Benefits Related OrgsNontaxableBenefitsRelatedOrgs	Total Compensation Filing OrgTotalCompensationFilingOrg	Total Compensation Related OrgsTotalCompensationRelatedOrgs	Comp Report Prior990 Filing OrgCompReportPrior990FilingOrg	Comp Report Prior990 Related OrgsCompReportPrior990RelatedOrgs
JOHN C REED MD PHD
671250	0	270000	0	1423	0	400755	0	26498	0	1369926	0	0	0
KRISTIINA VUORI MD PHD
606126	0	150000	0	877	0	329807	0	16080	0	1102890	0	0	0
GARY F RAISL EDD
423996	0	84000	0	3229	0	25772	0	24787	0	561784	0	0	0
MARGARET DUNBAR JD
162324	0	8037	0	1724	0	19211	0	1091	0	192387	0	0	0
STUART LIPTON MD PHD
439274	0	21809	0	3229	0	25821	0	32594	0	522727	0	0	0
CARL WARE PHD
340201	0	16875	0	2867	0	35459	0	14141	0	409543	0	0	0
DANIEL KELLY MD
437324	0	48280	0	2263	0	26044	0	24924	0	538835	0	0	0
PAUL LAIKIND PHD
308971	0	157200	0	2263	0	34570	0	25265	0	528269	0	0	0
JORGE MOSCAT PHD
281463	0	0	0	1305	0	22615	0	13884	0	319267	0	0	0
TARIQ RANA PHD
265251	0	15000	0	1087	0	25321	0	20645	0	327304	0	0	0
EDGAR GILLENWATERS
225709	0	38264	0	8652	0	29209	0	34157	0	335991	0	0	0

Form990 Schedule J Part III Form990ScheduleJPartIII (4 entries)

IdentifierIdentifier	Return ReferenceReturnReference	ExplanationExplanation
SUPPLEMENTAL COMPENSATION INFORMATION	SCHEDULE J, PART 1, QUESTION 1A	THE PRESIDENT USED FIRST CLASS TRAVEL AS AN UPGRADE WHEN AVAILABLE. SHE USED HER MILES IN CONJUNCTION WITH AN ADDITIONAL FEE PAID BY THE INSTITUTE. THIS WAS NOT TREATED AS TAXABLE COMPENSATION. HEALTH OR SOCIAL CLUB DUES ARE NEGOTIATED IN THE HIRING PROCESS FOR CERTAIN EMPLOYEES. THE AMOUNTS WERE TREATED AS TAXABLE COMPENSATION.
SUPPLEMENTAL NONQUALIFIED RETIREMENT PLAN	SCHEDULE J, PART I, QUESTION 4B	THE PARTICIPANTS OF THE 457(F) DEFERRED COMPENSATION PLAN ARE JOHN REED AND KRISTIINA VUORI. VESTING FOR JOHN REED OCCURS THE EARLIEST OF 1/1/2019, OR DISABILITY, OR INVOLUNTARY TERMINATION WITHOUT CAUSE, OR THE PARTICIPANT'S RESIGNATION FOR GOOD CAUSE, OR THE DATE OF TERMINATION OF THE PLAN. VESTING FOR KRISTIINA VUORI OCCURS THE EARLIEST OF 4/1/2015, OR INVOLUNTARY TERMINATION WITHOUT CAUSE, OR PARTICIPANT'S RESIGNATION FOR GOOD CAUSE, OR THE DATE OF TERMINATION OF THE PLAN. DISTRIBUTIONS FOR BOTH PARTICIPANTS IS A ONE-TIME LUMP SUM PAYMENT UPON VESTING OF 100% OF THE VALUE OF THE PARTICIPANT'S INVESTMENT (COMPRISED OF INSTITUTE CONTRIBUTIONS TO THE CORPUS PLUS ANY INVESTMENT GAINS OR LOSSES THEREON).
NON FIXED PAYMENTS	SCHEDULE J, PART I, QUESTION 7	SOME SENIOR EXECUTIVES HAVE EMPLOYMENT AGREEMENTS STIPULATING A BONUS WILL BE PAID TO THEM PROVIDED CERTAIN GOALS OR ACCOMPLISHMENTS ARE ACHIEVED.
RETIREMENT AND OTHER DEFERRED COMPENSATION	SCHEDULE J, PART II, COLUMN (C)	THE AMOUNT REPORTED IN SCHEDULE J, PART II, COLUMN (C) FOR JOHN REED INCLUDES AN ACCRUAL OF $350,000 RELATED TO THE 457(F) PLAN DESCRIBED ABOVE AND FOR KRISTIINA VUORI AN ACCRUAL OF $300,000 RELATED TO THE 457(F) PLAN DESCRIBED ABOVE. THESE AMOUNTS ARE NOT VESTED AND ARE SUBJECT TO A SUBSTANTIAL RISK OF FORFEITURE.

Schedule K IRS990ScheduleK

Form990 Schedule K Part I Form990ScheduleKPartI (3 entries)

Issuer EINIssuerEIN	CUSIP NumberCUSIPNumber	Date IssuedDateIssued	Issue PriceIssuePrice	Description Of PurposeDescriptionOfPurpose	DefeasedDefeased	On Behalf Of IssuerOnBehalfOfIssuer	Pool FinancingPoolFinancing
COUNTY OF SAN DIEGO
956000934	797391G60	2006-02-01	60572867	SEE SCHEDULE O	false	false	false
COUNTY OF SAN DIEGO
956000934	797391K99	2005-10-05	24500000	FINANCE PROPERTY AND CAPITAL EQUIP	false	false	false
CALIFORNIA STATEWIDE COMMUNITIES DEVELOPMENT AUTH
956000934		2008-08-01	15300000	PURCHASE EQUIPMENT	false	false	false

Form990 Schedule K Part II Form990ScheduleKPartII (3 entries)

Total ProceedsTotalProceeds	Amount In Reserve FundAmountInReserveFund	Refunding EscrowRefundingEscrow	Issuance Costs From ProceedsIssuanceCostsFromProceeds	Credit EnhancementCreditEnhancement	Capital ExpendituresCapitalExpenditures	Other Spent ProceedsOtherSpentProceeds	Year Of Subst CompletionYearOfSubstCompletion	Current RefundingCurrentRefunding	Advance RefundingAdvanceRefunding	Final Allocation MadeFinalAllocationMade	Adequate Books And Recds MaintaindAdequateBooksAndRecdsMaintaind
60572867	3958500	46326377	745537	0	9542453	0	2000	false	true	true	true
24500000	0	0	485141	198474	23816385	0	2006	false	false	true	true
15300000	0	0	300000	0	13869914	1130086	2012	false	false	true	true

Form990 Schedule K Part III Form990ScheduleKPartIII (3 entries)

Owning Bond Financed PropertyOwningBondFinancedProperty	Any Lease ArrangementsAnyLeaseArrangements	Mngment Cntrct Bond Financd PrprtyMngmentCntrctBondFinancdPrprty	Engage Bond Counsel ContractsEngageBondCounselContracts	Any Research AgreementsAnyResearchAgreements	Engage Bond Counsel ResearchEngageBondCounselResearch	Prcntge Prvt Business Use By OthersPrcntgePrvtBusinessUseByOthers	Total Private Business UseTotalPrivateBusinessUse	Post Issuance Compliance ProcdrsPostIssuanceComplianceProcdrs
false	true	true	true	true	true	0.03840	0.03840	true
false	false	false		false		0		true
false	true	true	true	true	true	0.05540	0.05540	true

Form990 Schedule K Part IV Form990ScheduleKPartIV (3 entries)

Form8038 T FiledForm8038TFiled	Variable Rate IssueVariableRateIssue	Hedge Identified In Books And RecdsHedgeIdentifiedInBooksAndRecds	Gross Proceeds Invested In GICGrossProceedsInvestedInGIC	Business Name Line1NameOfGICProvider/BusinessNameLine1	Gross Proceeds InvestedGrossProceedsInvested	Exception To RebateExceptionToRebate	Term Of HedgeTermOfHedge	Superintegrated HedgeSuperintegratedHedge	Hedge TerminatedHedgeTerminated
0
true	false	false	false	0	false	false
BANK OF AMERICA
false	true	true	false	0	false	false	25.	true	false
0
false	false	false	false	0	false	false

Form990 Schedule K Part VI Form990ScheduleKPartVI

Field	Value	IRS element (for citing)
Identifier	SEE SCHEDULE O FOR PART I, LINES A-C	Identifier
Return Reference	SEE SCHEDULE O FOR PART III, LINE 4, COLUMN (C)	ReturnReference

Schedule L IRS990ScheduleL

Loan Table LoanTable (5 entries)

Purpose Of LoanPurposeOfLoan	Loan From OrganizationLoanFromOrganization	Original PrincipalOriginalPrincipalAmount	Balance DueBalanceDue	DefaultDefault	Approved By BoardApprovedByBoard	Written AgreementWrittenAgreement
DANIEL KELLY
QUAL. EMPLOYEE RELOC	X	$500,000	479167	false	true	true
STUART LIPTON
QUAL. EMPLOYEE RELOC	X	$400,000	195251	false	true	true
GARY RAISL
QUAL. EMPLOYEE RELOC	X	$225,000	225000	false	true	true
JORGE MOSCAT
QUAL. EMPLOYEE RELOC	X	$200,000	97063	false	true	true
TARIQ RANA
QUAL. EMPLOYEE RELOC	X	$200,000	145737	false	true	true

Field	Value	IRS element (for citing)
Total Balance Due	1142218	TotalBalanceDue

Form990 Schedule L Part IV Form990ScheduleLPartIV (3 entries)

RelationshipRelationship	Amount Of TransactionAmountOfTransaction	Description Of TransactionDescriptionOfTransaction	Sharing Of RevenuesSharingOfRevenues
LIFE TECHNOLOGIES INVITROGEN
TRUSTEE - GREG LUCIER	1479591	SUPPLIES AND SERVICES	false
LOCKTON
TRUSTEE - DOUG OBENSHAIN	195144	INSURANCE SERVICES	false
PHILIP GRAHAM - SON OF TRUSTEE
TRUSTEE - GAYLE WILSON	146332	COMPENSATION	false

Schedule M IRS990ScheduleM

Field	Value	IRS element (for citing)
Works Of Art		WorksOfArt
Art Historical Treasures		ArtHistoricalTreasures
Art Fractional Interest		ArtFractionalInterest
Books And Publications		BooksAndPublications
Clothing And Household Goods		ClothingAndHouseholdGoods
Cars And Other Vehicles		CarsAndOtherVehicles
Boats And Planes		BoatsAndPlanes
Intellectual Property		IntellectualProperty

Securities Publicly Traded SecuritiesPubliclyTraded

Field	Value	IRS element (for citing)
Non Cash Checkbox	X	NonCashCheckbox
Number Of Contributions	11	NumberOfContributions
Noncash Contribs Rptd F990	1039599	NoncashContribsRptdF990
Method Of Determining Revenues	FMV	MethodOfDeterminingRevenues

Field	Value	IRS element (for citing)
Securities Closely Held Stock		SecuritiesCloselyHeldStock
Securities Prtnrshp Trust Intrsts		SecuritiesPrtnrshpTrustIntrsts
Securities Miscellaneous		SecuritiesMiscellaneous
Qualified Contrib Hist Struct		QualifiedContribHistStruct
Qualified Contrib Other		QualifiedContribOther
Real Estate Residential		RealEstateResidential
Real Estate Commercial		RealEstateCommercial
Real Estate Other		RealEstateOther
Collectibles		Collectibles

Food Inventory FoodInventory

Field	Value	IRS element (for citing)
Non Cash Checkbox	X	NonCashCheckbox
Number Of Contributions	1	NumberOfContributions
Noncash Contribs Rptd F990	1200	NoncashContribsRptdF990
Method Of Determining Revenues	COST/SELLING PRICE	MethodOfDeterminingRevenues

Field	Value	IRS element (for citing)
Drugs And Medical Supplies		DrugsAndMedicalSupplies
Taxidermy		Taxidermy
Historical Artifacts		HistoricalArtifacts
Scientific Specimens		ScientificSpecimens
Archaeological Artifacts		ArchaeologicalArtifacts

Other Non Cash Contributions Table OtherNonCashContributionsTable (4 entries)

Non Cash CheckboxNonCashCheckbox	DescriptionDescription	Number Of ContributionsNumberOfContributions	Noncash Contribs Rptd F990NoncashContribsRptdF990	Method Of Determining RevenuesMethodOfDeterminingRevenues
X	DONOR/FUNDRAISING PARTY	2	24312	COST/SELLING PRICE
X	MERCHANDISE AT EVENT	6	15510	COST/SELLING PRICE
X	SHOW TICKETS AND DINNER	2	2657	COST/SELLING PRICE
X	US MINT STAMPS	1	435	COST/SELLING PRICE

Field	Value	IRS element (for citing)
Number Of8283 Received	0	NumberOf8283Received
Any Property That Must Be Held	false	AnyPropertyThatMustBeHeld
Review Process Unusual NC Gifts	false	ReviewProcessUnusualNCGifts
Third Parties Used	false	ThirdPartiesUsed

Form990 Schedule M Part II Form990ScheduleMPartII

Field	Value	IRS element (for citing)
Identifier	CONTRIBUTIONS RECIEVED	Identifier
Return Reference	SCHEDULE M, PART I, COLUMN(B)	ReturnReference
Explanation	COLUMN B IS REPORTING A COMBINATION OF THE NUMBER OF CONTRIBUTIONS RECEIVED AND THE NUMBER OF ITEMS RECEIVED.	Explanation

Schedule O IRS990ScheduleO

General Explanation GeneralExplanation (11 entries)

IdentifierIdentifier	Return ReferenceReturnReference	ExplanationExplanation
ORGANIZATION'S MISSION	FORM 990 - PART I, LINE 1 & PART III, LINE 1	SANFORD BURNHAM MEDICAL RESEARCH INSTITUTE CONDUCTS WORLD-CLASS COLLABORATIVE RESEARCH DEDICATED TO FINDING CURES FOR HUMAN DISEASE, IMPROVING THE QUALITY OF LIFE, AND THUS CREATING A LEGACY FOR ITS EMPLOYEES, PARTNERS, DONORS, AND COMMUNITY.
PROGRAM SERVICE ACCOMPLISHMENTS	FORM 990, PART III, LINE 4A	SANFORD-BURNHAM MEDICAL RESEARCH INSTITUTE IS DEDICATED TO DISCOVERING THE FUNDAMENTAL MOLECULAR CAUSES OF DISEASE AND DEVISING THE INNOVATIVE THERAPIES OF TOMORROW. SANFORD-BURNHAM TAKES A UNIQUE, COLLABORATIVE APPROACH TO MEDICAL RESEARCH AND HAS ESTABLISHED MAJOR RESEARCH PROGRAMS IN CANCER, NEURODEGENERATION, DIABETES, AND INFECTIOUS, INFLAMMATORY, AND CHILDHOOD DISEASES. IN THE AREA OF CANCER RESEARCH: SWARMING NANOPARTICLES FIGHT CANCER. RESEARCHERS HAVE BEEN WORKING FOR DECADES TO DEVELOP NANOPARTICLES THAT DELIVER CANCER DRUGS DIRECTLY TO TUMORS, MINIMIZING THE TOXIC SIDE EFFECTS OF CHEMOTHERAPY. A TEAM OF RESEARCHERS, INCLUDING DR. ERKKI RUOSLAHTI, DESIGNED A DELIVERY SYSTEM IN WHICH NANOPARTICLES HOME IN ON A TUMOR AND THEN CALL IN A MUCH LARGER SECOND WAVE OF NANOPARTICLES TO DISPENSE AN ANTI-CANCER DRUG. THIS COMMUNICATION BETWEEN NANOPARTICLES, ENABLED BY THE BODY'S OWN BIOCHEMISTRY, BOOSTS DRUG DELIVERY TO TUMORS MORE THAN 40-FOLD IN MOUSE MODELS. THE STUDY WAS PUBLISHED IN "NATURE MATERIALS." HOW CANCER CELLS SURVIVE STRESS. CANCER CELLS SURVIVE DURING TIMES WHEN NUTRIENTS ARE SCARCE USING A PROCESS CALLED AUTOPHAGY. A STUDY LED BY THE LABORATORY OF DR. JOHN REED FOUND THAT A PROTEIN KNOWN AS BI-1 REGULATES THIS MECHANISM. AUTOPHAGY, LITERALLY MEANING "SELF-EATING," IS A WAY FOR CELLS TO RE-USE THEIR INTERNAL COMPONENTS AND THUS MAINTAIN CRITICAL LEVELS OF ENERGETIC MOLECULES. THE STUDY, PUBLISHED IN GENES AND DEVELOPMENT, ALSO DEMONSTRATED THAT MICE WITH LOW BI-1 HAVE LOWER AUTOPHAGY RATES. IN ADDITION, EXPERIMENTALLY REDUCING BI-1 EXPRESSION IMPAIRED TUMOR GROWTH IN MICE. THE WORK UNCOVERED A NEW AREA RELEVANT TO THE UNDERSTANDING OF MECHANISMS OF CANCER DEVELOPMENT AND PROGRESSION. MOLECULAR SWITCH THAT ALLOWS MELANOMA TO RESIST THERAPY, IDENTIFIED. THE NATIONAL CANCER INSTITUTE (NCI) ESTIMATES THAT AS MANY AS ONE IN 51 MEN AND WOMEN WILL BE DIAGNOSED WITH MELANOMA-THE DEADLIEST FORM OF SKIN CANCER-AT SOME POINT DURING THEIR LIFETIMES. A RESEARCH TEAM LED BY DR. ZE'EV RONAI HAS BEEN STUDYING A PROTEIN NAMED ACTIVATING TRANSCRIPTION FACTOR 2 (ATF2), WHICH IS ASSOCIATED WITH POOR PROGNOSIS IN MELANOMA. THE FINDING PROVIDES THE BASIS FOR HIGH-CONTENT SCREENING, IN COLLABORATION WITH SANFORD-BURNHAM'S CONRAD PREBYS CENTER FOR CHEMICAL GENOMICS, WHERE RESEARCHERS ARE LOOKING FOR SMALL MOLECULES THAT CAUSE ATF2'S EXIT FROM THE NUCLEUS, WITH THE EXPECTATION THOSE WILL ALSO BE ABLE TO SENSITIZE MELANOMA TO THERAPY. THE WEEK IT WAS PUBLISHED, THIS STUDY WAS SELECTED BY THE NATIONAL CANCER INSTITUTE (NCI) AS ONE OF THE PAPERS HIGHLIGHTED ON ITS HOMEPAGE. TOWARDS PERSONALIZED BREAST CANCER THERAPY. DR. TIMOTHY OSBORNE AND COLLABORATORS RECENTLY FOUND A UNIQUE FINGERPRINT OF A SUBSET OF BREAST CANCERS. THIS STUDY, PUBLISHED IN THE JOURNAL CELL, FOUND THAT MUTANT FORMS OF THE PROTEIN P53 "PIGGYBACK" ONTO THE STEROL REGULATORY ELEMENT BINDING PROTEIN-2 (SREBP-2) TO REGULATE GENES REQUIRED FOR FAT SYNTHESIS IN SOME BREAST TUMOR CELLS. THE PRODUCTION OF FAT IS AN ESSENTIAL MECHANISM FOR THE UNCONTROLLED GROWTH OF TUMOR CELLS. MUTATIONS IN P53 ARE AMONG THE MOST COMMON CHANGES IN CANCER. THEREFORE, THIS PATHWAY REPRESENTS A TARGET FOR NEW THERAPIES THAT COULD BE HIGHLY USEFUL FOR PATIENTS WITH THIS SPECIFIC DISEASE MARKER-A PERSONALIZED CANCER TREATMENT APPROACH. SEARCHING FOR NEW CANCER DRUGS THAT INHIBIT THE SPREAD OF TUMORS. METASTASIS IS THE MOST COMMON REASON THAT CANCER TREATMENTS FAIL. TO METASTASIZE, SOME TYPES OF CANCER CELLS RELY ON INVADOPODIA, CELLULAR MEMBRANE PROJECTIONS THAT ACT LIKE FEET, HELPING THEM "WALK" AWAY FROM THE PRIMARY TUMOR AND INVADE SURROUNDING TISSUES. DR. SARA COURTNEIDGE AND SCIENTISTS IN THE CONRAD PREBYS CENTER FOR CHEMICAL GENOMICS SCREENED A COLLECTION OF CHEMICAL COMPOUNDS AND SUCCESSFULLY IDENTIFIED SOME COMPOUNDS THAT INHIBIT INVADOPODIA FORMATION AND SOME THAT ACTUALLY INCREASE THEIR NUMBER. ONE OF THE PRO-INVADOPODIA COMPOUNDS WAS THE CHEMOTHERAPEUTIC AGENT PACLITAXEL (TAXOL)-A FINDING THAT MIGHT HAVE IMPLICATIONS FOR THE DRUG'S CURRENT USE IN TREATING CANCER, IMPLYING THAT TAXOL MIGHT MAKE MATTERS WORSE BY ENCOURAGING METASTASIS! THESE FINDINGS WERE PUBLISHED IN "SCIENCE SIGNALING." CANCER DRUG'S SECRET TO RESISTANCE. DRUG RESISTANCE IS A SERIOUS PROBLEM FOR CANCER PATIENTS-OVER TIME, A THERAPY THAT WAS ONCE PROVIDING SOME BENEFIT SIMPLY STOPS WORKING. DR. MATTHEW PETROSKI AND COLLEAGUES RECENTLY DISCOVERED HOW CANCER CELLS DEVELOP RESISTANCE TO A DRUG CALLED MLN4924. THIS EXPERIMENTAL THERAPY IS CURRENTLY BEING TESTED IN A NUMBER OF PHASE I AND PHASE I/II CLINICAL TRIALS TO DETERMINE ITS EFFICACY AGAINST SEVERAL DIFFERENT TYPES OF CANCER, INCLUDING MULTIPLE MYELOMA, LEUKEMIA, AND LYMPHOMA. THE RESEARCH WAS PUBLISHED ONLINE MARCH 19 BY "CELL REPORTS." IN THE AREA OF NEUROSCIENCE AND AGING RESEARCH: GETTING TO THE ROOT OF ALZHEIMER'S DISEASE. ALZHEIMER'S DISEASE IS CHARACTERIZED BY ABNORMAL PROTEINS THAT STICK TOGETHER IN LITTLE GLOBS, DISRUPTING COGNITIVE FUNCTION. THESE STICKY PROTEINS ARE MOSTLY MADE UP OF BETA-AMYLOID PEPTIDE. A RESEARCH TEAM LED BY DR. STUART LIPTON FOUND THAT BETA-AMYLOID-INDUCED DESTRUCTION OF SYNAPSES-THE CONNECTIONS THAT MEDIATE COMMUNICATION BETWEEN NERVE CELLS-IS DRIVEN BY A CHEMICAL MODIFICATION TO AN ENZYME CALLED CDK5. THE TEAM FOUND THAT THIS ALTERED FORM OF CDK5 (SNO-CDK5) WAS PREVALENT IN HUMAN ALZHEIMER'S DISEASE BRAINS, BUT NOT IN NORMAL BRAINS. THESE RESULTS, PUBLISHED IN THE "PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES USA," SUGGEST THAT SNO-CDK5 COULD BE TARGETED FOR THE DEVELOPMENT OF NEW ALZHEIMER'S DISEASE THERAPIES. A SNAPSHOT ON VITAMIN A FUNCTION. DR. GREGG DUESTER'S LABORATORY HAS BEEN WORKING ON VITAMIN A FUNCTION FOR MORE THAN 20 YEARS AND HAS PROVIDED MANY OF THE BREAKTHROUGHS, PARTICULARLY ITS FUNCTION IN GROWTH AND DEVELOPMENT AFTER BEING METABOLIZED TO RETINOIC ACID. THE DUESTER LAB RECENTLY REPORTED ON RETINOIC ACID SIGNALING IN THE JOURNAL "CELL" THAT SUMMARIZED THE PATHWAY FOR VITAMIN A METABOLISM TO RETINOIC ACID AND THE GENES REGULATED BY RETINOIC ACID DURING GROWTH AND DEVELOPMENT. RETINOIC ACID IS A KEY AGENT OF CELLULAR DIFFERENTIATION NEEDED FOR GENERATION OF TISSUES FROM STEM CELLS DURING EMBRYONIC DEVELOPMENT, PLUS IT HELPS ADULTS REGENERATE DAMAGED TISSUES AND PREVENTS CANCER CELL GROWTH. STEM CELLS AND SPINAL CORD REPAIR. DR. EVAN SNYDER WAS INVITED BY THE "NEW ENGLAND JOURNAL OF MEDICINE" TO PROVIDE A FORMULATION OF THE STATE-OF-THE-ART OF STEM CELL BIOLOGY AS IT APPLIES TO SPINAL CORD INJURY. HIS CRITIQUE AND ADVICE FOR FUTURE DIRECTIONS IN THAT FIELD WERE PUBLISHED AS PART OF THE "JOURNAL'S" SERIES ON "CLINICAL IMPLICATIONS OF BASIC RESEARCH." AN EASIER (AND SAFER) ROUTE TO STEM CELL THERAPIES. RECENTLY, SCIENTISTS HAVE FIGURED OUT HOW TO GENETICALLY ENGINEER A SPECIAL KIND OF STEM CELL CALLED AN INDUCED PLURIPOTENT STEM CELL (IPSC) FROM ALMOST ANY TYPE OF ADULT CELL, SUCH AS A SKIN CELL. RESEARCHERS CAN THEN USE IPSCS TO STUDY HUMAN DEVELOPMENT OR TO CREATE "DISEASE IN A DISH," A TECHNIQUE THAT ALLOWS THEM TO MODEL AN INDIVIDUAL PATIENT'S SPECIFIC DISEASE AND SCREEN FOR PERSONALIZED TREATMENTS. DR. TARIQ RANA AND HIS TEAM UNCOVERED TWO NEW CHEMICAL COMPOUNDS THAT HAVE THE POWER TO DIAL UP SOME GENES AND TONE DOWN OTHERS IN A WAY THAT GENERATES IPSCS IN A SAFER AND MORE PREDICTABLE WAY. THESE FINDINGS, PUBLISHED IN STEM CELLS, SIGNIFICANTLY ADVANCES IPSC RESEARCH, BRINGING THESE SPECIAL CELLS CLOSER TO THERAPEUTIC APPLICATIONS.
PROGRAM SERVICE ACCOMPLISHMENTS CONTINUED		IN THE AREA OF DIABETES AND OBESITY RESEARCH: SUGAR-BURNING MOUSE. MUSCLE PERFORMANCE AND GENERAL FITNESS ARE PARTLY DETERMINED BY HOW WELL YOUR MUSCLE CELLS CAN USE SUGAR AS A FUEL SOURCE. CERTAIN DISEASE STATES SUCH AS OBESITY OR DIABETES REDUCE THE MUSCLE'S CAPACITY TO BURN SUGAR. DR. DANIEL KELLY AND HIS LABORATORY UNRAVELED A MECHANISM THAT INCREASES SUGAR BURNING IN MUSCLE. THE TEAM FOUND THAT TRIGGERING THIS EFFECT IN MICE MIMICS THE EFFECTS OF EXERCISE TRAINING. THESE FINDINGS, PUBLISHED IN THE JOURNAL "GENES & DEVELOPMENT," REVEAL NEW CANDIDATE DRUG TARGETS FOR COMMON METABOLIC DISEASES, SUCH AS OBESITY-RELATED DIABETES. HEART HORMONE SHAPES FAT METABOLISM. A NEW STUDY LED BY DR. SHEILA COLLINS AND HER LABORATORY SUGGESTS THAT THE HEART PLAYS A ROLE IN BREAKING DOWN FAT. THE STUDY, PUBLISHED IN THE "JOURNAL OF CLINICAL INVESTIGATION," DETAILS HOW HORMONES RELEASED BY THE HEART STIMULATE FAT CELL METABOLISM. THE HEART HORMONES TURN ON A PROCESS IN FAT TISSUE SIMILAR TO WHAT IS ACTIVATED WHEN THE BODY IS EXPOSED TO COLD, LEADING TO THE BURNING OF FAT TO GENERATE HEAT. THIS STUDY ADDS ANOTHER DIMENSION TO OUR UNDERSTANDING OF HOW THE BODY REGULATES FAT TISSUE AND COULD LEAD TO NEW WAYS TO REDUCE WEIGHT IN OBESE PATIENTS. THIS STUDY WAS NAMED "RECOMMENDED READING" BY THE FACULTY OF 1000 (F1000), A PRESTIGIOUS GROUP OF SCIENTISTS. UNRAVELING THE MACHINERY OF TISSUE GLUCOSE UPTAKE. ALL CELLS NEED GLUCOSE TO PRODUCE THE ENERGY THEY NEED TO SURVIVE. A STUDY LED BY DR. ZHEN JIANG IDENTIFIED A PROTEIN-CALLED CDP138-WHICH IS RESPONSIBLE FOR ENSURING THAT GLUT4, A GLUCOSE TRANSPORTER RESPONSIBLE FOR GLUCOSE UPTAKE FROM THE BLOODSTREAM, IS PROPERLY INSERTED IN THE CELLULAR MEMBRANE. THESE RESULTS, PUBLISHED IN THE JOURNAL "CELL METABOLISM," PROVIDE A NEW UNDERSTANDING OF GLUCOSE METABOLISM DURING NORMAL PROCESSES SUCH AS EXERCISE, AS WELL AS PATHOLOGICAL PROCESSES SUCH AS DIABETES. ALL WEIGHT GAIN IS NOT THE SAME. A STUDY BY DR. STEVEN SMITH AND COLLEAGUES PROVIDES NEW NUTRITIONAL INFORMATION THAT COULD SHAPE THE DEVELOPMENT OF PUBLIC HEALTH POLICY RECOMMENDATIONS. THE STUDY, PUBLISHED IN THE "JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION" (JAMA), EXAMINED THE IMPACT OF DIETS CONTAINING VARYING AMOUNTS OF PROTEIN ON WEIGHT GAIN, BODY COMPOSITION, AND ENERGY EXPENDITURE. THE RESULTS OF THE STUDY REVEALED THAT INCREASING THE PERCENT OF DIETARY PROTEIN WITH OVERFEEDING LED TO MORE LEAN BODY MASS RATHER THAN SOLELY EXPANDING FAT MASS. THIS WORK IS THE FIRST TO ANALYZE THE IMPACT OF DIETARY PROTEIN ON CALORIE EXCESS AND PROVIDES NEW GUIDANCE FOR DIETARY COMPOSITION RECOMMENDATIONS. CAN BAD FAT BECOME GOOD FAT? IN A STUDY PUBLISHED IN CELL METABOLISM, DR. DEV SIKDER'S GROUP DISCOVERED THAT OREXIN, A HORMONE PRODUCED IN THE BRAIN, ACTIVATES CALORIE-BURNING BROWN FAT IN MICE. INTERESTINGLY, OREXIN DEFICIENCY IS ASSOCIATED WITH OBESITY IN HUMANS, SUGGESTING THAT OREXIN SUPPLEMENTATION COULD PROVE EFFECTIVE AS A NEW THERAPEUTIC APPROACH FOR THE TREATMENT OF OBESITY. GIVEN THAT MOST CURRENT WEIGHT LOSS DRUGS ARE AIMED AT REDUCING A PERSON'S APPETITE, AN OREXIN-BASED THERAPY WOULD REPRESENT A NEW CLASS OF FAT-FIGHTING DRUGS THAT INCREASE ENERGY EXPENDITURE. A LINK BETWEEN REGULATION OF PROTEIN SYNTHESIS AND DIABETES. IN THE PRESTIGIOUS "NEW ENGLAND JOURNAL OF MEDICINE," DR. RANDAL KAUFMAN DESCRIBED NEW FINDINGS THAT DEMONSTRATE HOW ALTERATIONS IN PROTEIN SYNTHESIS IN THE PANCREAS' INSULIN-PRODUCING BETA CELLS CAN CAUSE DIABETES. THE INSIGHTS MAY LEAD TO NEW THERAPEUTIC STRATEGIES TO TREAT DIABETES. IN THE AREA OF CHILDREN'S HEALTH RESEARCH: EXCITING CLINICAL TRIAL NEWS FOR CHILDREN WITH INHERITED BONE DISEASE. FOR THE PAST 15 YEARS, DR. JOS LUIS MILLN AND COLLEAGUES HAVE STUDIED HYPOPHOSPHATASIA, AN INHERITED DISEASE THAT MAKES BONES DANGEROUSLY FRAGILE. BUOYED BY THE INITIAL RESULTS TESTED IN A MOUSE MODEL, ENOBIA PHARMA RESEARCHERS AND COLLABORATORS BEGAN TESTING ENB-0040 IN YOUNG PATIENTS WITH INFANTILE HYPOPHOSPHATASIA-THE MOST SEVERE FORM OF THE DISEASE. NOW, A PAPER PUBLISHED IN THE "NEW ENGLAND JOURNAL OF MEDICINE" REVEALS THE RESULTS OF THIS CLINICAL TRIAL WHICH HAS BEEN LIFE-CHANGING FOR SOME OF THE STUDY'S PARTICIPANTS. THREE YEAR-OLD CORINNA, FOR EXAMPLE, COULD NOT WALK WHEN SHE BEGAN TAKING ENB-0040. JUST EIGHT WEEKS LATER, SHE WAS RUNNING AND JUMPING. RARE BONE DISORDER REVEALS NEW INSIGHTS INTO AUTISM. CHILDREN WITH MULTIPLE HEREDITARY EXOSTOSES (MHE), AN INHERITED GENETIC DISEASE, SUFFER FROM MULTIPLE GROWTHS ON THEIR BONES THAT CAUSE PAIN AND DISFIGUREMENT. SOME PARENTS HAVE LONG OBSERVED THAT THEIR CHILDREN WITH MHE ALSO EXPERIENCE AUTISM-LIKE SOCIAL PROBLEMS. RESEARCHERS LED BY DR. YU YAMAGUCHI RECENTLY USED A MOUSE MODEL OF MHE TO INVESTIGATE COGNITIVE FUNCTION. THEY FOUND THAT MICE WITH A GENETIC DEFECT THAT MODELS HUMAN MHE SHOW SYMPTOMS THAT MEET THE THREE DEFINING CHARACTERISTICS OF AUTISM: SOCIAL IMPAIRMENT, LANGUAGE DEFICITS, AND REPETITIVE BEHAVIOR. THE STUDY, PUBLISHED IN THE "PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES," ALSO DEFINES THE MOLECULAR AND PHYSIOLOGICAL BASIS OF THIS BEHAVIOR, PINPOINTING THE AMYGDALA AS THE REGION OF THE BRAIN CAUSING AUTISTIC SYMPTOMS. IN THE AREA OF INFECTIOUS AND INFLAMMATORY DISEASES: LIGHTENING THE BURDEN OF LUNG FIBROSIS. PEOPLE WITH PERSISTENT INFLAMMATION IN THE LUNGS OFTEN DEVELOP DEBILITATING SCAR TISSUE THAT MAKES BREATHING DIFFICULT. DR. CARL WARE AND COLLABORATORS RECENTLY REVEALED A KEY ROLE FOR CYTOKINES-SIGNALING MOLECULES THAT MEDIATE INFLAMMATION-IN ASTHMA AND RELATED LUNG DISORDERS. THE RESEARCH DEMONSTRATES THAT NEUTRALIZING ONE PARTICULAR CYTOKINE CALLED LIGHT, WHICH WAS FIRST DISCOVERED BY DR. WARE, BLOCKS THE FORMATION OF LUNG SCARRING IN MICE. THESE RESULTS, PUBLISHED IN "NATURE MEDICINE," IDENTIFY CONDITIONS THAT MIGHT BE ALLEVIATED BY DRUGS THAT BLOCK LIGHT. NEW DRUGS FOR BRAIN INFLAMMATION. DRUG SCREENING EFFORTS BY DRS. FRAYDOON RASTINEJAD, PENGXIANG HUANG, AND COLLABORATORS, IDENTIFIED SMALL MOLECULES THAT ALTER A CRUCIAL PROTEIN CONTROLLING IMMUNE CELL GENES THAT CAUSE BRAIN INFLAMMATION. THE RESEARCHERS SHOWED THAT THE MOLECULE-CALLED CARDIAC GLYCOSIDE DIGOXIN-SPECIFICALLY INHIBITS A GENE REGULATOR CALLED RORYT. DIGOXIN, AND RELATED COMPOUNDS THAT ARE LESS TOXIC, DELAYED THE ONSET OF AND REDUCED INFLAMMATION IN THE BRAINS OF MICE. REPURPOSING DIGOXIN TO INHIBIT INFLAMMATION PROVIDES A NEW APPROACH TO TREATING AUTOIMMUNE DISEASES. THE STUDY WAS PUBLISHED IN "NATURE." HOW THE BODY FENDS OFF INFECTION. TO INVADE ORGANISMS SUCH AS HUMANS, BACTERIA MAKE USE OF A PROTEIN CALLED FLAGELLIN, PART OF A TAIL-LIKE APPENDAGE THAT HELPS THE BACTERIA MOVE ABOUT. NOW, FOR THE FIRST TIME, DR. ANDREI OSTERMAN AND COLLEAGUES DETERMINED THE 3D STRUCTURE OF THE INTERACTION BETWEEN THIS CRITICAL BACTERIAL PROTEIN AND AN IMMUNE MOLECULE CALLED TLR5, SHEDDING LIGHT ON HOW THE BODY PROTECTS ITSELF FROM SUCH FOREIGN INVADERS. THE STUDY, PUBLISHED IN "SCIENCE" ADVANCES KNOWLEDGE THAT'S KEY TO THE DESIGN OF NEW THERAPEUTICS. FLAGELLIN IS A COMPONENT IN SOME VACCINES AND A DERIVATIVE OF THIS PROTEIN IS CURRENTLY BEING DEVELOPED AS A MEDICAL COUNTERMEASURE TO RADIATION. TURNING THE FIGHT AGAINST BACTERIA INTO A FIGHT AGAINST RHEUMATOID ARTHRITIS. THE COMPLEMENT SYSTEM IS ONE OF THE IMMUNE SYSTEM'S MOST IMPORTANT WEAPONS FOR FIGHTING OFF INFECTION. COMPLEMENT CONSISTS OF NINE PROTEINS (C1 THROUGH C9) THAT DIRECTLY BIND BACTERIA AND PUNCH HOLES (PORES) IN THEIR MEMBRANES. USING X-RAY CRYSTALLOGRAPHY, RESEARCHERS LED BY DR. ROBERT LIDDINGTON SOLVED THE CRYSTAL STRUCTURE OF ONE CRITICAL PROTEIN C6 AND ANALYZED OTHER STRUCTURES, PUBLISHING THEIR FINDINGS IN THE "JOURNAL OF BIOLOGICAL CHEMISTRY." THIS INFORMATION COULD LEAD TO NOVEL THERAPIES FOR A VARIETY OF INFLAMMATORY DISEASES SUCH AS RHEUMATOID ARTHRITIS.
PROCESS USED BY MANAGEMENT AND/OR GOVERNING BODY TO REVIEW FORM 990	FORM 990, PART VI, LINE 11B	THE 990 IS PREPARED BY THE FINANCE DEPARTMENT. IT IS REVIEWED BY THE INSTITUTE'S TAX ADVISORS, SELECTED MEMBERS OF MANAGEMENT INCLUDING OFFICERS, AND THE AUDIT COMMITTEE OF THE BOARD OF TRUSTEES AND PROVIDED TO MEMBERS OF THE BOARD PRIOR TO FILING.
DESCRIPTION OF PROCESS TO MONITOR TRANSACTIONS FOR CONFLICT OF INTEREST	FORM 990, PART VI, LINE 12C	CONFLICT OF INTEREST STATEMENTS ARE GIVEN TO MANAGEMENT STAFF AND PRINCIPAL INVESTIGATORS ON A PERIODIC BASIS TO REPORT ON CONFLICTS OR LACK OF CONFLICTS. THE STATEMENTS ARE REVIEWED ANNUALLY BY THE SENIOR DIRECTOR, INTELLECTUAL PROPERTY AND THE SENIOR DIRECTOR, SPONSORED RESEARCH, WITH A SUMMARY OF THE REVIEW PROVIDED TO THE EXECUTIVE VICE PRESIDENT/CAO/CFO/TREASURER. AN ASSESSMENT IS MADE TO WHETHER A CONFLICT CAN BE MANAGED BY THE EXISTING DEPARTMENTS AND PRACTICES. CONFLICTS ARE BROUGHT TO THE BOARD OF TRUSTEES ON AN AS NEEDED BASIS. CONFLICTS AND POTENTIAL CONFLICTS THAT INVOLVE THE CEO OR THE PRESIDENT ARE BROUGHT TO THE BOARD OF TRUSTEES TO ADDRESS ANY ACTUAL OR POTENTIAL POSSIBILITY THAT THE DESIGNATED REVIEWERS (i.e., SENIOR DIRECTOR, INTELLECTUAL PROPERTY AND THE SENIOR DIRECTOR, SPONSORED RESEARCH, AND THE EXECUTIVE VICE PRESIDENT/CAO/CFO/TREASURER) COULD BE PRESSURED TO MAKE BIASED DECISIONS IN MANAGING CONFLICTS INVOLVING THE CEO OR PRESIDENT. AS TO RESTRICTIONS IMPOSED: THE INSTITUTE WILL EMPLOY THE MECHANISM THAT IS THE BEST FIT WITH THE FACTS AND CIRCUMSTANCES OF ANY IDENTIFIED CONFLICT OF INTEREST. METHODS TO MANAGE POTENTIAL CONFLICTS/ENFORECEMENT MECHANISM: REVIEWING MANAGEMENT AND THE TECHNOLOGY TRANSFER COMMITTEE OF THE BOARD OF TRUSTEES ARE RESPONSIBLE FOR MANAGING, REDUCING, OR ELIMINATING REAL OR POTENTIAL CONFLICTS OF INTEREST. EXAMPLES OF CONDTIONS OR RESTRICTIONS THAT MIGHT BE IMPOSED TO MANAGE, REDUCE, OR ELIMINATE CONFLICTS OF INTERESTS INCLUDE: -PUBLIC DISCLOSURE OF SIGNIFICANT FINANCIAL INTERESTS -MONITORING OF RESEARCH BY INDEPENDENT REVIEWERS -MODIFICATION OF THE RESEARCH PLAN -DISQUALIFICATION FROM PARTICIPATION IN THE PORTION OF FUNDED RESEARCH THAT COULD BE AFFECTED BY SIGNIFICANT FINANCIAL INTEREST -DIVESTITURE OF SIGNIFICANT FINANCIAL INTERESTS -SEVERENCE OF RELATIONSHIPS THAT CREATE ACTUAL OR POTENTIAL CONFLICTS -REVIEW OF COMMERCIAL SPONSORED RESEARCH AGREEMENTS FOR SCIENTIFIC MERIT BY THE PROGRAM PLANNING COMMITTEE -REMOVAL OF AN AFFECTED PARTY FROM NEGOTIATIONS WITH A COMPANY WITH HE/SHE HAS SIGNIFICANT FINANCIAL INTEREST.
PROCESS USED TO DETERMINE COMPENSATION	FORM 990, PART VI, LINES 15A AND 15B	ANNUALLY, THE INSTITUTE REQUIRES BOARD OF TRUSTEE APPROVAL OF COMPENSATION ADJUSTMENTS AND TOTAL COMPENSATION LEVELS FOR ALL OFFICERS AND OTHER "DISQUALIFIED PERSONS" (AS DEFINED BY IRC SECTION 4958). THE COMPENSATION COMMITTEE, A COMMITTEE DESIGNATED BY THE BOARD, IS RESPONSIBLE FOR THE PROCESS AND ENGAGING AN INDEPENDENT CONSULTING FIRM TO ASSIST IT IN REVIEWING THE TOTAL COMPENSATION PACKAGES (INCLUDING CASH AND NON-CASH BENEFITS) FOR THESE IDENTIFIED PERSONS. THE CONSULTANT REVIEWS THE VARIOUS TYPES OF DIRECT CASH COMPENSATION INCLUDING BASE SALARIES AND ANNUAL INCENTIVE AWARD OPPORTUNITIES AND PAYMENTS. IN ADDITION, THE CONSULTANT PROVIDES THE COMMITTEE AN ASSESSMENT OF TOTAL COMPENSATION INCLUDING THE CASH COMPONENTS MENTIONED ABOVE, PLUS EXECUTIVE BENEFITS AND PERQUISITES. THE CONSULTANT COLLECTS INFORMATION FROM VARIOUS SOURCES COVERING NOT-FOR-PROFIT AND FOR-PROFIT ORGANIZATIONS SIMILAR IN SIZE AND REFLECTING THE TALENT MARKETS FROM WHICH THE INSTITUTE DRAWS EXECUTIVE TALENT. THE NUMBER OF FOR-PROFIT ORGANIZATIONS USED IN THE SURVEY PROCESS DOES NOT EXCEED 50% OF THE TOTAL ORGANIZATION USED. THE COMPENSATION COMMITTEE UTILIZES THIS STUDY ALONG WITH PERFORMANCE DATA FOR EACH INDIVIDUAL TO SUPPORT THEIR DELIBERATIONS AND REVIEW OF PAY LEVELS IN RELATION TO THE EXECUTIVE COMPENSATION PAY PHILOSOPHY AND THE ORGANIZATION'S MISSION. THE DETERMINATION OF EXECUTIVE COMPENSATION IS ALSO DESIGNED TO MEET THE "REBUTTABLE PRESUMPTION OF REASONABLENESS" STANDARD AS OUTLINED IN THE TREASURY REGULATIONS. DECISIONS BY THE COMMITTEE ARE CONTEMPORANEOUSLY DOCUMENTED. THE COMMITTEE PRESENTS THE STUDY FINDINGS AND THE RESULTING DECISIONS TO THE ENTIRE BOARD OF TRUSTEES. THE INSTITUTE'S EXECUTIVE COMPENSATION PHILOSOPHY, WHICH IS REVIEWED ANNUALLY, IS AS FOLLOWS: TARGET EXECUTIVE BASE SALARY AND TOTAL CASH COMPENSATION IS BETWEEN THE 50TH AND 75TH PERCENTILES BY BLENDING DATA FROM SIMILARLY SIZED BIOTECHNOLOGY ORGANIZATIONS FROM THE NOT-FOR-PROFIT AND FOR-PROFIT SECTOR, RESEARCH INSTITUTES AND LARGE UNIVERSITIES. THE PROCESS WAS LAST COMPLETED ON JUNE 8, 2012 FOR THE FOLLOWING 8 POSITIONS: 1) CHIEF EXECUTIVE OFFICER; 2) PRESIDENT/CANCER CENTER DIRECTOR; 3) EXECUTIVE VICE PRESIDENT, CHIEF ADMINISTRATIVE OFFICER, CHIEF FINANCIAL OFFICER, AND TREASURER; 4) SCIENTIFIC DIRECTOR, SBMRI AT LAKE NONA; 5) CENTER DIRECTOR, NEUROSCIENCE AGING AND STEM CELL RESEARCH CENTER; 6) CENTER DIRECTOR, INFECTIOUS AND INFLAMMATORY DISEASE CENTER; 7) SENIOR VICE PRESIDENT, BUSINESS DEVELOPMENT; 8) SENIOR DIRECTOR OF INTELLECTUAL PROPERTY AND LEGAL AFFAIRS, AND SECRETARY OF THE BOARD
AVAIL OF GOV DOCS, CONFLICT OF INTEREST POLICY & FIN STMTS TO GEN PUBLIC	FORM 990, PART VI, LINE 19	DOCUMENTS ARE AVAILABLE UPON REQUEST.
OTHER CHANGES IN NET ASSETS OR FUND BALANCES	FORM 990, PART XI, LINE 5	NET UNREALIZED GAIN (LOSS) ON INVESTMENTS: $(1,212,803) UNREALIZED GAIN (LOSS) ON INTEREST RATE SWAP: $(1,773,062) ROUNDING: $ 3 ------------ $(2,985,862)
SCHEDULE K, PART I, ROW A, COLUMN (F)		REFINANCE 1999 BONDS AND FINANCE CAPITAL IMPROVEMENTS & EQUIPMENT.
SCHEDULE K, PART I, ROWS A-C		FOR THE BOND ISSUES LISTED IN PART I, THE ALTERNATIVE PERIOD USED FOR THE REPORTING REQUIREMENTS IN THIS SECTION IS THE TWELVE MONTHS ENDED DECEMBER 31, 2011.
SCHEDULE K, PART III, LINE 4, COLUMN (C)		THE PERCENTAGE OF FINANCED PROPERTY USED IN A PRIVATE BUSINESS FOR THE ANNUAL MEASUREMENT PERIOD ENDING 12/31/2011 IS 5.54%. THE PRIVATE BUSINESS USE PERCENTAGE OVER THE LIFE OF THE BONDS THROUGH 12/31/2011 IS 3.27%. THE PROJECTED PRIVATE BUSINESS USE PERCENTAGE OVER THE LIFE OF THE BONDS IS 4.35%.

Schedule R IRS990ScheduleR

Form990 Schedule R Part IV Form990ScheduleRPartIV

Name Of Related Org NameOfRelatedOrg

Field	Value	IRS element (for citing)
Business Name Line1	CHARITABLE REMAINDER ANNUITY TRUST	BusinessNameLine1

Field	Value	IRS element (for citing)
Primary Activity	SUPPORT	PrimaryActivity
Legal Domicile State	CA	LegalDomicileState

Direct Controlling Entity Name DirectControllingEntityName

Field	Value	IRS element (for citing)
Business Name Line1	SBMRI	BusinessNameLine1

Field	Value	IRS element (for citing)
Type Of Entity	TRUST	TypeOfEntity

Field	Value	IRS element (for citing)
Receipt Of Int Ann Rents Royalties	false	ReceiptOfIntAnnRentsRoyalties
Gift Grant Or Cap Contr To Other Org	false	GiftGrantOrCapContrToOtherOrg
Gift Grant Or Cap Contr Fr Other Org	false	GiftGrantOrCapContrFrOtherOrg
Loans Or Guarantees To Other Org	false	LoansOrGuaranteesToOtherOrg
Loans Or Guarantees From Other Org	false	LoansOrGuaranteesFromOtherOrg
Sale Of Assets To Other Org	false	SaleOfAssetsToOtherOrg
Purchase Of Assets From Other Org	false	PurchaseOfAssetsFromOtherOrg
Exchange Of Assets	false	ExchangeOfAssets
Rental Of Facilities To Other Orgs	false	RentalOfFacilitiesToOtherOrgs
Rental Of Facilities Fr Other Orgs	false	RentalOfFacilitiesFrOtherOrgs
Perform Of Services For Other Orgs	false	PerformOfServicesForOtherOrgs
Perform Of Services By Other Orgs	false	PerformOfServicesByOtherOrgs
Sharing Of Facilities	false	SharingOfFacilities
Sharing Of Paid Employees	false	SharingOfPaidEmployees
Reimbursement Paid To Other Org	false	ReimbursementPaidToOtherOrg
Reimbursement Paid By Other Org	false	ReimbursementPaidByOtherOrg
Other Transfer To Other Org	false	OtherTransferToOtherOrg
Other Transfer From Other Org	false	OtherTransferFromOtherOrg